Seropositivity is associated with insulin resistance in patients with early inflammatory polyarthritis: Results from the Norfolk Arthritis Register (NOAR): An observational study

Arthritis Research and Therapy

Volumn 13, Issue 5, 2011, Pages

  Mirjafari, Hoda ^a   Farragher, Tracey M ^a,b   Verstappen, Suzanne M M ^a   Yates, Allen ^c   Bunn, Diane ^a   Marshall, Tarnya ^d   Lunt, Mark ^a   Symmons, Deborah P M ^a   Bruce, Ian N ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^d NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; RHEUMATOID FACTOR; TRIACYLGLYCEROL;

ADULT; AGED; ANTIBODY BLOOD LEVEL; ARTICLE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; COHORT ANALYSIS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE REGISTRY; FEMALE; GLUCOSE BLOOD LEVEL; HEALTH ASSESSMENT QUESTIONNAIRE; HOMEOSTASIS MODEL ASSESSMENT; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; JOINT EXAMINATION; JOINT SWELLING; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NORFOLK ISLAND; OBSERVATIONAL STUDY; POLYARTHRITIS; PRIMARY HEALTH CARE; PROTEIN BLOOD LEVEL; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; ARTHRITIS; BLOOD; COMPARATIVE STUDY; EARLY DIAGNOSIS; MIDDLE AGED; PHYSIOLOGY; REGISTER; UNITED STATES;

ADULT; ARTHRITIS; COHORT STUDIES; EARLY DIAGNOSIS; FEMALE; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; REGISTRIES; VIRGINIA;

EID: 80053172787     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3476     Document Type: Article

References (47)

