Inhibition of the transport of HIV in vitro using a pH-responsive synthetic mucin-like polymer system

Biomaterials

Volumn 32, Issue 33, 2011, Pages 8343-8355

  Mahalingam, Alamelu ^a   Jay, Julie I ^a   Langheinrich, Kristofer ^b   Shukair, Shetha ^c   McRaven, Mike D ^c   Rohan, Lisa C ^d   Herold, Betsy C ^e   Hope, Thomas J ^c   Kiser, Patrick F ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b Department of Electrical and Computer Engineering   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Biomimetic; Crosslinked polymer; HIV; PH responsive

Indexed keywords

ACIDIC PH; ACTIVE INGREDIENTS; BARRIER PROPERTIES; CHARACTERISTIC RELAXATION TIME; CROSS-LINKED POLYMERS; CROSSLINKED; CROSSLINKS; DELIVERY VEHICLE; DRUG DELIVERY VEHICLES; ELASTIC NETWORKS; HIV; IN-VITRO; METHACRYLAMIDES; MOUSE MODELS; NATURALLY OCCURRING; NEUTRAL PH; PH-RESPONSIVE; PHENYLBORONIC ACIDS; POLYMER BACKBONES; POLYMER NETWORKS; POLYMER SYSTEMS; SALICYLHYDROXAMIC ACID; SYNTHETIC POLYMERS; TARGET TISSUES; TRANSIENT NETWORK; TRANSPORT ASSAYS;

BIOMIMETICS; BODY FLUIDS; DISEASES; DRUG DELIVERY; ELASTIC MODULI; ORGANIC ACIDS; RELAXATION PROCESSES; TISSUE;

FUNCTIONAL POLYMERS;

2 HYDROXYPROPYL METHACRYLAMIDE; BENZENEBORONIC ACID; MUCIN; POLYMER; SALICYLHYDROXAMIC ACID; UNCLASSIFIED DRUG;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; CROSS LINKING; DRUG DELIVERY SYSTEM; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PH; POLYMERIZATION; PRIORITY JOURNAL; SEMINAL PLASMA; UTERINE CERVIX MUCUS; VAGINA MUCOSA; VIRUS INHIBITION; VIRUS TRANSMISSION; VISCOELASTICITY; YOUNG MODULUS;

ANIMALS; BORONIC ACIDS; FEMALE; FLUORESCENT DYES; HIV; HUMANS; HYDROGEN-ION CONCENTRATION; MACROPHAGES; MICE; MUCINS; POLYMERS; RHEOLOGY; SALICYLAMIDES; VAGINA;

EID: 80052962634     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.05.001     Document Type: Article

References (48)

