Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells

Drug Design, Development and Therapy

Volumn 5, Issue , 2011, Pages 299-309

  Tahanian, Elizabeth ^a   Sanchez, Luis Arguello ^a   Shiao, Tze Chieh ^a   Roy, René ^a   Annabi, Borhane ^a  

^a UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

Author keywords

Blood brain barrier; Flavonoids; Neuroinflammation; Nf b signal transduction inhibitors

Indexed keywords

APIGENIN; CYCLOOXYGENASE 2; FISETIN; FLAVONOID; GELATINASE B; I KAPPA B; LUTEOLIN; PHORBOL 13 ACETATE 12 MYRISTATE; CARCINOGEN; DRUG DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHORBOLOL MYRISTATE ACETATE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYCLOOXYGENASE 2 GENE; DRUG MECHANISM; DRUG STRUCTURE; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; MATRIX METALLOPROTEINASE 9 GENE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR GENE; ZYMOGRAPHY; BRAIN; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MICROVASCULATURE; PHOSPHORYLATION;

BLOOD-BRAIN BARRIER; BRAIN; CARCINOGENS; CELLS, CULTURED; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; ENDOTHELIAL CELLS; FLAVONOIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; I-KAPPA B PROTEINS; MATRIX METALLOPROTEINASE 9; MICROVESSELS; NF-KAPPA B; PHOSPHORYLATION; TETRADECANOYLPHORBOL ACETATE;

EID: 80052808981     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S19931     Document Type: Article

References (46)

1. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 1996;86:353-364.
2. Rojas A, Figueroa H, Morales E. Fueling inflammation at tumor microenvironment: the role of multiligand/RAGE axis. Carcinogenesis. 2010; 31:334-341.
3. Hayes A. Cancer, cyclo-oxygenase and nonsteroidal anti-inflammatory drugs - can we combine all three? Vet Comp Oncol. 2007;5:1-13.
4. Costa C, Soares R, Reis-Filho JS, et al. Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer. J Clin Pathol. 2002;55:429-434.
5. Fournier LS, Novikov V, Lucidi V, et al. MR monitoring of cyclooxygenase-2 inhibition of angiogenesis in a human breast cancer model in rats. Radiology. 2007;243:105-111.
6. Müller-Decker K, Fürstenberger G. The cyclooxygenase-2-mediated prostaglandin signaling is causally related to epithelial carcinogenesis. Mol Carcinog. 2007;46:705-710.
7. Breder CD, Saper CB. Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide. Brain Res. 1996;713:64-69.
8. Yamagata K, Andreasson KI, Kaufmann WE, et al. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron. 1993;11:371-386.
9. Cascante M, Boros LG, Comin-Anduix B, et al. Metabolic control analysis in drug discovery and disease. Nat Biotechnol. 2002;20:243-249.
10. Boros LG, Cascante M, Lee WN. Metabolic profiling of cell growth and death in cancer: applications in drug discovery. Drug Discov Today. 2002;7:364-372.
11. Lakka SS, Gondi CS, Rao JS. Proteases and glioma angiogenesis. Brain Pathol. 2005;15:327-341.
12. Bonoiu A, Mahajan SD, Ye L, et al. MMP-9 gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier. Brain Res. 2009;1282:142-155.
13. Annabi B, Rojas-Sutterlin S, Laroche M, et al. The diet-derived sulforaphane inhibits matrix metalloproteinase-9-activated human brain microvascular endothelial cell migration and tubulogenesis. Mol Nutr Food Res. 2008;52:692-700.
14. Roomi MW, Monterrey JC, Kalinovsky T, et al. Distinct patterns of matrix metalloproteinase-2 and -9 expression in normal human cell lines. Oncol Rep. 2009;21:821-826.
15. Jadhav U, Chigurupati S, Lakka SS, et al. Inhibition of matrix metalloproteinase- 9 reduces in vitro invasion and angiogenesis in human microvascular endothelial cells. Int J Oncol. 2004;25:1407-1414.
16. Craggs L, Kalaria RN. Revisiting dietary antioxidants, neurodegeneration and dementia. Neuroreport. 2001;22:1-3.
17. Rice-Evans C, Packer L, editors. Occurrence and Analysis. In: Flavonoids in Health and Disease. 2nd ed. New York: Marcel Dekker Inc; 2003:1-63.
18. Rusak G, Gutzeit HO, Ludwig-Muller J. Structurally related flavonoids with antioxidative properties differentially affect cell cycle progression and apoptosis of human acute leukemia cells. Nutr Res. 2005; 25:143-155.
19. Ruela-de-Sousa RR, Fuhler GM, Blom N, Ferreira CV, Aoyama H, Peppelenbosch MP. Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy. Cell Death Dis. 2010;1:e19.
20. Luqman S, Pezzuto JM. NFkappaB: a promising target for natural products in cancer chemoprevention. Phytother Res. 2010;24:949-963.
21. Tergaonkar V. NFkappaB pathway: a good signaling paradigm and therapeutic target. Int J Biochem Cell Biol. 2006;38:1647-1653.
22. Greiffenberg L, Goebel W, Kim KS, et al. Interaction of Listeria monocytogenes with human brain microvascular endothelial cells: InlBdependent invasion, long-term intracellular growth, and spread from macrophages to endothelial cells. Infect Immun. 1998;66:5260-5267.
23. Sina A, Lord-Dufour S, Annabi B. Cell-based evidence for aminopeptidase N/CD13 inhibitor actinonin targeting of MT1-MMP-mediated proMMP-2 activation. Cancer Lett. 2009;279:171-176.
24. McLaughlin N, Annabi B, Sik Kim K, et al. The response to brain tumor-derived growth factors is altered in radioresistant human brain endothelial cells. Cancer Biol Ther. 2006;5:1539-1545.
25. Lamy S, Gingras D, Béliveau R. Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. Cancer Res. 2002; 62:381-385.
26. Abécassis I, Olofsson B, Schmid M, et al. RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion. Exp Cell Res. 2003;291:363-376.
27. Annabi B, Currie JC, Moghrabi A, Béliveau R. Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg. Leuk Res. 2007;31: 1277-1284.
28. Tahanian E, Lord-Dufour S, Das A, Khosla C, Roy R, Annabi B. Inhibition of tubulogenesis and of carcinogen-mediated signaling in brain endothelial cells highlight the antiangiogenic properties of a mumbaistatin analog. Chem Biol Drug Des. 2010;75:481-488.
29. Annabi B, Vaillancourt-Jean E, Weil AG, Béliveau R. Pharmacological targeting of β-adrenergic receptor functions abrogates NF-κB signaling and MMP-9 secretion in medulloblastoma cells. Onco Targets Ther. 2010;3:219-226.
30. Neergheen VS, Bahorun T, Taylor EW, Jen LS, Aruoma OI. Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention. Toxicology. 2010;278: 229-241.
31. Dong J, Jimi E, Zeiss C, Hayden MS, Ghosh S. Constitutively active NF-kappaB triggers systemic TNFalpha-dependent inflammation and localized TNFalpha-independent inflammatory disease. Genes Dev. 2010;24:1709-1717.
32. Solt LA, May MJ. The IkappaB kinase complex: master regulator of NF-kappaB signalling. Immunol Res. 2008;42:3-18.
33. Mertens S, Noll T, Spahr R, et al. Energetic response of coronary endothelial cells to hypoxia. Am J Physiol. 1990;258:H689-H694.
34. Shryock JC, Rubio R, Berne RM. Release of adenosine from pig aortic endothelial cells during hypoxia and metabolic inhibition. Am J Physiol. 1988;254:H223-H229.
35. Liu SH, Lin CH, Hung SK, et al. Fisetin inhibits lipopolysaccharideinduced macrophage activation and dendritic cell maturation. J Agric Food Chem. 2010;58:10831-10839.
36. Sung B, Pandey MK, Aggarwal BB. Fisetin, an inhibitor of cyclindependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation. Mol Pharmacol. 2007;71:1703-1714.
37. Noh HJ, Sung EG, Kim JY, et al. Suppression of phorbol-12-myristate- 13-acetate-induced tumor cell invasion by apigenin via the inhibition of p38 mitogen-activated protein kinase-dependent matrix metalloproteinase- 9 expression. Oncol Rep. 2010;24:277-283.
38. Yi Lau GT, Leung LK. The dietary flavonoid apigenin blocks phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in breast cell lines. Food Chem Toxicol. 2010;48:3022-3027.
39. Kang OH, Lee JH, Kwon DY. Apigenin inhibits release of inflammatory mediators by blocking the NF-κB activation pathways in the HMC-1 cells. Immunopharmacol Immunotoxicol. In press.
40. Lin CW, Shen SC, Chien CC, Yang LY, Shia LT, Chen YC. 12-Otetradecanoylphorbol- 13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaBdependent MMP-9 expression. J Cell Physiol. 2010;225:472-481.
41. Cho HY, Thomas S, Golden EB, et al. Enhanced killing of chemoresistant breast cancer cells via controlled aggravation of ER stress. Cancer Lett. 2009;282:87-97.
42. Tahanian E, Peiro S, Annabi B. Low intracellular ATP levels exacerbate carcinogen-induced inflammatory stress response and inhibit in vitro tubulogenesis in human brain endothelial cells. J Inflamm Res. 2011; 4:1-10.
43. Lee HZ, Yang WH, Bao BY, Lo PL. Proteomic analysis reveals ATPdependent steps and chaperones involvement in luteolin-induced lung cancer CH27 cell apoptosis. Eur J Pharmacol. 2010;642:19-27.
44. Van Acker SA, Tromp MN, Haenen GR, van der Vijgh WJ, Bast A. Flavonoids as scavengers of nitric oxide radical. Biochem Biophys Res Commun. 1995;214:755-759.
45. Laughton MJ, Evans PJ, Moroney MA, Hoult JR, Halliwell B. Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability. Biochem Pharmacol. 1991;42:1673-1681.
46. Damas J, Bourdon V, Remacle-Volon G, Lecomte J. Pro-inflammatory flavonoids which are inhibitors of prostaglandin biosynthesis. Prostaglandins Leukot Med. 1985;19:11-24.