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Volumn 7, Issue 9, 2011, Pages 1087-1099

Genetic stratification of neuroblastoma for treatment tailoring

Author keywords

aCGH; epigenetic profile; genetic subtyping; neuroblastoma; PAM classifier; risk stratification; SNP

Indexed keywords

BIOLOGICAL MARKER; BLU PROTEIN; CASPASE 8; DCR2 PROTEIN; DCR4 PROTEIN; DNA; HIN 1 PROTEIN; NUCLEOSIDE DIPHOSPHATE KINASE A; ONCOPROTEIN; OSTEONECTIN; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; SURVIVIN; THROMBOSPONDIN 1; TIG 1 PROTEIN; TMS 1 PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 80052980232     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.11.87     Document Type: Review
Times cited : (7)

References (76)
  • 1
    • 77953523121 scopus 로고    scopus 로고
    • Recent advances in neuroblastoma
    • Maris JM. Recent advances in neuroblastoma. N Engl. J. Med. 362, 2202-2211 (2010).
    • (2010) N Engl. J. Med , vol.362 , pp. 2202-2211
    • Maris, J.M.1
  • 2
    • 0037366067 scopus 로고    scopus 로고
    • Neuroblastoma: Biological insights into a clinical enigma
    • DOI 10.1038/nrc1014
    • Brodeur GM. Neuroblastoma: biological insights into a clinical enigma. Nat. Rev. Cancer 3, 203-216 (2003). (Pubitemid 37328872)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.3 , pp. 203-216
    • Brodeur, G.M.1
  • 5
    • 34250683435 scopus 로고    scopus 로고
    • Neuroblastoma
    • DOI 10.1016/S0140-6736(07)60983-0, PII S0140673607609830
    • Maris JM, Hogarty MD, Bagatell R, Cohn SL. Neuroblastoma. Lancet 369, 2106-2120 (2007). (Pubitemid 46935947)
    • (2007) Lancet , vol.369 , Issue.9579 , pp. 2106-2120
    • Maris, J.M.1    Hogarty, M.D.2    Bagatell, R.3    Cohn, S.L.4
  • 9
    • 76049096740 scopus 로고    scopus 로고
    • Neuroblastoma in adolescents: Genetic and clinical characterisation
    • Castel V, Villamón E, Cañete A et al. Neuroblastoma in adolescents: genetic and clinical characterisation. Clin. Transl. Oncol. 12(1), 49-54 (2010).
    • (2010) Clin. Transl. Oncol , vol.12 , Issue.1 , pp. 49-54
    • Castel, V.1    Villamón, E.2    Cañete, A.3
  • 12
    • 33646505929 scopus 로고    scopus 로고
    • International neuroblastoma pathology classification adds independent prognostic information beyond the prognostic contribution of age
    • Sano H, Bonadio J, Gerbing RB et al. International neuroblastoma pathology classification adds independent prognostic information beyond the prognostic contribution of age. Eur. J. Cancer 42, 1113-1119 (2006).
    • (2006) Eur. J. Cancer , vol.42 , pp. 1113-1119
    • Sano, H.1    Bonadio, J.2    Gerbing, R.B.3
  • 13
    • 0021201236 scopus 로고
    • Cellular DNA content as a predictor of response to chemotherapy in infants with unresectable neuroblastoma
    • Look AT, Hayes FA, Nitschke R et al. Cellular DNA content as a predictor of response to chemotherapy in infants with unresectable neuroblastoma. N. Engl. J. Med. 311, 231-235 (1984). (Pubitemid 14087665)
    • (1984) New England Journal of Medicine , vol.311 , Issue.4 , pp. 231-235
    • Look, A.T.1    Hayes, F.A.2    Nitschke, R.3
  • 14
    • 0025979843 scopus 로고
    • Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: A Pediatric Oncology Group study
    • Look AT, Hayes FA, Shuster JJ et al. Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study. J. Clin. Oncol. 9, 581-591 (1991).
