Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 1: Perhydropyrrole[1,2-a]pyrazines

European Journal of Medicinal Chemistry

Volumn 46, Issue 10, 2011, Pages 4859-4869

  Dawidowski, MacIej ^a   Herold, Franciszek ^a   Chodkowski, Andrzej ^a   Kleps, Jerzy ^a   Szulczyk, Pawel ^a   Wilczek, Marcin ^b  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b UNIVERSITY OF WARSAW   (Poland)

Author keywords

2,6 Diketopiperazine; 2,6 Piperazinedione; Anticonvulsant activity; Chirality; Conformational analysis; Pyrrole 1,2 a pyrazine

Indexed keywords

2 (2 PHENYLETHYL) 4 PHENYL PERHYDROPYRROLE[1,2 ALPHA]PYRAZINE 1,3 DIONE HYDROCHLORIDE; 2 (2 PHENYLETHYL)PERHYDROPYRROLE[1,2 ALPHA]PYRAZINE 1,3 DIONE HYDROCHLORIDE; 2 (2PHENYLETHYL) 4 PHENYL PERHYDROPYRROLE[1,2 ALPHA]PYRAZINE 1,3 DIONE; 2 BENZYL 4 PHENYL PERHYDROPYRROLE[1,2 ALPHA]PYRAZINE 1,3 DIONE; 2 BENZYL 4 PHENYL PERHYDROPYRROLE[1,2 ALPHA]PYRAZINE 1,3 HYDROCHLORIDE; 2 METHYL 4 PHENYL PERHYDROPYRROLE[1,2 ALPHA]PYRAZINE 1,3 DIONE HYDROCHLORIDE; 2,6 DIKETOPIPERAZINE DERIVATIVE; ANTICONVULSIVE AGENT; ETHYL ALPHA(1,3 DIOXO 4 PHENYL PERHYDROPYRROLE[1,2 ALPHA]PYRAZIN 2 YL)ACETATE; PIPERAZINEDIONE; SODIUM ION; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CLONIC SEIZURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ROTAROD TEST; SEIZURE; SEIZURE THRESHOLD; STEREOCHEMISTRY;

ANIMALS; ANTICONVULSANTS; DIKETOPIPERAZINES; ELECTROSHOCK; EPILEPSY; HUMANS; MALE; MICE; MODELS, MOLECULAR; PENTYLENETETRAZOLE; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SEIZURES; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 80053187697     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.027     Document Type: Article

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