Impact of recipients' socio-economic status on patient and graft survival after liver transplantation: The IsMeTT experience

Digestive and Liver Disease

Volumn 43, Issue 11, 2011, Pages 893-898

  Gruttadauria, Salvatore ^a,b,c   Grosso, Giuseppe ^c   Mistretta, Antonio ^c   Pagano, Duilio ^a   Scianna, Giovanni ^a   Vizzini, Giovan Battista ^a   Cintorino, Davide ^a,b   Spada, Marco ^a,b   Basile, Francesco ^c   Gridelli, Bruno ^a,b  

^a MEDITERRANEAN INSTITUTE FOR TRANSPLANTATION AND ADVANCED SPECIALIZED THERAPIES ISMETT   (Italy)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c UNIVERSITY OF CATANIA   (Italy)

Author keywords

Complications; Liver transplantation; Outcome; Socioeconomic status

Indexed keywords

ADULT; ARTICLE; BODY MASS; COLD ISCHEMIA; COMORBIDITY; CULTURAL FACTOR; DEATH; EDUCATIONAL STATUS; FEMALE; FOLLOW UP; GRAFT RECIPIENT; GRAFT SURVIVAL; HEALTH CARE ACCESS; HEALTH CARE QUALITY; HUMAN; ITALY; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LOWEST INCOME GROUP; MAJOR CLINICAL STUDY; MALE; MODEL FOR END STAGE LIVER DISEASE SCORE; ORGAN DONOR; OVERALL SURVIVAL; PREDICTIVE VALUE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCORING SYSTEM; SOCIAL STATUS; SURVIVAL; SURVIVAL RATE; TREATMENT OUTCOME; TREATMENT REFUSAL;

ADULT; AGED; ANALYSIS OF VARIANCE; EDUCATIONAL STATUS; FEMALE; GRAFT SURVIVAL; HUMANS; ITALY; KAPLAN-MEIER ESTIMATE; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; SOCIOECONOMIC FACTORS;

EID: 80052938875     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2011.06.017     Document Type: Article

References (37)

