Effects of a 6-month cognitive intervention program on brain metabolism in amnestic mild cognitive impairment and mild alzheimer's disease

Journal of Alzheimer's Disease

Volumn 25, Issue 4, 2011, Pages 695-706

  Förster, Stefan ^a,h   Buschert, Verena C ^a,h   Buchholz, Hans Georg ^e   Teipel, Stefan J ^b,c   Friese, Uwe ^b,f   Zach, Christian ^a   La Fougere, Christian ^a   Rominger, Axel ^a   Drzezga, Alexander ^h   Hampel, Harald ^d   Bartenstein, Peter ^a   Buerger, Katharina ^a,g  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^d TRINITY COLLEGE DUBLIN   (Ireland)

^e JOHANNES GUTENBERG UNIVERSITY   (Germany)

^f UNIVERSITY OF OSNABRÜCK   (Germany)

^g LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^h TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Alzheimer's disease; cognitive intervention; cognitive stimulation; cognitive training; FDG PET; mild cognitive impairment

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ADULT; AGED; ALZHEIMER DISEASE; ALZHEIMER DISEASE ASSESSMENT SCALE COGNITIVE SUBSCALE; AMNESIA; AMNESTIC MILD COGNITIVE IMPAIRMENT; ANALYSIS OF VARIANCE; ARTICLE; BRAIN METABOLISM; BRAIN REGION; CLINICAL ARTICLE; CLINICAL ASSESSMENT TOOL; COGNITIVE INTERVENTION PROGRAM; CONTROLLED STUDY; FEMALE; GLUCOSE METABOLISM; HEALTH PROGRAM; HUMAN; MALE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; REST; TREATMENT DURATION;

EID: 80052861821     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-100996     Document Type: Article

References (39)