1. Hladik F., Hope T.J. HIV infection of the genital mucosa in women. Curr HIV/AIDS Rep 2009, 6(1):20-28.
2. Haase A.T. Targeting early infection to prevent HIV-1 mucosal transmission. Nature 2010, 464(7286):217-223.
3. Hladik F., Sakchalathorn P., Ballweber L., Lentz G., Fialkow M., Eschenbach D., et al. Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1. Immunity 2007, 26(2):257-270.
4. Lai S.K., Hida K., Shukair S., Wang Y.Y., Figueiredo A., Cone R., et al. Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus. J Virol 2009, 83(21):11196-11200.
5. Lai B.E., Geonnotti A.R., Desoto M.G., Montefiori D.C., Katz D.F. Semi-solid gels function as physical barriers to human immunodeficiency virus transport in vitro. Antivir Res 2010, 88(2):143-151.
6. Tevi-Benissan C., Belec L., Levy M., Schneider-Fauveau V., Si Mohamed A., Hallouin M.C., et al. In vivo semen-associated pH neutralization of cervicovaginal secretions. Clin Diagn Lab Immunol 1997, 4(3):367-374.
7. Lai B.E., Xie Y.Q., Lavine M.L., Szeri A.J., Owen D.H., Katz D.F. Dilution of microbicide gels with vaginal fluid and semen simulants: effect on rheological properties and coating flow. J Pharm Sci 2008, 97(2):1030-1038.
8. Sassi A.B., Isaacs C.E., Moncla B.J., Gupta P., Hillier S.L., Rohan L.C. Effects of physiological fluids on physical-chemical characteristics and activity of topical vaginal microbicide products. J Pharm Sci 2008, 97(8):3123-3139.
9. Quayle A.J., Xu C., Mayer K.H., Anderson D.J. T lymphocytes and macrophages, but not motile spermatozoa, are a significant source of human immunodeficiency virus in semen. J Infect Dis 1997, 176(4):960-968.
10. Maher D., Wu X., Schacker T., Horbul J., Southern P. HIV binding, penetration, and primary infection in human cervicovaginal tissue. Proc Natl Acad Sci 2005, 102(32):11504-11509.
11. Alvarez-Lorenzo C., Concheiro A. Intelligent drug delivery systems: polymeric micelles and hydrogels. Mini Rev Med Chem 2008, 8(11):1065-1074.
12. Bawa P., Pillay V., Choonara Y.E., du Toit L.C. Stimuli-responsive polymers and their applications in drug delivery. Biomed Mater 2009, 4(2):022001.
13. Saeed A.O., Magnússon J.P., Twaites B., Alexander C. Stimuli-responsive and 'active' polymers in drug delivery 2009, John Wiley & Sons, Ltd.
14. Soyez H., Schacht E. Polymeric carriers: advances in drug delivery. Pharm Technol Eur 1997, 9(10):50-56.
15. Traitel T., Goldbart R., Kost J. Smart polymers for responsive drug-delivery systems. J Biomater Sci Polym Ed 2008, 19(6):755-767.
16. Kieweg S.L., Katz D.F. Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing. J Pharm Sci 2007, 96(4):835-850.
17. Owen D.H., Peters J.J., Katz D.F. Rheological properties of contraceptive gels. Contraception 2000, 62(6):321-326.
18. Mahalingam A., Smith E., Fabian J., Damian F.R., Peters J.J., Clark M.R., et al. Design of a semisolid vaginal microbicide gel by relating composition to properties and performance. Pharm Res 2010, 27(11):2478-2491.
19. Owen DH, Peters JJ, Katz DF. Rheological properties of microbicidal formulations governing spreading and retention in the vagina and rectum. Presented at the Microbicides 2002; 12-15th May Antwerp, [Belgium].
20. Henderson M.H., Couchman G.M., Walmer D.K., Peters J.J., Owen D.H., Brown M.H., et al. Optical imaging and analysis of human vaginal coating by drug delivery formulations. Contraception 2007, 75(2):142-151.
21. Gupta K.M., Barnes S.R., Tangaro R.A., Roberts M.C., Owen D.H., Katz D.F., et al. Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles. J Pharm Sci 2007, 96(3):670-681.
22. Stolowitz M.L., Ahlem C., Hughes K.A., Kaiser R.J., Kesicki E.A., Li G., et al. Phenylboronic acid-salicylhydroxamic acid bioconjugates. 1. A novel boronic acid complex for protein immobilization. Bioconjug Chem 2001, 12(2):229-239.
23. Wiley J.P., Hughes K.A., Kaiser R.J., Kesicki E.A., Lund K.P., Stolowitz M.L. Phenylboronic acid-salicylhydroxamic acid bioconjugates. 2. Polyvalent immobilization of protein ligands for affinity chromatography. Bioconjug Chem 2001, 12(2):240-250.
24. Jay J.I., Shukair S., Langheinrich K., Hanson M.C., Cianci G.C., Johnson T.J., et al. Modulation of viscoelasticity and HIV transport as a function of pH in a reversibly crosslinked hydrogel. Adv Funct Mater 2009, 19(18):2969-2977.