1. Centers for Disease Control and Prevention (CDC) Hepatocellular carcinoma-United States, 2001-2006. Morb Mortal Wkly Rep 2010, 59:517-520.
2. Thuluvath P.J., Guidinger M.K., Fung J.J., et al. Liver transplantation in the United States, 1999-2008. Am J Transplant 2010, 10:1003-1019.
3. Norderstedt H., White D.L., El-Serag H.B. The changing pattern of epidemiology in hepatocellular carcinoma. Dig Liver Dis 2010, 42(Suppl 3):S206-S214.
4. Seeff L.B., Hoofnagle J.H. Epidemiology of hepatocellular carcinoma in areas of low hepatitis B and hepatitis C endemicity. Oncogene 2006, 26:3771-3777.
5. Deuffic-Burban S., Poynard T., Sulkowski M.S., et al. Estimating the future health burden of chronic hepatitis C and human immunodeficiency virus infections in the United States. J Viral Hepat 2007, 14:107-115.
6. Bhagat V., Mindikoglu A.L., Nudo C.G., et al. Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease. Liver Transpl 2009, 15:1814-1820.
7. Quintieri F., Pugliese O., Mattucci D.A., et al. Liver transplantation in Italy: analysis of risk factors associated with graft outcome. Prog Transplant 2006, 16:57-64.
8. Doyle H.R., Morelli F., McMichael J., Doria C., et al. Hepatic retransplantation-an analysis of risk factors associated with outcome. Transplantation 1996, 27:1499-1505.
9. Brown R.S., Lake J.R. The survival impact of liver transplantation in the MELD era, and the future for organ allocation and distribution. Am J Transplant 2005, 5:203-204.
10. Mor E., Gonwa T.A., Husberg B.S., Goldstein R.M., et al. Late-onset acute rejection in orthotopic liver transplantation-associated risk factors and outcome. Transplantation 1992, 54:821-824.
11. Berlakovich G.A., Langer F., Freundorfer E., et al. General compliance after liver transplantation for alcoholic cirrhosis. Transpl Int 2000, 13:129-135.
12. Bunzel B., Laederach-Hofmann K. Solid organ transplantation: are there predictors for posttransplant noncompliance?. A literature overview. Transplantation 2000, 70:711-716.
13. De Bleser L., Matteson M., Dobbels F., et al. Interventions to improve medication-adherence after transplantation: a systematic review. Transpl Int 2009, 22:780-797.
14. Takemoto S.K., Pinsky B.W., Schnitzler M.A., et al. A retrospective analysis of immunosuppression compliance, dose reduction and discontinuation in kidney transplant recipients. Am J Transplant 2007, 7:2704-2711.
15. Nair S., Eustace J., Thuluvath P.J. Effect of race on outcome of orthotopic liver transplantation. Lancet 2002, 359:287-293.
16. Artinyan A., Mailey B., Sanchez-Luege N., et al. Race, ethnicity, and socioeconomic status influence the survival of patients with hepatocellular carcinoma in the United States. Cancer 2010, 1:1367-1377.
17. Yoo H.Y., Galabova V., Edwin D., et al. Socioeconomic status does not affect the outcome of liver transplantation. Liver Transpl 2002, 8:1133-1137.
18. Yoo H.Y., Thuluvath P.J. Outcome of liver transplantation in adult recipients: influence of neighborhood income, education, and insurance. Liver Transpl 2004, 10:235-243.
19. World Health Organization Adherence to long-term therapies: evidence for action 2003, Available at, (accessed December 2010). http://www.who.int/chronic_conditions/en/adherence_report.pdf.
20. United Network of Organ Sharing. UNOS status. Available at: (accessed December 2010). http://www.unos.org/.
21. Gruttadauria S., Vizzini G., Biondo D., et al. Critical use of extended criteria donor liver grafts in adult-to-adult whole liver transplantation: a single-center experience. Liver Transpl 2008, 14:220-227.
22. Gruttadauria S., Pagano D., Echeverri G.J., et al. How to face organ shortage in liver transplantation in an area with low rate of deceased donation. Updat Surg 2010, 62:149-152.
23. Laederach-Hofmann K., Bunzel B. Noncompliance in organ transplant recipients: a literature review. Gen Hosp Psychiatry 2000, 22:412-424.
24. Angelico M., Cillo U., Fagiuoli S., et al. Liver Match, a prospective observational cohort study on liver transplantation in Italy: study design and current practice of donor-recipient matching. Dig Liver Dis 2010, 43:155-164.
25. Bryce C.L., Angus D.C., Arnold R.M., et al. Sociodemographic differences in early access to liver transplantation services. Am J Transplant 2009, 9:2092-2101.
26. Lubetkin E.I., Jia H., Franks P., Gold M.R. Relationship among sociodemographic factors, clinical conditions, and health-related quality of life: examining the EQ-5D in the U.S. general population. Qual Life Res 2005, 14:2187-2196.
27. Muennig P., Franks P., Jia H., et al. The income-associated burden of disease in the United States. Soc Sci Med 2005, 61:2018-2026. [Erratum in: Soc Sci Med. 2008; 66: 2390].
28. Duffy J.P., Kao K., Ko C.Y., et al. Long-term patient outcome and quality of life after liver transplantation: analysis of 20-year survivors. Ann Surg 2010, 252:652-661.
29. Kousoulas L., Neipp M., Barg-Hock H., et al. Health-related quality of life in adult transplant recipients more than 15 years after orthotopic liver transplantation. Transpl Int 2008, 21:1052-1058.
30. Short P.F., Mallonee E.L. Income disparities in the quality of life of cancer survivors. Med Care 2006, 44:16-23.
31. Miceli M., Di Lallo D., Perucci C.A. Absence of economic barriers does not reduce disparities in the access to renal transplantation: a population based study in a region of central Italy. Dialysis Register of Lazio Region. J Epidemiol Commun Health 2000, 54:157-158.
32. Grady K.L., Naftel D.C., Kobashigawa J., et al. Patterns and predictors of quality of life at 5 to 10 years after heart transplantation. J Heart Lung Transplant 2007, 26:535-543.
33. Chapman J.R. Compliance: the patient, the doctor, and the medication?. Transplantation 2004, 15:782-786.
34. Dew M.A., DiMartini A.F., De Vito D.A., et al. Rates and risk factors for nonadherence to the medical regimen after adult solid organ transplantation. Transplantation 2007, 83:858.
35. Friedman A.L., Geoghegan S.R., Noelle M., et al. Medication errors in the outpatient setting. Classification and root cause analysis. Arch Surg 2007, 142:278-283.
36. Haynes R.B., Ackloo E., Sahota N., et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev 2008.
37. Osterberg L., Blascke T. Adherence to medication. N Engl J Med 2005, 353:487-497.