Overexpression of centromere protein H is significantly associated with breast cancer progression and overall patient survival

Chinese Journal of Cancer

Volumn 30, Issue 9, 2011, Pages 627-637

  Liao, Wen Ting ^a,b   Feng, Yan ^a   Li, Men Lin ^a   Liu, Guang Lin ^a   Li, Man Zhi ^a   Zeng, Mu Sheng ^a   Song, Li Bing ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Biomarker; Breast cancer; Centromere protein H (CENP H); Prognosis; Proliferation

Indexed keywords

CENTROMERE PROTEIN H; KI 67 ANTIGEN; MESSENGER RNA; NUCLEAR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; CANCER CLASSIFICATION; CANCER GROWTH; CANCER STAGING; CELL IMMORTALIZATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; OVERALL SURVIVAL; PROGNOSIS; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; BREAST; BREAST NEOPLASMS; CELL LINE; CELL LINE, TUMOR; CHROMOSOMAL PROTEINS, NON-HISTONE; EPITHELIAL CELLS; FEMALE; FOLLOW-UP STUDIES; HUMANS; KI-67 ANTIGEN; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM STAGING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE; UP-REGULATION;

EID: 80053074469     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.010.10599     Document Type: Article

References (24)

1. Bieche I, Tozlu S, Girault I, et al. Identification of a three-gene expression signature of poor-pr ognosis breast carcinoma [J]. Mol Cancer, 2004,3(1):37.
2. Wang Y, Klijn JG, Zhang Y, et al. Gene-expression profiles to predict distant metastasis of lymph-no de-negative primary breast cancer [J]. Lancet, 2005,365(9460):671-679.
3. Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications [J]. Proc Natl Acad Sci U S A, 2001,98(19):10869-10874.
4. Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers [J]. Nature, 1997,386(6625):623-627.
5. Yoon DS, Wersto RP, Zhou W, et al. Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer [J]. Am J Pathol, 2002,161(2):391-397.
6. von Rosen A. Aneuploidy as a prognostic factor in breast cancer [J]. Med Oncol Tumor Pharmacother, 1989,6(2):117-120.
7. Nakopoulou L, Tsirmpa I, Giannopoulou I, et al. Aneuploidy of chromosome 20 in invasive breast cancer correlates with poor outcome [J]. Cancer Genet Cytogenet, 2002,134(2):127-132.
8. Hainsworth PJ, Raphael KL, Stillwell RG, et al. Cytogenetic features of twenty-six primary breast cancers [J]. Cancer Genet Cytogenet, 1991,53(2):205-218.
9. Pandis N, Heim S, Bardi G, et al. Chromosome analysis of 20 breast carcinomas: cytogenetic multiclonality and karyotypic-pathologic correlations [J]. Genes Chromosomes Cancer, 1993,6(1):51-57.
10. Pandis N, Idvall I, Bardi G, et al. Correlation between karyotypic pattern and clincopathologic features in 125 breast cancer cases [J]. Int J Cancer, 1996,66(2):191-196.
11. Sugata N, Munekata E, Todokoro K. Characterization of a novel kinetochore protein, CENP-H [J]. J Biol Chem, 1999,274 (39): 27343-27346.
12. Maiato H, DeLuca J, Salmon ED, et al. The dynamic kinetochore-microtubule interface [J]. J Cell Sci, 2004,117 (Pt 23):5461-5477.
13. Rajagopalan H, Lengauer C. Aneuploidy and cancer [J]. Nature, 2004,432(7015):338-341.
14. Sugata N, Li S, Earnshaw WC, et al. Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere-kinetochore complexes [J]. Hum Mol Genet, 2000,9(19):2919-2926.
15. Tomonaga T, Matsushita K, Ishibashi M, et al. Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy [J]. Cancer Res, 2005,65(11):4683-4689.
16. Shigeishi H, Higashikawa K, Ono S, et al. Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity [J]. Oncol Rep, 2006,16(5):1071-1075.
17. Guo XZ, Zhang G, Wang JY, et al. Prognostic relevance of centromere protein H expression in esophageal carcinoma [J]. BMC Cancer, 2008,8:233.
18. Liao WT, Song LB, Zhang HZ, et al. Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival [J]. Clin Cancer Res, 2007,13(2 Pt 1):508-514.
19. Liao WT, Wang X, Xu LH, et al. Centromere protein H is a novel prognostic marker for human nonsmall cell lung cancer progression and overall patient survival [J]. Cancer, 2009,115 (7):1507-1517.
20. Liao WT, Yu CP, Wu DH, et al. Upregulation of CENP-H in tongue cancer correlates with poor prognosis and progression [J]. J Exp Clin Cancer Res, 2009,28:74.
21. Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10 A mammary epithelial acini grown in three-dimensional basement membrane cultures [J]. Methods, 2003,30(3):256-268.
22. Song LB, Zeng MS, Liao WT, et al. Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells [J]. Cancer Res, 2006,66(12):6225-6232.
23. Zhou H, Kuang J, Zhong L, et al. Tumour amplified kinase stk15/btak induces centrosome amplification, aneuploidy and transformation [J]. Nat Genet, 1998,20(2):189-193.
24. O'Brien SL, Fagan A, Fox EJ, et al. CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer [J]. Int J Cancer, 2007,120 (7):1434-1443.