Global inhibition of reactive oxygen species (ROS) inhibits paclitaxel-induced painful peripheral neuropathy

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Fidanboylu, Mehmet ^a   Griffiths, Lisa A ^a   Flatters, Sarah J L ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

N TERT BUTYL ALPHA PHENYLNITRONE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TEMPOL; AMINE OXIDE; PACLITAXEL; PHENYL-N-TERT-BUTYLNITRONE; SCAVENGER;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; COLD SENSITIVITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; DRUG TOLERABILITY; HABITUATION; MALE; NONHUMAN; PAIN ASSESSMENT; PERIPHERAL NEUROPATHY; PHARMACOLOGICAL BLOCKING; RAT; ANIMAL; CHEMICALLY INDUCED DISORDER; METABOLISM; SPIN LABELING; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; CYCLIC N-OXIDES; FREE RADICAL SCAVENGERS; MALE; PACLITAXEL; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SPIN LABELS;

EID: 80053154846     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025212     Document Type: Article

References (42)

1. Nogales E, Wolf SG, Khan IA, Luduena RF, Downing KH, (1995) Structure of tubulin at 6.5 A and location of the taxol-binding site. Nature 375: 424-427.
2. Jordan MA, Kamath K, (2007) How do microtubule-targeted drugs work? An overview. Curr Cancer Drug Targets 7: 730-742.
3. Rowinsky EK, Eisenhauer EA, Chaudhry V, Arbuck SG, Donehower RC, (1993) Clinical toxicities encountered with paclitaxel (Taxol). Semin Oncol 20: 1-15.
4. Forsyth PA, Balmaceda C, Peterson K, Seidman AD, Brasher P, et al. (1997) Prospective study of paclitaxel-induced peripheral neuropathy with quantitative sensory testing. J Neurooncol 35: 47-53.
5. Dougherty PM, Cata JP, Cordella JV, Burton A, Weng HR, (2004) Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients. Pain 109: 132-142.
6. Windebank AJ, Grisold W, (2008) Chemotherapy-induced neuropathy. J Peripher Nerv Syst 13: 27-46.
7. Postma TJ, Vermorken JB, Liefting AJ, Pinedo HM, Heimans JJ, (1995) Paclitaxel-induced neuropathy. Ann Oncol 6: 489-494.
8. Akerley W, Glantz M, Choy H, Rege V, Sambandam S, et al. (1998) Phase I trial of weekly paclitaxel in advanced lung cancer. J Clin Oncol 16: 153-158.
9. van den Bent MJ, van Raaij-van den Aarssen VJ, Verweij J, Doorn PA, Sillevis Smitt PA, (1997) Progression of paclitaxel-induced neuropathy following discontinuation of treatment. Muscle Nerve 20: 750-752.
10. Rao RD, Michalak JC, Sloan JA, Loprinzi CL, Soori GS, et al. (2007) Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled, crossover trial (N00C3). Cancer 110: 2110-2118.
11. Rao RD, Flynn PJ, Sloan JA, Wong GY, Novotny P, et al. (2008) Efficacy of lamotrigine in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled trial, N01C3. Cancer 112: 2802-2808.
12. Kautio AL, Haanpaa M, Saarto T, Kalso E, (2008) Amitriptyline in the treatment of chemotherapy-induced neuropathic symptoms. J Pain Symptom Manage 35: 31-39.
13. Kautio AL, Haanpaa M, Leminen A, Kalso E, Kautiainen H, et al. (2009) Amitriptyline in the prevention of chemotherapy-induced neuropathic symptoms. Anticancer Res 29: 2601-2606.
14. Tal M, (1996) A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy. Neuroreport 7: 1382-1384.
15. Wagner R, Heckman HM, Myers RR, (1998) Wallerian degeneration and hyperalgesia after peripheral nerve injury are glutathione-dependent. Pain 77: 173-179.
16. Khalil Z, Liu T, Helme RD, (1999) Free radicals contribute to the reduction in peripheral vascular responses and the maintenance of thermal hyperalgesia in rats with chronic constriction injury. Pain 79: 31-37.
17. Rosenfeld J, Cook S, James R, (1997) Expression of superoxide dismutase following axotomy. Exp Neurol 147: 37-47.
18. Kim HK, Park SK, Zhou JL, Taglialatela G, Chung K, et al. (2004) Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. Pain 111: 116-124.
