A variant near the melanocortin-4 receptor gene regulates postprandial lipid metabolism in a healthy Caucasian population

British Journal of Nutrition

Volumn 106, Issue 4, 2011, Pages 468-471

  Perez Martinez, Pablo ^a   Garcia Rios, Antonio ^a   Delgado Lista, Javier ^a   Delgado Casado, Nieves ^a   Malagon, Maria M ^b   Marin, Carmen ^a   Gomez Luna, Purificacion ^a   Caballero, Javier ^a   Perez Jimenez, Francisco ^a   Lopez Miranda, Jose ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

Nutrigenomics; Polymorphisms; Postprandial lipaemia; TAG rich lipoproteins

Indexed keywords

ADENOSINE; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; CHOLESTEROL; GUANOSINE; LIPOPROTEIN; MELANOCORTIN 4 RECEPTOR; RETINOL; RETINOL PALMITATE; TRIACYLGLYCEROL;

ADULT; ALLELE; BLOOD SAMPLING; CAUCASIAN; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENERGY METABOLISM; FOOD COMPOSITION; FOOD INTAKE; GENE CONTROL; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN EXPERIMENT; LIPID METABOLISM; LIPOPROTEIN METABOLISM; MALE; NORMAL HUMAN; POSTPRANDIAL STATE; REVIEW; TRIACYLGLYCEROL BLOOD LEVEL; ULTRACENTRIFUGATION;

ADULT; ALLELES; APOLIPOPROTEIN B-48; CARDIOVASCULAR DISEASES; CHYLOMICRONS; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC ASSOCIATION STUDIES; HETEROZYGOTE; HUMANS; HYPERTRIGLYCERIDEMIA; KINETICS; LIPIDS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTPRANDIAL PERIOD; RECEPTOR, MELANOCORTIN, TYPE 4; RISK FACTORS; SPAIN; TRIGLYCERIDES; YOUNG ADULT;

EID: 80053006479     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114511002212     Document Type: Review

References (23)

1. Le NA & Walter MF (2007) The role of hypertriglyceridemia in atherosclerosis. Curr Atheroscler Rep 9, 110-115. (Pubitemid 47376981)
2. Perez-Martinez P, Delgado-Lista J, Perez-Jimenez F, et al. (2010) Update on genetics of postprandial lipemia. Atheroscler Suppl 11, 39-43.
3. Perez-Martinez P, Lopez-Miranda J, Perez-Jimenez F, et al. (2008) Influence of genetic factors in the modulation of postprandial lipemia. Atheroscler Suppl 9, 49-55.
4. Perez-Martinez P, Garcia-Rios A, Delgado-Lista J, et al. (2011) Nutrigenetics of the postprandial lipoprotein metabolism: evidences from human intervention studies. Curr Vasc Pharmacol 9, 287-291.
5. Gantz I, Miwa H, Konda Y, et al. (1993) Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J Biol Chem 268, 15174-15179. (Pubitemid 23206671)
6. Stutzmann F, Vatin V, Cauchi S, et al. (2007) Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. Hum Mol Genet 16, 1837-1844. (Pubitemid 47244532)
7. Heid IM, Vollmert C, Kronenberg F, et al. (2008) Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study. Obesity (Silver Spring) 16, 369-376. (Pubitemid 351271918)
8. Chambers JC, Elliott P, Zabaneh D, et al. (2008) Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet 40, 716-718. (Pubitemid 351748872)
9. Bronner G, Sattler AM, Hinney A, et al. (2006) The 103I variant of the melanocortin 4 receptor is associated with low serum triglyceride levels. J Clin Endocrinol Metab 91, 535-538. (Pubitemid 43236923)
10. Perez-Martinez P, Yiannakouris N, Lopez-Miranda J, et al. (2008) Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations. Am J Clin Nutr 87, 744-752. (Pubitemid 351364557)
11. Delgado-Lista J, Perez-Martinez P, Perez-Jimenez F, et al. (2010) ABCA1 gene variants regulate postprandial lipid metabolism in healthy men. Arterioscler Thromb Vasc Biol 30, 1051-1057.
12. Warnick GR, Benderson J & Albers JJ (1982) Dextran sulfate-Mg2\+ precipitation procedure for quantitation of highdensity-lipoprotein cholesterol. Clin Chem 28, 1379-1388. (Pubitemid 12125081)
13. RuotoloG, Zhang H, BentsianovV, et al. (1992) Protocol for the study of the metabolism of retinyl esters in plasma lipoproteins during postprandial lipemia. J Lipid Res 33, 1541-1549.
14. DeRuyter MG & De Leenheer AP (1978) Simultaneous determination of retinol and retinyl esters in serum or plasma by reversed-phase high-performance liquid chromatography. Clin Chem 24, 1920-1923. (Pubitemid 9049062)
15. Karpe F & Hamsten A (1994) Determination of apolipoproteins B-48 and B-100 in triglyceride-rich lipoproteins by analytical SDS-PAGE. J Lipid Res 35, 1311-1317. (Pubitemid 24209405)
16. Lairon D, Lopez-Miranda J & Williams C (2007) Methodology for studying postprandial lipid metabolism. Eur J Clin Nutr 61, 1145-1161. (Pubitemid 47521545)
17. Kolovou GD, Mikhailidis DP, Kovar J, et al. (2011) Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement. Curr Vasc Pharmacol 9, 258-270.
18. Tao YX (2005) Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. Mol Cell Endocrinol 239, 1-14.
19. Wisse BE, Frayo RS, Schwartz MW, et al. (2001) Reversal of cancer anorexia by blockade of central melanocortin receptors in rats. Endocrinology 142, 3292-3301. (Pubitemid 32681732)
20. Lin J, Choi YH, Hartzell DL, et al. (2003) CNS melanocortin and leptin effects on stearoyl-CoA desaturase-1 and resistin expression. Biochem Biophys Res Commun 311, 324-328. (Pubitemid 37340080)
21. Cohen P, Miyazaki M, Socci ND, et al. (2002) Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297, 240-243. (Pubitemid 34761283)
22. Rosmond R, Chagnon M, Bouchard C, et al. (2001) A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol. Diabetologia 44, 1335-1338. (Pubitemid 33010512)
23. Birney E, Stamatoyannopoulos JA, Dutta A, et al. (2007) Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447, 799-816. (Pubitemid 46920138)