Cytochrome P450 is regulated by noradrenergic and serotonergic systems

Pharmacological Research

Volumn 64, Issue 4, 2011, Pages 371-380

  Kot, Marta ^a   Daniel, Władysława A ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Brain structures; Neurotoxins; Neurotransmitters; Noradrenaline; Rat liver cytochrome P450; Serotonin

Indexed keywords

2 BROMO N (2 CHLOROETHYL) N ETHYLBENZYLAMINE; 5 HYDROXYINDOLEACETIC ACID; CHLORAMPHETAMINE; CORTICOSTERONE; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2A; CYTOCHROME P450 2B; CYTOCHROME P450 2C; CYTOCHROME P450 2C11; CYTOCHROME P450 2C6; CYTOCHROME P450 2D; CYTOCHROME P450 3A; DOPAMINE; FENCLONINE; GROWTH HORMONE; NEUROTOXIN; NEUROTRANSMITTER; NORADRENALIN; SEROTONIN; THYROID HORMONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; ENZYME ACTIVITY; ENZYME REGULATION; HORMONAL REGULATION; HYDROXYLATION; LIVER MICROSOME; MALE; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEROTONINERGIC SYSTEM;

ANIMALS; BENZYLAMINES; BRAIN; CYTOCHROME P-450 ENZYME SYSTEM; FENCLONINE; GENE EXPRESSION; LIVER; MALE; NOREPINEPHRINE; P-CHLOROAMPHETAMINE; RATS; RATS, WISTAR; SEROTONIN;

EID: 80052968133     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.06.020     Document Type: Article

References (83)

