A mixture of odorant molecules potentially indicating oestrus in mammals elicits penile erections in male rats

Behavioural Brain Research

Volumn 225, Issue 2, 2011, Pages 584-589

  Nielsen, Birte L ^a   Jerôme, Nathalie ^a   Saint Albin, Audrey ^a   Thonat, Catherine ^b   Briant, Christine ^c   Boué, Franck ^d   Rampin, Olivier ^a   Maurin, Yves ^a  

^a INRA   (France)

^b Bio Sens   (France)

^c Institut Français du Cheval et de l'Equitation Direction des Connaissances   (France)

^d De l'environnement et du travail   (France)

Author keywords

Behaviour; Carboxylic acids; Fox; Horse; Olfaction; Sexual receptiveness

Indexed keywords

BUTYRIC ACID; ISOBUTYRIC ACID; ISOVALERIC ACID; PROPIONIC ACID; VALERIC ACID;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ESTRUS; FECES; FEMALE; MALE; NONHUMAN; ODOR; PENIS ERECTION; PRIORITY JOURNAL; RAT; RECEPTIVE FIELD; SEXUAL BEHAVIOR; STIMULUS RESPONSE;

ADMINISTRATION, INHALATION; ANIMALS; CARBOXYLIC ACIDS; ESTRUS; FECES; FEMALE; FOXES; HORSES; MALE; ODORS; PENILE ERECTION; RATS; SEXUAL BEHAVIOR, ANIMAL;

EID: 80052967396     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.08.026     Document Type: Article

References (54)

