What is next for the genetics of multiple sclerosis?

Autoimmune Diseases

Volumn 1, Issue 1, 2011, Pages

  Ramagopalan, Sreeram V ^a,b,c   Dyment, David A ^d  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HISTONE; HLA DRB1 ANTIGEN; INTERLEUKIN 23 RECEPTOR;

ARTICLE; DNA METHYLATION; EPIGENETICS; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SCREENING; HEREDITY; HISTONE MODIFICATION; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 80052867514     PISSN: None     EISSN: 20900430     Source Type: Journal    
DOI: 10.4061/2011/519450     Document Type: Article

References (18)

1. Paty D. W., Ebers G. C., Multiple Sclerosis 1998 Philadelphia, Pa, USA Davis
2. Sadovnick A. D., Baird P. A., Ward R. H., Multiple sclerosis: updated risks for relatives American Journal of Medical Genetics 1988 29 3 533 541
3. Ebers G. C., Bulman D. E., Sadovnick A. D., A population-based study of multiple sclerosis in twins New England Journal of Medicine 1986 315 26 1638 1642 (Pubitemid 17052896)
4. Jersild C., Svejgaard A., Fog T., HL-A antigens and multiple sclerosis Lancet 1972 1 7762 1240 1241
5. Fogdell A., Hillert J., Sachs C., Olerup O., The multiple sclerosis- and narcolepsy-associated HLA class II haplotype includes the DRB50101 allele Tissue Antigens 1995 46 4 333 336
6. Hafler D. A., Compston A., Sawcer S., Lander E. S., Daly M. J., De Jager P. L., De Bakker P. I. W., Gabriel S. B., Mirel D. B., Ivinson A. J., Pericak-Vance M. A., Gregory S. G., Rioux J. D., McCauley J. L., Haines J. L., Barcellos L. F., Cree B., Oksenberg J. R., Hauser S. L., Risk alleles for multiple sclerosis identified by a genomewide study New England Journal of Medicine 2007 357 9 851 862 (Pubitemid 47347319)
7. De Jager P. L., Jia X., Wang J., De Bakker P. I. W., Ottoboni L., Aggarwal N. T., Piccio L., Raychaudhuri S., Tran D., Aubin C., Briskin R., Romano S., Baranzini S. E., McCauley J. L., Pericak-Vance M. A., Haines J. L., Gibson R. A., Naeglin Y., Uitdehaag B., Matthews P. M., Kappos L., Polman C., McArdle W. L., Strachan D. P., Evans D., Cross A. H., Daly M. J., Compston A., Sawcer S. J., Weiner H. L., Hauser S. L., Hafler D. A., Oksenberg J. R., Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci Nature Genetics 2009 41 7 776 782
8. Momozawa Y., Mni M., Nakamura K., Coppieters W., Almer S., Amininejad L., Cleynen I., Colombel J. -F., De Rijk P., Dewit O., Finkel Y., Gassull M. A., Goossens D., Laukens D., Lémann M., Libioulle C., O'Morain C., Reenaers C., Rutgeerts P., Tysk C., Zelenika D., Lathrop M., Del-Favero J., Hugot J. -P., De Vos M., Franchimont D., Vermeire S., Louis E., Georges M., Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease Nature Genetics 2011 43 1 43 47
9. The International Multiple Sclerosis Genetics Consortium (IMSGC), Evidence for polygenic susceptibility to multiple sclerosisthe shape of things to come American Journal of Human Genetics 2010 86 4 621 625
10. Durbin R. M., Abecasis G. R., Altshuler D. L., A map of human genome variation from population-scale sequencing Nature 2010 467 1061 1073
11. Cirulli E. T., Goldstein D. B., Uncovering the roles of rare variants in common disease through whole-genome sequencing Nature Reviews Genetics 2010 11 6 415 425
12. Craddock N., Hurles M. E., Cardin N., Pearson R. D., Plagnol V., Robson S., Vukcevic D., Barnes C., Conrad D. F., Giannoulatou E., Holmes C., Marchini J. L., Stirrups K., Tobin M. D., Wain L. V., Yau C., Aerts J., Ahmad T., Andrews T. D., Arbury H., Attwood A., Auton A., Ball S. G., Balmforth A. J., Barrett J. C., Barroso I., Barton A., Bennett A. J., Bhaskar S., Blaszczyk K., Bowes J., Brand O. J., Braund P. S., Bredin F., Breen G., Brown M. J., Bruce I. N., Bull J., Burren O. S., Burton J., Byrnes J., Caesar S., Clee C. M., Coffey A. J., Connell J. M. C., Cooper J. D., Dominiczak A. F., Downes K., Drummond