Odor identification deficits identify Parkinson's disease patients with poor cognitive performance

Movement Disorders

Volumn 26, Issue 11, 2011, Pages 2045-2050

  Damholdt, Malene Flensborg ^a   Borghammer, Per ^b   Larsen, Lars ^a   Østergaard, Karen ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Cognition; Odor identification; Olfaction; Parkinson's disease

Indexed keywords

DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; MONOAMINE OXIDASE B INHIBITOR;

AGED; ANOSMIA; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; EXECUTIVE FUNCTION; FEMALE; GERIATRIC DEPRESSION SCALE; HUMAN; LANGUAGE PROCESSING; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; PARKINSON DISEASE; PRIORITY JOURNAL; STROOP TEST; UNIFIED PARKINSON DISEASE RATING SCALE; VERBAL MEMORY; VISUAL MEMORY;

AGED; ANALYSIS OF VARIANCE; CHOICE BEHAVIOR; COGNITION DISORDERS; EXECUTIVE FUNCTION; FEMALE; HUMANS; MALE; MEMORY; MIDDLE AGED; MOOD DISORDERS; NEUROPSYCHOLOGICAL TESTS; OLFACTION DISORDERS; PARKINSON DISEASE; SMELL; VERBAL LEARNING;

EID: 80052967219     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.23782     Document Type: Article

References (44)

