Epidemic of Hepatitis B with high mortality in India: Association of fulminant disease with lack of CCL4 and natural killer T cells

Journal of Viral Hepatitis

Volumn 18, Issue 10, 2011, Pages

  Tripathy, A S ^a   Das, R ^a   Chadha, M S ^a   Arankalle, V A ^a  

^a NATIONAL INSTITUTE OF VIROLOGY   (India)

Author keywords

acute HBV patients; chemokine ligand 4; flow cytometry; fulminant HBV liver failure patients; hepatitis B outbreak; lymphocyte subsets; mutants

Indexed keywords

GAMMA INTERFERON; MACROPHAGE INFLAMMATORY PROTEIN 1BETA;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSPOT ASSAY; EPIDEMIC; FEMALE; FLOW CYTOMETRY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INDIA; LIVER FAILURE; MALE; MORTALITY; NATURAL KILLER CELL; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VIRUS HEPATITIS;

ADOLESCENT; ADULT; CHEMOKINE CCL4; CYTOKINES; DISEASE OUTBREAKS; FEMALE; HEPATITIS B; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HUMANS; INDIA; LIVER FAILURE; LYMPHOCYTE SUBSETS; MALE; MIDDLE AGED; MUTATION; NATURAL KILLER T-CELLS; PROMOTER REGIONS, GENETIC; YOUNG ADULT;

EID: 80052840343     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2011.01457.x     Document Type: Article

References (23)

1. Dunn C, Brunetto M, Reynolds G, et al. Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J Exp Med 2007; 204: 667-680. (Pubitemid 46457088)
2. Maini MK, Boni C, Lee CK, et al. The role of virus-specific CD8(+)cells in liver damage and viral control during persistent hepatitis B virus infection. J Exp Med 2000; 191: 1269-1280. (Pubitemid 30227116)
3. Webster GJM, Reignat S, Maini MK, et al. Incubation phase of acute hepatitis B in man: dynamic of cellular immune mechanisms. Hepatology 2000; 32: 1117-1124.
4. Xi-bing GU, Xiao-juan Y, Dong W, Zhong H, Yue-qin XU, Zhong-hua LU,. Relationship between serum HBV DNA level and HBV-specific, nonspecific cytotoxic T lymphocytes and natural killer cells in patients with chronic hepatitis B. Chin Med J 2009; 122: 2129-2132.
5. Baumert TF, Blum HE,. Hepatitis B virus mutations: molecular biology and clinical relevance. Vir Hep Rev 2000; 6: 177-192. (Pubitemid 32455019)
6. Lai ME, Solinas A, Mazzoleni AP, et al. The role of pre core hepatitis B virus mutants on the long-term outcome of chronic hepatitis B virus hepatitis: a longitudinal study. J Hepatol 1994; 20: 773-781. (Pubitemid 24216890)
7. Sato S, Suzuki K, Akahane Y, et al. Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis. Ann Intern Med 1995; 122: 241-248.
8. Thompson ND, Perz JF, Moorman AC, Holmberg SD,. Non hospital health care-Associated hepatitis B and C virus transmission: United States. Ann Intern Med 2009; 150: 33-39.
9. Arankalle VA, Gandhi S, Lole KS, Chadha MS, Gupte GM, Lokhande MU,. An outbreak of hepatitis B with high mortality in India: association with PreCore, Basal core promoter mutants and improperly sterilized syringes. J Viral Hepat 2011; 18: e20-e28.
10. Khuroo MS,. Viral hepatitis in international travellers: risks and prevention. Int J of Antimicrob Agents 2003; 21: 143-152. (Pubitemid 36298573)
11. Arankalle VA, Lole KS, Deshmukh TM, Chobe LP, Gandhe SS,. Evaluation of human (genotype 1) and swine (genotype 4)-ORF2-based ELISAs for anti-HEV IgM and IgG detection in an endemic country and search for type 4 human HEV infections. J Viral Hepat 2007; 14: 435-445. (Pubitemid 46744047)
12. Arankalle VA, Jha J, Favorov MO, Chaudhari A, Fields HA, Banerjee K,. Contribution of HEV and HCV in causing fulminant non-A, non-B hepatitis in Western India. J Viral Hepat 1995; 2: 189-193.
13. Lole KS, Arankalle VA,. Quantitation of hepatitis B virus DNA by real-time PCR using internal amplification control and dual TaqMan MGB probes. J Virol Methods 2006; 135: 83-90. Epub 2006 Mar 23. (Pubitemid 43728844)
14. Gandhe SS, Chadha MS, Arankalle VA,. Hepatitis B virus genotypes and serotypes in western India: lack of clinical significance. J Med Virol 2003; 69: 324-330. (Pubitemid 36158311)
15. Saravanabalaji S, Tripathy AS, Dhoot RR, Chadha MS, Kakrani AL, Arankalle VA,. Viral load, antibody titers and recombinant open reading frame 2 protein-induced TH1/TH2 cytokines and cellular immune responses in self-limiting and fulminant hepatitis e. Intervirology 2009; 52: 78-85. Epub 2009 Apr 28.
16. Boni C, Penna A, Ogg GS, et al. Lamivudine treatment can overcome cytotoxic T-cell hypo responsiveness in chronic hepatitis B: new prospective for immune therapy. Hepatology 2001; 33: 963-971. (Pubitemid 32246646)
17. Stoop JN, van der Molen RG, Baan CC, et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 2005; 41: 771-778. (Pubitemid 40462939)
18. Franzese O, Kennedy PT, Gehring AJ, et al. Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection. J Virol 2005; 79: 3322-3328. (Pubitemid 40327921)
19. Mark GS,. Hepatic NKT cells: friend or foe? Clin Sci 2008; 114: 457-466.
20. Wright H, Alex P, Nguyen T, et al. Multiplex cytokine profiling of initial therapeutic response in patients with chronic hepatitis C virus infection. Dig Dis Sci 2005; 50: 1793-1803. (Pubitemid 41417713)
21. Bigger CB, Guerra B, Brasky KM, et al. Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees. J Virol 2004; 78: 13779-13792. (Pubitemid 39612775)
22. Bozza FA, Cruz OG, Zagne SM, et al. Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity. BMC Infect Dis 2008; 8: 1-11.
23. Zimmermann HW, Seidler S, Nattermann J, et al. Functional contribution of elevated circulating and hepatic non-classical CD14+ CD16+ monocytes to inflammation and human liver fibrosis. PLoS ONE 2010; 5: 1-15.