Intralesional infusion of methotrexate as neoadjuvant therapy improves the cosmetic and functional results of surgery to treat keratoacanthoma: Results of a randomized trial;Ensayo clínico: la infiltración intralesional con metotrexato de forma neoadyuvante en la cirugía del queratoacantoma permite obtener mejores resultados estéticos y funcionales

Actas Dermo-Sifiliograficas

Volumn 102, Issue 8, 2011, Pages 605-615

  Martorell Calatayud, A ^a   Requena, C ^a   Nagore, E ^a   Sanmartin O ^a   Serra Guillen C ^a   Botella Estrada, R ^c   Sanz Motilva, V ^b   Llombart, B ^a   Alcaniz Moscardo A ^a   Guillen Barona C ^a  

^a INSTITUTO VALENCIANO DE ONCOLOGÍA   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^c HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

Clinical trial; Keratoacanthoma; Methotrexate; Squamous cell carcinoma; Surgery

Indexed keywords

METHOTREXATE;

ABSENCE OF SIDE EFFECTS; ADJUVANT THERAPY; ARTICLE; CANCER CHEMOTHERAPY; CANCER SURGERY; CLINICAL ARTICLE; DRUG EFFICACY; HOSPITAL ADMISSION; HUMAN; KERATOACANTHOMA; PREOPERATIVE CARE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TUMOR VOLUME;

EID: 80053013848     PISSN: 00017310     EISSN: 15782190     Source Type: Journal    
DOI: 10.1016/j.adengl.2011.03.012     Document Type: Article

References (39)

