A very high rate of inappropriate use of gastroprotection for nonsteroidal anti-inflammatory drug therapy in primary care: A cross-sectional study

Journal of Clinical Gastroenterology

Volumn 45, Issue 9, 2011, Pages 780-784

  Morini, Sergio ^a   Zullo, Angelo ^a   Oliveti, Diodato ^b   Chiriatti, Alberto ^c   Marmo, Riccardo ^d   Chiuri, Diana A E ^b   Marotti, Gemma ^b   Morelli, Lara ^b   Hassan, Cesare ^a  

^a NUOVO REGINA MARGHERITA HOSPITAL   (Italy)

^b ASL RM/A   (Italy)

^c General Practitioner FIMMG ^*  (Italy)

^d Curto Hospital   (Italy)

Author keywords

appropriateness; gastroprotection; nonsteroidal anti inflammatory drug; proton pump inhibitor

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; CLOPIDOGREL; ESOMEPRAZOLE; LANSOPRAZOLE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PANTOPRAZOLE; RANITIDINE; TICLOPIDINE;

ADULT; AGED; ARTICLE; CLINICAL ASSESSMENT; CROSS-SECTIONAL STUDY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PREDICTION; PRESCRIPTION; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; QUESTIONNAIRE; RISK FACTOR; STOMACH PROTECTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; CROSS-SECTIONAL STUDIES; FEMALE; GASTROINTESTINAL DISEASES; HUMANS; MALE; MIDDLE AGED; PHYSICIAN'S PRACTICE PATTERNS; PRIMARY HEALTH CARE; QUESTIONNAIRES; RISK FACTORS; YOUNG ADULT;

EID: 80052947545     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0b013e3182151be7     Document Type: Article

References (24)

1. Mahé I, Leizorovicz A, Caulin C, et al. Aspirin for the prevention of cardiovascular events in the elderly. Drugs Aging. 2003;20:999-1010. (Pubitemid 37363660)
2. Laine L, Hennekens C. Proton pump inhibitor and clopidogrel interaction: fact or fiction? Am J Gastroenterol. 2010;105:34-41.
3. Davis MP, Srivastava M. Demographics, assessment and management of pain in the elderly. Drugs Aging 2003;20:23-57. (Pubitemid 36127032)
4. Zullo A, Hassan C, Campo SM, et al. Bleeding peptic ulcer in the elderly: risk factors and prevention strategies. Drugs Aging. 2007;24:815-828. (Pubitemid 47553791)
5. Marmo R, Koch M, Cipolletta L, et al. Predicting mortality in non-variceal upper gastrointestinal bleeders: validation of the Italian PNED score and prospective comparison with the Rockall score. Am J Gastroenterol. 2010;105:1284-1291.
6. Scheiman JM, Hindley CE. Strategies to optimize treatment with NSAIDs in patients at risk for gastrointestinal and cardiovascular adverse events. Clin Ther. 2010;32:667-677.
7. Graham DY, Chan FKL. NSAIDs, risks, and gastroprotective strategies: current status and future. Gastroenterology. 2008;134:1240-1257.
8. Weil J, Langman MJS, Wainwright P, et al. Peptic ulcer bleeding: accessory risk factors and interactions with nonsteroidal anti-inflammatory drugs. Gut. 2000;46:27-31. (Pubitemid 30307672)
9. Lanas A, Garcia-Rodriguez LA, Arroyo MT, et al. Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin nonsteroidal anti-inflammatory drugs, aspirin and combinations. Gut. 2006;55:1731-1738. (Pubitemid 44893570)
10. Chan FK, Graham DY. Review article: prevention of non-steroidal anti-inflammatory drug gastrointestinalcomplications-review and recommendations based on risk assessment. Aliment Pharmacol Ther. 2004;19:1051-1061. (Pubitemid 38703517)
11. Yeomans ND, Tulassay Z, Juhász L, et al. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group. N Engl J Med. 1998; 338:719-726. (Pubitemid 28115090)
12. Hawkey CJ, Karrasch JA, Szczepañski L, et al. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. N Engl J Med. 1998;338:727-734. (Pubitemid 28115091)
13. Palmer KR. Non variceal gastrointestinal haemorrhage guidelines.Gut. 2002;51:1-6.
14. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum. 2000;43:1905-15.
15. Moens HJ, van Croonenborg JJ, Al MJ, et al. Guideline: NSAID use and the prevention of gastric damage. Ned Tijdschr Geneeskd. 2004;148:604-608. (Pubitemid 38418612)
16. Clinard F, Bardou M, Sgro C, et al. Non-steroidal anti-inflammatory and cytoprotective drug co-prescription in general practice? A general practitioner-based survey in France. Eur J Clin Pharmacol. 2001;57:737-743. (Pubitemid 34031267)
17. Sturkenboom MC, Burke TA, Dieleman JP, et al. Underutilization of preventive strategies in patients receiving NSAIDs. Rheumatology. 2003;42:23-31.
18. Smalley WE, Stein CM, Arbogast PG, et al. Underutilization of gastroprotective measures in patients receiving nonsteroidal antiinflammatory drugs. Arthritis Rheum. 2002;46:2195-2200.
19. Abraham NS, El-Serag HB, Johnson ML, et al. National adherence to evidence-based guidelines for the prescription of nonsteroidal anti-inflammatory drugs. Gastroenterology. 2005; 129:1171-1178. (Pubitemid 41446857)
20. Pilotto A, Franceschi M, Vitale DF, et al. Upper gastrointestinal symptoms and therapies in elderly outpatients, users of non-selective NSAIDs or coxibs. Aliment Pharmacol Ther. 2005;22:147-155. (Pubitemid 41039703)
21. Bianco MA, Rotondano G, Buri L, et al. Gastro-protective strategies in primary care in Italy: the "Gas.Pro" survey. Dig Liver Dis. 2010;42:359-364.
22. Murray M, Swan AV, Kiryluk S, et al. The Hawthorne effect in the measurement of adolescent smoking. J Epidemiol Commun Health. 1988;42:304-306.
23. Morini S, Hassan C, Meucci G, et al. Diagnostic yield of open access colonoscopy according to appropriateness. Gastrointest Endosc. 2001;54:175-179.
24. Hassan C, Bersani G, Buri L, et al. Appropriateness of upper-GI endoscopy: an Italian survey on behalf of the Italian Society of Digestive Endoscopy. Gastrointest Endosc. 2007;65:767-774.(Pubitemid 46629072)