메뉴 건너뛰기




Volumn 29, Issue 5, 2011, Pages 340-348

Effect of Moderate and High-Dose Simvastatin on Asymmetric Dimethylarginine-Homocysteine Metabolic Pathways in Patients with Newly Detected Severe Hypercholesterolemia

Author keywords

Asymmetric dimethylarginine; Endothelial dysfunction; Hypercholesterolemia; Low density lipoprotein cholesterol; Nitric oxide; Nitric oxide synthase; Simvastatin; Statins; Target; Total homocysteine

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; N(G),N(G) DIMETHYLARGININE; SIMVASTATIN; TRIACYLGLYCEROL;

EID: 80053155357     PISSN: 17555914     EISSN: 17555922     Source Type: Journal    
DOI: 10.1111/j.1755-5922.2010.00149.x     Document Type: Article
Times cited : (5)

References (44)
  • 1
    • 0034602617 scopus 로고    scopus 로고
    • Prevention Conference V: Beyond secondary prevention: Identifying the high-risk patient for primary prevention: Noninvasive tests of atherosclerotic burden: Writing Group III
    • Greenland P, Abrams J, Aurigemma GP, et al. Prevention Conference V: Beyond secondary prevention: Identifying the high-risk patient for primary prevention: Noninvasive tests of atherosclerotic burden: Writing Group III. Circulation 2000;101:e16-e22.
    • (2000) Circulation , vol.101
    • Greenland, P.1    Abrams, J.2    Aurigemma, G.P.3
  • 3
    • 15944393211 scopus 로고    scopus 로고
    • Under-treated high risk patients: Identifying patients in high-risk subgroup and treating them to LDL targets
    • Schuster H. Under-treated high risk patients: Identifying patients in high-risk subgroup and treating them to LDL targets Eur Heart J 2005;7(Suppl A):20-28.
    • (2005) Eur Heart J , vol.7 , Issue.SUPPL. A , pp. 20-28
    • Schuster, H.1
  • 4
    • 26644475970 scopus 로고    scopus 로고
    • The pleiotropic effects of statins: Relevance to their salutary effects. In: Mehta JL, editor
    • Pennsylvania: Saunders
    • Wolfrum S, Liao J. The pleiotropic effects of statins: Relevance to their salutary effects. In: Mehta JL, editor. Statins: Understanding clinical use. Pennsylvania: Saunders, 2004;163-187.
    • (2004) Statins: Understanding clinical use , pp. 163-187
    • Wolfrum, S.1    Liao, J.2
  • 5
    • 3142623027 scopus 로고    scopus 로고
    • The cardioprotective effects of statins
    • Davignon J. The cardioprotective effects of statins. Curr Atheroscler Rep 2004;6:27-35.
    • (2004) Curr Atheroscler Rep , vol.6 , pp. 27-35
    • Davignon, J.1
  • 6
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • Laufs U, La F, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998;97:1129-1135.
    • (1998) Circulation , vol.97 , pp. 1129-1135
    • Laufs, U.1    La, F.2    Plutzky, J.3    Liao, J.K.4
  • 7
    • 1242341478 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA): A key regulator of nitric oxide synthase
    • Böger RH, Vallance P, Cooke JP. Asymmetric dimethylarginine (ADMA): A key regulator of nitric oxide synthase. Atherosclerosis 2003;4(Suppl 4):1-3.
    • (2003) Atherosclerosis , vol.4 , Issue.SUPPL. 4 , pp. 1-3
    • Böger, R.H.1    Vallance, P.2    Cooke, J.P.3
  • 8
    • 0344306684 scopus 로고    scopus 로고
    • Association of asymmetric dimethylarginine and endothelial dysfunction
    • Böger RH. Association of asymmetric dimethylarginine and endothelial dysfunction. Clin Chem Lab Med 2003;41:1467-1472.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 1467-1472
    • Böger, R.H.1
  • 9
    • 2942610581 scopus 로고    scopus 로고
    • Dysfunction of endothelial nitric oxide synthase and atherosclerosis
    • Kawashima S, Yokoyama M. Dysfunction of endothelial nitric oxide synthase and atherosclerosis. Arterioscler Thromb Vasc Biol 2004;24:998-1005.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 998-1005
    • Kawashima, S.1    Yokoyama, M.2
  • 10
    • 31344473974 scopus 로고    scopus 로고
    • ADMA: An emerging cardiovascular risk factor
    • Böger RH, Cooke JP, Vallance P. ADMA: An emerging cardiovascular risk factor. Vasc Med 2005;10:S1-S2.
