9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors

Journal of Medicinal Chemistry

Volumn 54, Issue 18, 2011, Pages 6286-6294

  Kinoshita, Kazutomo ^a   Kobayashi, Takamitsu ^a   Asoh, Kohsuke ^a   Furuichi, Noriyuki ^a   Ito, Toshiya ^a   Kawada, Hatsuo ^a   Hara, Sousuke ^a   Ohwada, Jun ^a   Hattori, Kazuo ^a   Miyagi, Takuho ^a   Hong, Woo Sang ^b   Park, Min Jeong ^b   Takanashi, Kenji ^a   Tsukaguchi, Toshiyuki ^a   Sakamoto, Hiroshi ^a   Tsukuda, Takuo ^a   Oikawa, Nobuhiro ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b C and C Research Laboratories   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

9 ETHYL 6,6 DIMETHYL 8 (4 OXETAN 3 YL PIPERAZIN 1 YL) 11 OXO 6,11 DIHYDRO 5H BENZO[B]CARBAZOLE 3 CARBONITRILE; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; FEMALE; HAPLORHINI; IC 50; LARGE CELL LYMPHOMA; MALE; MOUSE; NONHUMAN; TUMOR XENOGRAFT; WEIGHT REDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBAZOLES; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MACACA FASCICULARIS; MALE; MICE; MICE, SCID; MICROSOMES, LIVER; MODELS, MOLECULAR; NEOPLASM TRANSPLANTATION; PIPERAZINES; RECEPTOR PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 80052791063     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200652u     Document Type: Article

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