    • (1991) J. Clin. Oncol , vol.9 , pp. 581-591
    • Look, A.T.1    Hayes, F.A.2    Shuster, J.J.3
  • 15
    • 17744381568 scopus 로고    scopus 로고
    • Prognostic significance of DNA di-tetraploidy in neuroblastoma
    • Ladenstein R, Ambros IM, Potschger U et al. Prognostic significance of DNA di-tetraploidy in neuroblastoma. Med. Pediatr. Oncol. 36, 83-92 (2001).
    • (2001) Med. Pediatr. Oncol , vol.36 , pp. 83-92
    • Ladenstein, R.1    Ambros, I.M.2    Potschger, U.3
  • 16
    • 65549156891 scopus 로고    scopus 로고
    • International consensus for neuroblastoma molecular diagnostics: Report from the International Neuroblastoma Risk Group (INRG) Biology Committee
    • □□ Emphasizes the necessity to identify significant genetic markers for neuroblastoma by reliable methods, and provide consensus for methodology nomenclature and future directions for neuroblastoma treatment management
    • Ambros PF, Ambros IM, Brodeur GM et al. International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee. Br. J. Cancer 100, 1471-1482 (2009). □□ Emphasizes the necessity to identify significant genetic markers for neuroblastoma by reliable methods, and provide consensus for methodology nomenclature and future directions for neuroblastoma treatment management.
    • (2009) Br. J. Cancer , vol.100 , pp. 1471-1482
    • Ambros, P.F.1    Ambros, I.M.2    Brodeur, G.M.3
  • 17
    • 58249093955 scopus 로고    scopus 로고
    • The International Neuroblastoma Risk Group (INRG) classification system: An INRG Task Force report
    • □□ Describes in details the new International Neuroblastoma Risk Group staging and classification system
    • Cohn SL, Pearson AD, London WB et al. The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. J. Clin. Oncol. 27, 289-297 (2009). □□ Describes in details the new International Neuroblastoma Risk Group staging and classification system.
    • (2009) J. Clin. Oncol , vol.27 , pp. 289-297
    • Cohn, S.L.1    Pearson, A.D.2    London, W.B.3
  • 18
    • 0022388606 scopus 로고
    • Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas
    • Seeger RC, Brodeur GM, Sather H et al. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N. Engl. J. Med. 313, 1111-1116 (1985). (Pubitemid 16216827)
    • (1985) New England Journal of Medicine , vol.313 , Issue.18 , pp. 1111-1116
    • Seeger, R.C.1    Brodeur, G.M.2    Sather, H.3
  • 19
    • 39749177356 scopus 로고    scopus 로고
    • Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: A report from the Children's Oncology Group
    • DOI 10.1200/JCO.2007.13.9493
    • Schneiderman J, London WB, Brodeur GM et al. Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group. J. Clin. Oncol. 26, 913-918 (2008). (Pubitemid 351398084)
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.6 , pp. 913-918
    • Schneiderman, J.1    London, W.B.2    Brodeur, G.M.3    Castleberry, R.P.4    Look, A.T.5    Cohn, S.L.6
  • 20
    • 58749083347 scopus 로고    scopus 로고
    • International Neuroblastoma Risk Group: Significance of MYCN amplification in international neuroblastoma staging system stage 1 and 2 neuroblastoma: A report from the International Neuroblastoma Risk Group database
    • Bagatell R, Beck-Popovic M, London W et al.; International Neuroblastoma Risk Group: Significance of MYCN amplification in international neuroblastoma staging system stage 1 and 2 neuroblastoma: a report from the International Neuroblastoma Risk Group database. J. Clin. Oncol. 27, 365-370 (2009).
