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Volumn 14, Issue 3, 2011, Pages 235-243

Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma

Author keywords

MMP 9; Neutrophil granulocyte; Pancreatic cancer; VEGF

Indexed keywords

BEVACIZUMAB; DOXYCYCLINE; GELATINASE B; VASCULOTROPIN;

EID: 80052719819     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-011-9207-3     Document Type: Article
Times cited : (116)

References (42)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • 4938153 10.1056/NEJM197111182852108 1:STN:280:DyaE38%2FgvVCqsQ%3D%3D
    • J Folkman 1971 Tumor angiogenesis: therapeutic implications N Engl J Med 285 21 1182 1186 4938153 10.1056/NEJM197111182852108 1:STN:280: DyaE38%2FgvVCqsQ%3D%3D
    • (1971) N Engl J Med , vol.285 , Issue.21 , pp. 1182-1186
    • Folkman, J.1
  • 2
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • DOI 10.1016/S0092-8674(00)80108-7
    • D Hanahan J Folkman 1996 Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis Cell 86 3 353 364 8756718 10.1016/S0092-8674(00)80108-7 1:CAS:528:DyaK28XltVSks7s%3D (Pubitemid 26272076)
    • (1996) Cell , vol.86 , Issue.3 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 3
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • DOI 10.1038/nrc909
    • N Ferrara 2002 VEGF and the quest for tumour angiogenesis factors Nat Rev Cancer 2 10 795 803 12360282 10.1038/nrc909 1:CAS:528:DC%2BD38XnsVGrtbk%3D (Pubitemid 37328914)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.10 , pp. 795-803
    • Ferrara, N.1
  • 5
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • DW Leung G Cachianes WJ Kuang DV Goeddel N Ferrara 1989 Vascular endothelial growth factor is a secreted angiogenic mitogen Science 246 4935 1306 1309 2479986 10.1126/science.2479986 1:CAS:528:DyaK3cXls1GltLo%3D (Pubitemid 20066716)
    • (1989) Science , vol.246 , Issue.4935 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.-J.3    Goeddel, D.V.4    Ferrara, N.5
  • 6
    • 0029010434 scopus 로고
    • Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
    • 7673356 1:CAS:528:DyaK2MXmsFOnsrs%3D
    • WG Roberts GE Palade 1995 Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor J Cell Sci 108 Pt 6 2369 2379 7673356 1:CAS:528:DyaK2MXmsFOnsrs%3D
    • (1995) J Cell Sci , vol.108 , Issue.PART 6 , pp. 2369-2379
    • Roberts, W.G.1    Palade, G.E.2
  • 7
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • 6823562 10.1126/science.6823562 1:STN:280:DyaL3s7hvF2mtw%3D%3D
    • DR Senger SJ Galli AM Dvorak CA Perruzzi VS Harvey HF Dvorak 1983 Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid Science 219 4587 983 985 6823562 10.1126/science.6823562 1:STN:280:DyaL3s7hvF2mtw%3D%3D
    • (1983) Science , vol.219 , Issue.4587 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 8
    • 0037805549 scopus 로고    scopus 로고
    • Basement membranes: Structure, assembly and role in tumour angiogenesis
    • DOI 10.1038/nrc1094
    • R Kalluri 2003 Basement membranes: structure, assembly and role in tumour angiogenesis Nat Rev Cancer 3 6 422 433 12778132 10.1038/nrc1094 1:CAS:528:DC%2BD3sXktFOnsbw%3D (Pubitemid 37328846)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.6 , pp. 422-433
    • Kalluri, R.1
  • 10
    • 33747602354 scopus 로고    scopus 로고
    • Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis
    • DOI 10.1073/pnas.0601807103
    • H Nozawa C Chiu D Hanahan 2006 Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis Proc Natl Acad Sci USA 103 33 12493 12498 16891410 10.1073/pnas.0601807103 1:CAS:528:DC%2BD28Xos1OjurY%3D (Pubitemid 44267286)
    • (2006) Proceedings of the National Academy of Sciences of the United States of America , vol.103 , Issue.33 , pp. 12493-12498
