Mitochondrial inhibitory factor 1 (IF1) is present in human serum and is positively correlated with HDL-cholesterol

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Genoux, Annelise ^a,b,c   Pons, Véronique ^a,b   Radojkovic, Claudia ^a,b   Roux Dalvai, Florence ^d   Combes, Guillaume ^a,b   Rolland, Corinne ^a,b   Malet, Nicole ^a,b   Monsarrat, Bernard ^d   Lopez, Frédéric ^a,b   Ruidavets, Jean Bernard ^b,e   Perret, Bertrand ^a,b,c   Martinez, Laurent O ^a,b  

^a University Hospital of Toulouse   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c TOULOUSE UNIVERSITY HOSPITAL   (France)

^d INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^e INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; MITOCHONDRIAL INHIBITORY FACTOR 1; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ATPASE INHIBITORY PROTEIN; PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; RECOMBINANT PROTEIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIPID BLOOD LEVEL; MALE; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN LOCALIZATION; SYSTEMIC CIRCULATION; BIOLOGICAL MODEL; BODY MASS; CELL MEMBRANE; ENDOCYTOSIS; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; HELA CELL; LIVER CELL; METABOLISM; MIDDLE AGED; MITOCHONDRION; PHYSIOLOGY;

RATTUS;

AGED; BLOOD GLUCOSE; BODY MASS INDEX; CELL MEMBRANE; CHOLESTEROL, HDL; ENDOCYTOSIS; FEMALE; GENE EXPRESSION REGULATION; HELA CELLS; HEPATOCYTES; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA; MODELS, BIOLOGICAL; PROTEINS; PROTON-TRANSLOCATING ATPASES; RECOMBINANT PROTEINS;

EID: 80052834062     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023949     Document Type: Article

References (28)

1. Rader DJ, (2006) Molecular regulation of HDL metabolism and function: implications for novel therapies. J Clin Invest 116: 3090-3100.
2. Rohrl C, Pagler TA, Strobl W, Ellinger A, Neumuller J, et al. (2010) Characterization of endocytic compartments after holo-high density lipoprotein particle uptake in HepG2 cells. Histochem Cell Biol 133: 261-272.
3. Graf GA, Connell PM, van der Westhuyzen DR, Smart EJ, (1999) The class B, type I scavenger receptor promotes the selective uptake of high density lipoprotein cholesterol ethers into caveolae. J Biol Chem 274: 12043-12048.
4. Harder CJ, Vassiliou G, McBride HM, McPherson R, (2006) Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy. J Lipid Res 47: 492-503.
5. Vantourout P, Radojkovic C, Lichtenstein L, Pons V, Champagne E, et al. (2010) Ecto-F(1)-ATPase: A moonlighting protein complex and an unexpected apoA-I receptor. World J Gastroenterol 16: 5925-5935.
6. Martinez LO, Jacquet S, Esteve JP, Rolland C, Cabezon E, et al. (2003) Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis. Nature 421: 75-79.
7. Jacquet S, Malaval C, Martinez LO, Sak K, Rolland C, et al. (2005) The nucleotide receptor P2Y13 is a key regulator of hepatic high-density lipoprotein (HDL) endocytosis. Cell Mol Life Sci 62: 2508-2515.
8. Fabre AC, Malaval C, Ben Addi A, Verdier C, Pons V, et al. (2010) P2Y13 receptor is critical for reverse cholesterol transport. Hepatology 52: 1477-1483.
9. Blom D, Yamin TT, Champy MF, Selloum M, Bedu E, et al. (2010) Altered lipoprotein metabolism in P2Y(13) knockout mice. Biochim Biophys Acta 1801: 1349-1360.
10. Pullman ME, Monroy GC, (1963) A Naturally Occurring Inhibitor of Mitochondrial Adenosine Triphosphatase. J Biol Chem 238: 3762-3769.
11. Green DW, Grover GJ, (2000) The IF(1) inhibitor protein of the mitochondrial F(1)F(0)-ATPase. Biochim Biophys Acta 1458: 343-355.
12. Cabezon E, Montgomery MG, Leslie AG, Walker JE, (2003) The structure of bovine F1-ATPase in complex with its regulatory protein IF1. Nat Struct Biol 10: 744-750.
13. Contessi S, Metelli G, Mavelli I, Lippe G, (2004) Diazoxide affects the IF1 inhibitor protein binding to F1 sector of beef heart F0F1ATPsynthase. Biochem Pharmacol 67: 1843-1851.
14. Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, et al. (2008) Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1. Cell Metab 8: 13-25.
15. Mangiullo R, Gnoni A, Leone A, Gnoni GV, Papa S, et al. (2008) Structural and functional characterization of F(o)F(1)-ATP synthase on the extracellular surface of rat hepatocytes. Biochim Biophys Acta 1777: 1326-1335.
16. Burwick NR, Wahl ML, Fang J, Zhong Z, Moser TL, et al. (2005) An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface. J Biol Chem 280: 1740-1745.
17. Cortes-Hernandez P, Dominguez-Ramirez L, Estrada-Bernal A, Montes-Sanchez DG, Zentella-Dehesa A, et al. (2005) The inhibitor protein of the F1F0-ATP synthase is associated to the external surface of endothelial cells. Biochem Biophys Res Commun 330: 844-849.
18. Contessi S, Comelli M, Cmet S, Lippe G, Mavelli I, (2007) IF(1) distribution in HepG2 cells in relation to ecto-F(0)F (1)ATPsynthase and calmodulin. J Bioenerg Biomembr 39: 291-300.
19. Giorgio V, Bisetto E, Franca R, Harris DA, Passamonti S, et al. (2010) The ectopic F(O)F(1) ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1. J Bioenerg Biomembr 42: 117-123.
20. Grau M, Bongard V, Fito M, Ruidavets JB, Sala J, et al. (2010) Prevalence of cardiovascular risk factors in men with stable coronary heart disease in France and Spain. Arch Cardiovasc Dis 103: 80-89.
21. Myszka DG, Morton TA, (1998) CLAMP: a biosensor kinetic data analysis program. Trends Biochem Sci 23: 149-150.
22. Friedewald WT, Levy RI, Fredrickson DS, (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.
23. Lange V, Picotti P, Domon B, Aebersold R, (2008) Selected reaction monitoring for quantitative proteomics: a tutorial. Mol Syst Biol 4: 222.
24. Cabezon E, Arechaga I, Jonathan P, Butler G, Walker JE, (2000) Dimerization of bovine F1-ATPase by binding the inhibitor protein, IF1. J Biol Chem 275: 28353-28355.
25. Cabezon E, Butler PJ, Runswick MJ, Walker JE, (2000) Modulation of the oligomerization state of the bovine F1-ATPase inhibitor protein, IF1, by pH. J Biol Chem 275: 25460-25464.
26. Collet X, Tall AR, Serajuddin H, Guendouzi K, Royer L, et al. (1999) Remodeling of HDL by CETP in vivo and by CETP and hepatic lipase in vitro results in enhanced uptake of HDL CE by cells expressing scavenger receptor B-I. J Lipid Res 40: 1185-1193.
27. Isaacs A, Sayed-Tabatabaei FA, Njajou OT, Witteman JC, van Duijn CM, (2004) The -514 C→T hepatic lipase promoter region polymorphism and plasma lipids: a meta-analysis. J Clin Endocrinol Metab 89: 3858-3863.
28. Arakaki N, Kita T, Shibata H, Higuti T, (2007) Cell-surface H+-ATP synthase as a potential molecular target for anti-obesity drugs. FEBS Lett 581: 3405-3409.