    • (2005) Vasc Med , vol.10
    • Böger, R.H.1    Cooke, J.P.2    Vallance, P.3
  • 11
    • 0033594888 scopus 로고    scopus 로고
    • Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase
    • Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP. Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999;99:3092-3095.
    • (1999) Circulation , vol.99 , pp. 3092-3095
    • Ito, A.1    Tsao, P.S.2    Adimoolam, S.3    Kimoto, M.4    Ogawa, T.5    Cooke, J.P.6
  • 12
    • 33645501775 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA): A novel risk marker in cardiovascular medicine and beyond
    • Böger RH. Asymmetric dimethylarginine (ADMA): A novel risk marker in cardiovascular medicine and beyond. Ann Med 2006;38:126-136.
    • (2006) Ann Med , vol.38 , pp. 126-136
    • Böger, R.H.1
  • 13
    • 0034698038 scopus 로고    scopus 로고
    • LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells
    • Böger RH, Sydow K, Borlak J, et al. LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells. Circ Res 2000;87:99-105.
    • (2000) Circ Res , vol.87 , pp. 99-105
    • Böger, R.H.1    Sydow, K.2    Borlak, J.3
  • 14
    • 0242322346 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction. It's role in hypercholesterolemia
    • Böger RH, Bode-Böger SM, Szuba A, et al. Asymmetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction. It's role in hypercholesterolemia. Circulation 1998;98:1842-1847.
    • (1998) Circulation , vol.98 , pp. 1842-1847
    • Böger, R.H.1    Bode-Böger, S.M.2    Szuba, A.3
  • 15
    • 0034687141 scopus 로고    scopus 로고
    • Angiogenesis is impaired by hypercholesterolemia. Role of asymmetric dimethylarginine
    • Jang JJ, Ho HKV, Kwan HH, Fajardo LF, Cooke JP. Angiogenesis is impaired by hypercholesterolemia. Role of asymmetric dimethylarginine. Circulation 2000;102: 1414-1419.
    • (2000) Circulation , vol.102 , pp. 1414-1419
    • Jang, J.J.1    Ho, H.K.V.2    Kwan, H.H.3    Fajardo, L.F.4    Cooke, J.P.5
  • 16
    • 18744388378 scopus 로고    scopus 로고
    • ADMA regulates angiogenesis: Genetic and metabolic evidence
    • Achan V, Ho HK, Heeschen C, et al. ADMA regulates angiogenesis: Genetic and metabolic evidence. Vasc Med 2005;10:7-14.
    • (2005) Vasc Med , vol.10 , pp. 7-14
    • Achan, V.1    Ho, H.K.2    Heeschen, C.3
  • 17
    • 31344444441 scopus 로고    scopus 로고
    • ADMA: Its role in vascular disease
    • Cooke JP. ADMA: Its role in vascular disease. Vasc Med 2005;10:S11-S17.
    • (2005) Vasc Med , vol.10
    • Cooke, J.P.1
  • 18
    • 33947305131 scopus 로고    scopus 로고
    • ADMA is independently related to flow-mediated vasodilation in subjects at low cardiovascular risk
    • Ardigo D, Stuehlinger M, Franzini L, et al. ADMA is independently related to flow-mediated vasodilation in subjects at low cardiovascular risk. Eur J Clin Invest 2007;37:263-269.
    • (2007) Eur J Clin Invest , vol.37 , pp. 263-269
    • Ardigo, D.1    Stuehlinger, M.2    Franzini, L.3
  • 19
    • 34548689666 scopus 로고    scopus 로고
    • Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young Finns study
    • Juonala M, Viikari J, Alfthan G, et al. Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young Finns study. Circulation 2007;116:1367-1373.
