Novel thiophenyl C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 19, 2011, Pages 5813-5832

  Lee, Suk Ho ^a,b   Song, Kwang Seop ^a   Kim, Jong Yup ^a   Kang, Misuk ^a   Lee, Jun Sung ^a   Cho, Seung Hwan ^a   Park, Hyun Ju ^b   Kim, Jeongmin ^a   Lee, Jinhwa ^a  

^a Green Cross Company   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

Dapagliflozin; Diabetes; Glucoside; SGLT; Thiophene

Indexed keywords

(5 BROMO 2 CHLOROTHIOPHEN 3 YL) (4 METHOXYPHENYL)METHANONE; (5 BROMO 2 METHYLTHIOPHEN 3 YL) (4 METHOXYPHENYL)METHANONE; 2 (5 CHLORO 4 (4 ISOPROPOXYBENZYL)THIOPEN 2 YL) 6 (HYDROXYMETHYL)TETRAHYDRO 2H PYRAN 3,4,5 TRIOL; 2 (5 CHLORO 4 (4 METHOXYBENZYL)THIOPEN 2 YL) 6 (HYDROXYMETHYL)TETRAHYDRO 2H PYRAN 3,4,5 TRIOL; 2 (5 CHLORO 4 [4 (CYCLOPENYLOXY)BENZYL]THIOPEN 2 YL) 6 (HYDROXYMETHYL)TETRAHYDRO 2H PYRAN 3,4,5 TRIOL; 2 (5 CHLORO 4 [4 (ETHYLTHIO)BENZYL]THIOPEN 2 YL) 6 (HYDROXYMETHYL)TETRAHYDRO 2H PYRAN 3,4,5 TRIOL; 2 (5 CHLORO 4 [4 (METHYLTHIO)BENZYL]THIOPEN 2 YL) 6 (HYDROXYMETHYL)TETRAHYDRO 2H PYRAN 3,4,5 TRIOL; 2 (5 CHLORO 4 [4 (TETRAHYDROFURAN 3 YLOXY)BENZYL]THIOPEN 2 YL) 6 (HYDROXYMETHYL)TETRAHYDRO 2H PYRAN 3,4,5 TRIOL; 2 (HYDROXYMETHYL) 6 [4 (4 METHOXYBENZYL) 5 METHYLTHIOPHEN 2 YL]TETRAHYDRO 2H PYRAN 3,4,5 TRIOL; 2 [4 (4 ETHOXYBENZYL) 5 METHYLTHIOPHEN 2 YL] 6 (HYDROXYMETHYL)TETRAHYDRO 2H PYRAN 3,4,5 TRIOL; 2 [4 (4 METHOXYBENZYL) 5 METHYLTHIOPEN 2 YL] 3,4,5 TRIS(TRIMETHYLSILYLOXY) 6 [(TRIMETHYLSILYLOXY)METHYL]TETRAHYDRO 2H PYRAN 2 OL; 2 [4 [[5 (4 FLUOROPHENYL)THIOPHEN 2 YL]METHYL] 5 METHYLTHIOPHEN 2 YL] 6 (HYDROXYMETHYL)TETRAHYDRO 2H PYRAN 3,4,5 TRIOL; 2 [5 CHLORO 4 (4 METHOXYBENZYL)THIOPEN 2 YL] 3,4,5 TRIS(TRIMETHYLSILYLOXY) 6 [(TRIMETHYLSILYLOXY)METHYL]TETRAHYDRO 2H PYRAN 2 OL; 2 [5 CHLORO 4 [[5 (4 FLUOROPHENYL)THIOPHEN 2 YL]METHYL]THIOPEN 2 YL] 6 (HYDROXYMETHYL)TETRAHYDRO 2H PYRAN 3,4,5 TRIOL; 3 [4 (ALLYLOXY)BENZYL] 5 BROMO 2 METHYLTHIOPHENE; 4 [(5 BROMO 2 CHLOROTHIOPHEN 3 YL)METHYL]PHENOL; 4 [(5 BROMO 2 METHYLTHIOPHEN 3 YL)METHYL]PHENOL; 5 BROMO 2 CHLORO 3 (4 ISOPROPOXYBENZYL)THIOPHENE; 5 BROMO 2 CHLORO 3 (4 METHOXYBENZYL)THIOPHENE; 5 BROMO 2 CHLORO 3 (4 PROPOXYBENZYL)THIOPHENE; 5 BROMO 2 CHLOROTHIOPHENE 3 CARBOXYLIC ACID; 5 BROMO 2 METHYLTHIOPHENE 3 CARBOXYLIC ACID; 5 BROMO 3 (4 METHOXYBENZYL) 2 METHYLTHIOPHENE; 5 IODO 3 (4 METHOXYBENZYL) 2 METHYLTHIOPHENE; ANTIDIABETIC AGENT; BENZYLTHIOPHENYL GLUCOSIDE DERIVATIVE; C ARYL GLUCOSIDE DERIVATIVE; NEW DRUG; SODIUM GLUCOSE COTRANSPORTER 2; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GLYCEMIC CONTROL; IC 50; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

GLUCOSIDES; HYPOGLYCEMIC AGENTS; SODIUM-GLUCOSE TRANSPORTER 2; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 80052937335     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.014     Document Type: Article

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