Are glutathione S-transferase null genotypes "null and void" of risk for ischemic vascular disease?

Circulation: Cardiovascular Genetics

Volumn 4, Issue 4, 2011, Pages 339-341

  Conklin, Daniel J ^a   Bhatnagar, Aruni ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Coronary disease; Editorials; Genetic polymorphisms; Metaanalysis; Polymorphism genetics

Indexed keywords

GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE T1;

CANCER RISK; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COPY NUMBER VARIATION; DETOXIFICATION; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ETHNIC DIFFERENCE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC POLYMORPHISM; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HUMAN GENOME; ISCHEMIC HEART DISEASE; META ANALYSIS (TOPIC); NULL ALLELE; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SMOKING; STUDY DESIGN; UPREGULATION;

DNA COPY NUMBER VARIATIONS; FEMALE; GLUTATHIONE TRANSFERASE; HUMANS; MALE; VASCULAR DISEASES;

EID: 80052704450     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.111.960526     Document Type: Review

References (11)

1. Bhatnagar A. Environmental cardiology: studying mechanistic links between pollution and heart disease. Circ Res. 2006;99:692-705. (Pubitemid 44498303)
2. Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005;45:51-88. (Pubitemid 40261798)
3. Noskov MS, Frikke-Schmidt R, Loft S, Sillesen H, Grande P, Nordestgaard BG, Tyjaerg-Hansen A. Copy number variation in glutathione S-transferases M1 and T1 and ischemic vascular disease: four studies and meta-analysis. Circ Cardio Genetics. 2011;4:418-428.
4. Conklin DJ, Haberzettl P, Lesgards JF, Prough RA, Srivastava S, Bhatnagar A. Increased sensitivity of glutathione s-transferase p-null mice to cyclophosphamide-induced urinary bladder toxicity. J Pharmacol Exp Ther. 2009;331:456-469.
5. Wang J, Zou L, Huang S, Lu F, Lang X, Han L, Song Z, Xu Z. Genetic polymorphisms of glutathione s-transferase genes gstm1, gstt1 and risk of coronary heart disease. Mutagenesis. 2010;25:365-369.
6. Wilson MH, Grant PJ, Hardie LJ, Wild CP. Glutathione S-transferase m1 null genotype is associated with a decreased risk of myocardial infarction. FASEB J. 2000;14:791-796. (Pubitemid 30198577)
7. Martin NJ, Collier AC, Bowen LD, Pritsos KL, Goodrich GG, Arger K, Cutter G, Pritsos CA. Polymorphisms in the NQO1, GSTT and GSTM genes are associated with coronary heart disease and biomarkers of oxidative stress. Mutat Res. 2009;674:93-100.
8. Ramana KV, Bhatnagar A, Srivastava S, Yadav UC, Awasthi S, Awasthi YC, Srivastava SK. Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNEglutathione conjugates in regulating cell growth. J Biol Chem. 2006;281: 17652-17660. (Pubitemid 44043077)
9. Pope CA III, Burnett RT, Krewski D, Jerrett M, Shi Y, Calle EE, Thun MJ. Cardiovascular mortality and exposure to airborne fine particulate matter and cigarette smoke: shape of the exposure-response relationship. Circulation. 2009;120:941-948.
10. Schane RE, Ling PM, Glantz SA. Health effects of light and intermittent smoking: a review. Circulation. 2010;121:1518-1522.
11. Barnoya J, Glantz SA. Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation. 2005;111:2684-2698. (Pubitemid 40740869)