1. Buschert V, Bokde AL, Hampel H Cognitive intervention in Alzheimer disease. Nat Rev Neurol 6, 508-517.
2. Valenzuela M, Sachdev P (2009) Can cognitive exercise prevent the onset of dementia? Systematic review of randomized clinical trials with longitudinal follow-up. Am J Geriatr Psychiatry 17, 179-187.
3. Valenzuela MJ, Sachdev P (2006) Brain reserve and dementia: a systematic review. Psychol Med 36, 441-454. (Pubitemid 43380997)
4. Belleville S (2008) Cognitive training for persons with mild cognitive impairment. Int Psychogeriatr 20, 57-66. (Pubitemid 350256068)
5. Sitzer DI, Twamley EW, Jeste DV (2006) Cognitive training in Alzheimer's disease: a meta-analysis of the literature. Acta Psychiatr Scand 114, 75-90. (Pubitemid 44034266)
6. Olazaran J, Reisberg B, Clare L, Cruz I, Pena-Casanova J, Del Ser T, Woods B, Beck C, Auer S, Lai C, Spector A, Fazio S, Bond J, Kivipelto M, Brodaty H, Rojo JM, Collins H, Teri L, Mittelman M, Orrell M, Feldman HH, Muniz R Nonpharmacological Therapies in Alzheimer's Disease: A Systematic Review of Efficacy. Dement Geriatr Cogn Disord 30, 161-178.
7. Herholz K (2003) PET studies in dementia. Ann Nucl Med 17, 79-89. (Pubitemid 36693059)
8. Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D (1996) Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 334, 752-758. (Pubitemid 26089356)
9. Alexander GE, Chen K, Pietrini P, Rapoport SI, Reiman EM (2002) Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies. Am J Psychiatry 159, 738-745. (Pubitemid 34465046)
10. Heiss WD, Kessler J, Slansky I, Mielke R, Szelies B, Herholz K (1993) Activation PET as an instrument to determine therapeutic efficacy in Alzheimer's disease. Ann N Y Acad Sci 695, 327-331. (Pubitemid 23348287)
11. Small GW, Silverman DH, Siddarth P, Ercoli LM, Miller KJ, Lavretsky H, Wright BC, Bookheimer SY, Barrio JR, Phelps ME (2006) Effects of a 14-day healthy longevity lifestyle pro-gramoncognition andbrain function. Am J Geriatr Psychiatry 14, 538-545. (Pubitemid 43849532)
12. Buschert VC, Friese U, Teipel SJ, Schneider P, Merensky W, Rujescu D, Moller HJ, Hampel H, Buerger K (2011) Effects of a newly developed cognitive intervention in amnestic mild cognitive impairment and mild Alzheimer's disease: a pilot study. J Alzheimers Dis. doi:10.3233/JAD-2011-100999
13. Lachman ME, Weaver SL, Bandura M, Elliott E, Lewkowicz CJ (1992) Improving memoryand control beliefs through cognitive restructuring and self-generated strategies. J Gerontol 47, P293-P299.
14. Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, Mellits ED, Clark C (1989) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessmentof Alzheimer's disease. Neurology 39, 1159-1165. (Pubitemid 19239715)
15. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944. (Pubitemid 14076461)
16. Scheltens P, Barkhof F, Leys D, Pruvo JP, Nauta JJ, Vermersch P, Steinling M, Valk J (1993) A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci 114, 7-12. (Pubitemid 23025201)
17. Stern Y (2006) Cognitive reserve and Alzheimer disease. Alzheimer Dis Assoc Disord 20, 112-117. (Pubitemid 44305911)
18. Reisberg B, Franssen EH, Hasan SM, Monteiro I, Boksay I, Souren LE, Kenowsky S, Auer SR, Elahi S, Kluger A (1999) Retrogenesis: clinical, physiologic, and pathologic mechanisms in brain aging, Alzheimer's and other dementing processes. Eur Arch Psychiatry Clin Neurosci 249 Suppl 3, 28-36.
19. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E (1999) Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 56, 303-308. (Pubitemid 29120227)
20. Perry RJ, Hodges JR (1999) Attention and executive deficits in Alzheimer's disease. A critical review. Brain 122 (Pt 3), 383-404. (Pubitemid 29110515)
21. Folstein M, Folstein S, McHugh P (1975) "Mini Mental State": A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
22. Rosen WG, Mohs RC, Davis KL (1984) A new rating scale for Alzheimer's disease. Am J Psychiatry 141, 1356-1364.
23. Friston KJ, Frith CD, Liddle PF, Frackowiak RS (1991) Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab 11, 690-699.
24. Yakushev I, Hammers A, Fellgiebel A, Schmidtmann I, Scheurich A, Buchholz HG, Peters J, Bartenstein P, Lieb K, Schreckenberger M (2009) SPM-based count normalization provides excellent discriminationofmild Alzheimer's disease and amnestic mild cognitive impairment from healthy aging. Neuroimage 44, 43-50.
25. Borghammer P, Aanerud J, Gjedde A (2009) Data-driven intensity normalization of PET group comparison studies is superior to global mean normalization. Neuroimage 46, 981-988.
26. Borghammer P, Cumming P, Aanerud J, Forster S, Gjedde A (2009) Subcortical elevation of metabolism in Parkinson's disease-A critical reappraisal in the context of global mean normalization. Neuroimage 47, 1514-1521.
27. Yakushev I, Landvogt C, Buchholz HG, Fellgiebel A, Hammers A, Scheurich A, Schmidtmann I, Gerhard A, Schreckenberger M, Bartenstein P (2008) Choice ofreference area in studies of Alzheimer's disease using positron emission tomography with fluorodeoxyglucose-F18. Psychiatry Res 164, 143-153.
28. Forster S, Teipel S, Zach C, Rominger A, Cumming P, Fougere CL, Yakushev I, Haslbeck M, Hampel H, Bartenstein P, Burger K (2010) FDG-PET mapping the brain substrates of visuo-constructive processing in Alzheimer s disease. J Psy-chiatr Res 44, 462-469.
29. Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, Kochunov PV, Nickerson D, Mikiten SA, Fox PT (2000) Automated Talairach atlas labels for functional brain mapping. Hum Brain Mapp 10, 120-131. (Pubitemid 30456920)
30. Ishii K, Willoch F, Minoshima S, Drzezga A, Ficaro EP, Cross DJ, Kuhl DE, Schwaiger M (2001) Statistical brain mapping of 18F-FDG PET in Alzheimer's disease: validation of anatomic standardization for atrophied brains. J Nucl Med 42, 548-557. (Pubitemid 32298272)
31. Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE (1997) Metabolic reductioninthe posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 42, 85-94. (Pubitemid 27304784)
32. Drzezga A, Riemenschneider M, Strassner B, Grimmer T, Peller M, Knoll A, Wagenpfeil S, Minoshima S, Schwaiger M, Kurz A (2005) Cerebral glucose metabolism in patients with AD and different APOE genotypes. Neurology 64, 102-107. (Pubitemid 40082944)
33. Minoshima S, Frey KA, Koeppe RA, Foster NL, Kuhl DE (1995) A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J Nucl Med 36, 1238-1248.
34. Drzezga A, Lautenschlager N, Siebner H, Riemenschneider M, Willoch F, Minoshima S, Schwaiger M, Kurz A (2003) Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study. Eur J Nucl Med Mol Imaging 30, 1104-1113. (Pubitemid 36988222)
35. Borghammer P, Jonsdottir KY, Cumming P, Ostergaard K, Vang K, Ashkanian M, Vafaee M, Iversen P, Gjedde A (2008) Normalization in PET group comparison studies-the importance of a valid reference region. Neuroimage 40, 529-540.
36. Wagner G, Koch K, Schachtzabel C, Schultz CC, Sauer H, Schlosser RG (2011) Structural brain alterations in patients with major depressive disorder and high risk for suicide: Evidence for a distinct neurobiological entity? Neuroimage 54, 1607-1614.
37. Haupt S, Axmacher N, Cohen MX, Elger CE, Fell J (2009) Activation of the caudal anterior cingulate cortex due to task-related interference in an auditory Stroop paradigm. Hum Brain Mapp 30, 3043-3056.
38. Crottaz-Herbette S, Menon V (2006) Where and when the anterior cingulate cortex modulates attentional response: combined fMRI and ERP evidence. J Cogn Neurosci 18, 766-780.
39. Margulies DS, Kelly AM, Uddin LQ, Biswal BB, Castellanos FX, Milham MP (2007) Mapping the functional connectivity of anterior cingulate cortex. Neuroimage 37, 579-588. (Pubitemid 47444255)