Direct costs of fractures in Canada and trends 1996-2006: A population-based cost-of-illness analysis

Journal of Bone and Mineral Research

Volumn 26, Issue 10, 2011, Pages 2419-2429

  Leslie, William D ^a   Metge, Colleen J ^a   Azimaee, Mahmoud ^a   Lix, Lisa M ^b   Finlayson, Gregory S ^a   Morin, Suzanne N ^c   Caetano, Patricia ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Canada; cohort study; costs; economic analysis; fractures; osteoporosis

Indexed keywords

ARTICLE; CANADA; CONTROLLED STUDY; FEMALE; FRACTURE; HEALTH CARE COST; HIP FRACTURE; HUMAN; HUMERUS FRACTURE; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; SEX RATIO; SPINE FRACTURE; WRIST FRACTURE;

COST OF ILLNESS; FEMALE; FRACTURES, BONE; HUMANS; MALE; MANITOBA; POPULATION SURVEILLANCE;

EID: 80053181086     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.457     Document Type: Article

References (35)

1. Lane NE,. Epidemiology, etiology, and diagnosis of osteoporosis. Am J Obstet Gynecol. 2006; 194 (2 Suppl): S3-11. (Pubitemid 43152482)
2. Berger C, Goltzman D, Langsetmo L, et al. Peak bone mass from longitudinal data: implications for the prevalence, pathophysiology, and diagnosis of osteoporosis. J Bone Miner Res. 2010; 25 (9): 1948-1957.
3. Adachi JD, Ioannidis G, Berger C, et al. The influence of osteoporotic fractures on health-related quality of life in community-dwelling men and women across Canada. Osteoporos Int. 2001; 12 (11): 903-8. (Pubitemid 34001002)
4. Hallberg I, Rosenqvist AM, Kartous L, Lofman O, Wahlstrom O, Toss G,. Health-related quality of life after osteoporotic fractures. Osteoporos Int. 2004; 15 (10): 834-41. (Pubitemid 39361955)
5. Abrahamsen B, van ST, Ariely R, Olson M, Cooper C,. Excess mortality following hip fracture: a systematic epidemiological review. Osteoporos Int. 2009; 20 (10): 1633-50.
6. Papaioannou A, Wiktorowicz ME, Adachi JD, et al. Mortality, Independence in Living and Re-fracture, One Year Following Hip Fracture in Canadians. J Soc Obstet Gynaecol Can. 2000; 22: 591-7.
7. Akobundu E, Ju J, Blatt L, Mullins CD,. Cost-of-illness studies: a review of current methods. Pharmacoeconomics. 2006; 24 (9): 869-90. (Pubitemid 44338298)
8. Drummond MF, Sculpher MJ, Torrance GW, O'Brien BJ, Stoddart GL., Methods for the economic evaluation of health care programs 3rd ed. New York: Oxford University Press; 2005.
9. Wiktorowicz ME, Goeree R, Papaioannou A, Adachi JD, Papadimitropoulos E,. Economic implications of hip fracture: health service use, institutional care and cost in Canada. Osteoporos Int. 2001; 12 (4): 271-8. (Pubitemid 34912733)
10. De Laet CE, van Hout BA, Burger H, Weel AE, Hofman A, Pols HA,. Incremental cost of medical care after hip fracture and first vertebral fracture: the Rotterdam study 1. Osteoporos Int. 1999; 10 (1): 66-72. (Pubitemid 29428017)
11. Pike C, Birnbaum HG, Schiller M, Sharma H, Burge R, Edgell ET,. Direct and indirect costs of non-vertebral fracture patients with osteoporosis in the US. Pharmacoeconomics. 2010; 28 (5): 395-409.
12. Shi N, Foley K, Lenhart G, Badamgarav E,. Direct healthcare costs of hip, vertebral, and non-hip, non-vertebral fractures. Bone. 2009; 45 (6): 1084-90.
13. Kilgore ML, Morrisey MA, Becker DJ, et al. Health care expenditures associated with skeletal fractures among Medicare beneficiaries, 1999-2005. J Bone Miner Res. 2009; 24 (12): 2050-5.
14. Mackey DC, Lui LY, Cawthon PM, et al. High-trauma fractures and low bone mineral density in older women and men. JAMA. 2007; 298 (20): 2381-8. (Pubitemid 350190779)
15. Roos NP,. Establishing a population data-based policy unit. Med Care. 1999; 37 (6 Suppl): JS15-26.
16. Adam T, Koopmanschap MA, Evans DB,. Cost-effectiveness analysis: can we reduce variability in costing methods ? Int J Technol Assess Health Care. 2003; 19 (2): 407-20. (Pubitemid 36818683)