1. A. Beham, S. Regauer, H.P. Soyer, and C. Beham-Schmid Keratoacanthoma: a clinically distinct variant of well-differentiated squamous cell carcinoma Adv Anat Pathol 5 1998 269 280
2. C.H. Manstein, C.J. Frauenhoffer, and J.E. Besden Keratoacanthoma: is it a real entity? Ann Plast Surg 40 1998 469 472 (Pubitemid 28215516)
3. L. Benest, R.P. Kaplan, R. Salit, and R. Moy Keratoacanthoma centrifugum marginatum of the lower extremity treated with Mohs micrographic surgery J Am Acad Dermatol 31 1994 501 502 (Pubitemid 24273328)
4. P.O. Larson Keratoacanthomas treated with Mohs' micrographic surgery (chemosurgery): a review of forty-three cases J Am Acad Dermatol 16 1987 1040 1044 (Pubitemid 17073139)
5. W.Y. Wong, R.V. Kolbusz, L.H. Goldberg, and A. Guana Treatment of a recurrent keratoacanthoma with oral isotretinoin Int J Dermatol 33 1994 579 583 (Pubitemid 24255809)
6. H. Goldschmidt, and W.K. Sherwin Radiation therapy of giant aggressive keratoacanthomas Arch Dermatol 129 1993 1162 1165 (Pubitemid 23272097)
7. M. Caccialanza, and N. Sopelana Radiation therapy of keratoacanthomas: results in 55 patients Int J Radiat Oncol Biol Phys 16 1989 475 477 (Pubitemid 19077214)
8. F. Reymann Treatment of keratoacanthomas with curettage Dermatologica 155 1997 90 96
9. J.A. Nedwich Evaluation of curettage and electrodesiccation in treatment of keratoacanthoma Australas J Dermatol 32 1991 137 141
10. A.T. Sheridan, and R.P. Dawber Curettage, electrosurgery and skin cancer Australas J Dermatol 41 2000 19 30 (Pubitemid 30136718)
11. E. Klein, H. Milgram, and H.L. Traenkle Tumors of the skin, II: keratoacanthoma, local effect of 5-fluorouracil (5-FU) Skin 1 1962 153 156
12. D.J. Bergin, N.A. Lapins, and T.A. Deffer Intralesional 5-fluorouracil for keratoacanthoma of the eyelid Ophthal Plast Reconstr Surg 2 1986 201 204 (Pubitemid 17028824)
13. C.M. Parker, and C.W. Hanke Large keratoacanthomas in difficult locations treated with intralesional 5-fluorouracil J Am Acad Dermatol 14 1986 770 777 (Pubitemid 16113969)
14. J.J. Thiele, M. Ziemer, S. Fuchs, and P. Elsner Combined 5-fluorouracil and Er:YAG laser treatment in a case of recurrent giant keratoacanthoma of the lower leg Dermatol Surg 30 2004 1556 1560 (Pubitemid 40053526)
15. J.L. Melton, B.R. Nelson, D.B. Stough, M.D. Brown, N.A. Swanson, and T.M. Johnson Treatment of keratoacanthomas with intralesional methotrexate J Am Acad Dermatol 25 1991 1017 1023
16. L.N. Hurst, and B.S. Gan Intralesional methotrexate in keratoacanthoma of the nose Br J Plast Surg 48 1995 243 246
17. C. Cuesta-Romero, and J. de Grado-Pena Intralesional methotrexate in solitary keratoacanthoma Arch Dermatol 134 1998 513 514
18. R. Remling, M. Mempel, N. Schnopp, D. Abeck, and J. Ring Intralesional methotrexate injection: an effective time and cost saving therapy alternative in keratoacanthomas that are difficult to treat surgically Hautarzt 51 2000 612 614 (Pubitemid 30629230)
19. K. Spieth, J. Gille, and R. Kaufmann Intralesional methotrexate as effective treatment in solitary giant keratoacanthoma of the lower lip Dermatology 200 2000 317 319 (Pubitemid 30451580)
20. M.A. Richard, J. Gachon, R. Choux, R. Laurans, G. Folchetti, and J.J. Grob Treatment of keratoacanthoma with intralesional methotrexate injections Ann Dermatol Venereol 127 2000 1097
21. J.G. de Visscher, K.G. van der Wal, R. Blanken, and F. Willemse Treatment of giant keratoacanthoma of the skin of the lower lip with intralesional methotrexate: a case report J Oral Maxillofac Surg 60 2002 93 95 (Pubitemid 34056301)
22. P.R. Cohen, K.E. Schulze, C.F. Teller, and B.R. Nelson Intralesional methotrexate for keratoacanthoma of the nose Skinmed 4 2005 393 395
23. N.M. Annest, M.J. VanBeck, C.J. Arpey, and D.C. Whitaker Intralesional metotrexate treatment for keratoacanthoma tumors: A retrospective study and review of the literature J Am Acad Dermatol 56 2007 989 993 (Pubitemid 46720214)
24. L.M. Good, M.D. Miller, and W.A. High Intralesional agents in the management of cutaneous malignancy: A review J Am Acad Dermatol 64 2011 413 422
25. C.K. Oh, H.S. Son, J.B. Lee, H.S. Jang, and K.S. Kwon Intralesional interferon alfa-2b treatment of keratoacanthomas J Am Acad Dermatol 51 2004 1040
26. M. Dendorfer, T. Oppel, A. Wollenberg, and J.C. Prinz Topical treatment with imiquimod may induce regression of facial kerato- acanthoma Eur J Dermatol 13 2003 80 82 (Pubitemid 36228516)
27. D.G. Brodland, and J.A. Zitelli Surgical margins for escision of primary cutaneous squamous cell carcinoma J Am Acad Dermatol 27 1992 241 248
28. R.A. Schwartz The keratoacanthoma review J Surg Oncol 12 1979 305 317
29. E. Hodak, R.E. Jones, and A.B. Ackerman Solitary keratoacanthomais a squamous cell carcinoma: three examples with metastases Am J Dermatopathol 15 1993 332 342
30. Mackie RH. Epidermal skin tumors. En: Champion RH, Burton JL, Ebling EJG, editors. Textbook of dermatology. 5th ed. Oxford: Blackwell;1992. p. 465-1470.
31. Brenn T, McKee PH. Tumors of the surface epithelium. En: McKee PH, Calonje E, Granter SR, editors. Pathology of the skin with clinical correlations. 3rd ed. London: Mosby Elsevier;2005. p.1221-6.
32. E. Calonje, and E. Wilson Jones Intravascular spread of keratoacanthoma: challenges in management Dermatol Surg 14 1998 414 417
33. P.H. Cooper, and J.T. Wolfe Perioral keratoacanthoma with extensive perineural invasion and intravenous growth Arch Dermatol 124 1988 1341 1397
34. F. Piscioli, G. Zumiani, S. Boi, and M. Cristofolini A gigantic, metastatizing keratoacanthoma: a report of a case and discussion on classification Am J Dermatopathol 6 1984 123 129 (Pubitemid 14134080)
35. N.S. Medalie Keratoacanthoma with perineural invasion Australas J Dermatol 43 2002 155
36. J.C. Mandrell, and D. Santa Cruz Keratoacanthoma: hyperplasia, benign neoplasm, or a type of squamous cell carcinoma? Semin Diagn Pathol 26 2009 150 163
37. E. Sánchez Yus, P. Simón, L. Requena, P. Ambrojo, and E. de Eusebio Solitary keratoacanthoma: a self-healing proliferation that frequently becomes malignant Am J Dermatopathol 22 2000 305 310 (Pubitemid 30618611)
38. D.D. Weedon, J. Malo, D. Brooks, and R. Williamson Squamous Cell Carcinoma Arising in Keratoacanthoma: A Neglected Phenomenon in the Elderly Am J Dermatopathol 32 2010 423 426
39. L. Ferrándiz, D. Moreno-Ramírez, A. Ruiz-de-Casas, A. Nieto-García, P. Moreno-Álvarez, and R. Galdeano Teledermatología prequirúgica en pacientes con cáncer cutáneo no melanoma. Evaluación económica Actas Dermosifiliogr 99 2008 795 802