    • (2009) J. Clin. Oncol , vol.27 , pp. 365-370
    • Bagatell, R.1    Beck-Popovic, M.2    London, W.3
  • 21
    • 39749177356 scopus 로고    scopus 로고
    • Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: A report from the Children's Oncology Group
    • DOI 10.1200/JCO.2007.13.9493
    • Schneiderman J, London WB, Brodeur GM, Castleberry RP, Look AT, Cohn SL. Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group. J. Clin. Oncol. 26(6), 913-918 (2008). (Pubitemid 351398084)
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.6 , pp. 913-918
    • Schneiderman, J.1    London, W.B.2    Brodeur, G.M.3    Castleberry, R.P.4    Look, A.T.5    Cohn, S.L.6
  • 22
    • 77953223713 scopus 로고    scopus 로고
    • 2p24 gain region harboring MYCN gene compared with MYCN amplified and nonamplified neuroblastoma
    • Jeison M, Ash S, Halevy-Berko G et al. 2p24 gain region harboring MYCN gene compared with MYCN amplified and nonamplified neuroblastoma. Am. J. Pathol. 176(6), 2616-2625 (2010).
    • (2010) Am. J. Pathol , vol.176 , Issue.6 , pp. 2616-2625
    • Jeison, M.1    Ash, S.2    Halevy-Berko, G.3
  • 23
    • 63449111226 scopus 로고    scopus 로고
    • Heterogeneity of the MYCN oncogene in neuroblastoma
    • Theissen J, Boensch M, Spitz R et al. Heterogeneity of the MYCN oncogene in neuroblastoma. Clin. Cancer Res. 15, 2085-2090 (2009).
    • (2009) Clin. Cancer Res , vol.15 , pp. 2085-2090
    • Theissen, J.1    Boensch, M.2    Spitz, R.3
  • 27
    • 79954611862 scopus 로고    scopus 로고
    • CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells
    • Henrich KO, Bauer T, Schulte J et al. CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells. Cancer Res. 71, 3142-3151 (2011).
    • (2011) Cancer Res , vol.71 , pp. 3142-3151
    • Henrich, K.O.1    Bauer, T.2    Schulte, J.3
  • 28
    • 36148965560 scopus 로고    scopus 로고
    • Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours
    • DOI 10.1038/sj.bjc.6604032, PII 6604032
    • Caren H, Fransson S, Ejeska K, Kogner P, Martinsson T. Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours. Br. J. Cancer 97, 1416-1424 (2007). (Pubitemid 350114785)
    • (2007) British Journal of Cancer , vol.97 , Issue.10 , pp. 1416-1424
    • Caren, H.1    Fransson, S.2    Ejeskar, K.3    Kogner, P.4    Martinsson, T.5
  • 31
    • 76849106660 scopus 로고    scopus 로고
    • Integrated genomic profiling identifies two distinct molecular subtypes with divergent outcome in neuroblastoma with loss of chromosome 11q
    • Fischer M, Bauer T, Oberthür A et al. Integrated genomic profiling identifies two distinct molecular subtypes with divergent outcome in neuroblastoma with loss of chromosome 11q. Oncogene 29, 865-875 (2010).
    • (2010) Oncogene , vol.29 , pp. 865-875
    • Fischer, M.1    Bauer, T.2    Oberthür, A.3
  • 32
    • 77749279754 scopus 로고    scopus 로고
    • High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset
    • Carén H, Kryh H, Nethander M et al. High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset. Proc. Natl Acad. Sci. USA 107, 4323-4328 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 4323-4328
    • Carén, H.1    Kryh, H.2    Nethander, M.3
  • 33
    • 47349090514 scopus 로고    scopus 로고
    • CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23
    • Michels E, Hoebeeck J, De Preter K et al. CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23. BMC Cancer 8, 173 (2008).
    • (2008) BMC Cancer , vol.8 , pp. 173
    • Michels, E.1    Hoebeeck, J.2    De Preter, K.3
  • 37
    • 54049094708 scopus 로고    scopus 로고
    • Identification of ALK as a major familial neuroblastoma predisposition gene
    • Mosse YP, Laudenslager M, Longo L et al. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature 455, 930-935 (2008).
