Thromboembolism in pediatric inflammatory bowel disease: Systematic review

Inflammatory Bowel Diseases

Volumn 17, Issue 10, 2011, Pages 2174-2183

  Lazzerini, Marzia ^a   Bramuzzo, Matteo ^b   Maschio, Massimo ^b   Martelossi, Stefano ^b   Ventura, Alessandro ^b  

^a INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

inflammatory bowel disease; pediatric; thromboembolism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ACETYLSALICYLIC ACID; ANTIBIOTIC AGENT; ANTICONVULSIVE AGENT; ANTIPLASMIN; AZATHIOPRINE; CYCLOSPORIN; FIBRINOLYTIC AGENT; INFLIXIMAB; LOW MOLECULAR WEIGHT HEPARIN; MANNITOL; MESALAZINE; PHOSPHOLIPID ANTIBODY; PROTEIN C; PROTHROMBIN; STEROID; TETRACOSACTIDE; TICLOPIDINE; WARFARIN;

ABDOMINAL THROMBOEMBOLISM; ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ARTERIAL THROMBOEMBOLISM; BASILAR ARTERY; BLINDNESS; CEREBRAL THROMBOEMBOLISM; CHILDHOOD DISEASE; COMORBIDITY; CROHN DISEASE; DEHYDRATION; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE DURATION; DISEASE EXACERBATION; ENDOCARDITIS; ENTERIC FEEDING; ENTERITIS; ENZYME DEFICIENCY; FIBRINOLYTIC THERAPY; GENE MUTATION; HEADACHE; HEMIPARESIS; HEMIPLEGIA; HUMAN; HYPERFIBRINOGENEMIA; HYPERHOMOCYSTEINEMIA; HYPEROMOCYSTINEMIA; HYPERTENSION; IMMOBILIZATION; IMMUNOSUPPRESSIVE TREATMENT; LUNG EMBOLISM; MIDDLE CEREBRAL ARTERY; MYOCARDITIS; OBESITY; POSTERIOR CEREBRAL ARTERY; PRIORITY JOURNAL; RETINIC THROMBOEMBOLISM; REVIEW; RISK FACTOR; SEIZURE; TAGAYASU VASCULITIS; THROMBOCYTOSIS; THROMBOEMBOLISM; ULCERATIVE COLITIS; VASCULITIS; VENOUS THROMBOEMBOLISM; VISUAL IMPAIRMENT;

ADULT; CHILD; HUMANS; INFLAMMATORY BOWEL DISEASES; RISK FACTORS; THROMBOEMBOLISM;

EID: 80052727980     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21563     Document Type: Review

References (80)

