New product development with discrete event simulation: Application to portfolio management for the pharmaceutical industry

Industrial and Engineering Chemistry Research

Volumn 50, Issue 18, 2011, Pages 10615-10629

  Perez Escobedo J L ^a   Azzaro Pantel, C ^a   Pibouleau, L ^a  

^a UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CLASSICAL PROBABILITIES; DECISION MAKERS; DISCRETE-EVENT SIMULATORS; ECONOMIC PROFITABILITY; EFFICIENT STRATEGY; EVALUATION CRITERIA; EVALUATION METHOD; FAILURE PROBABILITY; INTEGRAL PART; MODELING APPROACH; NEW PRODUCT DEVELOPMENT; NUMERICAL EXAMPLE; OBJECT ORIENTED TECHNIQUE; PHARMACEUTICAL INDUSTRY; PORTFOLIO MANAGEMENTS; REPRESENTATIVE SAMPLING; TIME TO MARKET;

DISCRETE EVENT SIMULATION; FINANCIAL DATA PROCESSING; INVESTMENTS; LAKES; PROFITABILITY;

PRODUCT DEVELOPMENT;

EID: 80052845685     PISSN: 08885885     EISSN: 15205045     Source Type: Journal    
DOI: 10.1021/ie200406s     Document Type: Article

References (31)