1. R.A. Prough, M.W. Linder, J.A. Pinaire, G.H. Xiao, and K.C. Falkner Hormonal regulation of hepatic enzymes involved in foreign compound metabolism FASEB J 10 1996 1369 1377 (Pubitemid 26347871)
2. H. Iber, Q. Chen, M. Sewer, and E.T. Morgan Regulation of hepatic cytochrome P450 2C11 by glucocorticoids Arch Biochem Biophys 345 1997 305 310 (Pubitemid 27400624)
3. C. Meredith, M.P. Scott, A.B. Renwick, R.J. Price, and B.G. Lake Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices Xenobiotica 33 2003 511 527 (Pubitemid 36688107)
4. K. Monostory, K. Kohalmy, R.A. Prough, L. Kóbori, and L. Vereczkey The effect of synthetic glucocorticoid, dexamethasone on CYP1A1 inducibility in adult rat and human hepatocytes FEBS Lett 579 2005 229 235 (Pubitemid 40023401)
5. K. Monostory, J.-M. Pascussi, L. Kóbori, and Z. Dvorak Hormonal regulation of CYP1A expression Drug Metab Rev 41 2009 547 572
6. J.M. Pascussi, S. Gerbal-Chaloin, C. Duret, M. Daujat-Chavanieu, M.J. Vilarem, and P. Maurel The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences Annu Rev Pharmacol Toxicol 48 2008 1 32 (Pubitemid 351738147)
7. O. Burk, and L. Wojnowski Cytochrome P450 3A and their regulation Naunyn Schmiedebergs Arch Pharmacol 369 2004 105 124 (Pubitemid 38161227)
8. G.G. Gibson, N.J. Plant, K. Swales, A. Ayrton, and W. El-Sankary Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man Xenobiotica 32 2002 165 206 (Pubitemid 34267348)
9. Z. Dvorak, and P. Pavek Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids Drug Metab Rev 42 2010 621 635
10. A.K. Agrawal, and B.H. Shapiro Differential expression of gender-dependent hepatic isoforms of cytochrome P-450 by pulse signals in the circulating masculine episodic growth hormone profile of the rat J Pharmacol Exp Ther 292 2000 228 237 (Pubitemid 30026375)
11. N.A. Pampori, A.K. Agrawal, and B.H. Shapiro Infusion of gender-dependent plasma growth hormone profiles into intact rats: effects of subcutaneous, intraperitoneal, and intravenous routes of rat and human growth hormone on endogenous circulating growth hormone profiles and expression of sexually dimorphic hepatic CYP isoforms Drug Metab Dispos 29 2001 8 16 (Pubitemid 32042156)
12. D.J. Waxman, and C. O'Connor Growth hormone regulation of sex-dependent liver gene expression Mol Endocrinol 20 2006 2613 2629 (Pubitemid 44833525)
13. D.J. Waxman Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression Biochem Pharmacol 37 1988 71 84 (Pubitemid 18016749)
14. N. Murayama, M. Shimada, Y. Yamazoe, and R. Kato Difference in the susceptibility of two phenobarbital-inducible forms, P450IIB1 and P450IIB2, to thyroid hormone- and growth hormone-induced suppression in rat liver: phenobarbital-inducible P450IIB2 suppression by thyroid hormone acting directly, but not through the pituitary system Mol Pharmacol 39 1991 811 817
15. C. Legraverend, A. Mode, S. Westin, A. Strom, H. Eguchi, and P.G. Zaphiropoulos Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion Mol Endocrinol 6 1992 259 266
16. S.S. Sundseth, J.A. Alberta, and D.J. Waxman Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes J Biol Chem 267 1992 3907 3914
17. D.J. Waxman, P.A. Ram, N.A. Pampori, and B.H. Shapiro Growth hormone regulation of male-specific rat liver P450 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate Mol Pharmacol 48 1995 790 797
18. N.A. Pampori, and B.H. Shapiro Feminization of hepatic cytochrome P450s by nominal levels of growth hormone in the feminine plasma profile Mol Pharmacol 50 1996 1148 1156 (Pubitemid 26384853)
19. M. Shimada, N. Murayama, K. Nagata, H. Hashimoto, H. Ishikawa, and Y. Yamazoe A specific loss of growth hormone abolished sex-dependent expression of hepatic cytochrome P450 in dwarf rats: reversal of the profiles by growth hormone-treatment Arch Biochem Biophys 337 1997 34 42 (Pubitemid 27198052)
20. D.J. Waxman, and M.G. Holloway Sex differences in the expression of hepatic drug metabolizing enzymes Mol Pharmacol 76 2009 215 228