    • (2007) Circulation , vol.116 , pp. 1367-1373
    • Juonala, M.1    Viikari, J.2    Alfthan, G.3
  • 20
    • 12244268005 scopus 로고    scopus 로고
    • Increased levels of asymmetric dimethylarginine in population at risk for atherosclerotic disease. Effects of pravastatin
    • Eid HM, Eritsland J, Larsen J, Arnesen H, Seljeflot I. Increased levels of asymmetric dimethylarginine in population at risk for atherosclerotic disease. Effects of pravastatin. Atherosclerosis 2003;166:279-284.
    • (2003) Atherosclerosis , vol.166 , pp. 279-284
    • Eid, H.M.1    Eritsland, J.2    Larsen, J.3    Arnesen, H.4    Seljeflot, I.5
  • 21
    • 1242295337 scopus 로고    scopus 로고
    • Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults
    • Janatuinen T, Laakso J, Laaksonen R, Nuutila P, Lehtimaki T, Raitakari OT, Knuuti J. Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood flow in young adults. Vasc Med 2003;8:185-189.
    • (2003) Vasc Med , vol.8 , pp. 185-189
    • Janatuinen, T.1    Laakso, J.2    Laaksonen, R.3    Nuutila, P.4    Lehtimaki, T.5    Raitakari, O.T.6    Knuuti, J.7
  • 22
    • 3142736452 scopus 로고    scopus 로고
    • Effect of simvastatin on endothelium-dependent vasorelaxation and endogenous nitric oxide synthase inhibitor
    • Jiang J, Jiang D, Tang Y, Li N, Deng H, Li Y. Effect of simvastatin on endothelium-dependent vasorelaxation and endogenous nitric oxide synthase inhibitor. Acta Pharmacol Sin 2004;25:893-901.
    • (2004) Acta Pharmacol Sin , vol.25 , pp. 893-901
    • Jiang, J.1    Jiang, D.2    Tang, Y.3    Li, N.4    Deng, H.5    Li, Y.6
  • 23
    • 0037402473 scopus 로고    scopus 로고
    • Effects of Simvastatin and L-Arginine on Vasodilation, nitric oxide metabolites and endogenous NOS inhibitors in hypercholesterolemic subjects
    • Periera EC, Bertolami MC, Faludi AA, Salem M, Bersch D, Abdalla D. Effects of Simvastatin and L-Arginine on Vasodilation, nitric oxide metabolites and endogenous NOS inhibitors in hypercholesterolemic subjects. Free Radic Res 2003;37:529-536.
    • (2003) Free Radic Res , vol.37 , pp. 529-536
    • Periera, E.C.1    Bertolami, M.C.2    Faludi, A.A.3    Salem, M.4    Bersch, D.5    Abdalla, D.6
  • 25
    • 1242296340 scopus 로고    scopus 로고
    • Asymmetrical dimethylarginine (ADMA) and risk of acute coronary events: Does statin treatment influence plasma ADMA levels?
    • Valkonen VP, Laakso J, Päivä H, et al. Asymmetrical dimethylarginine (ADMA) and risk of acute coronary events: Does statin treatment influence plasma ADMA levels? Atherosclerosis 2003;4(Suppl 4):19-22.
    • (2003) Atherosclerosis , vol.4 , Issue.SUPPL. 4 , pp. 19-22
    • Valkonen, V.P.1    Laakso, J.2    Päivä, H.3
  • 26
    • 33644669967 scopus 로고    scopus 로고
    • Effect of Atorvastatin on regional arterial stiffness in patients with type 2 diabetes mellitus
    • Shinohara KB, Shoji T, Kimoto E, et al. Effect of Atorvastatin on regional arterial stiffness in patients with type 2 diabetes mellitus. J Atheroscler Thromb 2005;12:205-210.
    • (2005) J Atheroscler Thromb , vol.12 , pp. 205-210
    • Shinohara, K.B.1    Shoji, T.2    Kimoto, E.3
  • 27
    • 34250329234 scopus 로고    scopus 로고
    • Effects of atorvastatin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine
    • Bolayirli IM, Aslan M, Balci H, Altug T, Hacibekiroglu M, Seven A. Effects of atorvastatin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine. Life Sci 2007;81:121-127.
