Common variants of the ACE gene and aneurysmal subarachnoid hemorrhage in a danish population: A case-control study

Journal of Neurosurgical Anesthesiology

Volumn 23, Issue 4, 2011, Pages 304-309

  Staalsø, Jonatan Myrup ^a   Nielsen, Morten ^a   Edsen, Troels ^a   Koefoed, Pernille ^a   Springborg, Jacob Bertram ^a   Moltke, Finn Borgbjerg ^a   Laursen, Henning ^a   Nielsen, Henning Bay ^a   Olsen, Niels Vidiendal ^a  

^a Rigshospitalet   (Denmark)

Author keywords

angiotensin converting enzyme; genetic polymorphism; haplotype; intracranial aneurysm; subarachnoid hemorrhage

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ACE GENE; ADULT; AGED; ALLELE; ARTICLE; BRAIN ARTERY ANEURYSM; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GENE; GENE DELETION; GENE INSERTION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HOMOZYGOTE; HUMAN; INTRACRANIAL ANEURYSM; INTRON; MAJOR CLINICAL STUDY; MALE; MIDDLE CEREBRAL ARTERY; POPULATION RESEARCH; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SUBARACHNOID HEMORRHAGE;

ADOLESCENT; ADULT; AGED; ALLELES; CASE-CONTROL STUDIES; DENMARK; DNA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, SINGLE NUCLEOTIDE; SUBARACHNOID HEMORRHAGE; YOUNG ADULT;

EID: 80052708117     PISSN: 08984921     EISSN: 15371921     Source Type: Journal    
DOI: 10.1097/ANA.0b013e318225c979     Document Type: Article

References (36)