1. Farragher TM, Goodson NJ, Naseem H, Silman AJ, Thomson W, Symmons D, Barton A: Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis. Arthritis Rheum 2008, 58:359-369
2. Goodson NJ, Wiles NJ, Lunt M, Barrett EM, Silman AJ, Symmons DP: Mortality in early inflammatory polyarthritis: cardiovascular mortality is increased in seropositive patients. Arthritis Rheum 2002, 46:2010-2019
3. Naz SM, Symmons DP: Mortality in established rheumatoid arthritis. Best Pract Res Clin Rheumatol 2007, 21:871-883
4. Naz SM, Farragher TM, Bunn DK, Symmons DP, Bruce IN: The influence of age at symptom onset and length of followup on mortality in patients with recent-onset inflammatory polyarthritis. Arthritis Rheum 2008, 58:985-989
5. Svenson KL, Lundqvist G, Wide L, Hallgren R: Impaired glucose handling in active rheumatoid arthritis: relationship to the secretion of insulin and counter-regulatory hormones. Metabolism 1987, 36:940-943
6. Svenson KL, Pollare T, Lithell H, Hallgren R: Impaired glucose handling in active rheumatoid arthritis: relationship to peripheral insulin resistance. Metabolism 1988, 37:125-130
7. La Montagna G, Cacciapuoti F, Buono R, Manzella D, Mennillo GA, Arciello A, Valentini G, Paolisso G: Insulin resistance is an independent risk factor for atherosclerosis in rheumatoid arthritis. Diab Vasc Dis Res 2007, 4:130-135
8. Dessein PH, Tobias M, Veller MG: Metabolic syndrome and subclinical atherosclerosis in rheumatoid arthritis. J Rheumatol 2006, 33:2425-2432
9. Dessein PH, Joffe BI: Insulin resistance and impaired beta cell function in rheumatoid arthritis. Arthritis Rheum 2006, 54:2765-2775
10. Chung CP, Avalos I, Oeser A, Gebretsadik T, Shintani A, Raggi P, Stein CM: High prevalence of the metabolic syndrome in patients with systemic lupus erythematosus: Association with disease characteristics and cardiovascular risk factors. Ann Rheum Dis 2007, 66:208-214
11. Facchini FS, Hollenbeck CB, Jeppesen J, Chen YD, Reaven GM: Insulin resistance and cigarette smoking. Lancet 1992, 339:1128-1130
12. Doran M: Rheumatoid arthritis and diabetes mellitus: Evidence for an association? J Rheumatol 2007, 34:460-462
13. Stavropoulos-Kalinoglou A, Metsios GS, Panoulas VF, Douglas KM, Nevill AM, Jamurtas AZ, Kita M, Koutedakis Y, Kitas GD: Associations of obesity with modifiable risk factors for the development of cardiovascular disease in patients with rheumatoid arthritis. Ann Rheum Dis 2009, 68:242-245
14. Chung CP, Oeser A, Solus JF, Gebretsadik T, Shintani A, Avalos I, Sokka T, Raggi P, Pincus T, Stein CM: Inflammation-associated insulin resistance: differential effects in rheumatoid arthritis and systemic lupus erythematosus define potential mechanisms. Arthritis Rheum 2008, 58:2105-2112
15. Gonzalez-Gay MA, De Matias JM, Gonzalez-Juanatey C, Garcia-Porrua C, Sanchez-Andrade A, Martin J, Llorca J: Anti-tumor necrosis factor-alpha blockade improves insulin resistance in patients with rheumatoid arthritis. Clin Exp Rheumatol 2006, 24:83-86
16. Oguz FM, Oguz A, Uzunlulu M: The effect of infliximab treatment on insulin resistance in patients with rheumatoid arthritis. Acta Clin Belg 2007, 62:218-222
17. Symmons DP, Silman AJ: The Norfolk Arthritis Register (NOAR). Clin Exp Rheumatol 2003, 21:S94-S99
18. Prevoo ML, van 't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL: Modified disease activity scores that include twenty-eightjoint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995, 38:44-48
19. Fries JF, Spitz P, Kraines RG, Holman HR: Measurement of patient outcome in arthritis. Arthritis Rheum 1980, 23:137-145
20. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988, 31:315-324
21. Radikova Z, Koska J, Huckova M, Ksinantova L, Imrich R, Vigas M, Tmovec T, Langer P, Sebokova E, Klimes I: Insulin sensitivity indices: a proposal of cut-off points for simple identification of insulin-resistant subjects. Exp Clin Endocrinol Diabetes 2006, 114:249-256
22. Gordillo-Moscoso A, Valadez-Castillo JF, Mandeville PB, Hernandez-Sierra JF: Comparison of equivalence and determination of diagnostic utility of min-mod and clamp methods for insulin resistance in diabetes free subjects: a meta-analysis. Endocrine 2004, 25:259-263
23. Dessein PH, Joffe BI, Stanwix AE, Christian BF, Veller M: Glucocorticoids and insulin sensitivity in rheumatoid arthritis. J Rheumatol 2004, 31:867-874
24. Chung CP, Oeser A, Solus JF, Gebretsadik T, Shintani A, Avalos I, Sokka T, Raggi P, Pincus T, Stein CM: Inflammation-associated insulin resistance: differential effects in rheumatoid arthritis and systemic lupus erythematosus define potential mechanisms. Arthritis Rheum 2008, 58:2105-2112
