Pitx2 regulates myosin heavy chain isoform expression and multi-innervation in extraocular muscle

Journal of Physiology

Volumn 589, Issue 18, 2011, Pages 4601-4614

  Zhou, Yuefang ^a   Liu, Dan ^a   Kaminski, Henry J ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYOSIN HEAVY CHAIN; TRANSCRIPTION FACTOR PITX2; TROPONIN I; TROPONIN T;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; EXTRAOCULAR MUSCLE; EYE MOVEMENT; MOUSE; MUSCLE CONTRACTILITY; MUSCLE DEVELOPMENT; MUSCLE INNERVATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

ANIMALS; HOMEODOMAIN PROTEINS; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; MUSCLE CONTRACTION; MYOFIBRILS; MYOSIN HEAVY CHAINS; OCULOMOTOR MUSCLES; PROTEIN ISOFORMS; TRANSCRIPTION FACTORS; TROPONIN I; TROPONIN T;

EID: 80052784843     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.207076     Document Type: Article

References (40)

1. Allen DL, Harrison BC & Leinwand LA (2000). Inactivation of myosin heavy chain genes in the mouse: diverse and unexpected phenotypes. Microsc Res Tech 50, 492-499.
2. Bicer S & Reiser PJ (2009). Myosin isoform expression in dog rectus muscles: patterns in global and orbital layers and among single fibers. Invest Ophthalmol Vis Sci 50, 157-167.
3. Bormioli SP, Sartore S, Vitadello M & Schiaffino S (1980). "Slow" myosins in vertebrae skeletal muscle. An immunofluorescence study. J Cell Biol 85, 672-681.
4. Bormioli SP, Torresan P, Sartore S, Moschini GB & Schiaffino S (1979). Immunohistochemical identification of slow-tonic fibers in human extrinsic eye muscles. Invest Ophthalmol Vis Sci 18, 303-306.
5. Bottinelli R, Betto R, Schiaffino S & Reggiani C (1994). Unloaded shortening velocity and myosin heavy chain and alkali light chain isoform composition in rat skeletal muscle fibres. J Physiol 478, 341-349.
6. Bottinelli R, Schiaffino S & Reggiani C (1991). Force-velocity relations and myosin heavy chain isoform compositions of skinned fibres from rat skeletal muscle. J Physiol 437, 655-672.
7. Briggs MM & Schachat F (2002). The superfast extraocular myosin (MYH13) is localized to the innervation zone in both the global and orbital layers of rabbit extraocular muscle. J Exp Biol 205, 3133-3142.
8. Brueckner JK, Itkis O & Porter JD (1996). Spatial and temporal patterns of myosin heavy chain expression in developing rat extraocular muscle. J Muscle Res Cell Motil 17, 297-312.
9. Crew JR, Falzari K & DiMario JX (2010). Muscle fiber type specific induction of slow myosin heavy chain 2 gene expression by electrical stimulation. Exp Cell Res 316, 1039-1049.
10. Diehl AG, Zareparsi S, Qian M, Khanna R, Angeles R & Gage PJ (2006). Extraocular muscle morphogenesis and gene expression are regulated by Pitx2 gene dose. Invest Ophthalmol Vis Sci 47, 1785-1793.
11. DiMario JX & Stockdale FE (1997). Both myoblast lineage and innervation determine fiber type and are required for expression of the slow myosin heavy chain 2 gene. Dev Biol 188, 167-180.
12. Fraterman S, Khurana TS & Rubinstein NA (2006). Identification of acetylcholine receptor subunits differentially expressed in singly and multiply innervated fibers of extraocular muscles. Invest Ophthalmol Vis Sci 47, 3828-3834.
13. Gage PJ, Suh H & Camper SA (1999). Dosage requirement of Pitx2 for development of multiple organs. Development 126, 4643-4651.
14. Gomes AV, Potter JD & Szczesna-Cordary D (2002). The role of troponins in muscle contraction. IUBMB Life 54, 323-333.
15. Hjalt TA & Semina EV (2005). Current molecular understanding of Axenfeld-Rieger syndrome. Expert Rev Mol Med 7, 1-17.
16. Jacoby J, Ko K, Weiss C & Rushbrook JI (1990). Systematic variation in myosin expression along extraocular muscle fibres of the adult rat. J Muscle Res Cell Motil 11, 25-40.
17. Jung HH, Lieber RL & Ryan AF (1998). Quantification of myosin heavy chain mRNA in somatic and branchial arch muscles using competitive PCR. Am J Physiol Cell Physiol 275, C68-74.