1. Monagle P, Adams M, Mahoney M, et al. Outcome of pediatric thromboembolic disease: a report from the Canadian Childhood Thrombophilia Registry. Pediatr Res. 2000; 47: 763-766.
2. Van Ommen CH, Heijboer H, Büller HR, et al. Venous thromboembolism in childhood: a prospective two-year registry in the Netherlands. J Pediatr. 2001; 139: 676-681.
3. Kuhle S, Massicotte P, Chan A, et al. Systemic thromboembolism in children: data from the 1-800-NO-CLOTS Consultation Service. Thromb Haemost. 2004; 92: 722-728.
4. Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines, 8th ed. Chest. 2008; 133: 381S-453S.
5. Grainge MJ, West J, Card TR,. Venous thromboembolism during active disease and remission in inflammatory bowel disease: a cohort study. Lancet. 2010; 375: 657-663.
6. Grip O, Svensson PJ, Lindgren S,. Inflammatory bowel disease promotes venous thrombosis earlier in life. Scand J Gastroenterol. 2000; 35: 619-623.
7. Nguyen GC, Sam J,. Rising prevalence of venous thromboembolism and its impact on mortality among hospitalized inflammatory bowel disease patients. Am J Gastroenterol. 2008; 103: 2272-2280.
8. Bernstein CN, Blanchard JF, Houston DS, et al. The incidence of deep venous thrombosis and pulmonary embolism among patients with inflammatory bowel disease: a population-based cohort study. Thromb Haemost. 2001; 85: 430-434.
9. Bernstein CN, Wajda A, Blanchard JF,. The incidence of arterial thromboembolic diseases in inflammatory bowel disease: a population-based study. Clin Gastroenterol Hepatol. 2008; 6: 41-45.
10. Dorn SD, Sandler RS,. Inflammatory bowel disease is not a risk factor for cardiovascular disease mortality: results from a systematic review and meta-analysis. Am J Gastroenterol. 2007; 102: 662-667.
11. Ha C, Magowan S, Accortt NA, et al. Risk of arterial thrombotic events in inflammatory bowel disease. Am J Gastroenterol. 2009; 104: 1445-1451.
12. Mayeux R, Fahn S,. Strokes and ulcerative colitis. Neurology. 1978; 28: 571-574.
13. Standridge S, de los Reyes E,. Inflammatory bowel disease and cerebrovascular arterial and venous thromboembolic events in 4 pediatric patients: a case series and review of the literature. J Child Neurol. 2008; 23: 59-66.
14. Lloyd-Still JD, Tomasi L,. Neurovascular and thromboembolic complications of inflammatory bowel disease in childhood. J Pediatr Gastroenterol Nutr. 1989; 9: 461-466.
15. Barclay AR, Keightley JM, Horrocks I, et al. Cerebral thromboembolic events in pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2010; 16: 677-683.
16. Talbot RW, Heppell J, Dozois RR, et al. Vascular complications of inflammatory bowel disease. Mayo Clin Proc. 1986; 61: 140-145.
17. Paradis K, Bernstein ML, Adelson JW,. Thrombosis as a complication of inflammatory bowel disease in children: a report of four cases. J Pediatr Gastroenterol Nutr. 1985; 4: 659-662.
18. del Rosario JF, Orenstein SR, Bhargava S, et al. Thrombotic complications in pediatric inflammatory bowel disease. Clin Pediatr (Phila). 1994; 33: 159-161.
19. Keene DL, Matzinger MA, Jacob PJ, et al. Cerebral vascular events associated with ulcerative colitis in children. Pediatr Neurol. 2001; 24: 238-243.
20. Kao A, Dlugos D, Hunter JV, et al. Anticoagulation therapy in cerebral sinovenous thrombosis and ulcerative colitis in children. J Child Neurol. 2002; 17: 479-482.
21. Schneiderman JH, Sharpe JA, Sutton DM,. Cerebral and retinal vascular complications of inflammatory bowel disease. Ann Neurol. 1979; 5: 331-337.
22. Okada T, Sasaki F, Minagawa N, et al. Postoperative portal and splenic vein thrombosis in children: identification of risk factors. Pediatr Surg Int. 2005; 21: 918-921.
23. Philips MF, Bagley LJ, Sinson GP, et al. Endovascular thrombolysis for symptomatic cerebral venous thrombosis. J Neurosurg. 1999; 90: 65-71.
24. Patterson M, Castiglioni L, Sampson L,. Chronic ulcerative colitis beginning in children and teenagers. A review of 43 patients. Am J Dig Dis. 1971; 16: 289-297.
25. Tomomasa T, Itoh K, Matsui A, et al. An infant with ulcerative colitis complicated by endocarditis and cerebral infarction. J Pediatr Gastroenterol Nutr. 1993; 17: 323-325.
26. Yassinger S, Adelman R, Cantor D, et al. Association of inflammatory bowel disease and large vascular lesions. Gastroenterology. 1976; 71: 844-846.