    • Nozawa, H.1    Chiu, C.2    Hanahan, D.3
  • 11
    • 38049177345 scopus 로고    scopus 로고
    • Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis
    • 10.1073/pnas.0706438104 18077379 10.1073/pnas.0706438104 1:CAS:528:DC%2BD1cXjslehtA%3D%3D
    • VC Ardi TA Kupriyanova EI Deryugina JP Quigley 2007 Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis Proc Natl Acad Sci USA 104 51 20262 20267 10.1073/pnas.0706438104 18077379 10.1073/pnas.0706438104 1:CAS:528:DC%2BD1cXjslehtA%3D%3D
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.51 , pp. 20262-20267
    • Ardi, V.C.1    Kupriyanova, T.A.2    Deryugina, E.I.3    Quigley, J.P.4
  • 12
    • 0037183997 scopus 로고    scopus 로고
    • Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165
    • 12114504 10.1074/jbc.M201674200 1:CAS:528:DC%2BD38XnsVCjtrY%3D
    • G Hashimoto I Inoki Y Fujii T Aoki E Ikeda Y Okada 2002 Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165 J Biol Chem 277 39 36288 36295 12114504 10.1074/jbc.M201674200 1:CAS:528:DC%2BD38XnsVCjtrY%3D
    • (2002) J Biol Chem , vol.277 , Issue.39 , pp. 36288-36295
    • Hashimoto, G.1    Inoki, I.2    Fujii, Y.3    Aoki, T.4    Ikeda, E.5    Okada, Y.6
  • 14
    • 39849100541 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: Role of bone marrow-derived myelomonocytic cells
    • DOI 10.1016/j.ccr.2007.11.032, PII S1535610808000020
    • GO Ahn JM Brown 2008 Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells Cancer Cell 13 3 193 205 10.1016/j.ccr.2007.11.032 18328424 10.1016/j.ccr.2007.11.032 1:CAS:528:DC%2BD1cXjsVKgsrc%3D (Pubitemid 351318369)
    • (2008) Cancer Cell , vol.13 , Issue.3 , pp. 193-205
    • Ahn, G.-O.1    Brown, J.M.2
  • 15
    • 36048991140 scopus 로고    scopus 로고
    • Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice
    • DOI 10.1593/neo.07742
    • T Nakamura T Kuwai JS Kim D Fan SJ Kim IJ Fidler 2007 Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice Neoplasia 9 11 979 986 18030366 10.1593/neo.07742 1:CAS:528:DC%2BD2sXhtl2rtrrI (Pubitemid 350086443)
    • (2007) Neoplasia , vol.9 , Issue.11 , pp. 979-986
    • Nakamura, T.1    Kuwai, T.2    Kim, J.-S.3    Fan, D.4    Kim, S.-J.5    Fidler, I.J.6
  • 16
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • DOI 10.1016/j.cell.2006.01.007, PII S0092867406000559
    • J Condeelis JW Pollard 2006 Macrophages: obligate partners for tumor cell migration, invasion, and metastasis Cell 124 2 263 266 10.1016/j.cell.2006.01. 007 16439202 10.1016/j.cell.2006.01.007 1:CAS:528:DC%2BD28Xht1KktLo%3D (Pubitemid 43121975)
    • (2006) Cell , vol.124 , Issue.2 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 18
    • 0034721666 scopus 로고    scopus 로고
    • MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
    • 11081634 10.1016/S0092-8674(00)00139-2 1:CAS:528:DC%2BD3cXnvF2ksLg%3D
    • LM Coussens CL Tinkle D Hanahan Z Werb 2000 MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis Cell 103 3 481 490 11081634 10.1016/S0092-8674(00)00139-2 1:CAS:528:DC%2BD3cXnvF2ksLg%3D
    • (2000) Cell , vol.103 , Issue.3 , pp. 481-490
    • Coussens, L.M.1    Tinkle, C.L.2    Hanahan, D.3    Werb, Z.4
  • 19
    • 71849112654 scopus 로고    scopus 로고
    • Desmoplasia of pancreatic ductal adenocarcinoma
    • 19896098 10.1016/j.cgh.2009.07.039 1:CAS:528:DC%2BC3cXlsFOjtw%3D%3D
    • S Pandol M Edderkaoui I Gukovsky A Lugea A Gukovskaya 2009 Desmoplasia of pancreatic ductal adenocarcinoma Clin Gastroenterol Hepatol 7 11 Suppl S44 S47 19896098 10.1016/j.cgh.2009.07.039 1:CAS:528:DC%2BC3cXlsFOjtw%3D%3D
    • (2009) Clin Gastroenterol Hepatol , vol.7 , Issue.11 SUPPL.
