Rationale and design of the DeFACTO (Determination of Fractional Flow Reserve by Anatomic Computed Tomographic AngiOgraphy) study

Journal of Cardiovascular Computed Tomography

Volumn 5, Issue 5, 2011, Pages 301-309

  Min, James K ^a   Berman, Daniel S ^a   Budoff, Matthew J ^b   Jaffer, Farouc A ^c   Leipsic, Jonathon ^d   Leon, Martin B ^e   Mancini, G B John ^d   Mauri, Laura ^f   Schwartz, Robert S ^g   Shaw, Leslee J ^h  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e NewYork Presbyterian Hospital   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g MINNEAPOLIS HEART INSTITUTE FOUNDATION   (United States)

^h EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Computed tomography; Coronary artery disease; Fractional flow reserve

Indexed keywords

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; CLINICAL TRIAL; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CORONARY ARTERY CIRCUMFLEX BRANCH; CORONARY ARTERY OBSTRUCTION; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FRACTIONAL FLOW RESERVE; HUMAN; INVASIVE PROCEDURE; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RIGHT CORONARY ARTERY; SENSITIVITY AND SPECIFICITY; STUDY DESIGN;

CORONARY ANGIOGRAPHY; CORONARY STENOSIS; EUROPE; FRACTIONAL FLOW RESERVE, MYOCARDIAL; HUMANS; MODELS, CARDIOVASCULAR; MYOCARDIAL ISCHEMIA; NORTH AMERICA; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; RADIOGRAPHIC IMAGE INTERPRETATION, COMPUTER-ASSISTED; REPUBLIC OF KOREA; RESEARCH DESIGN; TOMOGRAPHY, X-RAY COMPUTED;

EID: 80052944165     PISSN: 19345925     EISSN: 1876861X     Source Type: Journal    
DOI: 10.1016/j.jcct.2011.08.003     Document Type: Article

References (23)

