Thioacetamide intoxication triggers transcriptional up-regulation but enzyme inactivation of UDP-glucuronosyltransferases

Drug Metabolism and Disposition

Volumn 39, Issue 10, 2011, Pages 1815-1822

  Hao, Haiping ^a   Zhang, Lifang ^a   Jiang, Shan ^a   Sun, Shiqing ^a   Gong, Ping ^a   Xie, Yuan ^a   Zhou, Xueyan ^a   Wang, Guangji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; DIMETHYLDIPHENYLBICARBOXYLATE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 2B1; ISOENZYME; LIGNAN; LIVER PROTECTIVE AGENT; MESSENGER RNA; PLANT EXTRACT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SCHISANDRA EXTRACT; SERUM ALBUMIN; THIOACETAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; LIVER FIBROSIS; LIVER FUNCTION; LIVER PROTECTION; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; BIOLOGICAL MARKERS; DIOXOLES; GLUCURONOSYLTRANSFERASE; LIGNANS; LIVER; LIVER CIRRHOSIS; MALE; PROTECTIVE AGENTS; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SCHISANDRA; THIOACETAMIDE; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

RATTUS; SCHISANDRA;

EID: 80053147375     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.039172     Document Type: Article

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