1. Achiraman S., Archunan G. 1-Iodo-2methylundecane, a putative estrus-specific urinary chemo-signal of female mouse (Mus musculus). Theriogenology 2006, 66:1913-1920.
2. Ågmo A. Male rat sexual behavior. Brain Res Protoc 1997, 1:203-209.
3. Ågmo A. Copulation-contingent aversive conditioning and sexual incentive motivation in male rats: evidence for a two-stage process of sexual behaviour. Physiol Behav 2002, 77:425-435.
4. Ågmo A. Unconditioned sexual incentive motivation in the male Norway rat (Rattus norvegicus). J Comp Psychol 2003, 117(1):3-14.
5. Ågmo A. On the concept of sexual arousal: A simpler alternative. Horm Behav 2008, 53:312-314.
6. Apfelbach R., Blanchard C.D., Blanchard R.J., Hayes R.A., McGregor I.S. The effects of predator odors in mammalian prey species: a review of field and laboratory studies. Neurosci Biobehav Rev 2005, 29:1123-1144.
7. 1H NMR spectroscopy of urine and pattern recognition. Anal Biochem 2001, 295:194-202.
8. Briant C., Gaudé Y., Bruneau B., Yvon J.M., Guillaume D., Bouakkaz A. Olfaction is not absolutely necessary for detection of the estrous mare by the stallion. Anim Reprod Sci 2010, 121S:S120-S122.
9. Carr W.J., Hirsch J.T., Balazs J.M. Responses of male rats to odors from familiar vs novel females. Behav Neural Biol 1980, 29:331-337.
10. Coureaud G., Langlois D., Sicard G., Schaal B. Newborn rabbit responsiveness to the mammary pheromone is concentration-dependent. Chem Senses 2004, 29:341-350.
11. Cowley J.J., Brooksbank B.W.L. Human exposure to putative pheromones and changes in aspects of social behavior. J Steroid Biochem Mol Biol 1991, 39:647-659.
12. Curtis R.F., Ballantine J.A., Keverne E.B., Bonsall R.W., Michael R.P. Identification of primate sexual pheromones and the properties of synthetic attractants. Nature 1971, 232:396-398.
13. Dehnhard M., Claus R. Reliability criteria of a bioassay using rats trained to detect estrus-specific odor in cow urine. Theriogenology 1988, 30(6):1127-1138.
14. Dielenberg R.A., McGregor I.S. Defensive behaviour in rats towards predatory odors: a review. Neurosci Biobehav Rev 2001, 25:597-609.
15. EU Directive. Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. Official Journal of the European Union, 20.10.2010;L276/33-79.
16. Fillion T.J., Blass E.M. Infantile behavioural reactivity to oestrous chemostimuli in Norway rats. Anim Behav 1986, 34:123-133.
17. Fine J.M., Sorensen P.W. Production and fate of the sea lamprey migratory pheromone. Curr Opin Neurobiol 2010, 8:458-467.
18. Goodwin D. Horse behaviour: evolution, domestication and feralisation. The Welfare of Horses 2002, 19-44. Kluwer, Dordrecht. N. Waran (Ed.).
19. Gross-Isseroff R., Lancet D. Concentration-dependent changes to perceived odor quality. Chem Senses 1988, 13:191-204.
20. Hoffmann H., Janssen E., Turner S.L. Classical conditioning of sexual arousal in women and men: effects of varying awareness and biological relevance of the conditioned stimulus. Arch Sex Behav 2004, 33:43-53.
21. Hradecký P. Volatile fatty acids in urine and vaginal secretions of cows during reproductive cycle. J Chem Ecol 1986, 12(1):187-196.
22. Jorgenson J.W., Novotny M., Carmack M., Copland G.B., Wilson S.R., Katona S., Whitten W.K. Chemical scent constituents in the urine of the red fox (Vulpes vulpes L.) during winter season. Science 1978, 199:796-798.
23. Kiddy C.A., Mitchell D.S., Bolt D.J., Hawk H.W. Detection of estrus-related odors in cows by trained dogs. Biol Reprod 1978, 19:389-395.
24. Kimura R. Volatile substances in feces, urine and urine-marked feces of feral horses. Can J Anim Sci 2001, 81:411-420.
25. Kippin T.E., Pfaus J.G. The nature of the conditioned response mediating olfactory conditioned ejaculatory preference in the male rat. Behav Brain Res 2001, 122:11-24.
26. Klemm W.R., Hawkins G.N., De Los Santos E. Identification of compounds in bovine cervico-vaginal mucus extracts that evoke male sexual behavior. Chem Senses 1987, 12:77-87.
27. Kumar K.R., Archunan G., Jeyaraman R., Narasimhan S. Chemical characterization of bovine urine with special reference to oestrus. Vet Res Commun 2000, 24:445-454.
28. Kvitvik I.-L., Berg K.M., Ågmo A. A neutral odor may become a sexual incentive through classical conditioning in male rats. Learn Motiv 2010, 4:11-21.
29. Ladewig J., Hart B.L. Demonstration of estrus-related odors in cow urine by operant conditioning of rats. Biol Reprod 1981, 24:1165-1169.
