Hypertrophy of hippocampal end folium neurons in patients with mesial temporal lobe epilepsy

Neuropathology

Volumn 31, Issue 5, 2011, Pages 476-485

  Ryufuku, Masae ^a   Toyoshima, Yasuko ^a   Kitaura, Hiroki ^a   Zheng, Yingjun ^a   Fu, Yong Juan ^a   Miyahara, Hiroaki ^a   Murakami, Hiroatsu ^b   Masuda, Hiroshi ^b   Kameyama, Shigeki ^b   Takahashi, Hitoshi ^a   Kakita, Akiyoshi ^a  

^a NIIGATA UNIVERSITY   (Japan)

^b NISHI NIIGATA CHUO NATIONAL HOSPITAL   (Japan)

Author keywords

CA4 subfield; Dysmorphic neuron; Hippocampal sclerosis; Neuronal hypertrophy; Pathology

Indexed keywords

HEAT SHOCK PROTEIN 70; NEUROFILAMENT PROTEIN;

ADULT; ARTICLE; BRAIN NERVE CELL; BRAIN REGION; CELL LOSS; CELL NUCLEUS; CELL STRESS; CELL STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HIPPOCAMPAL SCLEROSIS; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; MALE; PERIKARYON; PRIORITY JOURNAL; TEMPORAL LOBE EPILEPSY;

ADULT; EPILEPSY, TEMPORAL LOBE; FEMALE; HIPPOCAMPUS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HYPERTROPHY; MALE; MIDDLE AGED; NEURONS; YOUNG ADULT;

EID: 80053110224     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/j.1440-1789.2010.01191.x     Document Type: Article

References (42)