19. Gao X, Kim HK, Chung JM, Chung K, (2007) Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain. Pain 131: 262-271.
20. Tanabe M, Nagatani Y, Saitoh K, Takasu K, Ono H, (2009) Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice. Neuropharmacology 56: 702-708.
21. Lee I, Kim HK, Kim JH, Chung K, Chung JM, (2007) The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons. Pain 133: 9-17.
22. Schwartz ES, Lee I, Chung K, Chung JM, (2008) Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice. Pain.
23. Wang J, Cochran V, Abdi S, Chung JM, Chung K, et al. (2008) Phenyl N-t-butylnitrone, a reactive oxygen species scavenger, reduces zymosan-induced visceral pain in rats. Neurosci Lett 439: 216-219.
24. Wang ZQ, Porreca F, Cuzzocrea S, Galen K, Lightfoot R, et al. (2004) A newly identified role for superoxide in inflammatory pain. J Pharmacol Exp Ther 309: 869-878.
25. Khattab MM, (2006) TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion. Eur J Pharmacol 548: 167-173.
26. Park ES, Gao X, Chung JM, Chung K, (2006) Levels of mitochondrial reactive oxygen species increase in rat neuropathic spinal dorsal horn neurons. Neurosci Lett 391: 108-111.
27. Schwartz ES, Kim HY, Wang J, Lee I, Klann E, et al. (2009) Persistent pain is dependent on spinal mitochondrial antioxidant levels. J Neurosci 29: 159-168.
28. Flatters SJL, Bennett GJ, (2006) Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction. Pain 122: 245-257.
29. Zimmermann M, (1983) Ethical guidelines for investigations of experimental pain in conscious animals [editorial]. Pain 16: 109-110.
30. Polomano RC, Mannes AJ, Clark US, Bennett GJ, (2001) A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel. Pain 94: 293-304.
31. Flatters SJL, Bennett GJ, (2004) Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. Pain 109: 150-161.
32. Flatters SJL, Xiao WH, Bennett GJ, (2006) Acetyl-l-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy. Neurosci Lett 397: 219-223.
33. Kim HK, Zhang YP, Gwak YS, Abdi S, (2010) Phenyl N-tert-butylnitrone, a free radical scavenger, reduces mechanical allodynia in chemotherapy-induced neuropathic pain in rats. Anesthesiology 112: 432-439.
34. Cavaletti G, Cavalletti E, Montaguti P, Oggioni N, De Negri O, et al. (1997) Effect on the peripheral nervous system of the short-term intravenous administration of paclitaxel in the rat. Neurotoxicology 18: 137-145.
35. Cliffer KD, Siuciak JA, Carson SR, Radley HE, Park JS, et al. (1998) Physiological characterization of Taxol-induced large-fiber sensory neuropathy in the rat. Ann Neurol 43: 46-55.
36. Authier N, Gillet JP, Fialip J, Eschalier A, Coudore F, (2000) Description of a short-term Taxol-induced nociceptive neuropathy in rats. Brain Res 887: 239-249.
37. Campana WM, Eskeland N, Calcutt NA, Misasi R, Myers RR, et al. (1998) Prosaptide prevents paclitaxel neurotoxicity. Neurotoxicology 19: 237-244.
38. Cavaletti G, Tredici G, Braga M, Tazzari S, (1995) Experimental peripheral neuropathy induced in adult rats by repeated intraperitoneal administration of taxol. Exp Neurol 133: 64-72.
39. Jin HW, Flatters SJL, Xiao WH, Mulhern HL, Bennett GJ, (2008) Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-l-carnitine: Effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells. Exp Neurol 210: 229-237.
40. Siau C, Xiao W, Bennett GJ, (2006) Paclitaxel- and vincristine-evoked painful peripheral neuropathies: loss of epidermal innervation and activation of Langerhans cells. Exp Neurol 201: 507-514.
41. Boyette-Davis J, Xin W, Zhang H, Dougherty PM, (2011) Intraepidermal nerve fiber loss corresponds to the development of Taxol-induced hyperalgesia and can be prevented by treatment with minocycline. Pain 152: 308-313.
42. Cata JP, Weng HR, Dougherty PM, (2008) The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats. Brain Res 1229: 100-110.