27. Mezoff AG, Cohen MB, Maisel SK, et al. Crohn disease in an infant with central nervous system thrombosis and protein-losing enteropathy. J Pediatr. 1990; 117: 436-439.
28. Ertem D, Ozguven E, Acar Y, et al. Thromboembolic complications in children with Crohn's disease. J Pediatr Gastroenterol Nutr. 1999; 28: 540-541.
29. Junge U, Wienke J, Schüler A,. Acute Budd-Chiari syndrome, portal and splenic vein thrombosis in a patient with ulcerative colitis associated with antiphospholipid antibodies and protein C deficiency. Z Gastroenterol. 2001; 39: 845-852.
30. Kraut J, Berman JH, Gunasekaran TS, et al. Hepatic vein thrombosis (Budd-Chiari syndrome) in an adolescent with ulcerative colitis. J Pediatr Gastroenterol Nutr. 1997; 25: 417-420.
31. Rahhal RM, Pashankar DS, Bishop WP,. Ulcerative colitis complicated by ischemic colitis and Budd Chiari syndrome. J Pediatr Gastroenterol Nutr. 2005; 40: 94-97.
32. Socha P, Ryzko J, Janczyk W, et al. Hepatic vein thrombosis as a complication of ulcerative colitis in a 12-year-old patient. Dig Dis Sci. 2007; 52: 1293-1298.
33. Tung JY, Johnson JL, Liacouras CA,. Portal-mesenteric pylephlebitis with hepatic abscesses in a patient with Crohn's disease treated successfully with anticoagulation and antibiotics. J Pediatr Gastroenterol Nutr. 1996; 23: 474-478.
34. Ross AS, Gasparaitis A, Hurst R, et al. Superior mesenteric vein thrombosis after colectomy in a patient with Crohn'sdisease. Nat Clin Pract Gastroenterol Hepatol. 2005; 2: 281-285.
35. Olm M, Massanes F, Estruch R, et al. Iliocaval vein thrombosis as a presentation of Crohn's disease. J Clin Gastroenterol. 1990; 12: 600-601.
36. Calderon A, Wong JW, Becker LE,. Multiple cerebral venous thromboses in a child with ulcerative colitis. Clin Pediatr (Phila). 1993; 32: 169-171.
37. Rosen I, Berkovitz D, Soudack M, et al. Cerebral vein thrombosis in a child with Crohn's disease. Isr Med Assoc J. 2007; 9: 620-621.
38. Björgell O, Nilsson P, Nilsson A, et al. Isolated internal iliac vein thrombosis. J Ultrasound Med. 1998; 17: 671-673.
39. Stajer D, Gorjup V,. Myopericarditis, pleuritis and deep venous thrombosis in ulcerative colitis masquerading as pulmonary embolism. Intensive Care Med. 1996; 22: 1134-1135.
40. Symmonds RE Jr, van Heerden JA, Reitemeier RJ,. An unusual extracolonic manifestation of chronic ulcerative colitis. Dis Colon Rectum. 1978; 21: 496-500.
41. Béchade D, Desramé J, Sallansonnet-Froment M, et al. Cerebral venous thrombosis and ulcerative colitis. Rev Med Interne. 2006; 27: 958-961.
42. Gormally SM, Bourke W, Kierse B, et al. Isolated cerebral thrombo-embolism and Crohn disease. Eur J Pediatr. 1995; 154: 815-818.
43. Milandre L, Monges D, Dor V, et al. Cerebral phlebitis and Crohn disease. Rev Neurol (Paris). 1992; 148: 139-144.
44. Markowitz RL, Ment LR, Gryboski JD,. Cerebral thromboembolic disease in pediatric and adult inflammatory bowel disease: case report and review of the literature. J Pediatr Gastroenterol Nutr. 1989; 8: 413-420.
45. Bridger S, Evans N, Parker A, et al. Multiple cerebral venous thromboses in a child with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 1997; 25: 533-536.
46. Akobeng AK, Miller V, Thomas AG,. Epilepsy and Crohn's disease in children. J Pediatr Gastroenterol Nutr. 1998; 26: 458-460.
47. Al-Malik H, Green MR,. Cerebral venous thrombosis as a complication of Crohn disease: a case report. J Pediatr Gastroenterol Nutr. 2001; 32: 209-211.
48. Hassan KO, Jenkins HR,. Multiple venous thrombosis in inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 1998; 27: 616-617.
49. Macrì A, La Spina P, Terranova ML, et al. Ulcerative colitis complicated by dural sina venous thrombosis. Int J Colorectal Dis. 2002; 17: 61-62.
50. Lionetti P, Salvestrini C, Trapani S, et al. An 18-month-old child with seizures and bloody diarrhea. Inflamm Bowel Dis. 2005; 11: 209-210.
51. Fukuhara T, Tsuchida S, Kinugasa K, et al. A case of pontine lacunar infarction with ulcerative colitis. Clin Neurol Neurosurg. 1993; 95: 159-162.
52. Rousseau B, Bélanger C, Lacoursière Y, et al. Ulcerative colitis and cerebral venous thrombosis. Union Med Can. 1975; 104: 414-417.
53. Thorsteinsson GS, Magnussson M, Hallberg LM, et al. Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis. World J Gastroenterol. 2008; 14: 4576-4579.
54. McQueen A,. "I think she's just crazy." Lancet. 2005; 365: 1513.