1. Budoff M.J., Dowe D., Jollis J.G., Gitter M., Sutherland J., Halamert E., Scherer M., Bellinger R., Martin A., Benton R., Delago A., Min J.K. Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J Am Coll Cardiol 2008, 52:1724-1732.
2. Miller J.M., Rochitte C.E., Dewey M., Arbab-Zadeh A., Niinuma H., Gottlieb I., Paul N., Clouse M.E., Shapiro E.P., Hoe J., Lardo A.C., Bush D.E., de Roos A., Cox C., Brinker J., Lima J.A. Diagnostic performance of coronary angiography by 64-row CT. N Engl J Med 2008, 359:2324-2336.
3. Meijboom W.B., Meijs M.F., Schuijf J.D., Cramer M.J., Mollet N.R., van Mieghem C.A., Nieman K., van Werkhoven J.M., Pundziute G., Weustink A.C., de Vos A.M., Pugliese F., Rensing B., Jukema J.W., Bax J.J., Prokop M., Doevendans P.A., Hunink M.G., Krestin G.P., de Feyter P.J. Diagnostic accuracy of 64-slice computed tomography coronary angiography: a prospective, multicenter, multivendor study. J Am Coll Cardiol 2008, 52:2135-2144.
4. Di Carli M.F., Dorbala S., Curillova Z., Kwong R.J., Goldhaber S.Z., Rybicki J.F., Hachamovitch R. Relationship between CT coronary angiography and stress perfusion imaging in patients with suspected ischemic heart disease assessed by integrated PET-CT imaging. J Nucl Cardiol 2007, 4:799-809.
5. Rispler S., Keidar Z., Ghersin E., Roguin A., Soil A., Dragu R., Litmanovich D., Frenkel A., Aronson D., Engel A., Beyar R., Israel O. Integrated single-photon emission computed tomography and computed tomography coronary angiography for the assessment of hemodynamically significant coronary artery lesions. J Am Coll Cardiol 2007, 49:1059-1067.
6. Hacker M., Jakobs T., Hack N., Nikolaou K., Becker C., von Ziegler F., Knez A., Konig A., Klauss V., R eiser M., Hahn K., Tiling R. Sixty-four slice spiral CT angiography does not predict the functional relevance of coronary artery stenoses in patients with stable angina. Eur J Nucl Med Mol Imaging 2007, 34:4-10.
7. van Werkhoven J.M., Schuijf J.D., Jukema J.W., Kroft L.J., Stokkel M.P., Dibbets-Schneider P., Pundziute G., Scholte A.J., van der Wall E.E., Bax J.J. Anatomic correlates of a normal perfusion scan using 64-slice computed tomographic coronary angiography. Am J Cardiol 2008, 101:40-45.
8. van Werkhoven J.M., Heijenbrok M.W., Schuijf J.D., Jukema J.W., van der Wall E.E., Schreur J.H., Bax J.J. Combined non-invasive anatomical and functional assessment with MSCT and MRI for the detection of significant coronary artery disease in patients with an intermediate pre-test likelihood. Heart 2010, 96:425-431.
9. Schuijf J.D., Bax J.J. CT angiography: an alternative to nuclear perfusion imaging?. Heart 2008, 94:255-257.
10. Kern M.J., Samady H. Current concepts of integrated coronary physiology in the catheterization laboratory. J Am Coll Cardiol 2010, 55:173-185.
11. Melikian N., De B.P., Tonino P., De Winter O., Wyffels E., Bartunek J., Heyndrickx G.R., Fearon W.F., Pijls N.H., Wigns W., De Bruyne B. Fractional flow reserve and myocardial perfusion imaging in patients with angiographic multivessel coronary artery disease. JACC Cardiovasc Interv 2010, 3:307-314.
12. Pijls N.H., Fearon W.F., Tonino P.A., Siebert U., Ikeno F., Bornschein B., van't Veer M., Klauss V., Manoharan G., Engstrom T., Oldroyd K.G., Ver Lee P.N., MacCarthy P.A., De Bruyne B., FAME Study Investigators Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study. J Am Coll Cardiol 2010, 56:177-184.
13. Tonino P.A., De B.B., Pijls N.H., Siebert U., Ikeno F., van't Veer M., Klauss V., Manoharan G., Engstrom T., Oldroyd K.G., Ver Lee P.N., MacCarthy P.A., Fearon W.E. FAME Study Investigators: Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med 2009, 360:213-224.
14. Tonino P.A., Fearon W.F., De Bruyne B., Oldroyd K.G., Leesar M.A., Ver Lee P.N., Maccarthy P.A., Van't Veer M., Pijls N.H. Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J Am Coll Cardiol 2010, 55:2816-2821.
15. Pijls N.H., van Schaardenburgh P., Manoharan G., Boersma E., Bech J.W., van't Veer M., Bar F., Hoorntje J., Koolen J., Wijns W., de Bruyne B. Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER Study. J Am Coll Cardiol 2007, 49:2105-2111.
16. Berger A., Botman K.J., MacCarthy P.A., Wijns W., Bartunek J., Heyndrickx G.R., Pils N.H., De Bruyne B. Long-term clinical outcome after fractional flow reserve-guided percutaneous coronary intervention in patients with multivessel disease. J Am Coll Cardiol 2005, 46:438-442.
17. Kim H.J., Jansen K.E., Taylor C.A. Incorporating autoregulatory mechanisms of the cardiovascular system in three-dimensional finite element models of arterial blood flow. Ann Biomed Eng 2010, 38:2314-2330.
18. Kim H.J., Vignon-Clementel I.E., Coogan J.S., Figueroa C.A., Jansen K.E., Taylor C.A. Patient-specific modeling of blood flow and pressure in human coronary arteries. Ann Biomed Eng 2010, 38:3195-3209.
19. Koo BK, Erglis A, Doh JH, Daniels DV, Jegere S, Kim HS, Dunning A, Defrance T, Lansky A, Leipsic J, Min JK: Diagnosis of ischemia-causing coronary stenoses by non-invasive fractional flow reserve computed from coronary CT angiograms: results from the Prospective Multicenter DISCOVER-FLOW Study. J Am Coll Cardiol. In press.
20. Uren N.G., Melin J.A., de B.B., Wijns W., Baudhuin T., Camici P.G. Relation between myocardial blood flow and the severity of coronary-artery stenosis. N Engl J Med 1994, 330:1782-1788.
21. Abbara S., Arbab-Zadeh A., Callister T.Q., Desai M.Y., Mamuya W., Thomson L., Weigold W.G. SCCT guidelines for performance of coronary computed tomographic angiography: a report of the Society of Cardiovascular Computed Tomography Guidelines Committee. J Cardiovasc Comput Tomogr 2009, 3:190-204.
22. Raff G.L., Abidov A., Achenbach S., Berman D.S., Doxt L.M., Budoff M.J., Cheng V., DeFrance T., Hellinger J.C., Karlsberg R.P. Society of Cardiovascular Computed Tomographhy: SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography. J Cardiovasc Comput Tomogr 2009, 3:122-136.
23. Smith S.C., Feldman T.E., Hirshfeld J.W., Jacobs A.K., Kern M.J., King S.B., Morrison D.A., O'Neill W.W., Schaff H.V., Whitlow P.L., Williams D.O., Antman E.M., Smith S.C., Adams C.D., Anderson J.L., Faxon D.P., Fuster V., Halperin J.L., Hiratzka L.F., Hunt S.A., Jacobs A.K., Nishimura R., Ornato J.P., Page R.L., Riegel B. Catheter Cardiovasc Interv 2006, 67:87-112. American College of Cardiology/American Heart Association Task Force on Practice Guidelines; ACC/AHA/SCAI Writing Committee to Update the 2011 Guidelines for Percuatenous Coronary Intervention: ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention-summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI Writing Committee to update the 2001 Guidelines for Percutaneous Coronary Intervention).