1. Feigin VL, Rinkel GJE, Lawes CMM, et al. Risk factors for subarachnoid hemorrhage: an updated systematic review of epidemiological studies. Stroke. 2005;36:2773-2780.
2. Schievink WI, Schaid DJ, Michels VV, et al. Familial aneurysmal subarachnoid hemorrhage: a community-based study. J Neurosurg. 1995;83:426-429.
3. Fischer T, Johnsen SP, Pedersen L, et al. Seasonal variation in hospitalization and case fatality of subarachnoid hemorrhageFa nationwide Danish study on 9,367 patients. Neuroepidemiology. 2005;24:32-37. (Pubitemid 39664105)
4. Ronkainen A, Hernesniemi J, Ryynanen M. Familial subarachnoid hemorrhage in east Finland, 1977-1990. Neurosurgery. 1993;33: 787-796; discussion 796-797.
5. Lindgaard L, Eskesen V, Gjerris F, et al. Familial aggregation of intracranial aneurysms in an Inuit patient population in Kalaallit Nunaat (Greenland). Neurosurgery. 2003;52:357-362; discussion 362-363.
6. Agerholm-Larsen B, Tybjaerg-Hansen A, Schnohr P, et al. ACE gene polymorphism explains 30% to 40% of variability in serum ACE activity in both women and men in the population at large: the Copenhagen City Heart Study. Atherosclerosis. 1999;147:425-427. (Pubitemid 29512279)
7. Slowik A, Borratynska A, Pera J, et al. II genotype of the angiotensin-converting enzyme gene increases the risk for subar-achnoid hemorrhage from ruptured aneurysm. Stroke. 2004;35: 1594-1597. (Pubitemid 38823631)
8. Pannu H, Kim DH, Seaman CR, et al. Lack of an association between the angiotensin-converting enzyme insertion/deletion polymorphism and intracranial aneurysms in a Caucasian population in the United States. J Neurosurg. 2005;103:92-96. (Pubitemid 43193940)
9. Keramatipour M, McConnell RS, Kirkpatrick P, et al. The ACE I allele is associated with increased risk for ruptured intracranial aneurysms. J Med Genet. 2000;37:498-500. (Pubitemid 30428235)
10. Little J, Higgins JPT, Ioannidis JPA, et al. Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement. J Clin Epidemiol. 2009;62:597-608.
11. Springborg JB, Møller C, Gideon P, et al. Erythropoietin in patients with aneurysmal subarachnoid haemorrhage: a double blind randomised clinical trial. Acta Neurochir (Wien). 2007;149: 1089-1101.
12. Keavney B, McKenzie CA, Connell JM, et al. Measured haplotype analysis of the angiotensin-I converting enzyme gene. Hum Mol Genet. 1998;7:1745-1751. (Pubitemid 28464149)
13. Suehiro T, Morita T, Inoue M, et al. Increased amount of the angiotensin-converting enzyme (ACE) mRNA originating from the ACE allele with deletion. Hum Genet. 2004;115:91-96. (Pubitemid 39010922)
14. Shanmugam V, Sell KW, Saha BK. Mistyping ACE heterozygotes. PCR Methods Appl. 1993;3:120-121.
15. Warnes G with contributions from Gregor Gorjanc, Friedrich Leisch and Michael Man. Genetics: Population Genetics. R package version 1.3.4. 2008. Available at http://www.R-project.org. (Accessed 3 November 2010).
16. Development Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. 2010. Available at: http://www.R-project.org. (Accessed 3 November 2010).
17. Genz A, Bretz F, Miwa T, et al. mvtnorm: Multivariate Normal and t Distributions. R package version 0.9-92. 2010. Available at: http://CRAN.R-project.org/package=mvtnorm. (Accessed 3 November 2010).
18. Genz A, Bretz F. Computation of Multivariate Normal and t Probabilities. Lecture Notes in Statistics. Vol. 195. Heidelberg: Springer-Verlage; 2009.
19. Conneely KN, Boehnke M. So Many Correlated Tests, So Little Time! Rapid Adjustment of P Values for Multiple Correlated Tests. Am J Hum Genet. 2007;81. Available at: http://www.ncbi.nlm.nih.gov.ep.fjernadgang.kb.dk/pubmed/17966093. (Accessed 3 November 2010).
20. Stephens M, Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet. 2003;73:1162-1169. (Pubitemid 37414228)
21. Kongable GL, Lanzino G, Germanson TP, et al. Gender-related differences in aneurysmal subarachnoid hemorrhage. J Neurosur-gery. 1996;84:43-48. (Pubitemid 26006995)
22. McColgan P, Thant KZ, Sharma P. The genetics of sporadic ruptured and unruptured intracranial aneurysms: a genetic meta-analysis of 8 genes and 13 polymorphisms in approximately 20,000 individuals. J Neurosurg. 2010;112:714-721.
23. Yasuno K, Bilguvar K, Bijlenga P, et al. Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nat Genet. 2010;42:420-425.
24. Agerholm-Larsen B, Tybjaerg-Hansen A, Frikke-Schmidt R, et al. ACE gene polymorphism as a risk factor for ischemic cerebrovas-cular disease. Ann Intern Med. 1997;127:346-355. (Pubitemid 27362742)
25. Rigat B, Hubert C, Alhenc-Gelas F, et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990;86:1343-1346. (Pubitemid 20370444)
26. Danser AH, Schalekamp MA, Bax WA, et al. Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation. 1995;92:1387-1388.
27. Catto A, Carter AM, Barrett JH, et al. Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Cerebrovascular Disease. Stroke. 1996;27:435-440. (Pubitemid 26081438)
28. Sayed-Tabatabaei FA, Oostra BA, Isaacs A, et al. ACE polymorphisms. Circ Res. 2006;98:1123-1133. (Pubitemid 43948098)
29. Kehoe PG, Katzov H, Feuk L, et al. Haplotypes extending across ACE are associated with Alzheimer's disease. Hum Mol Genet. 2003;12:859-867. (Pubitemid 36504028)
30. Ohkuma H, Suzuki S, Fujita S, et al. Role of a decreased expression of the local renin-angiotensin system in the etiology of cerebral aneurysms. Circulation. 2003;108:785-787. (Pubitemid 37022117)
31. Ariza M, del Matarin M, Junque C, et al. Influence of angiotensin-converting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2006;18:39-44. (Pubitemid 43277255)
32. Paulson OB, Strandgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev. 1990;2:161-192.
33. Fassot C, Lambert G, Elghozi JL, et al. Impact of the renin-angiotensin system on cerebral perfusion following subarachnoid haemorrhage in the rat. J Physiol. 2001;535:533-540. (Pubitemid 32825688)
34. Andrews P, Papadakis N, Gavras H. Reversal of experimental acute cerebral vasospasm by angiotensin converting enzyme. Stroke. 1982;13:480-483. (Pubitemid 12040067)
35. Katzov H, Bennet AM, Kehoe P, et al. A cladistic model of ACE sequence variation with implications for myocardial infarction, Alzheimer disease and obesity. Hum Mol Genet. 2004; 13:2647-2657. (Pubitemid 39485413)
36. Fenger M, Linneberg A, Werge T, et al. Analysis of heterogeneity and epistasis in physiological mixed populations by combined structural equation modelling and latent class analysis. BMC Genet. 2008;9:43 doi:10.1186/1471-2156- 9-43.