    • (2008) Nature , vol.455 , pp. 930-935
    • Mosse, Y.P.1    Laudenslager, M.2    Longo, L.3
  • 38
    • 54049120220 scopus 로고    scopus 로고
    • Activating mutations in ALK provide a therapeutic target in neuroblastoma
    • George RE, Sanda T, Hanna M et al. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature 455, 975-978 (2008).
    • (2008) Nature , vol.455 , pp. 975-978
    • George, R.E.1    Sanda, T.2    Hanna, M.3
  • 39
    • 54049149961 scopus 로고    scopus 로고
    • Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
    • Janoueix-Lerosey I, Lequin D, Brugieres L et al. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature 455, 967-970 (2008).
    • (2008) Nature , vol.455 , pp. 967-970
    • Janoueix-Lerosey, I.1    Lequin, D.2    Brugieres, L.3
  • 40
    • 54049118823 scopus 로고    scopus 로고
    • Oncogenic mutations of ALK kinase in neuroblastoma
    • Chen Y, Takita J, Choi YL et al. Oncogenic mutations of ALK kinase in neuroblastoma. Nature 455, 971-974 (2008).
    • (2008) Nature , vol.455 , pp. 971-974
    • Chen, Y.1    Takita, J.2    Choi, Y.L.3
  • 42
    • 58249093954 scopus 로고    scopus 로고
    • The International Neuroblastoma Risk Group (INRG) staging system: An INRG Task Force report
    • INRG Task Force
    • Monclair T, Brodeur GM, Ambros PF et al.; INRG Task Force. The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J. Clin. Oncol. 27, 298-303 (2009).
    • (2009) J. Clin. Oncol , vol.27 , pp. 298-303
    • Monclair, T.1    Brodeur, G.M.2    Ambros, P.F.3
  • 43
    • 70350144841 scopus 로고    scopus 로고
    • Neuroblastoma: Biology and staging
    • Mueller S, Matthay KK. Neuroblastoma: biology and staging. Curr. Oncol. Rep. 11(6), 431-438 (2009).
    • (2009) Curr. Oncol. Rep , vol.11 , Issue.6 , pp. 431-438
    • Mueller, S.1    Matthay, K.K.2
  • 45
    • 0031665929 scopus 로고    scopus 로고
    • Genetic heterogeneity of neuroblastoma studied by comparative geneomic hybridization
    • Vandesompele J, Van Roy N, Van Gele M et al. Genetic heterogeneity of neuroblastoma studied by comparative geneomic hybridization. Genes Chromosomes Cancer 23 151-152 (1998).
    • (1998) Genes Chromosomes Cancer , vol.23 , pp. 151-152
    • Vandesompele, J.1    Van Roy, N.2    Van Gele, M.3
  • 49
    • 38349064796 scopus 로고    scopus 로고
    • Novel risk stratification of patients with neuroblastoma by genomic signature, which is independent of molecular signature
    • Tomioka N, Oba S, Ohira M et al. Novel risk stratification of patients with neuroblastoma by genomic signature, which is independent of molecular signature. Oncogene 27, 441-449 (2008).
    • (2008) Oncogene , vol.27 , pp. 441-449
    • Tomioka, N.1    Oba, S.2    Ohira, M.3
  • 50
    • 61449220975 scopus 로고    scopus 로고
    • Overall genomic pattern is a predictor of outcome in neuroblastoma
    • □□ Analyzed a cohort of neuroblastoma by array comparative genomic hybridization and suggests that any segmental alteration is associated with an increased risk or relapse, being the overall genomic pattern more indicative of disease behavior than individual genetic markers
    • Janoueix-Lerosey I, Schleiermacher G, Michels E et al. Overall genomic pattern is a predictor of outcome in neuroblastoma. J. Clin. Oncol. 27, 1026-1033 (2009). □□ Analyzed a cohort of neuroblastoma by array comparative genomic hybridization and suggests that any segmental alteration is associated with an increased risk or relapse, being the overall genomic pattern more indicative of disease behavior than individual genetic markers.