25. Roberts M.C., Hanson M.C., Massey A.P., Karren E.A., Kiser P.F. Dynamically restructuring hydrogel networks formed with reversible covalent crosslinks. Adv Mater 2007, 19(18):2503-2507.
26. Roberts M.C., Mahalingam A., Hanson M.C., Kiser P.F. Chemorheology of phenylboronate-salicylhydroxamate crosslinked hydrogel networks with a sulfonated polymer backbone. Macromolecules 2008, 41(22):8832-8840.
27. Springsteen G., Wang B. A detailed examination of boronic acid-diol complexation. Tetrahedron 2002, 58(26):5291-5300.
28. Rihova B., Bilej M., Vetvicka V., Ulbrich K., Strohalm J., Kopecek J., et al. Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin: immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro. Biomaterials 1989, 10(5):335-342.
29. Carlstedt I., Lindgren H., Sheehan J.K., Ulmsten U., Wingerup L. Isolation and characterization of human cervical-mucus glycoproteins. Biochem J 1983, 211(1):13-22.
30. Owen D.H., Katz D.F. A review of the physical and chemical properties of human semen and the formulation of a semen simulant. J Androl 2005, 26(4):459-469.
31. Madsen F., Eberth K., Smart J.D. A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration. J Control Release 1998, 50(1-3):167-178.
32. Hagerstrom H., Edsman K. Limitations of the rheological mucoadhesion method: the effect of the choice of conditions and the rheological synergism parameter. Eur J Pharm Sci 2003, 18(5):349-357.
33. Fichorova R.N., Rheinwald J.G., Anderson D.J. Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical, and vaginal epithelium that maintain expression of tissue-specific differentiation proteins. Biol Reprod 1997, 57(4):847-855.
34. Ayehunie S., Cannon C., Lamore S., Kubilus J., Anderson D.J., Pudney J., et al. Organotypic human vaginal-ectocervical tissue model for irritation studies of spermicides, microbicides, and feminine-care products. Toxicol In Vitro 2006, 20(5):689-698.
35. Cummins J.E., Guarner J., Flowers L., Guenthner P.C., Bartlett J., Morken T., et al. Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture. Antimicrob Agents Chemother 2007, 51(5):1770-1779.
36. Rohan L.C., Moncla B.J., Kunjara Na Ayudhya R.P., Cost M., Huang Y., Gai F., et al. In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide. PLoS One 2010, 5(2):e9310.
37. Hermanson G.T. Bioconjugate techniques 2008, Academic Press. 2nd ed.
38. McDonald D., Vodicka M.A., Lucero G., Svitkina T.M., Borisy G.G., Emerman M., et al. Visualization of the intracellular behavior of HIV in living cells. J Cell Biol 2002, 159(3):441-452.
39. Robb I.D., Smeulders J.B.A.F. The rheological properties of weak gels of poly(vinyl alcohol) and sodium borate. Polymer 1997, 38(9):2165-2169.
40. Das Neves J., Da Silva M.V., Goncalves M.P., Amaral M.H., Bahia M.F. Rheological properties of vaginal hydrophilic polymer gels. Curr Drug Deliv 2009, 6(1):83-92.
41. Ide N., Sato T., Miyamoto T., Fukuda T. Thermoreversible hydrogel of short-chain O-(2,3-Dihydroxypropyl)cellulose/borax aqueous solution. Microscopic versus macroscopic properties. Macromolecules 1998, 31(25):8878-8885.
42. Choplin L., Sabatié J. Threshold-type shear-thickening in polymeric solutions. Rheol Acta 1986, 25(6):570-579.
43. Inoue T., Osaki K. Rheological properties of poly(vinyl alcohol)/sodium borate aqueous solutions. Rheol Acta 1993, 32:550-555.
44. Okado H.H. Vaginal drug delivery 2001, Taylor and Francis Inc, NY. 1st ed.
45. Valentine M.T., Kaplan P.D., Thota D., Crocker J.C., Gisler T., Prud'homme R.K., et al. Investigating the microenvironments of inhomogeneous soft materials with multiple particle tracking. Phys Rev E 2001, 64(6):061506.
46. Wirtz D. Particle-tracking microrheology of living cells: principles and applications. Annu Rev Biophys 2009, 38:301-326.
47. Tien D., Schnaare R.L., Kang F., Cohl G., McCormick T.J., Moench T.R., et al. In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trials. AIDS Res Hum Retroviruses 2005, 21(10):845-853.
48. Fichorova R.N., Bajpai M., Chandra N., Hsiu J.G., Spangler M., Ratnam V., et al. Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives. Biol Reprod 2004, 71(3):761-769.