    • Pandol, S.1    Edderkaoui, M.2    Gukovsky, I.3    Lugea, A.4    Gukovskaya, A.5
  • 20
    • 77649152752 scopus 로고    scopus 로고
    • Tumor-derived intercellular adhesion molecule-1 mediates tumor-associated leukocyte infiltration in orthotopic pancreatic xenografts
    • 10.1258/ebm.2009.009215 1:CAS:528:DC%2BC3cXpsFejtbs%3D
    • CL Roland SP Dineen JE Toombs JG Carbon CW Smith RA Brekken CC Barnett Jr 2010 Tumor-derived intercellular adhesion molecule-1 mediates tumor-associated leukocyte infiltration in orthotopic pancreatic xenografts Exp Biol Med(Maywood) 235 2 263 270 10.1258/ebm.2009.009215 1:CAS:528:DC%2BC3cXpsFejtbs%3D
    • (2010) Exp Biol Med(Maywood) , vol.235 , Issue.2 , pp. 263-270
    • Roland, C.L.1    Dineen, S.P.2    Toombs, J.E.3    Carbon, J.G.4    Smith, C.W.5    Brekken, R.A.6    Barnett Jr., C.C.7
  • 21
    • 0036334059 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their role in pancreatic cancer: A review of preclinical studies and clinical trials
    • DOI 10.1245/aso.2002.9.7.668
    • M Bloomston EE Zervos AS Rosemurgy 2nd 2002 Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trials Ann Surg Oncol 9 7 668 674 12167581 10.1007/BF02574483 (Pubitemid 34857984)
    • (2002) Annals of Surgical Oncology , vol.9 , Issue.7 , pp. 668-674
    • Bloomston, M.1    Zervos, E.E.2    Rosemurgy II, A.S.3
  • 22
    • 0038501002 scopus 로고    scopus 로고
    • Evaluation of vascular endothelial growth factor blockade and matrix metalloproteinase inhibition as a combination therapy for experimental human pancreatic cancer
    • discussion 227-228. doi: S1091255X02001579
    • Hotz HG, Hines OJ, Hotz B, Foitzik T, Buhr HJ, Reber HA (2003) Evaluation of vascular endothelial growth factor blockade and matrix metalloproteinase inhibition as a combination therapy for experimental human pancreatic cancer. J Gastrointest Surg 7 (2): 220-227; discussion 227-228. doi: S1091255X02001579
    • (2003) J Gastrointest Surg , vol.7 , Issue.2 , pp. 220-227
    • Hotz, H.G.1    Hines, O.J.2    Hotz, B.3    Foitzik, T.4    Buhr, H.J.5    Reber, H.A.6
  • 23
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • 10.1038/sj.bjc.6600446 12107836 10.1038/sj.bjc.6600446 1:CAS:528:DC%2BD38XltFeksLw%3D
    • SR Bramhall J Schulz J Nemunaitis PD Brown M Baillet JA Buckels 2002 A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer Br J Cancer 87 2 161 167 10.1038/sj.bjc.6600446 12107836 10.1038/sj.bjc.6600446 1:CAS:528:DC%2BD38XltFeksLw%3D
    • (2002) Br J Cancer , vol.87 , Issue.2 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3    Brown, P.D.4    Baillet, M.5    Buckels, J.A.6
  • 25
    • 0035424135 scopus 로고    scopus 로고
    • Marimastat as first-line therapy for patients with unresectable pancreatic cancer: A randomized trial
