Synthesis of 3- and 21-monosulfates of [2,2,3β,4,4- 2H 5]-tetrahydrocorticosteroids in the 5β-series as internal standards for mass spectrometry

Steroids

Volumn 76, Issue 12, 2011, Pages 1232-1240

  Ikegawa, Shigeo ^a   Nagae, Kaori ^a   Mabuchi, Takayuki ^a   Okihara, Rika ^a,c   Hasegawa, Maki ^a,d   Minematsu, Toshie ^a   Iida, Takashi ^b   Mitamura, Kuniko ^a  

^a KINKI UNIVERSITY   (Japan)

^b NIHON UNIVERSITY   (Japan)

^c SETSUNAN UNIVERSITY   (Japan)

^d Sumika Chemicals Analysis Service Ltd   (Japan)

Author keywords

Electrospray ionization; Hydrogen deuterium exchange; Internal standard; Mass spectrometry; Multiple deuteration; Sodium borodeuteride

Indexed keywords

17,20:20,21 BISMETHYLENEDIOXY 11BETA HYDROXY 4 PREGNEN 3 ONE; 17,20:20,21 BISMETHYLENEDIOXY 11BETA HYDROXY 5BETA PREGNAN 3 ONE; 17,20:20,21 BISMETHYLENEDIOXY 3ALPHA HYDROXY 5BETA PREGNAN 11 ONE; 17,20:20,21 ISMETHYLENEDIOXY 5BETA PREGNAN 3 ONE; 3ALPHA ACETOXY 17,20:20,21 BISMETHYLENEDIOXY 11BETA HYDROXY 5BETA PREGNAN; 3ALPHA ACETOXY 17,20:20,21 BISMETHYLENEDIOXY 5BETA PREGNAN 11 ONE; [2,2,3BETA,4,4 D5] 17,20:20,21 BISMETHYLENDIOXY 3ALPHA HYDROXY 5BETA PREGNAN 11 ONE; [2,2,3BETA,4,4 D5] 17,20:20,21 BISMETHYLENEDIOXY 3ALPHA HYDROXY 5BETA PREGNANE; [2,2,3BETA,4,4 D5] 17,20:20,21 BISMETHYLENEDIOXY 3ALPHA,11BETA DIHYDROXY 5 BETA PREGNAN; [2,2,3BETA,4,4 D5] 3ALPHA ACETOXY 17,20:20,21 BISMETHYLENDIOXY 11BETA HYDROXY 5BETA PREGNAN; [2,2,3BETA,4,4 D5] 3ALPHA ACETOXY 17,20:20,21 TRIHYDROXY 5BETA PREGNAN 20 ONE; [2,2,3BETA,4,4 D5] 3ALPHA ACETOXY 17ALPHA,21 DIHYDROXY 5BETA PREGNAN 11,20 DIONE; [2,2,3BETA,4,4 D5] 3ALPHA ACETOXY 17ALPHA,21 DIHYDROXY 5BETA PREGNAN 20 ONE; CORTODOXONE; HYDROCORTISONE; HYDROFLUORIC ACID; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ISOTOPE DILUTION ASSAY; LIQUID CHROMATOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; STANDARD; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SULFATION;

ADRENAL CORTEX HORMONES; CHROMATOGRAPHY, LIQUID; KETOSTEROIDS; MASS SPECTROMETRY; REFERENCE STANDARDS;

EID: 80052740224     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2011.05.014     Document Type: Article

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