    • (2009) J. Clin. Oncol , vol.27 , pp. 1026-1033
    • Janoueix-Lerosey, I.1    Schleiermacher, G.2    Michels, E.3
  • 51
    • 77955477995 scopus 로고    scopus 로고
    • Accumulation of segmental alterations determines progression in neuroblastoma
    • Schleiermacher G, Janoueix-Lerosey I, Ribeiro A et al. Accumulation of segmental alterations determines progression in neuroblastoma, J. Clin. Oncol. 28, 3122-3130 (2010).
    • (2010) J. Clin. Oncol , vol.28 , pp. 3122-3130
    • Schleiermacher, G.1    Janoueix-Lerosey, I.2    Ribeiro, A.3
  • 52
    • 23944464412 scopus 로고    scopus 로고
    • Measurement and relevance of neuroblastoma DNA copy number changes in the post-genome era
    • DOI 10.1016/j.canlet.2005.02.052, PII S0304383505003630
    • Mossé YP, Greshock J, Weber BL, Maris JM. Measurement and relevance of neuroblastoma DNA copy number changes in the postgenome era. Cancer Lett. 228, 83-90 (2005). (Pubitemid 41188428)
    • (2005) Cancer Letters , vol.228 , Issue.1-2 , pp. 83-90
    • Mosse, Y.P.1    Greshock, J.2    Weber, B.L.3    Maris, J.M.4
  • 54
    • 35648978472 scopus 로고    scopus 로고
    • Genome-wide analysis of neuroblastoma using high-density single nucleotide polymorphism arrays
    • George R, Attiyeh E, Li S et al. Genome-wide analysis of neuroblastoma using high-density single nucleotide polymorphism arrays. PloS One 2, E255-E277 (2007).
    • (2007) PloS One , vol.2
    • George, R.1    Attiyeh, E.2    Li, S.3
  • 55
    • 33845965035 scopus 로고    scopus 로고
    • High-resolution analysis of allelic imbalance in neuroblastoma cell lines by single nucleotide polymorphism arrays
    • DOI 10.1016/j.cancergencyto.2006.08.012, PII S0165460806005668
    • Carr J, Bown NP, Case MC et al. High resolution analysis of allelic imbalance in neuroblastoma cell lines by single nucleotide polymorphism arrays. Cancer Genet. Cytogenet. 172, 127-138 (2007). (Pubitemid 46043573)
    • (2007) Cancer Genetics and Cytogenetics , vol.172 , Issue.2 , pp. 127-138
    • Carr, J.1    Bown, N.P.2    Case, M.C.3    Hall, A.G.4    Lunec, J.5    Tweddle, D.A.6
  • 56
    • 50849086751 scopus 로고    scopus 로고
    • High-resolution array copy number analyses for detection of deletion, gain, amplifcation and copy-neutral LOH in primary neuroblastoma tumors: Four cases of homozygous deletions of the CDKN2A gene
    • Carén H, Erichsen J, Olsson L et al. High-resolution array copy number analyses for detection of deletion, gain, amplifcation and copy-neutral LOH in primary neuroblastoma tumors: four cases of homozygous deletions of the CDKN2A gene. BMC Genomics 9, 353-365 (2008).
    • (2008) BMC Genomics , vol.9 , pp. 353-365
    • Carén, H.1    Erichsen, J.2    Olsson, L.3
  • 57
    • 50849086751 scopus 로고    scopus 로고
    • High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: Four cases of homozygous deletions of the CDKN2A gene
    • Caren H, Erichsen J, Olsson L et al. High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: four cases of homozygous deletions of the CDKN2A gene. BMC Genomics 9, 353-365 (2008).