    • SR Bramhall A Rosemurgy PD Brown C Bowry JA Buckels 2001 Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial J Clin Oncol 19 15 3447 3455 11481349 1:CAS:528: DC%2BD3MXmtlGhuro%3D (Pubitemid 32730080)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.15 , pp. 3447-3455
    • Bramhall, S.R.1    Rosemurgy, A.2    Brown, P.D.3    Bowry, C.4    Buckles, J.A.C.5
  • 27
    • 50249087586 scopus 로고    scopus 로고
    • A phase II study evaluating bevacizumab in combination with fixed-dose rate gemcitabine and low-dose cisplatin for metastatic pancreatic cancer: Is an anti-VEGF strategy still applicable?
    • 18379729 10.1007/s10637-008-9127-2 1:CAS:528:DC%2BD1cXhtVSku7fI
    • AH Ko E Dito B Schillinger AP Venook Z Xu EK Bergsland D Wong J Scott J Hwang MA Tempero 2008 A phase II study evaluating bevacizumab in combination with fixed-dose rate gemcitabine and low-dose cisplatin for metastatic pancreatic cancer: is an anti-VEGF strategy still applicable? Invest New Drugs 26 5 463 471 18379729 10.1007/s10637-008-9127-2 1:CAS:528:DC%2BD1cXhtVSku7fI
    • (2008) Invest New Drugs , vol.26 , Issue.5 , pp. 463-471
    • Ko, A.H.1    Dito, E.2    Schillinger, B.3    Venook, A.P.4    Xu, Z.5    Bergsland, E.K.6    Wong, D.7    Scott, J.8    Hwang, J.9    Tempero, M.A.10
  • 29
    • 0032200444 scopus 로고    scopus 로고
    • Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms
    • 9972117 10.1177/08959374980120010501 1:STN:280:DyaK1M7jvVSltg%3D%3D
    • LM Golub HM Lee ME Ryan WV Giannobile J Payne T Sorsa 1998 Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms Adv Dent Res 12 2 12 26 9972117 10.1177/08959374980120010501 1:STN:280: DyaK1M7jvVSltg%3D%3D
    • (1998) Adv Dent Res , vol.12 , Issue.2 , pp. 12-26
    • Golub, L.M.1    Lee, H.M.2    Ryan, M.E.3    Giannobile, W.V.4    Payne, J.5    Sorsa, T.6
  • 30
    • 0032198241 scopus 로고    scopus 로고
    • Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells
    • 9972133 10.1177/08959374980120010301 1:STN:280:DyaK1M7jvVSrsg%3D%3D
    • R Hanemaaijer H Visser P Koolwijk T Sorsa T Salo LM Golub VW van Hinsbergh 1998 Inhibition of MMP synthesis by doxycycline and chemically modified tetracyclines (CMTs) in human endothelial cells Adv Dent Res 12 2 114 118 9972133 10.1177/08959374980120010301 1:STN:280:DyaK1M7jvVSrsg%3D%3D
    • (1998) Adv Dent Res , vol.12 , Issue.2 , pp. 114-118
    • Hanemaaijer, R.1    Visser, H.2    Koolwijk, P.3    Sorsa, T.4    Salo, T.5    Golub, L.M.6    Van Hinsbergh, V.W.7
  • 31
    • 0015822275 scopus 로고
    • Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria
    • 4355998 10.1172/JCI107470 1:STN:280:DyaE2c%2FitFKgug%3D%3D
    • EA Jaffe RL Nachman CG Becker CR Minick 1973 Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria J Clin Invest 52 11 2745 2756 4355998 10.1172/JCI107470 1:STN:280:DyaE2c%2FitFKgug%3D%3D
    • (1973) J Clin Invest , vol.52 , Issue.11 , pp. 2745-2756
