Relationship between plasma concentrations of valproic acid and hepatotoxicity in patients receiving high doses;Relation entre les concentrations plasmatiques d'acide valproïque et la survenue d'une hépatotoxicité

Revue Neurologique

Volumn 167, Issue 8-9, 2011, Pages 600-606

  Ghozzi, H ^a   Hakim, A ^a   Sahnoun, Z ^a   Ben Mahmoud, L ^a   Atheymen, R ^a   Hammami, S ^a   Zeghal, K ^a  

^a UNIVERSITY OF SFAX   (Tunisia)

Author keywords

Adverse effects; Anti epileptic drugs association; Drugs; Hepatotoxicity; High doses; Valpro c acid

Indexed keywords

CARBAMAZEPINE; PHENOBARBITAL; VALPROIC ACID;

ARTICLE; DRUG BLOOD LEVEL; DRUG MEGADOSE; DRUG MONITORING; EPILEPSY; HUMAN; LABORATORY; LIVER TOXICITY; MAJOR CLINICAL STUDY;

ADOLESCENT; ADULT; AGED; ANTICONVULSANTS; BILIRUBIN; CARBAMAZEPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG MONITORING; DRUG-INDUCED LIVER INJURY; EPILEPSY; FEMALE; HUMANS; INFANT; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; PHENOBARBITAL; RISK ASSESSMENT; VALPROIC ACID; YOUNG ADULT;

EID: 80052735739     PISSN: 00353787     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurol.2011.02.035     Document Type: Article

References (39)