1. Schmidt, C.; Grossmann, I. Optimization models for the scheduling of testing tasks in new product development Ind. Eng. Chem. Res. 1996, 35, 3498-3510 (Pubitemid 126474878)
2. Jain, V.; Grossmann, I. Resource constrained scheduling of test in new product development Ind. Eng. Chem. Res. 1999, 38, 3013-3036
3. Subramanian, D.; Pekny, J.; Reklaitis, G.; Blau, G. Simulation- optimization framework for stochastic optimization of R&D pipeline management AIChE J. 2003, 49, 96-112 (Pubitemid 36378215)
4. Shah, N. Pharmaceutical supply chains: Key issues and strategies for optimization Comput. Chem. Eng. 2004, 28, 929-941 (Pubitemid 38520950)
5. Blau, G. E.; Pekny, J. F.; Varma, V. A.; Bunch, P. R. Managing a Portfolio of Interdependent New Product Candidates in the Pharmaceutical Industry J. Prod. Innovat. Manage. 2004, 21, 227-245
6. Aguilar-Lasserre, A. A.; Azzaro-Pantel, C.; Pibouleau, L.; Domenech, S. Enhanced Genetic Algorithm-Based Fuzzy Multiobjective Strategy to Multiproduct Batch Plant Design Anal. Des. Intell. Syst. Using Soft Comput. Techn. 2007, 41, 590-599
7. Bérard, F.; Azzaro-Pantel, C.; Domenech, S.; Pibouleau, L.; Floquet, P. Combinatorial study of multipurpose batch plant planning. Computer Aided Chemical Engineering; Vol.15, 2003, pp 720-725; Process Systems Engineering 2003, 8th International Symposium on Process Systems Engineering.
8. Bérard, F.; Azzaro-Pantel, C.; Pibouleau, L.; Domenech, S. Computer Aided Chemical Engineering; Vol. 14, 2003, pp 35-40. European Symposium on Computer Aided Process Engineering-13, 36th European Symposium of the Working Party on Computer Aided Process Engineering.
9. Bérard, F.; Azzaro-Pantel, C.; Pibouleau, L.; Domenech, S.; Navarre, D.; Pantel, M. Towards and incremental development of discrete-event simulators for batch plants: Use of object-oriented concepts Comput. Chem. Eng. 1999, 23, 565-568
10. Rajapakse, A.; Titchener-Hooker, N. J.; Farid, S. S. Modelling of the biopharmaceutical drug development pathway and portfolio management Comput. Chem. Eng. 2005, 29, 1357-1368 (Pubitemid 40630981)
11. Rajapakse, A.; Titchener-Hooker, N. J.; Farid, S. S. Integrated approach to improving the value potential of biopharmaceutical R&D portfolios while mitigating risk J. Chem. Technol. Biotechnol. 2006, 81, 1705-1714 (Pubitemid 44489064)
12. Varma, V. A.; Pekny, J. F.; Blau, G. E.; Reklaitis, G. V. A framework for addressing stochastic and combinatorial aspects of scheduling and resource allocation in pharmaceutical R&D pipelines Comput. Chem. Eng. 2008, 32, 1000-1015 (Pubitemid 351199687)
13. Klir, G. J.; Wierman, M. J. Uncertainty-Based Information: Elements of Generalized Information Theory; Physica-Verlag: Heidelberg, Germany, 1999.
14. Buckley, J.; Hayashi, Y. Applications of fuzzy chaos to fuzzy simulation Fuzzy Sets Syst. 1998, 99, 151-157 (Pubitemid 128654960)
15. Yang, Y.; Xu, X.; Zhang, W. Design neural networks based fuzzy logic Fuzzy Sets Syst. 2000, 114, 325-328
16. Kuroda, M.; Wang, Z. Fuzzy job shop scheduling Int. J. Prod. Econ. 1996, 44, 45-51 (Pubitemid 126393179)
17. Alefeld, G.; Herzberger, J. Introduction to Interval Computations; Academic Press: New York, 1983.
18. Moore, R. E. Interval Analysis; Prentice Hall: Upper Saddle River, NJ, 1966.
19. Moens, D.; Vandepitte, D. Interval sensitivity theory and its application to frequency response envelope analysis of uncertain structures Comput. Methods Appl. Mech. Eng. 2007, 196, 21-24
20. Muhanna, R.; Mullen, R.; Zhang, H. Interval finite element as a basis for generalized models of uncertainty in engineering mechanics Reliab. Comput. 2007, 13, 173-194 (Pubitemid 46122520)
21. Zadeh, L. Inform. Control 1965, 8, 338-353
22. Dubois, D.; Prade, H. Fuzzy Sets and Systems: Theory and Applications; Academic Press: New York, 1980.
23. Zimmermann, H. Fuzzy Set Theory and Its Applications; Kluwer Academic Publishers: Dordrecht, The Netherlands, 1992.
24. Bandemer, H.; Gottwald, S. Fuzzy Sets, Fuzzy Logic, Fuzzy Methods with Applications; Wiley: New York, 1995.
25. Dubois, D.; Prade, H. Possibility theory; Plenum Press: New York, 1986.
26. Grieco, A.; Nucci, F.; Anglani, A. Representation of fuzzy time variables in discrete event simulation Integr. Comput.-Aided Eng. 2003, 10, 305-318
27. Azzaro, C.; Floquet, P.; Pibouleau, L.; Domenech, S. A fuzzy discrete-event simulation model. Nguyen, Q.; Le, T., Eds.; Australia-Pacific Forum on Intelligent Processing and Manufacturing of Materials, Golds Coast, Queenland, Australia, July 14-17, 1997, pp 125-134.
28. Nguyen, Q.; Le, T. A fuzzy discrete-event simulation model. In Proceedings of the Australia-Pacific Forum on Intelligent Processing and Manufacturing of Materials; 1997.
29. Senties, O. B.; Azzaro-Pantel, C.; Pibouleau, L.; Domenech, S. Multiobjective scheduling for semiconductor manufacturing plants Comput. Chem. Eng. 2010, 34 (4) 555-566
30. Zhang, H.; Tam, C.; Li, H. Modeling uncertain activity duration by fuzzy number and discrete-event simulation Eur. J. Oper. Res. 2005, 164, 715-729 (Pubitemid 40114592)
31. Bojadziev, G.; Bojadziev, M. Fuzzy Logic for Business, Finance and Management; World Scientific Publishing Co.: Singapore, 1997.