    • Jaffe, E.A.1    Nachman, R.L.2    Becker, C.G.3    Minick, C.R.4
  • 32
    • 0014368928 scopus 로고
    • Separation of leukocytes from blood and bone marrow. Introduction
    • 5707208 1:STN:280:DyaF1M7gtFKrtQ%3D%3D
    • A Boyum 1968 Separation of leukocytes from blood and bone marrow. Introduction Scand J Clin Lab Invest Suppl 97 7 5707208 1:STN:280: DyaF1M7gtFKrtQ%3D%3D
    • (1968) Scand J Clin Lab Invest Suppl , vol.97 , pp. 7
    • Boyum, A.1
  • 33
    • 0032583125 scopus 로고    scopus 로고
    • Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation
    • DOI 10.1083/jcb.143.5.1341
    • T Korff HG Augustin 1998 Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation J Cell Biol 143 5 1341 1352 9832561 10.1083/jcb.143.5.1341 1:CAS:528:DyaK1cXnvVKkurc%3D (Pubitemid 28559834)
    • (1998) Journal of Cell Biology , vol.143 , Issue.5 , pp. 1341-1352
    • Korff, T.1    Augustin, H.G.2
  • 34
    • 0032748089 scopus 로고    scopus 로고
    • Tensional forces in fibrillar extracellular matrices control directional capillary sprouting
    • T Korff HG Augustin 1999 Tensional forces in fibrillar extracellular matrices control directional capillary sprouting J Cell Sci 112 Pt 19 3249 3258 10504330 1:CAS:528:DyaK1MXntFOjurY%3D (Pubitemid 29507205)
    • (1999) Journal of Cell Science , vol.112 , Issue.19 , pp. 3249-3258
    • Korff, T.1    Augustin, H.G.2
  • 35
    • 31344458952 scopus 로고    scopus 로고
    • Structure and function of matrix metalloproteinases and TIMPs
    • DOI 10.1016/j.cardiores.2005.12.002, PII S0008636305005651
    • H Nagase R Visse G Murphy 2006 Structure and function of matrix metalloproteinases and TIMPs Cardiovasc Res 69 3 562 573 16405877 10.1016/j.cardiores.2005.12.002 1:CAS:528:DC%2BD28XotVKitg%3D%3D (Pubitemid 43139720)
    • (2006) Cardiovascular Research , vol.69 , Issue.3 , pp. 562-573
    • Nagase, H.1    Visse, R.2    Murphy, G.3
  • 36
    • 0035188727 scopus 로고    scopus 로고
    • How matrix metalloproteinases regulate cell behavior
    • DOI 10.1146/annurev.cellbio.17.1.463
    • MD Sternlicht Z Werb 2001 How matrix metalloproteinases regulate cell behavior Annu Rev Cell Dev Biol 17 463 516 11687497 10.1146/annurev.cellbio.17. 1.463 1:CAS:528:DC%2BD3MXos1Omsbs%3D (Pubitemid 33096184)
    • (2001) Annual Review of Cell and Developmental Biology , vol.17 , pp. 463-516
    • Sternlicht, M.D.1    Werb, Z.2
  • 37
    • 0028947020 scopus 로고
    • Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type i collagen generating the specific 3/4- and 1/4-length fragments
    • 7890717 10.1074/jbc.270.11.5872 1:CAS:528:DyaK2MXksVCntrk%3D
    • RT Aimes JP Quigley 1995 Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments J Biol Chem 270 11 5872 5876 7890717 10.1074/jbc.270.11.5872 1:CAS:528:DyaK2MXksVCntrk%3D
    • (1995) J Biol Chem , vol.270 , Issue.11 , pp. 5872-5876
    • Aimes, R.T.1    Quigley, J.P.2
  • 38