17. Manitoba Centre for Health Policy. Population Health Research Data Repository. [University of Manitoba: U of M-Medicine]. 2010. Available at:; accessed July 1, 2010.
18. Roos LL Jr, Roos NP, Cageorge SM, Nicol JP,. How good are the data? Reliability of one health care data bank. Med Care. 1982; 20 (3): 266-76. (Pubitemid 12077083)
19. Roos LL, Gupta S, Soodeen RA, Jebamani L,. Data quality in an information-rich environment: Canada as an example. Can J Aging. 2005; 24 (Suppl 1): 153-70. (Pubitemid 40910640)
20. Roos LL, Nicol JP,. A research registry: uses, development, and accuracy. J Clin Epidemiol. 1999; 52 (1): 39-47. (Pubitemid 29064272)
21. Kozyrskyj AL, Mustard CA,. Validation of an electronic, population-based prescription database. Ann Pharmacother. 1998; 32 (11): 1152-7. (Pubitemid 28543459)
22. Curtis JR, Mudano AS, Solomon DH, Xi J, Melton ME, Saag KG,. Identification and validation of vertebral compression fractures using administrative claims data. Med Care. 2009; 47 (1): 69-72.
23. Curtis JR, Taylor AJ, Matthews RS, et al. " Pathologic" fractures: should these be included in epidemiologic studies of osteoporotic fractures ? Osteoporos Int. 2009; 20 (11): 1969-72.
24. Shanahan M, Steinbach C, Burchill C, Friesen D, Black C,. Adding up provincial expenditures on health care for Manitobans: a POPULIS project. Population Health Information System. Med Care. 1999; 37 (6 Suppl): JS60-82.
25. Baladi JF., Canadian Coordinating Office for Health Technology Assessment. A Guidance Document for the Costing Process. [Health Technology Assessment, Ottawa, Canada]. August, 1996. Available at; accessed July 2010.
26. Finlayson G, Reimer J, Dahl J, Stargardter M, McGowan K., The direct cost of hospitalizations in Manitoba 2005/06. [Manitoba Centre for Health Policy]. 2010. Available at:; accessed March 2009.
27. Finlayson G, Ekuma O, Yogendran MS, Burland E, Forget E., The additional cost of chronic disease in Manitoba. [Manitoba Centre for Health Policy]. 2010. Available at.
28. Pink GH, Bolley HB,. Physicians in health care management: 4. Case Mix Groups and Resource Intensity Weights: physicians and hospital funding. CMAJ. 1994; 150 (8): 1255-61. (Pubitemid 24168475)
29. Pink GH, Bolley HB,. Physicians in health care management: 3. Case Mix Groups and Resource Intensity Weights: an overview for physicians. CMAJ. 1994; 150 (6): 889-94. (Pubitemid 24144099)
30. Smith NS, Weiner JP,. Applying population-based case mix adjustment in managed care: the Johns Hopkins Ambulatory Care Group system. Manag Care Q. 1994; 2 (3): 21-34.
31. Leslie WD, Derksen S, Prior HJ, Lix LM, Metge C, O'Neil J,. The interaction of ethnicity and chronic disease as risk factors for osteoporotic fractures: a comparison in Canadian Aboriginals and non-Aboriginals. Osteoporos Int. 2006; 17 (9): 1358-68. (Pubitemid 44127323)
32. Pike C, Birnbaum HG, Schiller M, Swallow E, Burge RT, Edgell ET,. Economic burden of privately insured non-vertebral fracture patients with osteoporosis over a 2-year period in the US. Osteoporos Int. 2011; 22 (1): 47-56.
33. Nevitt MC, Ettinger B, Black DM, et al. The association of radiographically detected vertebral fractures with back pain and function: a prospective study. Ann Intern Med. 1998; 128 (10): 793-800. (Pubitemid 28267711)
34. Berg K, Intrator O,. Postacute care following stroke or hip fracture: single services and combinations used by Medicare beneficiaries (1987-1992). J Aging Health. 1999; 11 (1): 27-48. (Pubitemid 29063766)
35. Lonnroos E, Kautiainen H, Sund R, et al. Utilization of inpatient care before and after hip fracture: a population-based study. Osteoporos Int. 2009; 20 (6): 879-86.