Prefrontal cortex glutathione S-transferase levels in patients with bipolar disorder, major depression and schizophrenia

International Journal of Neuropsychopharmacology

Volumn 14, Issue 8, 2011, Pages 1069-1074

  Gawryluk, Jeremy W ^a   Wang, Jun Feng ^a   Andreazza, Ana C ^a   Shao, Li ^a   Yatham, Lakshmi N ^a   Young, L Trevor ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Antioxidant; bipolar disorder; glutathione S transferase; major depressive disorder; schizophrenia

Indexed keywords

GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE MU; GLUTATHIONE TRANSFERASE P1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BIPOLAR DISORDER; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MAJOR DEPRESSION; MALE; MORTALITY; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADULT; BIPOLAR DISORDER; BRAIN; CONTROL GROUPS; DEPRESSIVE DISORDER, MAJOR; FEMALE; GLUTATHIONE TRANSFERASE; HUMANS; MALE; MIDDLE AGED; PREFRONTAL CORTEX; SCHIZOPHRENIA;

EID: 80053019809     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145711000617     Document Type: Article

References (26)

1. Abdalla DS, Monteiro HP, Oliveira JA, Bechara EJ (1986). Activities of superoxide dismutase and glutathione peroxidase in schizophrenic and manic-depressive patients. Clinical Chemistry 32, 805-807. (Pubitemid 17028354)
2. Andreazza AC, Cassini C, Rosa AR, Leite MC, et al. (2007). Serum 100B and antioxidant enzymes in bipolar patients. Journal of Psychiatric Research 41, 523-529. (Pubitemid 46227446)
3. Andreazza AC, Kapczinski F, Kauer-Sant'anna M, Walz JC, et al. (2009). 3-Nitrotyrosine and glutathione antioxidant system in patients in the early and late stages of bipolar disorder. Journal of Psychiatry & Neuroscience 34, 263-271.
4. Andreazza AC, Shao L, Wang JF, Young LT (2010). Decreased mitochondrial complex I activity and increased oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder. Archives of General Psychiatry 67, 360-368.
5. Baez S, Segura-Aguilar J, Widersten M, Johansson AS, et al. (1997). Glutathione transferases catalyse the detoxification of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes. Biochemical Journal 324, 25-28. (Pubitemid 27229361)
6. Bakare A, Shao L, Young L, Wang JF (2009). Mood stabilizing drugs lamotrignine and olanzapine increase expression and activity of glutathione S-transferase in primary cultured rat cerebral cortical cells. Neuroscience Letters 455, 70-73.
7. Benes FM, Matzilevich D, Burke RE, Walsh J (2006). The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia. Molecular Psychiatry 11, 241-251.
8. Berk M, Copolov DL, Dean O, Lu K, et al. (2008a). N-Acetyl cysteine for depressive symptoms in bipolar disorder-a double-blind randomized placebo-controlled trial. Biological Psychiatry 64, 468-475.
9. Berk M, Copolov DL, Dean O, Lu K, et al. (2008b). N-Acetyl cysteine as a glutathione precursor for Schizophrenia-a double blind, randomized, placebo-controlled trial. Biological Psychiatry 64, 361-368.
10. Carder PJ, al-Nafussi A, Rahilly M, Lauder J, et al. (1990). Glutathione S-transferase detoxification enzymes in cervical neoplasia. Journal of Pathology 162, 303-308.
11. Cui J, Shao L, Young LT, Wang JF (2007). Role of glutathione in neuroprotective effects of mood stabilizing drugs lithium and valproate. Neuroscience 144, 1447-1453. (Pubitemid 46123817)
12. Dourado DFAR, Fernandes PA, Ramos MJ (2008). Mammalian cytosolic glutathione transferases. Current Protein and Peptide Science 9, 1-13.
13. Dowlatshahi D, MacQueen G, Wang J, Reiach J, et al. (1999). G protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death. Journal of Neurochemistry 73, 1121-1126. (Pubitemid 29395470)
14. Gawryluk JW, Wang JF, Andreazza A, Shao L, Young LT (2011). Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders. International Journal of Neuropsychopharmacology 14, 123-130.
15. Hayes JD, Flanagan JU, Jowsey IR (2005). Glutathione transferases. Annual Review of Pharmacology and Toxicology 45, 51-88. (Pubitemid 40261798)
16. Hayes JD, Strange RC (1995). Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress. Free Radical Research 22, 193-207.
17. Knable MB, Barci BM, Webster MJ, Meador-Woodruff J, et al. (2004). Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. Molecular Psychiatry 9, 609-620. (Pubitemid 38850441)
18. Kuloglu M, Ustundag B, Atmaca M, Tezcan AE (2002). Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder. Cell Biochemistry and Function 20, 171-175.
19. Ng F, Berk M, Dean O, Bush AI (2008). Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. International Journal of Neuropsychopharmacology 11, 851-876.
20. Shao L, Cui J, Young LT, Wang JF (2008). The effect of mood stabilizer lithium on expression and activity of glutathione s-transferase isoenzymes. Neuroscience 151, 518-524.
21. Solano F, Hearing VJ, Garci-Borron JC (2000). Neurotoxicity due to o-quinones: neuromelanin formation and possible mechanisms for o-quinone detoxification. Neurotoxicity Research 1, 153-169.
22. Sun X, Wang JF, Tseng M, Young LT (2006). Down regulation in components of mitochondrial electron transport chain in post-mortem frontal cortex from subjects with bipolar disorder. Journal of Psychiatry Research 31, 189-196. (Pubitemid 43954738)
23. Theodore C, Singh SV, Hong TD, Awasthi YC (1985). Glutathione S-transferases of human brain. Biochemical Journal 225, 375-382.
24. Torrey EF, Webster M, Knable M, Johnston N, et al. (2000). Stanley Foundation brain collection and neuropathology consortium. Schizophrenia Research 44, 151-155. (Pubitemid 30411930)
25. Wang JF, Shao L, Sun X, Young LT (2004). Glutathione S-transferase is a novel target for mood stabilizing drugs in primary cultured neurons. Journal of Neurochemistry 88, 1477-1484. (Pubitemid 38366924)
26. Wang JF, Shao L, Sun X, Young LT (2009). Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia. Bipolar Disorder 11, 523-529.