    • 0035903020 scopus 로고    scopus 로고
    • Specific collagenolysis by gelatinase A, MMP-2, is determined by the hemopexin domain and not the fibronectin-like domain
    • DOI 10.1016/S0014-5793(01)02723-5, PII S0014579301027235
    • ML Patterson SJ Atkinson V Knauper G Murphy 2001 Specific collagenolysis by gelatinase A, MMP-2, is determined by the hemopexin domain and not the fibronectin-like domain FEBS Lett 503 2-3 158 162 11513874 10.1016/S0014- 5793(01)02723-5 1:CAS:528:DC%2BD3MXmtFWit7w%3D (Pubitemid 32763197)
    • (2001) FEBS Letters , vol.503 , Issue.2-3 , pp. 158-162
    • Patterson, M.L.1    Atkinson, S.J.2    Knauper, V.3    Murphy, G.4
  • 39
    • 8644267728 scopus 로고    scopus 로고
    • TIMP-1 inhibits microvascular endothelial cell migration by MMP-dependent and MMP-independent mechanisms
    • DOI 10.1016/j.yexcr.2004.08.002, PII S0014482704004410
    • T Akahane M Akahane A Shah CM Connor UP Thorgeirsson 2004 TIMP-1 inhibits microvascular endothelial cell migration by MMP-dependent and MMP-independent mechanisms Exp Cell Res 301 2 158 167 10.1016/j.yexcr.2004.08.002 15530852 10.1016/j.yexcr.2004.08.002 1:CAS:528:DC%2BD2cXpsVOksLg%3D (Pubitemid 39504969)
    • (2004) Experimental Cell Research , vol.301 , Issue.2 , pp. 158-167
    • Akahane, T.1    Akahane, M.2    Shah, A.3    Connor, C.M.4    Thorgeirsson, U.P.5
  • 40
    • 54049107708 scopus 로고    scopus 로고
    • Role of the hemopexin domain of matrix metalloproteinases in cell migration
    • 10.1002/jcp.21535 18636552 10.1002/jcp.21535 1:CAS:528:DC%2BD1cXhtlOqt73J
    • A Dufour NS Sampson S Zucker J Cao 2008 Role of the hemopexin domain of matrix metalloproteinases in cell migration J Cell Physiol 217 3 643 651 10.1002/jcp.21535 18636552 10.1002/jcp.21535 1:CAS:528:DC%2BD1cXhtlOqt73J
    • (2008) J Cell Physiol , vol.217 , Issue.3 , pp. 643-651
    • Dufour, A.1    Sampson, N.S.2    Zucker, S.3    Cao, J.4
  • 41
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • 19249680 10.1016/j.ccr.2009.01.027 1:CAS:528:DC%2BD1MXltFSmtbY%3D
    • M Paez-Ribes E Allen J Hudock T Takeda H Okuyama F Vinals M Inoue G Bergers D Hanahan O Casanovas 2009 Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis Cancer Cell 15 3 220 231 19249680 10.1016/j.ccr.2009.01.027 1:CAS:528: DC%2BD1MXltFSmtbY%3D
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3    Takeda, T.4    Okuyama, H.5    Vinals, F.6    Inoue, M.7    Bergers, G.8    Hanahan, D.9    Casanovas, O.10
  • 42
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • 19249681 10.1016/j.ccr.2009.01.021 1:CAS:528:DC%2BD1MXltFSmtbc%3D
    • JM Ebos CR Lee W Cruz-Munoz GA Bjarnason JG Christensen RS Kerbel 2009 Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis Cancer Cell 15 3 232 239 19249681 10.1016/j.ccr.2009.01.021 1:CAS:528:DC%2BD1MXltFSmtbc%3D
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.