Parenteral opioids in emergency medicine - A systematic review of efficacy and safety

Scandinavian Journal of Pain

Volumn 2, Issue 4, 2011, Pages 187-194

  Niemi Murola, Leila ^a,b   Unkuri, Jani ^a   Hamunen, Katri ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Meilahti Hospital   (Finland)

Author keywords

Emergency medicine; Opioid; Pain

Indexed keywords

ALFENTANIL; BUTORPHANOL; FENTANYL; HYDROMORPHONE; MORPHINE; NALOXONE; OPIATE; PARACETAMOL; PETHIDINE; PLACEBO; SUFENTANIL; TRAMADOL;

ABDOMINAL PAIN; ACUTE ABDOMEN; ANALGESIA; DIAGNOSTIC ACCURACY; DROWSINESS; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; EMERGENCY CARE; EMERGENCY MEDICINE; EMERGENCY WARD; HUMAN; ISCHEMIC CHEST PAIN; KIDNEY COLIC; MUSCULOSKELETAL PAIN; NAUSEA; NUMERICAL RATING SCALE; PAIN; PAIN ASSESSMENT; PATIENT SATISFACTION; PELVIS PAIN SYNDROME; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RATING SCALE; REVIEW; SEDATION; SIDE EFFECT; SYSTEMATIC REVIEW; THORAX PAIN; VISUAL ANALOG SCALE; VITAL SIGN; VOMITING;

EID: 80053164221     PISSN: 18778860     EISSN: 18778879     Source Type: Journal    
DOI: 10.1016/j.sjpain.2011.05.008     Document Type: Review

References (39)

