High prevalence of nonconvulsive and subtle status epilepticus in an ICU of a tertiary care center: A three-year observational cohort study

Epilepsy Research

Volumn 96, Issue 1-2, 2011, Pages 140-150

  Rudin, Diana ^a   Grize, Leticia ^b,c   Schindler, Christian ^b,c   Marsch, Stephan ^a   Rüegg, Stephan ^a   Sutter, Raoul ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Cohort study; Intensive care unit; Nonconvulsive status epilepticus; Outcome; Refractory status epilepticus; Subtle status epilepticus

Indexed keywords

CLONAZEPAM; DIAZEPAM; ETIRACETAM; LORAZEPAM; MIDAZOLAM; PHENYTOIN; PROPOFOL; VALPROIC ACID;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DEMOGRAPHY; DISEASE COURSE; DISEASE DURATION; EPILEPTIC STATE; FATALITY; FEMALE; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NONCONVULSIVE STATUS EPILEPTICUS; OBSERVATIONAL STUDY; PREVALENCE; PRIORITY JOURNAL; SUBTLE STATUS EPILEPTICUS; TERTIARY HEALTH CARE; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ALGORITHMS; ANTICONVULSANTS; COHORT STUDIES; ELECTROENCEPHALOGRAPHY; FEMALE; HOSPITALIZATION; HOSPITALS; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; MIDDLE AGED; OBSERVATION; OUTCOME ASSESSMENT (HEALTH CARE); PREVALENCE; RETROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; STATUS EPILEPTICUS; SWITZERLAND; YOUNG ADULT;

EID: 80052848748     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2011.05.018     Document Type: Article

References (48)