1. Mesholam RI, Moberg PJ, Mahr RN, Doty RL. Olfaction in neurodegenerative disease-a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. Arch Neurol 1998; 55: 84-90.
2. Doty RL, Deems DA, Stellar S. Olfactory dysfunction in parkinsonism: a general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology 1988; 38: 1237-1244.
3. Haehner A, Hummel T, Reichmann H. Olfactory dysfunction as a diagnostic marker for Parkinson's disease. Expert Rev Neurother 2009; 9: 1773-1779.
4. Meusel T, Westermann B, Fuhr P, Hummel T, Welge-Lüssen. The course of olfactory deficits in patients with Parkinson's disease-a study based on psychophysical and electrophysiological measures. Neurosci Lett 2010; 486: 166-170.
5. Boesveldt S, Verbaan D, Knol DL, et al. A comparative study of odor identification and odor discrimination deficits in Parkinson's disease. Mov Disord 2008; 23: 1984-1990.
6. Swan GE, Carmelli D. Impaired olfaction predicts cognitive decline in nondemented older adults. Neuroepidemiology 2002; 21: 58-67.
7. Westervelt HJ, Ruffolo JS, Tremont G. Assessing olfaction in the neuropsychological exam: the relationship between odor identification and cognition in older adults. Arch Clin Neuropsychol 2005; 20: 761-769.
8. Doty RL, Riklan M, Deems DA, Reynolds C, Stellar S. The olfactory and cognitive deficits of Parkinson's disease: evidence for independence. Ann Neurol 1989; 25: 166-171.
9. Postuma R, Gagnon J. Cognition and olfaction in Parkinson's disease. Brain 2010; 2133: e160.
10. Bohnen NI, Muller MLTM, Kotagal V, et al. Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson's disease. Brain 2010; 133: 1747-1754.
11. Bohnen NI, Albin RL. The cholinergic system and Parkinson disease. Behav Brain Res 2010 [Epub ahead of print].
12. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed., text revision. Washington, DC: American Psychiatric Association; 2000.
13. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992; 55: 181-184.
14. Folstein MF, Folstein SE, McHugh PR. 'Mini mental state.' A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
15. Doty RL, Marcus A, Lee WW. Development of the 12-item cross-cultural smell identification test (CC-SIT). Laryngoscope 1996; 106: 353-356.
16. Djernes JK, Kvist E, Olesen F, Munk-Joergensen P, Gulmann NC. Validation of a Danish translation of the Geriatric Depression Scale-15 as a screening tool for depression among community living frail elderly. Ugeskrift for Laeger 2004; 166: 905-909.
17. Sheikh JI, Yesavage JA. Geriatric Depression Scale (GDS): Recent evidence and development of a shorter version. Clin Gerontol 1986; 5: 165-173.
18. Fahn S, Elton R, members of the UPDRS Development Committee. The Unified Parkinson's Disease Rating Scale in recent developments. In: Parkinson's Disease. Florham Park, NJ: Macmillan Healthcare Information; 1987: 153.
19. Louis ED, Levy G, Côte LJ, Mejia H, Fahn S, Marder K. Diagnosing Parkinson's disease using videotaped neurological examinations: validity and factors that contribute to incorrect diagnoses. Mov Disord 2002; 17: 513-517.
20. Lozano AM, Lang AE, Galvez-Jimenez N, et al. Effect of GPi pallidotomy on motor function in Parkinson's disease. Lancet 1995; 346: 1383-1387.
21. Axelrod B, Henry R, Woodward J. Analysis of an abbreviated form of the Wisconsin Card Sorting Test. Clin Neuropsychol 1992: 27-31
22. Kaplan E, Goodglass H, Weintraub S. Boston Naming Test. Philadelphia: Lea & Febiger; 1983.
23. Nelson H. The National Adult Reading Test (NART): test manual. NFER Nelson; 1978.
24. Bucks RS. Development and validation of the Location Learning Test (LLT): a test of visuo-spatial learning designed for use with older adults and in dementia. Clin Neuropsychol 1997; 11: 273-286.
25. Golden C. Stroop Color and Word Test: A Manual for Clinical and Experimental Uses. Chicago, IL: Skoelting; 1978.
26. Rey A. L'examen clinique en psychologie. Paris: Presses Universitaires de France; 1964.
27. Schmidt M. Rey Auditory Verbal Learning Test: A Handbook. Los Angeles CA: Western Psychological Services; 1996.
28. Bechara A, Damasio AR, Damasio H, Anderson SW. Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 1994; 50: 7-15.
29. Lezak MD, Howieson DB, Loring DW, Hannay HJ, Fischer JS. Neuropsychological Assessment. 4th ed. New York: Oxford University Press; 2004.
30. Potagas C, Dellatolas G, Ziegler M, Leveteau J, Bathien N, Leod MP, Rondot P. Clinical assessment of olfactory dysfunction in Parkinson's disease. Mov Disord 1998; 13: 394-399.
31. Bohnen NI, Gedela S, Herath P, Constantine GM, Moore RY. Selective hyposmia in Parkinson disease: association with hippocampal dopamine activity. Neurosci Lett 2008; 447: 12-16.
32. Hudry J, Thobois S, Broussolle E, Adeleine P, Royet JP. Evidence for deficiencies in perceptual and semantic olfactory processes in Parkinson's disease. Chem Senses 2003; 28: 537-543.
33. Morgan CD, Nordin S, Murphy C. Odor identification as an early marker for Alzheimer's disease: Impact of lexical functioning and detection sensitivity. J Clin Exp Neuropsychol 1995; 17: 793-803.
34. Murphy C, Cain WS, Gilmore MM, Skinner RB. Sensory and semantic factors in recognition memory for odors and graphic stimuli: elderly versus young persons. Amer J Psychol 1991; 104: 161-192.
35. Demattè ML, Sanabria D, Spence C. Olfactory discrimination: when vision matters? Chem Senses 2009; 34: 103-109.
36. Stockhorst U, Pietrowsky R. Olfactory perception, communication, and the nose-to-brain pathway. Physiol Behav 2004; 83: 3-11.
37. Yeshurun Y, Dudai Y, Sobel N. Working memory across nostrils. Behav Neurosci 2008; 122: 1031-1037.
38. Bohnen NI, Gedela S, Kuwabara H, et al. Selective hyposmia and nigrostriatal dopaminergic denervation in Parkinson's disease. J Neurol 2007; 254: 84-90.
39. Westermann B, Wattendorf E, Schwerdtfeger U, et al. Functional imaging of the cerebral olfactory system in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 2008; 79: 19-24.
40. Takeda A, Saito N, Baba T, et al. Functional imaging studies of hyposmia in Parkinson's disease. J Neurol Sci 2010; 289: 36-39.
41. Paolini A, McKenzie J. Effects of lesions in the horizontal diagonal band nucleus on olfactory habituation in the rat. Neuroscience 1993; 57: 717-724.
42. Carballo-Márquez A. Muscarinic receptor blockade in ventral hippocampus and prelimbic cortex impairs memory for socially transmitted food preference. Hippocampus 2009; 19: 446-455.
43. Carballo-Mairquez A, Vale-Martinez A, Guillazo-Blanch G, Marti-Nicolovious M. Differential effects of muscarinic receptor blockade in prelimbic cortex on acquisition and memory formation of an odor-reward task. Learn Mem 2007; 14: 616-624.
44. Salthouse TA, Lichty W. Tests of the neural noise hypothesis of age-related cognitive change. J Gerontol 1985; 40: 443-450.