1. Grenman D., Niemi-Murola L., Kalso E. Management of pain in a surgical emergency unit - underlying factors affecting its' successful delivery. Acute Pain 2008, 10:137-144.
2. Rupp T., Delaney K.A. Inadequate analgesia in emergency medicine. Ann Emerg Med 2004, 4:494-503.
3. Yanuka M., Soffer D., Halpern P. An interventional study to improve the quality of analgesia in the emergency department. CJEM 2008, 10:435-439.
4. Ricard-Hibon A., Ducasse J.L., Ravaud P., Wood C., Viel E., Chauvin M., Brunet F., Bleichner G. Quality control programme for acute pain management in emergency medicine: a national survey. Eur J Emerg Med 2004, 11:198-203.
5. Gaakeer M.I., van Lieshout J.M., Bierens J.J.L.M. Pain management in the emergency department: a review of present protocols in The Netherlands. Eur J Emerg Med 2010, 17:286-289.
6. Bounes V.M., Barniol C., Minville V., Houze-Cerfon C.H., Dicasse J.L. Predictors of pain relief and adverse events in patients receiving opioids in a prehospital setting. Am J Emerg Med 2010, [Epub ahead of print].
7. O'Connor A.B., Zwemer F.L., Hays D.P., Changyong F. Intravenous opioid dosing and outcomes in emergency patients: a prospective cohort analysis. Am J Emerg Med 2010, 28:1041-1050.
8. Howard R., Carter B., Curry J., Morton N., Rivett K., Rose M., Tyrrell J., Walker S., Williams G., Association of Paediatric Anaesthetists of Great Britain and Ireland Pain assessment. Paediatr Anaesth 2008, 18(May (Suppl 1)):14-18.
9. Olkkola K.T., Hamunen K., Maunuksela E.L. Clinical pharmacokinetics and pharmacodynamics of opioid analgesics in infants and children. Clin Pharmacokinet 1995, 28:385-404.
10. Moher D., Liberati A., Tetzlaff J., Altman DG and the Prisma group Preferred reporting items for systematic reviews and meta-analyses: the Prisma statement. Ann Intern med 2009, 151:264-269.
11. Jadad A.R., Moore R.A., Carroll D., Jenkinson C., Reynolds D.J., Cavaghan D.J., McQuay H.J. Assessing the quality of reports of randomized clinical trials: is blinding?. Control Clin Trials 1996, 17:1-12.
12. Bounes V., Charpentier S., Houze-Cerfon C.H., Bellard C., Ducassé J.L. Is there an ideal morphine dose for prehospital treatment of severe acute pain? A randomized, double-blind comparison of 2 doses. Am J Emerg Med 2008, 26:148-154.
13. Bounes V., Barthelemy R., Diez O., Charpentier S., Montastruc J.L., Ducasse J.L. Sufentanil is not superior to morphine for the treatment of adult traumatic pain in an emergency setting: a randomized, double-blind, out-of-hospital trail. Ann Emerg Med 2010, 56:509-516.
14. Galinski M., Dolveck F., Borron S.W., Tual L., Van Laer V., Lardeur J.Y., Lapostolle F., Adnet F. A randomized, double-blind study comparing morphine with fentanyl in prehospital analgesia. Am J Emerg Med 2005, 23:114-119.
15. Silfvast T., Saarnivaara L. Comparison of alfentanil and morphine in the prehospital treatment of patients with acute ischaemic-type chest pain. Eur J Emerg Med 2001, 8:275-278.
16. Vergnion M., Degesves S., Garcet L., Magotteaux V. Tramadol, an alternative to morphine for treating posttraumatic pain in the prehospital situation. Anesth Analg 2001, 92:1543-1546.
17. Attard A.R., Corlett M.J., Kidner N.J., Leslie A.P., Fraser I.A. Safety of early pain relief for acute abdominal pain. Brit Med J 1992, 305:554-556.
18. Bartfield J.M., Flint R.D., McErlean M., Broderick J. Nebulized fentanyl for relief of abdominal pain. Acad Emerg Med 2003, 10:215-218.
19. Bektas F., Eken C., Karadeniz O., Goksu E., Cubuk M., Cete Y. Intravenous paracetamol or morphine for the treatment of renal colic: a randomized, placebo-controlled trial. Ann Emerg Med 2009, 54:568-574.
20. Birnbaum A., Esses D., Bijur P.E., Holden L., Gallagher E.J. Randomized double-blind placebo-controlled trial of two intravenous morphine dosages (0.10mg/kg and 0.15mg/kg) in emergency department patients with moderate to severe acute pain. Ann Emerg Med 2007, 49:445-453.
21. Chang A.K., Bijur P.E., Meyer R.H., Kenny Mk, Solorzano C., Gallagher E.J. Safety and Efficacy of hydromorphone as an analgesic alternative to morphine in acute pain: a randomized clinical trial. Ann Emerg Med 2006, 48:164-172.
22. Chang A.K. Efficacy and safety profile of a single dose of hydromorphone compared with morphine in older adults with acute, severe pain: a prospective, randomized, double-blind clinical trial. Am J Ger Pharmacother 2009, 7:1-10.
23. Eray O., Cete Y., Oktay C., Karsli B., Cete N., Ersoy F. Intravenous single-dose tramadol versus meperidine for pain relief in renal colic. Eur J Anaesth 2002, 19:368-370.
24. Gallagher E.J., Esses D., Lee C., Lahn Michael, Bijur P.E. Randomized clinical trial of morphine in acute abdominal pain. Ann Emerg Med 2006, 48:150-160.
25. Jasani N.B., O'Connor R.E., Bouzokis J.K. Comparison of hydromorphone and meperidine for ureteral colic. Acad Emerg Med 1994, 1:539-543.
26. Lovecchio F., Oster N., Sturmann K., Nelson L.S., Flasher S., Finger R. The use of analgesics in patients with acute abdominal pain. J Emerg Med 1997, 15:775-779.
27. Miller P.L., Ernst A.A. Sex differences in analgesia: a randomized trial of u versus k opioid agonists. Southern Med J 2004, 97:35-41.
28. O'Connor A., Schug S.A., Cardwell H. A comparison of the efficacy and safety of morphine and pethidine as analgesia for suspected renal colic in the emergency setting. J Accid Emerg Med 2000, 17:261-264.
29. Pace S., Burke T.F. Intravenous morphine for early pain relief in patients with acute abdominal pain. Acad Emerg Med 1996, 3:1086-1092.
30. Thomas S.H., Silen W., Cheema F. Effects of morphine analgesia on diagnostic accuracy in emergency department patients with abdominal pain: a prospective, randomized trail. J Am Coll Surg 2003, 196:18-31.
31. Vermeulen B., Morabia A., Unger P.F., Goehring C., Grangier C., Skljarov I., Terrier F. Acute appendicitis: influence of early pain relief on the accuracy of clinical and US findings in the decision to operate - a randomized trial. Radiology 1999, 210:639-643.
32. Macintyre P.E., Scott D.A., Schug S.A., Visser E.J., Walker S.M. Acute pain management: scientific evidence 2010, Australian and New Zealand College of Anaesthetist and Faculty of Pain Medicine. http://www.anzca.edu.au/resources/book-and-publications, 3rd ed.
33. Patenwala A.E., Keim S.M., Erstad B.L. Intravenous opioids for severe acute pain in the emergency department. Ann Pharmacotherapy 2010, 44:1800-1809.
34. McIntyre P.E., Jarvis D.A. Age is the best predictor of postoperative morphine requirements. Pain 1996, 64:357-364.
35. Klepstad P., Dale O., Skorpen F., Borchgrevink P.C., Kaasa S. Genetic variability and clinical efficacy of morphine. Acta Anaesthesiol Scand 2005, 49:902-908.
36. Jones J.J., Johnson K., McNinch Age as a risk factor for inadequate emergency department analgesia. Am J Emerg Med 1996, 14:157-160.
37. Bellville J.W., Forrest W.H., Miller E., Brown B.W. Influence of age on pain relief from analgesics. A study of postoperative patients. JAMA 1971, 27(217):1835-1841.
38. Liukas A., Kuusniemi K., Aantaa R., Virolainen P., Neuvonen M., Neuvonen P.J., Olkkola K.T. Plasma concentrations of oral oxycodone are greatly increased in the elderly. Clin Pharm Ther 2008, 84:462-467.
39. Chang A.K., Bijur P.E., Napolitano A., Lupow J., Gallagher E.J. Two milligrams i.v. hydromorphone is efficacious for treating pain but is associated with oxygen desaturation. J Opioid Manag 2009, 5:75-80.