    • (2008) BMC Genomics , vol.9 , pp. 353-365
    • Caren, H.1    Erichsen, J.2    Olsson, L.3
  • 60
    • 79951836741 scopus 로고    scopus 로고
    • A multilocus technique for risk evaluation of patients with neuroblastoma
    • □ Interlaboratory study to establish and validate the PCR-based multiplex ligation-dependent probe amplification technique for neuroblastoma that is cost effective, reliable and reproducible
    • Ambros IM, Brunner B, Aigner G et al. A multilocus technique for risk evaluation of patients with neuroblastoma. Clin. Cancer Res. 17, 792-804 (2011). □ Interlaboratory study to establish and validate the PCR-based multiplex ligation-dependent probe amplification technique for neuroblastoma that is cost effective, reliable and reproducible.
    • (2011) Clin. Cancer Res , vol.17 , pp. 792-804
    • Ambros, I.M.1    Brunner, B.2    Aigner, G.3
  • 61
    • 48349140362 scopus 로고    scopus 로고
    • Comparison of different techniques for the detection of genetic risk-identifying chromosomal gains and losses in neuroblastoma
    • Villamón E, Piqueras M, Mackintosh C et al. Comparison of different techniques for the detection of genetic risk-identifying chromosomal gains and losses in neuroblastoma. Virchow Arch. 453, 47-55 (2008).
    • (2008) Virchow Arch , vol.453 , pp. 47-55
    • Villamón, E.1    Piqueras, M.2    Mackintosh, C.3
  • 63
    • 67649372693 scopus 로고    scopus 로고
    • Predicting outcomes for children with neuroblastoma using a multigene-expression signature: A retrospective SIOPEN/COG/GPOH study
    • Vermeulen J, De Preter K, Naranjo A et al. Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study. Lancet 10, 663-671 (2009).
    • (2009) Lancet , vol.10 , pp. 663-671
    • Vermeulen, J.1    De Preter, K.2    Naranjo, A.3
  • 64
    • 77955287153 scopus 로고    scopus 로고
    • Prognostic impact of gene expression-based classification for neuroblastoma
    • Oberthuer A, Hero B, Berthold F et al. Prognostic impact of gene expression-based classification for neuroblastoma. J. Clin. Oncol. 28, 3506-3515 (2010).
    • (2010) J. Clin. Oncol , vol.28 , pp. 3506-3515
    • Oberthuer, A.1    Hero, B.2    Berthold, F.3
  • 65
    • 69849095172 scopus 로고    scopus 로고
    • Molecular characterization and classification of neuroblastoma
    • □ Valuable report reviewing updated molecular information obtained by genome-wide methods and altered signaling pathways in aggressive neuroblastoma
    • Oberthuer A, Theissen J, Westermann F, Hero B, Fischer M. Molecular characterization and classification of neuroblastoma. Future Oncol. 5(5), 625-639 (2009). □ Valuable report reviewing updated molecular information obtained by genome-wide methods and altered signaling pathways in aggressive neuroblastoma.
    • (2009) Future Oncol , vol.5 , Issue.5 , pp. 625-639
    • Oberthuer, A.1    Theissen, J.2    Westermann, F.3    Hero, B.4    Fischer, M.5
  • 66
    • 78751696047 scopus 로고    scopus 로고
    • The role of complex genomic alterations in neuroblastoma risk estimation
    • Fischer M, Berthold F. The role of complex genomic alterations in neuroblastoma risk estimation. Genome Med. 2, 31-34 (2010).