21. Y. Yamazoe, N. Murayama, M. Shimada, and R. Kato Thyroid hormone suppression of hepatic levels of phenobarbital-inducible P-450b and P-450e, and other neonatal P-450s in hypophysectomized rats Biochem Biophys Res Commun 160 1989 609 614 (Pubitemid 19140583)
22. Y. Yamazoe, X. Ling, N. Murayama, D. Gong, K. Nagata, and R. Kato Modulation of hepatic level of microsomal testosterone 7 alpha-hydroxylase, P-450a (P450IIA), by thyroid hormone and growth hormone in rat liver J Biochem 108 1990 599 603 (Pubitemid 20336673)
23. D.J. Waxman, P.A. Ram, G. Notani, G.A. LeBlanc, J.A. Alberta, and J.J. Morrissey Pituitary regulation of the male-specific steroid 6 beta-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational level Mol Endocrinol 4 1990 447 454
24. C. Liddle, B.J. Goodwin, J. George, M. Tapner, and G.C. Farrell Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes J Clin Endocrinol Metab 83 1998 2411 2416 (Pubitemid 28503039)
25. N. Nishimura, J. Yonemoto, Y. Miyabara, Y. Fujii-Kuriyama, and C. Tohyama Altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo- p-dioxin in aryl hydrocarbon receptor-null mice Arch Toxicol 79 2005 260 267 (Pubitemid 40768448)
26. N. Takahashi, N. Inui, H. Morita, K. Takeuchi, S. Uchida, and H. Watanabe Effect of thyroid hormone on the activity of CYP3A enzyme in humans J Clin Pharmacol 50 2010 88 93
27. P.A. Ram, and D.J. Waxman Hepatic P450 expression in hypothyroid rats: differential responsiveness of male-specific P450 forms 2a (IIIA2), 2c (IIC11), and RLM2(IIA2) to thyroid hormone Mol Endocrinol 5 1991 13 20 (Pubitemid 21902079)
28. Z. Zidek, P. Anzenbacher, and E. Kmoníčková Current status and challenges of cytokine pharmacology Br J Pharmacol 157 2009 342 361
29. S. Feldman, N. Conforti, and J. Weidenfeld Limbic pathways and hypothalamic neurotransmitters mediating adrenocortical responses to neural stimuli Neurosci Biobehav Rev 19 1995 235 240
30. S. Reichlin Neuroendocrinology of the pituitary gland Toxicol Pathol 17 1989 250 255 (Pubitemid 19218936)
31. L.W. Swanson, and P.E. Sawchenko Paraventricular nucleus: a site for the integration of neuroendocrine and autonomic mechanisms Neuroendocrinology 31 1980 410 417 (Pubitemid 11250989)
32. P. Skett, and J.A. Gusrtafsson Hypothalamo-pituitary regulation of liver function Med Biol 57 1979 374 389 (Pubitemid 10127873)
33. J. Wójcikowski, and W. Daniel The brain dopaminergic system as an important center regulating liver cytochrome P450 in the rat Expert Opin Drug Metab Toxicol 5 2009 631 645
34. A. Haduch, J. Wójcikowski, and W.A. Daniel The effect of tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs) and newer antidepressant drugs on the activity and level of rat CYP3A Eur Neuropsychopharmacol 16 2006 178 186 (Pubitemid 43358008)
35. W.A. Daniel The influence of long-term treatment with psychotropic drugs on cytochrome P450: the involvement of different mechanisms Expert Opin Drug Metab Toxicol 1 2005 203 217
36. A. Rane, Z. Liu, C.J. Henderson, and R. Wolf Divergent regulation of cytochrome P450 enzymes by morphine and pethidine: a neuroendocrine mechanism? Mol Pharmacol 47 1995 57 64
37. M. Konstandi, D. Kostakis, P. Harkitis, M. Marselos, E.O. Johnson, and K. Adamidis Role of adrenoceptor-linked signaling pathways in the regulation of CYP1A1 gene expression Biochem Pharmacol 69 2005 277 287 (Pubitemid 41556574)
38. M. Konstandi, D. Kostakis, P. Harkitis, E.O. Johnson, M. Marselos, and K. Adamidis Benzo(α)pyrene-induced up-regulation of CYP1A2 gene expression: role of adrenoceptor-linked signaling pathways Life Sci 79 2006 331 341 (Pubitemid 43817047)
39. G. Jaim-Etcheverry, and L.M. Zieher 2-chloroethylamines: new chemical tools fort he study of the noradrenergic neurons Trends Pharmacol Sci 4 1983 473 475
40. S.B. Ross Long-term effects of N-2-chlorethyl-N-ethyl-2-bromobenzylamine hydrochloride on noradrenergic neurons in the rat brain and heart Br J Pharmacol 58 1976 521 527
41. R.W. Fuller Effects of p-chloroamphetamine on brain serotonin neurons Neurochem Res 5 1992 449 456