25. Yazdani-Biuki B, Stelzl H, Brezinschek HP, Hermann J, Mueller T, Krippl P, Graninger W, Wascher TC: Improvement of insulin sensitivity in insulin resistant subjects during prolonged treatment with the anti-TNF-alpha antibody infliximab. Eur J Clin Invest 2004, 34:641-642
26. Svenson KL, Lundqvist G, Wide L, Hallgren R: Impaired glucose handling in active rheumatoid arthritis: effects of corticosteroids and antirheumatic treatment. Metabolism 1987, 36:944-948
27. Pannacciulli N, Cantatore FP, Minenna A, Bellacicco M, Giorgino R, De Pergola G: C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult women. Int J Obes Relat Metab Disord 2001, 25:1416-1420
28. Dessein PH, Joffe BI, Stanwix AE: Inflammation, insulin resistance, and aberrant lipid metabolism as cardiovascular risk factors in rheumatoid arthritis. J Rheumatol 2003, 30:1403-1405
29. Pamuk ON, Unlu E, Cakir N: Role of insulin resistance in increased frequency of atherosclerosis detected by carotid ultrasonography in rheumatoid arthritis. J Rheumatol 2006, 33:2447-2452
30. Rotter V, Nagaev I, Smith U: Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 2003, 278:45777-45784
31. Borst SE: The role of TNF-alpha in insulin resistance. Endocrine 2004, 23:177-182
32. Rosenvinge A, Krogh-Madsen R, Baslund B, Pedersen BK: Insulin resistance in patients with rheumatoid arthritis: effect of anti-TNFalpha therapy. Scand J Rheumatol 2007, 36:91-96
33. Segal T, Webb E, Viner R, Pusey C, Wild G, Allgrove J: Severe insulin resistance secondary to insulin antibodies: successful treatment with the immunosuppressant MMF. Pediatr Diabetes 2008, 9:250-254
34. Svenson KL, Lundqvist G, Wide L, Hallgren R: Impaired glucose handling in active rheumatoid arthritis: effects of corticosteroids and antirheumatic treatment. Metabolism 1987, 36:944-948
35. Farragher TM, Goodson NJ, Naseem H, Silman AJ, Thomson W, Symmons D, Barton A: Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis. Arthritis Rheum 2008, 58:359-369
36. Goodson NJ, Wiles NJ, Lunt M, Barrett EM, Silman AJ, Symmons DPM: Excess cardiovascular mortality occurs in the early years of seropositive inflammatory polyarthritis. Arthritis Rheum 2001, 44:S53
37. Naz SM, Farrager TM, Bunn DK, Symmons DPM, Bruce IN: Nodules and rheumatoid factor status both independently predict early and late cardiovascular Disease mortality in inflammatory polyarthritis: results from a primary-care based cohort. Arthritis Rheum 2007, 56:S414
38. Luukkainen R, Saltyshev M, Pakkasela R, Nordqavist E, Huhtala H, Hakala M: Relationship of rheumatoid factor to lung diffusion capacity in smoking and non-smoking patients with rheumatoid arthritis. Scand J Rheumatol 1995, 24:119-120
39. van Zeben D, Hazes JM, Zwinderman AH, Cats A, van der Voort EA, Breedveld FC: Clinical significance of rheumatoid factors in early rheumatoid arthritis: results of a follow up study. Ann Rheum Dis 1992, 51:1029-1035
40. Aoki S, Imai K, Yachi A: Soluble intercellular adhesion molecule-1 (ICAM-1) antigen in patients with rheumatoid arthritis. Scand J Immunol 1993, 38:485-490
41. Dessein PH, Joffe BI, Singh S: Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis. Arthritis Res Ther 2005, 7:R634-R643
42. Gonzalez-Juanatey C, Testa A, Garcia-Castelo A, Garcia-Porrua C, Llorca J, Vidan J, Hajeer AH, Ollier WE, Mattey DL, Gonzales-Gay MA: HLA-DRB1 status affects endothelial function in treated patients with rheumatoid arthritis. Am J Med 2003, 114:647-652
43. Muniyappa R, Iantorno M, Quon MJ: An integrated view of insulin resistance and endothelial dysfunction. Endocrinol Metab Clin North Am 2008, 37:685-711
44. Mattey DL, Dawes PT, Clarke S, Fisher J, Brownfield A, Thomson W, Hajeer AH, Ollier WE: Relationship among the HLA-DRB1 shared epitope, smoking, and rheumatoid factor production in rheumatoid arthritis. Arthritis Care Res 2002, 4:403-407
45. Lee HS, Irigoyen P, Kern M, Lee A, Batliwalla F, Khalili H, Wolfe F, Lum RF, Massarotti E, Weisman M, Bombardier C, Karlson EW, Criswell LA, Vlietinck R, Gregersen PK: Interaction between smoking, the shared epitope, and anti-cyclic citrullinated peptide: a mixed picture in three large North American rheumatoid arthritis cohorts. Arthritis Rheum 2007, 56:1745-1753
46. Symmons DP, Bankhead CR, Harrison BJ, Brennan P, Barrett EM, Scott DG, Silman AJ: Blood transfusion, smoking, and obesity as risk factors for the development of rheumatoid arthritis: results from a primary care-based incident case-control study in Norfolk, England. Arthritis Rheum 1997, 40:1955-1961
47. Despres JP, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, Rodés-Cabau J, Bertrand OF, Poirier P: Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol 2008, 28:1039-1049