30. Le Danvic C., Gérard O., Joly C., Ponsart C., Chemineau P., Humblot P., Nagnan-Le Meillour P Enhancing bull libido by female urinary chemical cues with special reference to estrus. Proceedings of the 26th Annual Meeting of the International Society of Chemical Ecology 2010, 223.
31. Le Magnen J. Les phénomènes olfacto-sexuels chez le rat blanc. Arch Sci Physiol 1952, 6:295-331.
32. Marinier S.L., Alexander A.J., Waring G.H. Flehmen behaviour in the domestic horse: Discrimination of conspecific odours. Appl Anim Behav Sci 1988, 19:227-237.
33. Martín J., Barja I., López P. Chemical scent constituents in feces of wild Iberian wolves (Canis lupus signatus). Biochem Syst Ecol 2010, 38:1096-1102.
34. Michael R.P., Bonsall R.W., Kutner M. Volatile fatty acids " copulins" , in human vaginal secretions. Psychoneuroendocrino 1975, 1(2):153-163.
35. Michael R.P., Bonsall R.W., Warner P. Human vaginal secretions: Volatile fatty acid content. Science 1974, 186:1217-1219.
36. Michael R.P., Keverne E.B., Bonsall R.W. Pheromones: isolation of male sex attractants from a female primate. Science 1971, 172:964-966.
37. Mitchell J.B., Stewart J. Facilitation of sexual behaviors in the male rat in the presence of stimuli previously paired with systemic injections of morphine. Pharmacol Biochem Behav 1990, 35(2):367-372.
38. Moore C.L., Jordan L., Wong L. Early olfactory experience, novelty, and choice of sexual partner by male rats. Physiol Behav 1996, 60:1361-1367.
39. Rampin O., Jérôme N., Briant C., Boué F., Maurin Y. Are oestrus odours species specific?. Behav Brain Res 2006, 172:169-172.
40. Rasmussen L.E., Lee T.D., Roelofs W.L., Zhang A., Daves G.D. Insect pheromone in elephants. Nature 1996, 379:684.
41. Rasmussen L.E., Lee T.D., Zhang A., Roelofs W.L., Daves G.D. Purification, identification, concentration and bioactivity of (Z)-7-dodecen-1-yl acetate: sex pheromone of the female Asian elephant, Elephas maximus. Chem Senses 1997, 22:417-437.
42. Rasmussen L.E., Schmidt M.J., Henneous R., Groves D., Daves G.D. Asian bull elephants: Flehmen-like responses to extractable components in female elephant estrous urine. Science 1982, 217:159-162.
43. Sachs B.D. Penile erection in response to remote cues from females: albino rats severely impaired relative to pigmented strains. Physiol Behav 1996, 60:803-808.
44. Sachs B.D. Erection evoked in male rats by airborne scent from estrous females. Physiol Behav 1997, 62:921-924.
45. Sachs B.D., Akasofu K., Citron J.H., Daniels S.B., Natoli J.H. Noncontact stimulation from estrous females evokes penile erection in rats. Physiol Behav 1994, 55:1073-1079.
46. Salo P. Determining the odor thresholds for some compounds in alcoholic beverages. J Food Sci 1970, 35:95-99.
47. Sankar R., Archunan G. Flehmen response in bull: role of vaginal mucus and other body fluids of bovine with special reference to estrus. Behav Process 2004, 67:81-86.
48. Sankar R., Archunan G. Identification of putative pheromones in bovine (Bos taurus) feces in relation to estrus detection. Anim Reprod Sci 2008, 103:149-153.
49. Sankar R., Archunan G., Habara Y. Detection of oestrous-related odour in bovine (Bos taurus) saliva: bioassay of identified compounds. Animal 2007, 1:1321-1327.
50. Sherwin C.M., Christiansen S.B., Duncan I.J.H., Erhard H.W., Lay D.C., Mench J.A., O'Connor C.E., Petherick C.J. Guidelines for the ethical use of animals in applied animal behaviour research. Appl Anim Behav Sci 2003, 81:291-305.
51. Sokolov V.E., Khorlina I.M. Pheromones in mammals: study of the volatile acid composition in vaginal secretions of mink Mustela vison Briss (in Russian). Dok Akad Nauk USSR 1976, 228(1):225-227.
52. Stahlbaum C.C., Houpt K.A. The role of the Flehmen response in the behavioral repertoire of the stallion. Physiol Behav 1989, 45:1207-1214.
53. Vickers N.J., Christensen T.A., Mustaparta H., Baker T.C. Chemical communication in heliothine moths. Ill. Flight behaviour of male Helicoverpa zea and Heliothis virescens in response to varying ratios of intra- and interspecific sex pheromone components. J Comp Physiol 1991, 169:275-280.
54. Yener T., Tunc A.T., Aslan H., Aytan H., Caliskan A.C. Determination of oestrous cycle of the rats by direct examination: how reliable?. Anat Histol Embryol 2007, 36:75-77.