18. Khanna S, Richmonds CR, Kaminski HJ & Porter JD (2003). Molecular organization of the extraocular muscle neuromuscular junction: partial conservation of and divergence from the skeletal muscle prototype. Invest Ophthalmol Vis Sci 44, 1918-1926.
19. Kjellgren D, Thornell LE, Andersen J & Pedrosa-Domellof F (2003). Myosin heavy chain isoforms in human extraocular muscles. Invest Ophthalmol Vis Sci 44, 1419-1425.
20. Kranjc BS, Sketelj J, Albis AD, Ambroz M & Erzen I (2000). Fibre types and myosin heavy chain expression in the ocular medial rectus muscle of the adult rat. J Muscle Res Cell Motil 21, 753-761.
21. Lim SJ, Jung HH & Cho YA (2006). Postnatal development of myosin heavy chain isoforms in rat extraocular muscles. Mol Vis 12, 243-250.
22. Lin CR, Kioussi C, O'Connell S, Briata P, Szeto D, Liu F, Izpisua-Belmonte JC & Rosenfeld MG (1999). Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature 401, 279-282.
23. Martin DM, Skidmore JM, Fox SE, Gage PJ & Camper SA (2002). Pitx2 distinguishes subtypes of terminally differentiated neurons in the developing mouse neuroepithelium. Dev Biol 252, 84-99.
24. Martin DM, Skidmore JM, Philips ST, Vieira C, Gage PJ, Condie BG, Raphael Y, Martinez S & Camper SA (2004). PITX2 is required for normal development of neurons in the mouse subthalamic nucleus and midbrain. Dev Biol 267, 93-108.
25. McLoon LK, Rios L & Wirtschafter JD (1999). Complex three-dimensional patterns of myosin isoform expression: differences between and within specific extraocular muscles. J Muscle Res Cell Motil 20, 771-783.
26. Pette D (2002). The adaptive potential of skeletal muscle fibers. Can J Appl Physiol 27, 423-448.
27. Pette D & Staron RS (1997). Mammalian skeletal muscle fiber type transitions. Int Rev Cytol 170, 143-223.
28. Piedra ME, Icardo JM, Albajar M, Rodriguez-Rey JC & Ros MA (1998). Pitx2 participates in the late phase of the pathway controlling left-right asymmetry. Cell 94, 319-324.
29. Resnicow DI, Deacon JC, Warrick HM, Spudich JA & Leinwand LA (2010). Functional diversity among a family of human skeletal muscle myosin motors. Proc Natl Acad Sci U S A 107, 1053-1058.
30. Rossi AC, Mammucari C, Argentini C, Reggiani C & Schiaffino S (2010). Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles. J Physiol 588, 353-364.
31. Rubinstein NA & Hoh JF (2000). The distribution of myosin heavy chain isoforms among rat extraocular muscle fiber types. Invest Ophthalmol Vis Sci 41, 3391-3398.
32. Rubinstein NA, Porter JD & Hoh JF (2004). The development of longitudinal variation of myosin isoforms in the orbital fibers of extraocular muscles of rats. Invest Ophthalmol Vis Sci 45, 3067-3072.
33. Ruff R, Kaminski H, Maas E & Spiegel P (1989). Ocular muscles: physiology and structure-function correlations. Bull Soc Belge Ophtalmol 237, 321-352.
34. Ryan AK, Blumberg B, Rodriguez-Esteban C, Yonei-Tamura S, Tamura K, Tsukui T, de la Pena J, Sabbagh W, Greenwald J, Choe S, Norris DP, Robertson EJ, Evans RM, Rosenfeld MG & Izpisua Belmonte JC (1998). Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature 394, 545-551.
35. Sartore S, Mascarello F, Rowlerson A, Gorza L, Ausoni S, Vianello M & Schiaffino S (1987). Fibre types in extraocular muscles: a new myosin isoform in the fast fibres. J Muscle Res Cell Motil 8, 161-172.
36. Schachat F & Briggs MM (2002). Phylogenetic implications of the superfast myosin in extraocular muscles. J Exp Biol 205, 2189-2201.
37. Spencer RF & Porter JD (2006). Biological organization of the extraocular muscles. Prog Brain Res 151, 43-80.
38. Wieczorek DF, Periasamy M, Butler-Browne GS, Whalen RG & Nadal-Ginard B (1985). Co-expression of multiple myosin heavy chain genes, in addition to a tissue-specific one, in extraocular musculature. J Cell Biol 101, 618-629.
39. Zhou Y, Cheng G, Dieter L, Hjalt TA, Andrade FH, Stahl JS & Kaminski HJ (2009). An altered phenotype in a conditional knockout of Pitx2 in extraocular muscle. Invest Ophthalmol Vis Sci 50, 4531-4541.
40. Zhou Y, Liu D & Kaminski HJ (2010). Myosin heavy chain expression in mouse extraocular muscle: more complex than expected. Invest Ophthalmol Vis Sci 51, 6355-6363.