Novel ophthalmic timolol meleate liposomal-hydrogel and its improved local glaucomatous therapeutic effect in vivo

Drug Delivery

Volumn 18, Issue 7, 2011, Pages 502-510

  Hui Hui, Zhang ^a,b,c   Qiu Hua, Luo ^c   Zhi Jun, Yang ^a   Wei San, Pan ^c   Shu Fang, Nie ^a,d  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b Shenyang Sinqi Pharmaceutical Co Ltd   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^d Wuhan University of Bioengineering   (China)

Author keywords

ammonium sulfate gradient pH regulation; glaucoma; liposomal hydrogel; liposome; ocular delivery; timolol mealate

Indexed keywords

AMMONIUM SULFATE; DIETHYLENE GLYCOL MONOETHYL ETHER; EYE DROPS; LIPOSOME; TIMOLOL MALEATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORNEA; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG PENETRATION; DRUG RETENTION; GLAUCOMA; HISTOPATHOLOGY; HYDROGEL; IN VIVO STUDY; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RABBIT; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

ADMINISTRATION, OPHTHALMIC; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOLOGICAL AVAILABILITY; CORNEA; DISEASE MODELS, ANIMAL; DRUG STABILITY; DRUG STORAGE; GLAUCOMA; HYDROGELS; HYDROGEN-ION CONCENTRATION; INTRAOCULAR PRESSURE; LIPOSOMES; MALE; PARTICLE SIZE; PERMEABILITY; RABBITS; TIMOLOL;

EID: 80052927975     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2011.595839     Document Type: Article

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