1. S. Alqahtani, P. Federico, and R.P. Myers A case of valproate-induced hyperammonemic encephalopathy: look beyond the liver CMAJ 177 6 2007 568 569 (Pubitemid 47437052)
2. G.D. Anderson, A.A. Acheampong, A.J. Wilensky, and R.H. Levy Effect of valproate dose on formation of hepatotoxic metabolites Epilepsia 33 1992 736 742
3. R.J. Andrade, M.I. Lucena, J. Aguilar, M.D. Lazo, R. Camargo, and P. Moreno Chronic liver injury related to use of bentazepam: an unusual instance of benzodiazepine hepatotoxicity Dig Dis Sci 45 2000 1400 1404 (Pubitemid 30636517)
4. R. Bédry, and F. Parrot Intoxications graves par l'acide valproïque Reanimation 13 2004 324 333 (Pubitemid 38891431)
5. T.P. Bohan, E. Helton, I. McDonald, S. König, S. Gazitt, and T. Sugimoto Effect of L-carnitine treatment for valproate induced hepatotoxicity Neurology. 22 56 2001 1405 1409 (Pubitemid 32455310)
6. B. Cenraud, B. Pautrizel, O. Berets, and P. Loiseau Severe vigilance disturbances: a rare complication of sodium valproate treatment Rev Electroencephalogr Neurophysiol Clin 10 1980 376 380 (Pubitemid 11079090)
7. D.W. Chadwick, W.J. Cumming, I. Livingstone, and N.E. Cartlidge Acute intoxication with sodium valproate Ann Neurol 6 1979 552 553 (Pubitemid 10174417)
8. D.L. Coulter, and Carnitine Valproate, and toxicity J Child Neurol 6 1991 7 14
9. D.C. De Vivo, T.P. Bohan, D.L. Coulter, F.E. Dreifuss, R.S. Greenwood, and D.R. Nordli Jr. L-carnitine supplementation in childhood epilepsy: current perspectives Epilepsia 39 1998 1216 1225 (Pubitemid 28516036)
10. M. Dossing, and P.B. Andreasen Drug-induced liver disease in Denmark. An analysis of 572 cases of hepatotoxicity reported to the Danish Board of Adverse Reactions to Drugs Scand J Gastroenterol 17 1982 205 211 (Pubitemid 12185523)
11. F.E. Dreifuss, and D.H. Langer Hepatic considerations in the use of antiepileptic drugs Epilepsia 28Suppl2 1987 S23 29
12. S. Gopaul, K. Farrell, and F. Abbott Effects of age and polytherapy, risk factors of valproic acid (VPA) hepatotoxicity, on the excretion of thiol conjugates of (E)-2,4-diene VPA in people with epilepsy taking VPA Epilepsia 44 3 2003 322 328 (Pubitemid 36343762)
13. Granel B, Gavaret M, Le Baut X, Sautereau N, Rodriguez D, Rossi P, et al. Valproate-induced hyperammonemic encephalopathy. Rev Med Interne 2010 [Epub ahead of print].
14. K. Kasakun, and F. Abbott In vivo formation of the thiol conjugates of reactive metabolites of 4-ene VPA and its analogue 4-pentanoic acid Drug Metab dispo 21 1993 1098 1106 (Pubitemid 23348348)
15. J.W. Kesterson, G.R. Granneman, and J.M. Macchinist The hepatotoxicity of valproïc acid and its metabolites in rats. I. toxicologic, biochemical and histopathologic studies Hepathology 4 1984 1143 1152 (Pubitemid 15192265)
16. S.A. Koenig, M. Schenk, C. Sick, E. Holm, C. Heubner, and A. Weiss Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: review of valproate hepatotoxicity in adults Epilepsia 40 1999 1036 1040 (Pubitemid 29316062)
17. S.A. Koenig, D. Buesing, E. Longin, R. Oehring, P. Häussermann, and G. Kluger Valproic acid-induced hepatopathy: nine new fatalities in Germany from 1994 to 2003 Epilepsia 47 12 2006 2027 2031 (Pubitemid 44952253)
18. B.D. Kossak, E. Schmidt-Sommerfeld, J.H. Tonsgard, and D. Schoeller Fatty acid b -oxydation during valproic acid therapy and the rôle of carnitine Ann Neurol 30 1991 448 449
19. Th. Lempérire Historique du développement du valproate dans les troubles bipolaires L'encéphale 27 2001 365 372
20. T.L. Litovitz, W. Klein-Schwartz, S. White, D.J. Cobaugh, J. Youniss, and J.C. Omslaer 2000 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System Am J Emerg Med 19 2001 337 395 (Pubitemid 32848064)
21. C. Marescaux, L. Rumbach, J.M. Warter, M. Collard, F. Rohmer, and G. Micheletti Stuporous states during treatment with sodium valproate. Pathogenetic hypotheses Rev Neurol (Paris) 137 1981 241 254 (Pubitemid 11046405)
22. P.J.W. McKee, J. Blacklaw, E. Butler, R.A. Gillham, and M.J. Brodie Variability and clinical relevance of the interaction between sodium valproate and carbamazepine in epileptic patients Epilepsy Research 11 1992 193 198
23. K. Murakami, T. Sugimoto, M. Woo, N. Nishida, and H. Muro Effect of L-carnitine supplementation on acute valproate intoxication Epilepsia 37 1996 687 689 (Pubitemid 26250003)
24. V.M. Piñeiro-Carrero, and E.O. Piñeiro Liver Pediatrics 113 2004 1097 1106 (Pubitemid 38437364)
25. P.V. Rai Acute intoxication during a cpmbined treatment of sodium valproate and phenobarbitone H. Meinardi, A.J. Rowan, Advances in Epileptology 1978 SwetZertlinger Amsterdam 366 369
26. J.Y. Raskind, and G.M. El-Chaar The role of carnitine supplementation during valproic acid therapy Ann Pharmacother 34 2000 630 638 (Pubitemid 30257492)
27. R.N. Ratnaike, G.J. Schapel, G. Purdie, R.H. Rischbieth, and S. Hoffmann Hyperammonaemia and hepatotoxicity during chronic valproate therapy: enhancement by combination with other antiepileptic drugs Br J Clin Pharmacol 22 1986 100 103 (Pubitemid 17177212)
28. A.E. Rettie, P.R. Sheffels, K.R. Korzekwa, F.J. Gonzales, R.M. Philpot, and T.A. Baillie CYP 4 isoenzyme specificity and the relationship between oméga-hydroxylation and terminal desaturation of valproic acid Biochemistry 34 1995 7889 7895
29. C. Ricard, K. Martin, M. Tournier, B. Bégaud, and H. Verdoux Troubles cognitifs, syndrome extrapyramidal et hyperammoniémie sous traitement thymorégulateur par divalproate de sodium: propos d'un cas Encephale 31 2005 98 101 (Pubitemid 40459925)
30. A. Romero-Falcón, E. de la Santa-Belda, R. Garcia-Contreras, and J.M. Varela A case of valproate-associated hepatotoxicity treated with L-carnitine Eur J Intern Med 14 2003 338 340 (Pubitemid 37108731)
31. J.C. Sackellares, S.I. Lee, and F.E. Dreifuss Stupor following administration of valproic acid to patients receiving other antiepileptic drugs Epilepsia 20 1979 697 703 (Pubitemid 10215232)
32. D. Scheffner, S. König, I. Rauterberg-Ruland, W. Kochen, W.J. Hofmann, and S. Unkelbach Fatal liver failure in 16 children with valproate therapy Epilepsia 29 1988 530 542
33. S. Sekin, S. Alsancak, C. Baaran-Küükgergin, and M. Uysal The effect of chronic diazepam administration on lipid peroxidation and Ca2+ -ATPase activity in rat liver Acta Biol Hung 58 2007 441 443 (Pubitemid 351160508)
34. N. Segura-Bruna, A. Rodriguez-Campello, V. Puente, and J. Roquer Valproate-induced hyperammonemic encephalopathy Acta Neurol Scand 114 2006 1 7 (Pubitemid 43873517)
35. H.A. Spiller, E.P. Krenzelok, W. Klein-Schwartz, M.L. Winter, J.A. Weber, and D.R. Sollee Multicenter Case Series of Valproic acid Ingestion: Serum Concentrations and Toxicity Clin Toxicol 38 2000 755 760 (Pubitemid 32047302)
36. E. Spina, F. Pisani, and E. Perucca Clinically significant pharmacokinetic drug interactions with carbamazepine. An update Clin Pharmacokinet 31 1996 198 214 (Pubitemid 26335906)
37. H.S. Subhash, R.J. Heddle, D.W. Schultz, J. Ring, and C.H. Thompson Hepatic encephalopathy precipitated by sodium valproate therapy Med J Aust 188 2008 549
38. J.M. Warter, Marescaux Ch, Brandt Ch, L. Rumbach, G. Micheletti, and G. Chabrier Sodium valproate associated with phenobarbital: effects on ammonia metabolism in humans Epilepsia 24 1983 628 633 (Pubitemid 14225338)
39. W.A. Watson, T.L. Litovitz, G.C. Rodgers Jr. , W. Klein-Schwartz, J. Youniss, and S.R. Rose 2002 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System Am J Emerg Med 21 5 2003 353 421