Applications of headspace moisture analysis for investigating the water dynamics within a sealed vial containing freeze-dried material

PDA Journal of Pharmaceutical Science and Technology

Volumn 65, Issue 1, 2011, Pages 2-11

  Cook, Ann Isobel ^a   Ward, Kevin Richard ^a  

^a Biopharma Technology Ltd   (United Kingdom)

Author keywords

Amorphous; Crystalline; Freeze dried; Frequency modulation spectroscopy; Headspace; Karl fischer; Lyophilization; Moisture; Residual water

Indexed keywords

SUCROSE; WATER; VACCINE;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; COULOMETRY; CRYSTALLIZATION; DYNAMICS; FREEZE DRYING; FREQUENCY MODULATION SPECTROSCOPY; GEOMETRY; HEADSPACE MOISTURE ANALYSIS; KARL FISCHER COULOMETRIC TITRATION; QUALITY CONTROL; SPECTROSCOPY; TEMPERATURE DEPENDENCE; VALIDATION PROCESS; WATER DYNAMIC; MEDICINAL CHEMISTRY; REGRESSION ANALYSIS; TEMPERATURE;

CHEMISTRY, PHARMACEUTICAL; FREEZE DRYING; LEAST-SQUARES ANALYSIS; SPECTRUM ANALYSIS; SUCROSE; TEMPERATURE; VACCINES; WATER;

EID: 80052991208     PISSN: 10797440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

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