1. Davies KG, Hermann BP, Dohan FC Jr, Foley KT, Bush AJ, Wyler AR. Relationship of hippocampal sclerosis to duration and age of onset of epilepsy, and childhood febrile seizures in temporal lobectomy patients. Epilepsy Res 1996; 24: 119-126.
2. Fuerst D, Shah J, Kupsky WJ etal. Volumetric MRI, pathological, and neuropsychological progression in hippocampal sclerosis. Neurology 2001; 57: 184-188.
3. Mathern GW, Adelson PD, Cahan LD, Leite JP. Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited. Prog Brain Res 2002; 135: 237-251.
4. Watson C, Nielsen SL, Cobb C, Burgermann R, Williamson B. Pathological grading system for hippocampal sclerosis: correlation with magnetic resonance image-based volume measurements of the hippocampus. J Epilepsy 1996; 9: 56-64.
5. Wyler AR, Dohan FC, Schweitzer JB, Berry AD. A grading system for mesial temporal pathology (hippocampal sclerosis) from anterior temporal lobectomy. J Epilepsy 1992; 5: 220-225.
6. VanLandingham KE, Heinz ER, Cavazos JE, Lewis DV. Magnetic resonance imaging evidence of hippocampal injury after prolonged focal febrile convulsions. Ann Neurol 1998; 43: 413-426.
7. O'Brien TJ, So EL, Meyer FB, Parisi JE, Jack CR. Progressive hippocampal atrophy in chronic intractable temporal lobe epilepsy. Ann Neurol 1999; 45: 526-529.
8. Jackson GD, Chambers BR, Berkovic SF. Hippocampal sclerosis: development in adult life. Dev Neurosci 1999; 21: 207-214.
9. Briellmann R, Berkovic SF, Syngeniotis A, King MA, Jackson GD. Seizure associated hippocampal volume loss: a longitudinal magnetic resonance study of temporal lobe epilepsy. Ann Neurol 2002; 51: 641-644.
10. Baulac M, Grissac ND, Hasboun D etal. Hippocampal developmental changes in patients with partial epilepsy: magnetic resonance imaging and clinical aspects. Neurology 1998; 44: 223-233.
11. Fernández G, Effenberger O, Vinz B etal. Hippocampal malformation as a cause of familial febrile convulsions and subsequent hippocampal sclerosis. Neurology 1998; 50: 909-917.
12. Grunewald RA, Farrow T, Vaughan P, Rittey CDC, Mundy J. A magnetic resonance study of complicated early childhood convulsions. J Neurol Neurosurg Psychiatry 2001; 71: 638-642.
13. Blümcke I, Thom M, Wiestler OD. Ammon's horn sclerosis: a maldevelopmental disorder associated with temporal lobe epilepsy. Brain Pathology 2002; 12: 199-211.
14. Sloviter RS, Kudrimoti HS, Laxer KD etal. "Tectonic" hippocampal malformations in patients with temporal lobe epilepsy. Epilepsy Res 2004; 59: 123-153.
15. Blümcke I, Zuschratter W, Schewe J-C etal. Cellular pathology of hilar neurons in Ammon's horn sclerosis. J Comp Neurol 1999; 41: 437-453.
16. Thom M, D'Arrigo C, Scaravilli F. Hippocampal sclerosis with hypertrophy of end folium pyramidal cells. Acta Neuropathol 1999; 98: 107-110.
17. Thom M, Sisodiya SM, Beckett A etal. Cytoarchitectural abnormalities in hippocampal sclerosis. J Neuropathol Exp Neurol 2002; 61: 510-519.
18. da Silva AV, Houzel JC, Yacubian EMT etal. Dysmorphic neurons in patients with temporal lobe epilepsy. Brain Res 2006; 1072: 200-207.
19. Palmini A, Najm I, Avanzini G etal. Terminology and classification of the cortical dysplasias. Neurology 2004; 62: S2-S8.
20. Dawodu S, Thom M. Quantitative neuropathology of the entorhinal cortex region in patients with hippocampal sclerosis and temporal lobe epilepsy. Epilepsia 2005; 46: 23-30.
21. Blümcke I, Pauli E, Clustmann H etal. A new clinico-pathological classification system for mesial temporal sclerosis. Acta Neuropathol 2007; 113: 235-244.
22. Thom M, Eriksson S, Martinian L etal. Temporal lobe sclerosis associated with hippocampal sclerosis in temporal lobe epilepsy: neuropathological features. J Neuropathol Exp Neurol 2009; 68: 928-938.
23. Hadjivassiliou G, Martinian L, Squier W etal. The application of cortical layer markers in the evaluation of cortical dysplasias in epilepsy. Acta Neuropathol 2010; 120: 517-528.
24. Duvernoy HM. The Human Hippocampus. Functional Anatomy, Vascularization and Serial Sections with MRI. Heidelberg: Springer, 2005.
25. Vinters HV, De Rosa MJ, Farrell MA. Neuropathologic study of resected cerebral tissue from patients with infantile spasms. Epilepsia 1993; 34: 772-779.
26. Lim C, Mufson EJ, Kordower JH, Blume HW, Madsen JR, Saper CB. Connections of the hippocampal formation in humans. II. The endfolial fibre pathway. J Comp Neurol 1997; 385: 352-371.
27. Bothwell S, Meredith GE, Phillips J etal. Neuronal hypertrophy in neocortex of patients with temporal lobe epilepsy. J Neurosci 2001; 21: 4789-4800.
28. 4 parvalbumin-immunoreactive interneurons in patients with Ammon's horn sclerosis. J Neuropathol Exp Neurol 1997; 56: 988-998.
29. Andrioli A, Alonso-Nanclares L, Arellano JI, DeFelipe J. Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus. Neuroscience 2007; 149: 131-143.
30. Jellinger K. Hypertrophy of the inferior olives. Report on 29 cases. Z Neurol 1973; 205: 153-174.
31. Everall IP, Luthert PJ, Lantos PL. Neuronal number and volume alterations in the neocortex of HIV infected individuals. J Neurol Neurosurg Psychiatry 1993; 56: 481-486.
32. Neal JW, Pearson RCA, Cole G, Powell TPS. Neuronal hypertrophy in the pars reticulata of the substantia nigra in Parkinson's disease. Neuropathol Appl Neurobiol 1991; 17: 203-206.
33. Thom M, Sisodiya SM, Lin WR etal. Bilateral isolated hippocampal malformation in temporal lobe epilepsy. Neurology 2002; 58: 1683-1686.
34. Sen A, Thom M, Martinian L, Dawodu S, Sisodiya SM. Hippocampal malformations do not necessarily evolve into hippocampal sclerosis. Epilepsia 2005; 46: 939-943.
35. Kim SH, Cho Y-J, Kim HS etal. Balloon cells and dysmorphic neurons in the hippocampus associated with epileptic amnesic syndrome: a case report. Epilepsia 2008; 49: 905-909.
36. Thom M, Martinian L, Caboclo LO, McEvoy AW, Sisodiya SM. Balloon cells associated with granule cell dispersion in the dentate gyrus in hippocampal sclerosis. Acta Neuropathol 2008; 115: 697-700.
37. Zhao C, Deng W, Gage FH. Mechanisms and functional implications of adult neurogenesis. Cell 2008; 132: 645-660.
38. Dubé C, André V, Covolan L, Ferrandon A, Marescaux C, Nehlig A. C-Fos, Jun D and HSP72 immunoreactivity, and neuronal injury following lithium-pilocarpine induced status epilepticus in immature and adult rats. Mol Brain Res 1998; 63: 139-154.
39. Yang T, Hsu C, Liao W, Chuang JS. Heat shock protein 70 expression in epilepsy suggests stress rather than protection. Acta Neuropathol 2008; 115: 219-230.
40. Gass P, Prior P, Kiessling M. Correlation between seizure intensity and stress protein expression after limbic epilepsy in the rat brain. Neuroscience 1995; 65: 27-36.
41. Thom M, Seetah S, Sisodiya S, Koepp M, Scaravilli F. Sudden and unexpected death in epilepsy (SUDEP): evidence of acute neuronal injury using HSP-70 and c-Jun immunohistochemistry. Neuropathol Appl Neurobiol 2003; 29: 132-143.
42. Lagalwar S, Berry RW, Binder LI. Relation of hippocampal phosphor-SAPK/JNK granules in Alzheimer's disease and tauopathies to granulovacuolar degeneration bodies. Acta Neuropathol 2007; 113: 63-73.