    • (2007) Life Sci , vol.81 , pp. 121-127
    • Bolayirli, I.M.1    Aslan, M.2    Balci, H.3    Altug, T.4    Hacibekiroglu, M.5    Seven, A.6
  • 28
    • 0037083163 scopus 로고    scopus 로고
    • Effects of Atorvastatin on oxidized low-density lipoprotein, low-density lipoprotein subfraction distribution and remnants lipoprotein in patients with mixed hyperlipoproteinemia
    • 2002;:-
    • Sasaki S, Kuwahara N, Kunitomo K, et al. Effects of Atorvastatin on oxidized low-density lipoprotein, low-density lipoprotein subfraction distribution and remnants lipoprotein in patients with mixed hyperlipoproteinemia. Am J Cardiol 2002;89:386-389.
    • Am J Cardiol , vol.89 , pp. 386-389
    • Sasaki, S.1    Kuwahara, N.2    Kunitomo, K.3
  • 29
    • 3142606890 scopus 로고    scopus 로고
    • Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia
    • Lu TM, Ding YA, Leu HB. Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia. Am J Cardiol 2004;94:157-161.
    • (2004) Am J Cardiol , vol.94 , pp. 157-161
    • Lu, T.M.1    Ding, Y.A.2    Leu, H.B.3
  • 30
    • 49449118649 scopus 로고    scopus 로고
    • Short term fluvastatin treatment lowers serum asymmetric dimethylarginine levels in patients with metabolic syndrome
    • Oguz A, Uzunlulu M. Short term fluvastatin treatment lowers serum asymmetric dimethylarginine levels in patients with metabolic syndrome. Int Heart J 2008;49:303-311.
    • (2008) Int Heart J , vol.49 , pp. 303-311
    • Oguz, A.1    Uzunlulu, M.2
  • 31
    • 10744232622 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) modulates endothelial function-therapeutic implications
    • Böger RH. Asymmetric dimethylarginine (ADMA) modulates endothelial function-therapeutic implications. Vasc Med 2003;8:149-151.
    • (2003) Vasc Med , vol.8 , pp. 149-151
    • Böger, R.H.1
  • 32
    • 0032890205 scopus 로고    scopus 로고
    • Mortality in treated heterozygous familial hypercholesterolemia: Implications for clinical management
    • Scientific Steering Committee on behalf of the Simon Broome Register Group.
    • Scientific Steering Committee on behalf of the Simon Broome Register Group. Mortality in treated heterozygous familial hypercholesterolemia: Implications for clinical management. Atherosclerosis 1999;142:105-112.
    • (1999) Atherosclerosis , vol.142 , pp. 105-112
  • 33
    • 58149185949 scopus 로고    scopus 로고
    • Role of some biomarkers of atherogenic risk in the screening for molecular defects in the low density lipoprotein receptor in severe hypercholesterolemia
    • Vladimirova-Kitova LG, Deneva TI, Angelova E, Bichev AN, Nikolov FP. Role of some biomarkers of atherogenic risk in the screening for molecular defects in the low density lipoprotein receptor in severe hypercholesterolemia. Folia Med 2008;50:14-22.
    • (2008) Folia Med , vol.50 , pp. 14-22
    • Vladimirova-Kitova, L.G.1    Deneva, T.I.2    Angelova, E.3    Bichev, A.N.4    Nikolov, F.P.5
  • 34
    • 54249118627 scopus 로고    scopus 로고
    • Relationship of asymmetric dimethylarginine with flow-mediated dilation in subjects with newly detected severe hypercholesterolemia
    • Vladimirova-Kitova LG, Deneva T, Angelova E, Nikolov F, Marinov B, Mateva N. Relationship of asymmetric dimethylarginine with flow-mediated dilation in subjects with newly detected severe hypercholesterolemia. Clin Physiol Funct Imaging 2008;28:417-425.
