Imaging of zebrafish In Vivo with second-harmonic generation reveals shortened sarcomeres associated with myopathy induced by statin

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Huang, Shih Hao ^a   Hsiao, Chung Der ^b   Lin, Dar Shong ^c   Chow, Cho Yen ^a   Chang, Chia Jen ^a   Liau, Ian ^a  

^a NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^b CHUNG YUAN CHRISTIAN UNIVERSITY   (Taiwan)

^c MACKAY MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CHOLESTEROL; CREATINE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LAVASTATIN; MEVALONIC ACID; MYOSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG SAFETY; HISTOPATHOLOGY; IMAGING SYSTEM; IN VIVO STUDY; MUSCLE CELL; MYOPATHY; NONHUMAN; OUTCOME ASSESSMENT; SARCOMERE LENGTH; SECOND HARMONIC GENERATION IMAGING; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; ZEBRA FISH; ANIMAL; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG EFFECT; FEMALE; FIBER; GROWTH, DEVELOPMENT AND AGING; IMAGE PROCESSING; LARVA; MALE; METABOLISM; METHODOLOGY; MULTIPHOTON MICROSCOPY; MUSCLE CONTRACTION; MUSCLE DISEASE; PATHOPHYSIOLOGY; PHYSIOLOGY; SARCOMERE; TIME;

DANIO RERIO;

ANIMALS; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMAGE PROCESSING, COMPUTER-ASSISTED; LARVA; MALE; MEVALONIC ACID; MICROFIBRILS; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUSCULAR DISEASES; SARCOMERES; TIME FACTORS; ZEBRAFISH;

EID: 80053109690     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024764     Document Type: Article

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