H. E., Dudakia D., Dunham A., Ebbs B., Eccles D., Edkins S., Edwards C., Elliot A., Emery P., Evans D. M., Evans G., Eyre S., Farmer A., Ferrier I. N., Feuk L., Fitzgerald T., Flynn E., Forbes A., Forty L., Franklyn J. A., Freathy R. M., Gibbs P., Gilbert P., Gokumen O., Gordon-Smith K., Gray E., Green E., Groves C. J., Grozeva D., Gwilliam R., Hall A., Hammond N., Hardy M., Harrison P., Hassanali N., Hebaishi H., Hines S., Hinks A., Hitman G. A., Hocking L., Howard E., Howard P., Howson J. M. M., Hughes D., Hunt S., Isaacs J. D., Jain M., Jewell D. P., Johnson T., Jolley J. D., Jones I. R., Jones L. A., Kirov G., Langford C. F., Lango-Allen H., Lathrop G. M., Lee J., Lee K. L., Lees C., Lewis K., Lindgren C. M., Maisuria-Armer M., Maller J., Mansfield J., Martin P., Massey D. C. O., McArdle W. L., McGuffin P., McLay K. E., Mentzer A., Mimmack M. L., Morgan A. E., Morris A. P., Mowat C., Myers S., Newman W., Nimmo E. R., O'Donovan M. C., Onipinla A., Onyiah I., Ovington N. R., Owen M. J., Palin K., Parnell K., Pernet D., Perry J. R. B., Phillips A., Pinto D., Prescott N. J., Prokopenko I., Quail M. A., Rafelt S., Rayner N. W., Redon R., Reid D. M., Renwick A., Ring S. M., Robertson N., Russell E., Clair D. S., Sambrook J. G., Sanderson J. D., Schuilenburg H., Scott C. E., Scott R., Seal S., Shaw-Hawkins S., Shields B. M., Simmonds M. J., Smyth D. J., Somaskantharajah E., Spanova K., Steer S., Stephens J., Stevens H. E., Stone M. A., Su Z., Symmons D. P. M., Thompson J. R., Thomson W., Travers M. E., Turnbull C., Valsesia A., Walker M., Walker N. M., Wallace C., Warren-Perry M., Watkins N. A., Webster J., Weedon M. N., Wilson A. G., Woodburn M., Wordsworth B. P., Young A. H., Zeggini E., Carter N. P., Frayling T. M., Lee C., McVean G., Munroe P. B., Palotie A., Sawcer S. J., Scherer S. W., Strachan D. P., Tyler-Smith C., Brown M. A., Burton P. R., Caulfield M. J., Compston A., Farrall M., Gough S. C. L., Hall A. S., Hattersley A. T., Hill A. V. S., Mathew C. G., Pembrey M., Satsangi J., Stratton M. R., Worthington J., Deloukas P., Duncanson A., Kwiatkowski D. P., McCarthy M. I., Ouwehand W. H., Parkes M., Rahman N., Todd J. A., Samani N. J., Donnelly P., Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls Nature 2010 464 7289 713 720
13. Ramagopalan S. V., Ebers G. C., Epistasis: multiple sclerosis and the major histocompatibility complex Neurology 2009 72 6 566 567
14. Ebers G. C., Sadovnick A. D., Dyment D. A., Yee I. M. L., Willer C. J., Risch N., Parent-of-origin effect in multiple sclerosis: observations in half-siblings Lancet 2004 363 9423 1773 1774 (Pubitemid 38698382)
15. Handel A. E., Ebers G. C., Ramagopalan S. V., Epigenetics: molecular mechanisms and implications for disease Trends in Molecular Medicine 2010 16 1 7 16
16. Baranzini S. E., Mudge J., Van Velkinburgh J. C., Khankhanian P., Khrebtukova I., Miller N. A., Zhang LU., Farmer A. D., Bell C. J., Kim R. W., May G. D., Woodward J. E., Caillier S. J., McElroy J. P., Gomez R., Pando M. J., Clendenen L. E., Ganusova E. E., Schilkey F. D., Ramaraj T., Khan O. A., Huntley J. J., Luo S., Kwok P. Y., Wu T. D., Schroth G. P., Oksenberg J. R., Hauser S. L., Kingsmore S. F., Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis Nature 2010 464 7293 1351 1356
17. Javierre B. M., Fernandez A. F., Richter J., Al-Shahrour F., Ignacio Martin-Subero J., Rodriguez-Ubreva J., Berdasco M., Fraga M. F., O'Hanlon T. P., Rider L. G., Jacinto F. V., Javier Lopez-Longo F., Dopazo J., Forn M., Peinado M. A., Carreo L., Sawalha A. H., Harley J. B., Siebert R., Esteller M., Miller F. W., Ballestar E., Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus Genome Research 2010 20 2 170 179
18. Kong A., Steinthorsdottir V., Masson G., Parental origin of sequence variants associated with complex diseases Nature 2009 462 7275 868 874