Concerns about the antidepressant-like effects of high-dose ketamine in mice

Psychopharmacology

Volumn 215, Issue 4, 2011, Pages 813-

  Yang, Jianjun ^a   Zhou, Zhiqiang ^a   Yang, Chun ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

KETAMINE; ANTIDEPRESSANT AGENT;

ANTIDEPRESSANT ACTIVITY; ATAXIA; BEHAVIOR CHANGE; DEPRESSION; DRUG MEGADOSE; EXPERIMENTAL TEST; FORCED SWIMMING TEST; LETTER; LOCOMOTION; MAZE TEST; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; SCHIZOPHRENIA; STEREOTYPY; TAIL SUSPENSION TEST; ANIMAL; ANIMAL BEHAVIOR; BAGG ALBINO MOUSE; DOSE RESPONSE; DRUG EFFECT; IMMOBILIZATION; MOUSE; NOTE; SWIMMING;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HINDLIMB SUSPENSION; KETAMINE; MICE; MICE, INBRED BALB C; SWIMMING;

EID: 80052903832     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2308-2     Document Type: Letter

References (4)

1. Bechtholt-Gompf AJ, Smith KL, John CS, Kang HH, Carlezon WA Jr, Cohen BM, Ongür D (2011) CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacy. Psychopharmacology (Berl) (in press)
2. Engin E, Treit D, Dickson CT (2009) Anxiolytic- and antidepressantlike properties of ketamine in behavioral and neurophysiological animal models. Neuroscience 161:359-369
3. Machado-Vieira R, Salvadore G, Diazgranados N, Zarate CA Jr (2009) Ketamine and the next generation of antidepressants with a rapid onset of action. Pharmacol Ther 123:143-150
4. Razoux F, Garcia R, Léna I (2007) Ketamine, at a dose that disrupts motor behavior and latent inhibition, enhances prefrontal cortex synaptic efficacy and glutamate release in the nucleus accumbens. Neuropsychopharmacology 32:719-727