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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 20, 2011, Pages 6042-6048

Design, synthesis and SAR of indazole and benzoisoxazole containing 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists

(9) Zhang, Xuqing a Hufnagel, Heather a Hou, Cuifen a Opas, Evan a McKenney, Sandra a Crysler, Carl a O'Neill, John a Johnson, Dana a Sui, Zhihua a

a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT (United States)

Author keywords

Benzoisoxazole; CCR2; Indazole

Indexed keywords

CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; CYCLOHEXANE DERIVATIVE; INDAZOLE DERIVATIVE; ISOXAZOLE DERIVATIVE; POTASSIUM CHANNEL HERG; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; CELL LINE; CYCLOHEXANES; DOGS; DRUG DESIGN; HUMANS; INDAZOLES; OXAZOLES; RATS; RECEPTORS, CCR2; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATORS;

EID: 80052920859 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.08.074 Document Type: Article

Times cited : (11)

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