1. Agan K., Afsar N., Midi I., Us O., Balosso S., Aykut-Bingol C. Predictors of refractoriness in a Turkish status epilepticus data bank. Epilepsy Behav. 2009, 14(4):651-654.
2. Alroughani R., Javidan M., Qasem A., Alotaibi N. Non-convulsive status epilepticus; the rate of occurrence in a general hospital. Seizure 2009, 18(1):38-42.
3. Aminoff M.J., Simon R.P. Status epilepticus: causes, clinical features and consequences in 98 patients. Am. J. Med. 1980, 69(5):657-666.
4. Celesia G.G. Modern concepts of status epilepticus. JAMA 1976, 235(15):1571-1574.
5. Celesia G.G., Messert B., Murphy M.J. Status epilepticus of late adult onset. Neurology 1972, 22(10):1047-1055.
6. Chin R.F.M., Neville B.G.R., Scott R.C. A systematic review of the epidemiology of status epilepticus. Eur. J. Neurol. 2004, 11(12):800-810.
7. Claassen J., Lokin J.K., Fitzsimmons B.-F.M., Mendelsohn F.A., Mayer S.A. Predictors of functional disability and mortality after status epilepticus. Neurology 2002, 58(1):139-142.
8. Coeytaux A., Jallon P., Galobardes B., Morabia A. Incidence of status epilepticus in French-speaking Switzerland: (EPISTAR). Neurology 2000, 55(5):693-697.
9. DeLorenzo R.J., Hauser W.A., Towne A.R., Boggs J.G., Pellock J.M., Penberthy L., Garnett L., Fortner C.A., Ko D. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology 1996, 46(4):1029-1035.
10. DeLorenzo R.J., Kirmani R.J., Deshpande L.S., Jakkampudi V., Towne A.R., Waterhouse E., Garnett L., Ramakrishnan V. Comparisons of the mortality and clinical presentations of status epilepticus in private practice community and university hospital settings in Richmond, Virginia. Seizure 2009, 18(6):405-411.
11. DeLorenzo R.J., Towne A.R., Pellock J.M., Ko D. Status epilepticus in children, adults, and the elderly. Epilepsia 1992, 33(Suppl. 4):15-25.
12. DeLorenzo R.J., Garnett L.K., Towne A.R., Waterhouse Y.E.J., Boggs J.G., Morton L., Afzal Choudhry M., Barnes T., Ko D. Comparison of status epilepticus with prolonged seizure episodes lasting from 10 to 29min. Epilepsia 1999, 40(2):164-169.
13. DeLorenzo R.J., Waterhouse E.J., Towne A.R., Boggs J.G., Ko D., DeLorenzo G.A., Brown A., Garnett L. Persistent nonconvulsive status epilepticus after the control of convulsive status epilepticus. Epilepsia 1998, 39(8):833-840.
14. Dunne J.W., Summers Q.A., Stewart-Wynne E.G. Non-convulsive status epilepticus: a prospective study in an adult general hospital. QJM 1987, 62(2):117-126.
15. Garzon E., Fernandes R., Sakamoto A.C. Analysis of clinical characteristics and risk factors for mortality in human status epilepticus. Seizure 2003, 12(6):337-345.
16. Holtkamp M., Othman J., Buchheim K., Masuhr F., Schielke E., Meierkord H. A " malignant" variant of status epilepticus. Arch. Neurol. 2005, 62(9):1428-1431.
17. Jenssen S., Gracely E.J., Sperling M.R. How long do most seizures last? A systematic comparison of seizures recorded in the epilepsy monitoring unit. Epilepsia 2006, 47(9):1499-1503.
18. Khan R.B., Yerremesetty P.K., Lindstrom D., McGill L.J. Emergency EEG and factors associated with nonconvulsive status epilepticus. J. Natl. Med. Assoc. 2001, 93(10):359-362.
19. Knake S., Rosenow F., Vescovi M., Oertel W.H., Mueller H.-H., Wirbatz A., Katsarou N., Hamer H.M. Incidence of status epilepticus in adults in Germany: a prospective, population-based study. Epilepsia 2001, 42(6):714-718.
20. Koubeissi M., Alshekhlee A. In-hospital mortality of generalized convulsive status epilepticus: a large US sample. Neurology 2007, 69(9):886-893.
21. Legriel S., Mourvillier B., Bele N., Amaro J., Fouet P., Manet P., Hilpert F. Outcomes in 140 critically ill patients with status epilepticus. Intensive Care Med. 2007, 34(3):476-480.
22. Logroscino G., Castaneda D.C., Cascino G., Hauser W.A. Status epilepticus without an underlying cause and risk of death: a population-based study. Arch. Neurol. 2008, 65(2):221-224.
23. Logroscino G., Hesdorffer D.C., Cascino G., Annegers J.F., Hauser W.A. Short-term mortality after a first episode of status epilepticus. Epilepsia 1997, 38(12):1344-1349.
24. Lowenstein D.H., Alldredge B.K. Status epilepticus. N. Engl. J. Med. 1998, 338(14):970-976.
25. Lowenstein D.H., Alldredge B.K. Status epilepticus at an urban public hospital in the 1980s. Neurology 1993, 43(3):483-488.
26. Mayer S.A., Claassen J., Lokin J., Mendelsohn F., Dennis L.J., Fitzsimmons B.F. Refractory status epilepticus: frequency, risk factors, and impact on outcome. Arch. Neurol. 2002, 59(2):205-210.
27. Moshé S.L., Garant D.S., Sperber E.F., Velísková J., Kubová H., Brown L.L. Ontogeny and topography of seizure regulation by the substantia nigra. Brain Dev. 1995, 17(Suppl. 1):61-72.
28. Penberthy L.T., Towne A.R., Garnett L.K., Perlin J.B., DeLorenzo R.J. Estimating the economic burden of status epilepticus to the health care system. Seizure 2005, 14(1):46-51.
29. Privitera M., Hoffman M., Moore J.L., Jester D. EEG detection of nontonic-clonic status epilepticus in patients with altered consciousness. Epilepsy Res. 1994, 18(2):155-166.
30. Privitera M.D., Strawsburg R.H. Electroencephalographic monitoring in the emergency department. Emerg. Med. Clin. North. Am. 1994, 12(4):1089-1100.
31. Rossetti A.O., Hurwitz S., Logroscino G., Bromfield E.B. Prognosis of status epilepticus: role of aetiology, age, and consciousness impairment at presentation. J. Neurol. Neurosurg. Psychiatry 2006, 77(5):611-615.
32. Rossetti A.O., Logroscino G., Bromfield E.B. Refractory status epilepticus: effect of treatment aggressiveness on prognosis. Arch. Neurol. 2005, 62(11):1698-1703.
33. Rüegg S. Non-convulsive status epilepticus in adults - an overview. Schweiz. Arch. Neurol. Psychiatr. 2008, 159:53-83.
34. Rüegg S., Hunziker P., Marsch S., Schindler C. Association of environmental factors with the onset of status epilepticus. Epilepsy Behav. 2008, 12(1):66-73.
35. Sagduyu A., Tarlaci S., Sirin H. Generalized tonic-clonic status epilepticus: causes, treatment, complications and predictors of case fatality. J. Neurol. 1998, 245(10):640-646.
36. Shneker B.F., Fountain N.B. Assessment of acute morbidity and mortality in nonconvulsive status epilepticus. Neurology 2003, 61(8):1066-1073.
37. Shorvon S.D. Prognosis and outcome of status epilepticus. Status Epilepticus: Its Clinical Features and Treatment in Children and Adults 1994, Cambridge University Press, pp. 293-312.
38. Standley C.A., Mason B.A., Cotton D.B. Differential regulation of seizure activity in the hippocampus of male and female rats. Am. J. Obstet. Gynecol. 1995, 173(4):1160-1165.
39. Sung C.Y., Chu N.S. Status epilepticus in the elderly: etiology, seizure type and outcome. Acta Neurol. Scand. 1989, 80(1):51-56.
40. Theodore W.H., Porter R.J., Penry J.K. Complex partial seizures: clinical characteristics and differetial diagnosis. Neurology 1983, 33(9):1115-1121.
41. Towne A.R., Pellock J.M., Ko D., DeLorenzo R.J. Determinants of mortality in status epilepticus. Epilepsia 1994, 35(1):27-34.
42. Towne A.R., Waterhouse E.J., Boggs J.G., Garnett L.K., Brown A.J., Smith J.R., DeLorenzo R.J. Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology 2000, 54(2):340-345.
43. Towne A.R. Epidemiology and outcomes of status epilepticus in the elderly. Int. Rev. Neurobiol. 2007, 81:111-127.
44. Treiman D.M., Meyers P.D., Walton P.D., Collins J.F., Colling C., Rowan A.J., Handforth A., Faught E., Calabrese V.P., Uthman B.M., Ramsay R.E., Mamdani M.B. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N. Engl. J. Med. 1998, 339(12):792-798.
45. Treiman D.M., Walton N.Y., Kendrick C. A progressive sequence of electroencephalographic changes during generalized convulsive status epilepticus. Epilepsy Res. 1990, 5(1):49-60.
46. Waterhouse E.J., DeLorenzo R.J. Status epilepticus in older patients: epidemiology and treatment options. Drugs Aging 2001, 18(2):133-142.
47. Waterhouse E.J., Garnett L.K., Towne A.R., Morton L.D., Barnes T., Ko D., DeLorenzo R.J. Prospective population-based study of intermittent and continuous convulsive status epilepticus in Richmond, Virginia. Epilepsia 1999, 40(6):752-758.
48. Treatment of convulsive status epilepticus: recommendations of the Epilepsy Foundation of America's Working Group on Status Epilepticus. JAMA 1993, 270(7):854-859. Working Group on Status Epilepticus.