A systematic modeling approach to elucidate the triggering of the stringent response in recombinant E. coli systems

Advances in Intelligent and Soft Computing

Volumn 93, Issue , 2011, Pages 313-320

  Carneiro, Sónia ^a   Ferreira, Eugénio C ^a   Rocha, Isabel ^a  

^a UNIVERSITY OF MINHO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BASAL LEVELS; BIOSYNTHETIC PRECURSORS; E. COLI; HYBRID MODELING; METABOLIC NETWORK; RECOMBINANT E. COLI; RECOMBINANT PROTEIN; SYSTEMATIC MODELING;

AMINO ACIDS; BIOSYNTHESIS; ESCHERICHIA COLI; GROWTH KINETICS; METABOLISM; PROTEINS;

BIOINFORMATICS;

EID: 80052939870     PISSN: 18675662     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-19914-1_41     Document Type: Conference Paper

References (13)

1. Bentley, W.E., Kompala, D.S.: A novel structured kinetic modeling approach for the analysis of plasmid instability in recombinant bacterial cultures. Biotechnology and Bioengineering 33, 49-61 (1989) (Pubitemid 19010125)
2. Harcum, S.W.: Structured model to predict intracellular amino acid shortages during recombinant protein overexpression in E. coil. Journal of Biotechnology 93(3), 189-202 (2002) (Pubitemid 34084854)
3. Hoffmann, F., Rinas, U.: Stress induced by recombinant protein production in Escherichia coli. Advances in Biochemical Engineering / Biotechnology 89, 73-92 (2004)
4. Jain, V., Kumar, M., Chatterji, D.: ppGpp: Stringent response and survival. Journal of Microbiology 44(1), 1-10 (2006) (Pubitemid 44891239)
5. Mukherjee, T.K., Raghavan, A., Chatterji, D.: Shortage of nutrients in bacteria: The stringent response. Current Science 75(7), 684-689 (1998) (Pubitemid 128681046)
6. Neidhardt, F.C., Ingraham, J.L., Schaechter, M.: Physiology of the bacterial cell - a molecular approach. Sinauer Associates, Sunderland, USA (1990)
7. Palaiomylitou, M.A., Matis, K.A., Zouboulis, A.I., Kyriakidis, D.A.: A kinetic model describing cell growth and production of highly active, recombinant ice nucleation protein in Escherichia coli. Biotechnology and Bioengineering 78(3), 321-332 (2002) (Pubitemid 34712376)
8. Reed, J.L., Vo, T.D., Schilling, C.H., Palsson, B.O.: An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Genome Biology 4(9), R54 (2003)
9. Rocha, I., Maia, P., Evangelista, P., Vilaca, P., Soares, S., Pinto, J.P., Nielsen, J., Patil, K.R., Ferreira, E.C., Rocha, M.: OptFlux: An open-source software platform for in silico metabolic engineering. BMC Systems Biology 4, 45 (2010)
10. Schmidt, H., Jirstrand, M.: Systems Biology Toolbox for MATLAB: A computational platform for research in systems biology. Bioinformatics 22(4), 514-515 (2006) (Pubitemid 43231434)
11. Schweder, T., Hofmann, K., Hecker, M.: Escherichia coli K12 rel A strains as safe hosts for expression of recombinant DNA. Applied Microbiology and Biotechnology 42(5), 718-723 (1995)
12. Torok, I., Kari, C.: Accumulation of pp Gpp in a rel A mutant of Escherichia coli during amino acid starvation. Journal of Biological Chemistry 255(9), 3838-3840 (1980) (Pubitemid 10053017)
13. Varma, A., Palsson, B.O.: Metabolic Flux Balancing - Basic Concepts, Scientific and Practical Use. Bio-Technology 12(10), 994-998 (1994)