    • (2008) Clin Physiol Funct Imaging , vol.28 , pp. 417-425
    • Vladimirova-Kitova, L.G.1    Deneva, T.2    Angelova, E.3    Nikolov, F.4    Marinov, B.5    Mateva, N.6
  • 36
    • 0034745613 scopus 로고    scopus 로고
    • High-dose simvastatin (80 mg/day) decreases plasma concentrations of total homocysteine in patients with hypercholesterolemia
    • Lüftjohann D, Sigit JI, Locatelli S, Bergmann K. High-dose simvastatin (80 mg/day) decreases plasma concentrations of total homocysteine in patients with hypercholesterolemia. Atherosclerosis 2001;155:265-266.
    • (2001) Atherosclerosis , vol.155 , pp. 265-266
    • Lüftjohann, D.1    Sigit, J.I.2    Locatelli, S.3    Bergmann, K.4
  • 37
    • 0347355493 scopus 로고    scopus 로고
    • Lipid-lowering drugs and homocysteine a comparison between statins and other lipid-lowering drugs [letter]
    • Jankowski P, Kawecka-Jaszcz K. Lipid-lowering drugs and homocysteine a comparison between statins and other lipid-lowering drugs [letter]. Atherosclerosis 2004;172:191-194.
    • (2004) Atherosclerosis , vol.172 , pp. 191-194
    • Jankowski, P.1    Kawecka-Jaszcz, K.2
  • 38
    • 0037211997 scopus 로고    scopus 로고
    • Letter to the editor: Statins and homocysteine
    • Miltiadous G, Papakostas J. Letter to the editor: Statins and homocysteine. Atherosclerosis 2003;166:199-200.
    • (2003) Atherosclerosis , vol.166 , pp. 199-200
    • Miltiadous, G.1    Papakostas, J.2
  • 39
    • 34249824593 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilatation by Simvastatin
    • Böger GI, Rudolf TK, Renke M, et al. Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilatation by Simvastatin. J Am Coll Cardiol 2007;49:2274-2282.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 2274-2282
    • Böger, G.I.1    Rudolf, T.K.2    Renke, M.3
  • 40
    • 33645881669 scopus 로고    scopus 로고
    • Statin safety: A systematic review
    • Law M, Rudnicka AR. Statin safety: A systematic review. Am J Cardiol 2006;97:52C-60C.
    • (2006) Am J Cardiol , vol.97
    • Law, M.1    Rudnicka, A.R.2
  • 41
    • 33645870418 scopus 로고    scopus 로고
    • Statin safety: Lessons from new drug applications for marketed statins
    • Jacobson TA. Statin safety: Lessons from new drug applications for marketed statins. Am J Cardiol 2006;97:44C-51C.
    • (2006) Am J Cardiol , vol.97
    • Jacobson, T.A.1
  • 42
    • 4544243333 scopus 로고    scopus 로고
    • Early intensive vs a delayed conservative Simvastatin strategy in patients with acute coronary syndromes
    • De Lemos J, Blazing MA, Wiviott SD, et al. Early intensive vs a delayed conservative Simvastatin strategy in patients with acute coronary syndromes. JAMA 2004;292:1307-1316.
    • (2004) JAMA , vol.292 , pp. 1307-1316
    • De Lemos, J.1    Blazing, M.A.2    Wiviott, S.D.3
  • 43
    • 77949394499 scopus 로고    scopus 로고
    • SEARCH Collaborative Group, "SLCO1B1 variants and statin-induced myopathy-a genomewide study
    • Link E, Parish S, Armitage J, et al. SEARCH Collaborative Group, "SLCO1B1 variants and statin-induced myopathy-a genomewide study. N Engl J Med 2008;359:856-858.
    • (2008) N Engl J Med , vol.359 , pp. 856-858
    • Link, E.1    Parish, S.2    Armitage, J.3
  • 44
    • 0033637470 scopus 로고    scopus 로고
    • Endothelial dysfunction in hypercholesterolemia: Mechanism, pathophysiological importance and therapeutic interventions
    • Landmesser ULF, Hornig B, Drexler H. Endothelial dysfunction in hypercholesterolemia: Mechanism, pathophysiological importance and therapeutic interventions. Semin Thromb Hemost 2000;26:529-537.
    • (2000) Semin Thromb Hemost , vol.26 , pp. 529-537
    • Landmesser, U.L.F.1    Hornig, B.2    Drexler, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.