Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: A prospective randomised clinical trial

European Journal of Anaesthesiology

Volumn 28, Issue 9, 2011, Pages 640-645

  Köner, Özge ^a   Türe, Hatice ^a   Mercan, Arzu ^a   Menda, Ferdi ^a   Sözübir, Selami ^a  

^a YEDITEPE UNIVERSITY   (Turkey)

Author keywords

Children; Emergence agitation; Hydroxyzine; Midazolam; Sevoflurane

Indexed keywords

HYDROXYZINE; MIDAZOLAM; SEVOFLURANE;

AGITATION; ANESTHESIA COMPLICATION; ANESTHESIA INDUCTION; CAUDAL ANESTHESIA; CHILD; CLINICAL EVALUATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG QUALITY; FEMALE; GENERAL ANESTHESIA; HUMAN; MAJOR CLINICAL STUDY; MALE; PAEDIATRIC ANESTHESIA EMERGENCE DELIRIUM; PAIN ASSESSMENT; PEDIATRICS; POSTOPERATIVE PAIN; PREMEDICATION; PRESCHOOL CHILD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REVIEW; SCHOOL CHILD; SEDATION;

AKATHISIA, DRUG-INDUCED; ANESTHESIA RECOVERY PERIOD; ANESTHESIA, CAUDAL; ANESTHETICS, INHALATION; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HISTAMINE H1 ANTAGONISTS; HUMANS; HYDROXYZINE; HYPNOTICS AND SEDATIVES; INFANT; MALE; METHYL ETHERS; MIDAZOLAM; PAIN, POSTOPERATIVE; PILOT PROJECTS; PROSPECTIVE STUDIES;

EID: 80052752668     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e328344db1a     Document Type: Review

References (27)