55. Zimmer JA, Garg BP, O'Neill DP, et al. Teaching neuroImage: MRI visualization of papilledema associated with cerebral sinovenous thrombosis in a child. Neurology. 2008; 71: e12-13.
56. Robison NJ, Dawlabani N, Lastra CR, et al. Cerebral sinus thrombosis in a child with active ulcerative colitis and factor V Leiden. Pediatr Blood Cancer. 2009; 52: 867-869.
57. Pohl JF, Mulne A, Chambers LJ, et al. Extensive venous thrombosis in a pediatric patient with Crohn's disease. Inflamm Bowel Dis. 2009; 15: 807-808.
58. Witteman BJ, Weterman IT, Griffioen G, et al. Intestinal obstruction caused by non-absorbable tablets and Budd-Chiari syndrome in a patient with Crohn's disease. Ned Tijdschr Geneeskd. 1991; 135: 766-769.
59. Shigemori Y, Koshinaga M, Suma T, et al. Superior sagittal sinus thrombosis suffered as a complication of ulcerative colitis: case report. No Shinkei Geka. 2006; 34: 939-942.
60. Ennaifer R, Moussa A, Mouelhi L, et al. Cerebral venous sinus thrombosis as presenting feature of ulcerative colitis. Acta Gastroenterol Belg. 2009; 72: 350-353.
61. Zitomersky NL, Verhave M, Trenor CC 3rd,. Thrombosis and inflammatory bowel disease: a call for improved awareness and prevention. Inflamm Bowel Dis. 2010 [Epub ahead of print].
62. Smeeth L, Cook C, Thomas S, et al. Risk of deep vein thrombosis and pulmonary embolism after acute infection in a community setting. Lancet. 2006; 367: 1075-1079.
63. Ganesan V, Prengler M, McShane MA, et al. Investigation of risk factors in children with arterial ischemic stroke. Ann Neurol. 2003; 53: 167-173.
64. Bernstein CN, Singh S, Graff LA, et al. A prospective population-based study of triggers of symptomatic flares in IBD. Am J Gastroenterol. 2010; 105: 1994-2002.
65. Solem CA, Loftus EV, Tremaine WJ, et al. Venous thromboembolism in inflammatory bowel disease. Am J Gastroenterol. 2004; 99: 97-101.
66. Petitpain N, Gambier N, Wahl D, et al. Arterial and venous thromboembolic events during anti-TNF therapy: a study of 85 spontaneous reports in the period 2000-2006. Biomed Mater Eng. 2009; 19: 355-364.
67. Young G, Albisetti M, Bonduel M, et al. Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies. Circulation. 2008; 118: 1373-1382
68. Haywood S, Liesner R, Pindora S, et al. Thrombophilia and first arterial ischaemic stroke: a systematic review. Arch Dis Child. 2005; 90: 402-405
69. Koutroubakis IE,. Venous thromboembolism in hospitalized inflammatory bowel disease patients: the magnitude of the problem is staggering. Am J Gastroenterol. 2008; 103: 2281-2283.
70. Binion DG, Rafiee P,. Is inflammatory bowel disease a vascular disease? Targeting angiogenesis improves chronic inflammation in inflammatory bowel disease. Gastroenterology. 2009; 136: 400-403.
71. Goldenberg NA, Bernard TJ, Fullerton HJ, et al. International Pediatric Stroke Study Group. Antithrombotic treatments, outcomes, and prognostic factors in acute childhood-onset arterial ischaemic stroke: a multicentre, observational, cohort study. Lancet Neurol. 2009; 8: 1120-1127.
72. Carter MJ, Lobo AJ, Travis SP,. Guidelines for the management of inflammatory bowel disease in adults. Gut. 2004; 53: V1-V16.
73. Nguyen GC, Yeo EL,. Prophylaxis of venous thromboembolism in IBD. Lancet. 2010; 375: 616-617.
74. Paediatric Stroke Working Group. Stroke in childhood: clinical guidelines for diagnosis, management and rehabilitation. London: Royal College of Physicians; 2004.
75. Monagle P, Chan A, Massicotte P, et al. Antithrombotic therapy in children: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004; 126: S645-687.
76. Monagle P, Chalmers E, Chan A, et al. Antithrombotic therapy in neonates and children. American College of Chest Physicians evidence-based clinical practice guidelines, 8th ed. Chest. 2008; 133: S887-968.
77. Roach ES, Golomb MR, Adams R, et al. Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke. 2008; 39: 2644-2691.
78. DeVeber G, Kirkham F,. Guidelines for the treatment and prevention of stroke in children. Lancet Neurol. 2008; 7: 983-985.
79. Pappachan J, Kirkham FJ,. Cerebrovascular disease and stroke. Arch Dis Child. 2008; 93: 890-898.
80. Shen J, Ran ZH, Tong JL, et al. Meta-analysis: the utility and safety of heparin in the treatment of active ulcerative colitis. Aliment Pharmacol Ther. 2007; 26: 653-663.