    • (2010) Genome Med , vol.2 , pp. 31-34
    • Fischer, M.1    Berthold, F.2
  • 67
    • 33846922849 scopus 로고    scopus 로고
    • Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas
    • DOI 10.1016/j.canlet.2006.05.001, PII S0304383506003740
    • Abe M, Westermann F, Nakagawara A, Takato T, Schwab M, Ushijima T. Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas. Cancer Lett. 18, 253-258 (2007). (Pubitemid 46240612)
    • (2007) Cancer Letters , vol.247 , Issue.2 , pp. 253-258
    • Abe, M.1    Westermann, F.2    Nakagawara, A.3    Takato, T.4    Schwab, M.5    Ushijima, T.6
  • 69
    • 34250633589 scopus 로고    scopus 로고
    • Methylation of CASP8, DCR2, and HIN-1 in neuoblastoma
    • Yang Q, Kiernan CM, Tian Y et al. Methylation of CASP8, DCR2, and HIN-1 in neuoblastoma. Clin. Cancer Res. 13, 3191-3197 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 3191-3197
    • Yang, Q.1    Kiernan, C.M.2    Tian, Y.3
  • 70
    • 77953346844 scopus 로고    scopus 로고
    • Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines
    • Yang Q, Tian Y, Ostler K et al. Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines. BMC Cancer 10, 286-295 (2010).
    • (2010) BMC Cancer , vol.10 , pp. 286-295
    • Yang, Q.1    Tian, Y.2    Ostler, K.3
  • 71
    • 0026541358 scopus 로고
    • Length of telomeric repeats in neuroblastoma: Correlation with prognosis and other biological characteristics
    • Hiyama E, Hiyama K, Yokoyama T, Ichikawa T, Matsuura Y. Length of telomeric repeats in neuroblastoma: correlation with prognosis and other biological characteristics. Jpn J. Cancer Res. 83, 159-164 (1992).
    • (1992) Jpn J. Cancer Res , vol.83 , pp. 159-164
    • Hiyama, E.1    Hiyama, K.2    Yokoyama, T.3    Ichikawa, T.4    Matsuura, Y.5
  • 73
    • 79851490466 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres - An enhanced chromosomal instability in aggressive non-MYCN amplified and telomere elongated neuroblastomas
    • Lundberg G, Sehic D, Lansberg J et al. Alternative lengthening of telomeres - an enhanced chromosomal instability in aggressive non-MYCN amplified and telomere elongated neuroblastomas. Genes Chromosomes Cancer 50, 250-262 (2011).
    • (2011) Genes Chromosomes Cancer , vol.50 , pp. 250-262
    • Lundberg, G.1    Sehic, D.2    Lansberg, J.3
  • 74
    • 67649306417 scopus 로고    scopus 로고
    • Are molecular neuroblastoma classifiers ready for prime time?
    • Volchenboum SL, Cohn SL. Are molecular neuroblastoma classifiers ready for prime time? Lancet Oncol. 10, 641-642 (2009).
    • (2009) Lancet Oncol , vol.10 , pp. 641-642
    • Volchenboum, S.L.1    Cohn, S.L.2
  • 75
    • 61449242771 scopus 로고    scopus 로고
    • Progress in defining and treating high-risk neuroblastoma: Lessons from the bench and bedside
    • Volchenboum SL, Cohn SL. Progress in defining and treating high-risk neuroblastoma: lessons from the bench and bedside. J. Clin. Oncol. 27, 1003-1004 (2009).
    • (2009) J. Clin. Oncol , vol.27 , pp. 1003-1004
    • Volchenboum, S.L.1    Cohn, S.L.2
  • 76
    • 77950840735 scopus 로고    scopus 로고
    • The emerging molecular pathogenesis of neuroblastoma: Implications for improved risk assessment and targeted therapy
    • Van Roy N, De Preter K, Hoebeeck J et al. The emerging molecular pathogenesis of neuroblastoma: implications for improved risk assessment and targeted therapy. Genome Med. 1, 74 (2009).
    • (2009) Genome Med , vol.1 , pp. 74
    • Van Roy, N.1    De Preter, K.2    Hoebeeck, J.3


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