1. Galinkin JL, Fazi LM, Cuy RM, et al. Use of intranasal fentanyl in children undergoing myringotomy and tube placement during halothane and sevoflurane anesthesia. Anesthesiology 2000; 93:1378-1383.
2. Cravero J, Surgenor S, Whalen K. Emergence agitation in paediatric patients after sevoflurane anaesthesia and no surgery: a comparison with halothane. Paediatr Anaesth 2000; 10:419-424. (Pubitemid 30471363)
3. Sikich N, Lerman J. Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale. Anesthesiology 2004; 100:1138-1145. (Pubitemid 38541968)
4. Arai YC, Fukunaga K, Hirota S. Comparison of a combination of midazolam and diazepam alone as oral premedication on preanesthetic and emergence condition in children. Acta Anaesthesiol Scand 2005; 49:698-701. (Pubitemid 40593518)
5. Riva J, Lejbasiewicz G, Papa M, et al. Oral premedication with midazolam in paediatric anaesthesia: effects on sedation and gastric contents. Paediatr Anaesth 1997; 7:191-196. (Pubitemid 27244711)
6. Kagan A, Katz J, Efrat R, Eidelman LA. Premedication with midazolam in young children: a comparison of four routes of administration. Paediatr Anaesth 2002; 12:685-689. (Pubitemid 35478084)
7. Cohen IT, Drewsen S, Hannallah RS. Propofol or midazolam do not reduce the incidence of emergence agitation associated with desflurane anaesthesia in children undergoing adenotonsillectomy. Paediatr Anaesth 2002; 12:604-609. (Pubitemid 35266466)
8. Kubo N, Shirakawa T, Kuno T, Tanaka C. Antimuscarinic effects of antihistamines: quantitative evaluation by receptor-binding assay. Jpn J Pharmacol 1987; 43:277-282. (Pubitemid 17034958)
9. Snyder SH, Snowman AM. Receptor effects of cetirizine. Ann Allergy 1987; 59:4-8. (Pubitemid 18026397)
10. Lader M, Scotto JC. A multicentre double-blind comparison of hydroxyzine, buspirone and placebo in patients with generalized anxiety disorder. Psychopharmacology 1998; 139:402-406. (Pubitemid 28435037)
11. Llorca PM, Spadone C, Sol O, et al. Efficacy and safety of hydroxyzine in the treatment of generalized anxiety disorder: a 3-month double-blind study. J Clin Psychiatry 2002; 11:1020-1027. (Pubitemid 35388062)
12. Faytrouny M, Okte Z, Kucukyavuz Z. Comparison of two different dosages of hydroxyzine for sedation in the pediatric dental patient. IntlJ Pediatr Dent 2007; 17:378-382.
13. Baygin O, Bodur H, Isik B. Effectiveness of premedication agents administered prior to nitrous oxide/oxygen. Eur J Anaesthesiol 2010; 27:341-346.
14. Needleman HL, Joshi A, Griffith DG. Conscious sedation of pediatric dental patients using chloral hydrate, hydroxyzine, and nitrous oxide: a retrospective study of 382 sedations. Pediatr Dent 1995; 17:424-431.
15. Abu-Shahwan I, Chowdary K. Ketamine is effective in decreasing the incidence of emergence agitation in children undergoing dental repair under sevoflurane general anaesthesia. Paediatr Anaesth 2007; 17:846-850. (Pubitemid 47221161)
16. Buttner W, Finke W. Analysis of behavioral and physiological parameters for the assessment of postoperative analgesic demand in newborns, infants and young children: a comprehensive report on seven consecutive studies. Paediatr Anaesth 2000; 10:303-318. (Pubitemid 30331173)
17. Khalil S, Philbrook L, Rabb M, et al. Sublingual midazolam premedication in children: a dose-response study. Paediatr Anaesth 1998; 8:461-465. (Pubitemid 28523405)
18. *Power 3: a flexible statistical power analysis program for the social behavioral and biomedical sciences. Behav Res Methods 2007; 39:175-191.
19. Yasui Y, Masaki E, Kato F. Sevoflurane directly excites locus coeruleus neurons of rats. Anesthesiology 2007; 107:992-1002. (Pubitemid 350175682)
20. Guler G, Akin A, Tosun Z, et al. Single dose dexmedetomidine reduces agitation and provides smooth extubation after paediatric adenotonsillectomy. Paediatr Anaesth 2005; 15:762-766. (Pubitemid 43960893)
21. Weldon BC, Bell M, Craddock T. The effects of caudal analgesia on emergence agitation in children after sevoflurane versus halothane anesthesia. Anesth Analg 2004; 98:321-326. (Pubitemid 38129372)
22. Finkel JC, Cohen IT, Hannallah RS, et al. The effects of intranasal fentanyl on the emergence characteristics after sevoflurane anesthesia in children undergoing surgery for bilateral myringotomy tube placement. Anesth Analg 2001; 92:1164-1168. (Pubitemid 32385936)
23. Simons FE, Simons KJ, Becker AB, Haydey RP. Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis. J Pediatr 1984; 104:123-127. (Pubitemid 14178475)
24. Shapira J, Holan G, Guelmann M, Cahan S. Evaluation of the effect of nitrous oxide and hydroxyzine in controlling the behavior of the paediatric dental patient. Pediatr Dent 1992; 14:167-170.
25. Viitanen H, Annila P, Viitanen M, Tarkkila P. Premedication with midazolam delays recovery after ambulatory sevoflurane anesthesia in children. Anesth Analg 1999; 89:75-79. (Pubitemid 29293312)
26. Kulka PJ, Bressem M, Wiebalck A, Tryba M. Prevention of 'postsevoflurane delirium' with midazolam. Anaesthesist 2001; 50:401-405.
27. Aouad MT, Kanazi GE, Siddik-Sayyid SM, et al. Preoperative caudal block prevents emergence agitation in children following sevoflurane anaesthesia. Acta Anaesthesiol Scand 2005; 49:300-304. (Pubitemid 40432520)