42. C. Köhler, S.B. Ross, B. Srebro, and S.O. Ogren Long-term biochemical and behavioral effects of p-chloroamphetamine in the rat Ann N Y Acad Sci 305 1978 645 663 (Pubitemid 8354248)
43. M.E. Molliver, U.V. Berger, D.C. Molliver, E. O'Hearn, and M.A. Wilson Neurotoxicity of MDMA and related compounds: anatomic studies Ann N Y Acad Sci 600 1990 649 661
44. E. Sanders-Bush, J.A. Bushing, and F. Sulser Long-term effects of p-chloroamphetamine and related drugs on central serotonergic mechanisms J Pharmacol Exp Ther 192 1975 33 41
45. K.J. Miller, D.C. Anderholm, and M.M. Ames Metabolic activation of the serotonergic neurotoxin para-chloroamphetamine to chemically reactive intermediates by hepatic and brain microsomal preparation Biochem Pharmacol 35 1986 1737 1742 (Pubitemid 16067795)
46. T.K. Murray, J.L. Wiliams, A. Misra, M.J. Colado, and A.R. Green The spin trap reagent PBN attenuates degeneration of 5-HT neurons in rat brain induced by p-chloroamphetamine but not fenfluramine Neuropharmacology 35 1996 1615 1620 (Pubitemid 27026490)
47. E. Jéquier, W. Lovenberg, and A. Sjoerdsma Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin Mol Pharmacol 3 1967 274 278
48. D.H. Park, D.M. Stone, H. Baker, K.S. Kim, and T.H. Joh Early induction of rat brain tryptophan hydroxylase (TPH) mRNA following parachlorophenylalanine (PCPA) treatment Brain Res Mol Brain Res 22 1994 20 28 (Pubitemid 24063621)
49. W.A. Daniel, A. Haduch, M. Syrek, and J. Boksa Direct and indirect interactions between antidepressant drugs and CYP2C6 in the rat liver during long-term treatment Eur Neuropsychopharmacol 16 2006 580 587 (Pubitemid 44716661)
50. F. Fornai, M.G. Alessandr, M.T. Torracca, L. Bassi, V. Scalori, and G.U. Corsini Noradrenergic modulation of methamphetamine-induced striatal dopamine depletion Ann N Y Acad Sci 844 1998 166 177 (Pubitemid 28367805)
51. I. Korzeniewska-Rybicka, and A. Płaźnik Role of serotonergic and noradrenergic systems in a model of visceral pain Pol J Pharmacol 53 2001 475 480 (Pubitemid 33143729)
52. E. Przegaliński, L. Jaworska, and K. Gołembiowska The effect of p-chloroamphetamine and p-chlorophenylalanine on the level of thyrotropin-releasing hormone and its receptors in some brain structures and lumbar spinal cord of the rat Neuropeptides 23 1992 19 25
53. W. Legrum, G. Stuehmeier, and K.J. Netter Cobalt as a modifier of microsomal monooxgenases in mice Toxicol Appl Pharmacol 48 1979 195 204 (Pubitemid 9197365)
54. K.J. Netter A method for the direct measurement of O-demethylation in liver microsomes and its use in studying microsome inhibition by SKF-525-A Naunyn Schmiedebergs Arch Exp Pathol Pharmacol 238 1960 292 300
55. A.S. Basile, A. Janowsky, K. Golembiowska, M. Kowalska, E. Tam, and M. Benvenist Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain J Pharmacol Exp Ther 321 2007 1208 1225 (Pubitemid 46762716)
56. M. Kot, and W.A. Daniel Relative contribution of rat cytochrome P450 isoforms to the metabolism of caffeine: the pathway and concentration dependence Biochem Pharmacol 75 2008 1538 1549
57. T. Hiroi, S. Imaoka, and Y. Funae Dopamine formation from tyramine by CYP2D6 Biochem Biophys Res Commun 249 1998 838 843 (Pubitemid 28441925)
58. A. Haduch, J. Wójcikowski, and W.A. Daniel Effect of selected antidepressant drugs on cytochrome P450 2B (CYP2B) in rat liver. An in vitro and in vivo study Pharmacol Rep 60 2008 957 965
59. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
60. M. Konstandi, M.A. Lang, D. Kostakis, E.O. Johnson, and M. Marselos Predominant role of peripheral catecholamines in the stress-induced modulation of CYP1A2 inducibility by benzo(alpha)pyrene Basic Clin Pharmacol Toxicol 102 2008 35 44 (Pubitemid 350294082)
61. O. Kotsovolou, M. Ingelman-Sundberg, M.A. Lang, M. Marselos, D.H. Overstreet, and Z. Papadopoulou-Daifoti Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression Prog Neuropsychopharmacol Biol Psychiatry 34 2010 1075 1084
