Abnormal histone modifications in PBMCs from patients with psoriasis vulgaris

European Journal of Dermatology

Volumn 21, Issue 4, 2011, Pages 552-557

  Zhang, Peng ^a   Su, Yuwen ^a   Zhao, Ming ^a   Huang, Wei ^a   Lu, Qianjin ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Histone acetylation; Histone methylation; Histone modifications; Peripheral blood mononuclear cells; Psoriasis vulgaris

Indexed keywords

HISTONE H3; HISTONE H4; MESSENGER RNA; PROTEIN H3K27; PROTEIN H3K4; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BETA ACTIN GENE; CBP GENE; CHROMATIN; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; ENHANCER OF ZESTE HOMOLOG 2 GENE; GENE; GENE EXPRESSION; GENETIC DISORDER; HISTONE ACETYLATION; HISTONE DEACETYLASE 1 GENE; HISTONE DEACETYLASE 2 GENE; HISTONE DEACETYLASE 4 GENE; HISTONE DEACETYLASE 5 GENE; HISTONE DEACETYLASE 7 GENE; HISTONE METHYLATION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; MOLECULAR PATHOLOGY; P300 GENE; PCAF GENE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN DETERMINATION; PSORIASIS VULGARIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SILENT MATING TYPE INFORMATION REGULATION 2 HOMOLOG 1 GENE; SUV39H1 GENE; SUV39H2 GENE;

ACETYLATION; ADULT; DNA METHYLATION; FEMALE; HISTONES; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; PSORIASIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC;

EID: 80053009376     PISSN: 11671122     EISSN: 19524013     Source Type: Journal    
DOI: 10.1684/ejd.2011.1383     Document Type: Article

References (36)

1. Christophers E. Psoriasis-epidemiology and clinical spectrum. Clin Exp Dermatol 2001; 26: 314-20.
2. Griffiths CE, Barker JN. Pathogenesis and clinical features of psoriasis. Lancet 2007; 370: 263-71.
3. Gaspari AA. Innate and adaptive immunity and the pathophysiology of psoriasis. J Am Acad Dermatol 2006; 54: S67-80.
4. Davidson A, Diamond B. Autoimmune diseases. N Engl J Med 2001; 345: 340-50.
5. Krueger GG, Duvic M. Epidemiology of psoriasis: clinical issues. J Invest Dermatol 1994; 102: 14S-8S.
6. Grolleau-Julius A, Ray D, Yung RL. The Role of Epigenetics in Aging and Autoimmunity. Clin Rev Allergy Immunol 2009;
7. Brooks WH, Le Dantec C, Pers JO, Youinou P, Renaudineau Y. Epigenetics and autoimmunity. J Autoimmun 2010; 34: J207-19.
8. Kornberg RD, Lorch Y. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 1999; 98: 285-94.
9. Kouzarides T. Chromatin modifications and their function. Cell 2007; 128: 693-705.
10. Gregory PD, Wagner K, Horz W. Histone acetylation and chromatin remodeling. Exp Cell Res 2001; 265: 195-202.
11. Bernstein BE, Meissner A, Lander ES. The mammalian epigenome. Cell 2007; 128: 669-81.
12. Esteller M. Epigenetics in cancer. N Engl J Med 2008; 358: 1148-59.
13. Kondo Y, Shen L, Cheng AS, et al. Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat. Genet 2008; 40: 741-50.
14. Bos JD. Psoriasis, innate immunity, and gene pools. J Am Acad Dermatol 2007; 56: 468-71.
15. Okubo Y, Koga M. Peripheral blood monocytes in psoriatic patients overproduce cytokines. J Dermatol Sci 1998; 17: 223-32.
16. Brody I. Dermal and epidermal involvement in the evolution of acute eruptive guttate psoriasis vulgaris. J Invest Dermatol 1984; 82: 465-70.
17. Zhang P, Su Y, Chen H, Zhao M, Lu Q. Abnormal DNA methylation in skin lesions and PBMCs of patients with psoriasis vulgaris. J Dermatol Sci 2010; 60: 40-2.
18. Vaissière T, Sawan Carla T, Herceg Z. Epigenetic interplay between histone modifications and DNA methylation in gene silencing. Mutation Research/Reviews in Mutation Research 2008; 659: 40-8.
19. Lehrmann H, Pritchard LL, Harel-Bellan A. Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation. Adv Cancer Res 2002; 86: 41-65.
20. Willis-Martinez D, Richards HW, Timchenko NA, Medrano EE. Role of HDAC1 in senescence, aging, and cancer. Exp Gerontol 2010; 45: 279-85.
21. Tovar-Castillo LE, Cancino-Diaz JC, Garcia-Vazquez F, et al. Under-expression of VHL and over-expression of HDAC-1, HIF-1alpha, LL-37, and IAP-2 in affected skin biopsies of patients with psoriasis. Int J Dermatol 2007; 46: 239-46.
22. Haigis MC, Guarente LP. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev 2006; 20: 2913-21.
23. Fulco M, Schiltz RL, Iezzi S, King MT, Zhao P, Kashiwaya Y. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell 2003; 12: 51-62.
24. Picard F, Kurtev M, Chung N, et al. Sirt1promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004; 429: 771-6.
25. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005; 434: 113-8.
26. Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol 2006; 4: e31.
27. Blander G, Bhimavarapu A, Mammone T, et al. SIRT1 promotes differentiation of normal human keratinocytes. J Invest Dermatol 2009; 129: 41-9.
28. Rice JC, Briggs SD, Ueberheide B, et al. Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell 2003 12: 1591-8.
29. Cao R, Zhang Y. The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr Opin Genet Dev 2004; 14: 155-64.
30. Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 2002; 419: 624-9.
31. Collett K, Eide GE, Arnes J, Stefansson IM, Eide J, Braaten A. Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clin Cancer Res 2006; 12: 1168-74.
32. Weikert S, Christoph F, Kollermann J, Muller M, Schrader M, Miller K. Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas. Int J Mol Med 2005; 16: 349-53.
33. McHugh JB, Fullen DR, Ma L, Kleer CG, Su LD. Expression of polycomb group protein EZH2 in nevi and melanoma. J Cutan Pathol 2007; 34: 597-600.
34. Tsaprouni LG, Ito K, Powell JJ, Adcock IM, Punchard N. Differential patterns of histone acetylation in inflammatory bowel diseases. J Inflamm (Lond) 2011; 8: 1.
35. Ito K, Caramori G, Lim S, et al. Expression and activity of histone deacetylases in human asthmatic airways. Am J Respir Crit Care Med 2002; 166: 392-6.
36. Huber LC, Brock M, Hemmatazad H, et al. Histone deacetylase/ acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients. Arthritis Rheum 2007; 56: 1087-93.