62. J. Wójcikowski, K. Gołembiowska, and W.A. Daniel The regulation of liver cytochrome P450 by the brain dopaminergic system Curr Drug Metab 8 2007 631 638 (Pubitemid 47209100)
63. J. Wójcikowski, K. Gołembiowska, and W.A. Daniel Regulation of liver cytochrome P450 by activation of brain dopaminergic system: physiological and pharmacological implications Biochem Pharmacol 76 2008 258 267
64. S. Al-Damluji Adrenergic control of the secretion of anterior pituitary hormones Baillieres Clin Endocrinol Metab 7 1993 355 392 (Pubitemid 23138255)
65. H.S. Jørgensen Studies on the neuroendocrine role of serotonin Dan Med Bull 54 2007 266 288 (Pubitemid 351890220)
66. L. Krulich Central neurotransmitters and the secretion of prolactin, GH, LH and TSH Annu Rev Physiol 41 1979 603 615
67. C.D. McMahon, R.P. Radecliff, K.J. Lookingland, and H.A. Tucker Neuroregulation of growth hormone secretion in domestic animals Domest Anim Endocrinol 20 2001 65 87 (Pubitemid 32411131)
68. E.E. Müller Some aspects of the neurotransmitter control of anterior pituitary function Pharmacol Res 21 1989 75 85 (Pubitemid 19107175)
69. K. Pacak, M. Palkovits, I.J. Kopin, and D.S. Goldstein Stress-induced norepinephrine release in the hypothalamic paraventricular nucleus and pituitary-adrenocortical and sympathoadrenal activity: in vivo microdialysis studies Front Neuroendocrinol 16 1995 89 150
70. J. Strobl, and M.J. Thomas Human growth hormone Pharmacol Rev 46 1994 1 34 (Pubitemid 24100617)
71. J. Tuomisto, and P. Männistö Neurotransmitter regulation of anterior pituitary hormones Pharmacol Rev 37 1985 249 332 (Pubitemid 16107648)
72. R.I. Weiner, and W.F. Ganong Role of brain monoamines and histamine in regulation of anterior pituitary secretion Physiol Rev 58 1978 905 976 (Pubitemid 9081949)
73. K. Itoi, T. Suda, F. Tozawa, I. Dobashi, N. Ohmori, and Y. Sakai Microinjection of norepinephrine into the paraventricular nucleus of the hypothalamus stimulates corticotropin-releasing factor gene expression in conscious rats Endocrinology 135 1994 2177 2182 (Pubitemid 24363917)
74. N. Uyama, A. Geerts, and H. Reynaert Neural connections between the hypothalamus and the liver Anat Rec Discov Mol Cell Evol Biol 280 2004 808 820 (Pubitemid 39330960)
75. G. Guellaen, M. Yates-Aggerbeck, G. Vauquelin, D. Strosberg, and J. Hanoune Characterization with [3H] dihydroergocryptine of the alpha-adrenergic receptor of the hepatic plasma membrane. Comparison with the beta-adrenergic receptor in normal and adrenalectomized rats J Biol Chem 253 1978 1114 1120 (Pubitemid 8288830)
76. R.G. Ruddell, D.A. Mann, and G.A. Ramm The function of serotonin within the liver J Hepatol 48 2008 666 675
77. J. McKinney, P.M. Knappskog, and J. Haavik Different properties of the central and peripheral forms of human tryptophan hydroxylase J Neurochem 2 2005 311 320 (Pubitemid 40194022)
78. D.J. Walther, and M. Bader A unique central tryptophan hydroxylase isoform Biochem Pharmacol 66 2003 1673 1680 (Pubitemid 37249312)
79. B. Oesch-Bartlomowicz, A. Huelster, O. Wiss, P. Antoniou-Lipfert, C. Dietrich, and M. Arand Aryl hydrocarbon receptor activation by cAMP vs. dioxin: divergent signaling pathways Proc Natl Acad Sci USA 102 2005 9218 9223 (Pubitemid 40923544)
80. B. Oesch-Bartlomowicz, and F. Oesch Fast regulation of cytochrome P450 activities by phosphorylation and consequences for drug metabolism and toxicity Biol Chem 383 2002 1587 1592 (Pubitemid 35282978)
81. M. Kubera, M. Maes, G. Kenis, Y.K. Kim, and W. Lasoń Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6 Psychiatry Res 134 2005 251 258 (Pubitemid 40693942)
82. M. Kubera, G. Kenis, E. Bosmans, S. Scharpé, and M. Maes Effects of serotonin and serotonergic agonists and antagonists on the production of interferon-gamma and interleukin-10 Neuropsychopharmacology 23 2000 89 98 (Pubitemid 30408315)
83. H. Engler, R. Doenlen, C. Riether, A. Engler, H.O. Besedovsky, and A. Del Rey Chemical destruction of brain noradrenergic neurons affects splenic cytokine production J Neuroimmunol 219 2010 75 80