-
1
-
-
0028783948
-
The national institute of neurological disorders and stroke rt-pa stroke study group: Tissue plasminogen activator for acute ischemic stroke
-
The national institute of neurological disorders and stroke rt-pa stroke study group: Tissue plasminogen activator for acute ischemic stroke. N Engl J Med (1995) 333: 1581-1587.
-
(1995)
N Engl J Med
, vol.333
, pp. 1581-1587
-
-
Jayanthi, J.1
-
2
-
-
0343118114
-
The ninds t-pa stroke study group: Intracerebral hemorrhage after intravenous t-pa therapy for ischemic stroke
-
The ninds t-pa stroke study group: Intracerebral hemorrhage after intravenous t-pa therapy for ischemic stroke. Stroke (1997) 28: 2109-2118.
-
(1997)
Stroke
, vol.28
, pp. 2109-2118
-
-
-
3
-
-
32144461723
-
Stroke and neurovascular protection
-
del Zoppo GJ: Stroke and neurovascular protection. N Engl J Med (2006) 354: 553-555.
-
(2006)
N Engl J Med
, vol.354
, pp. 553-555
-
-
del Zoppo, G.J.1
-
4
-
-
48249103532
-
Tissue plasminogen activator (tpa) and matrix metalloproteinases in the pathogenesis of stroke: Therapeutic strategies
-
Adibhatla RM and Hatcher JF: Tissue plasminogen activator (tpa) and matrix metalloproteinases in the pathogenesis of stroke: Therapeutic strategies. CNS Neurol Disord Drug Targets (2008) 7: 243-253.
-
(2008)
CNS Neurol Disord Drug Targets
, vol.7
, pp. 243-253
-
-
Adibhatla, R.M.1
Hatcher, J.F.2
-
5
-
-
77952513645
-
Inflammatory mechanisms in ischemic stroke: Role of inflammatory cells
-
Jin R, Yang G and Li G: Inflammatory mechanisms in ischemic stroke: Role of inflammatory cells. J Leukoc Biol (2010) 87: 779-789.
-
(2010)
J Leukoc Biol
, vol.87
, pp. 779-789
-
-
Jin, R.1
Yang, G.2
Li, G.3
-
6
-
-
0348141856
-
Neutrophil infiltration increases matrix metallopro-teinase-9 in the ischemic brain after occlusion/reperfusion of the middle cerebral artery in rats
-
Justicia C, Panes J, Sole S, Cervera A, Deulofeu R, Chamorro A and Planas AM: Neutrophil infiltration increases matrix metallopro-teinase-9 in the ischemic brain after occlusion/reperfusion of the middle cerebral artery in rats. J Cereb Blood Flow Metab (2003) 23: 1430-1440.
-
(2003)
J Cereb Blood Flow Metab
, vol.23
, pp. 1430-1440
-
-
Justicia, C.1
Panes, J.2
Sole, S.3
Cervera, A.4
Deulofeu, R.5
Chamorro, A.6
Planas, A.M.7
-
7
-
-
58149357031
-
Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice
-
McColl BW, Rothwell NJ and Allan SM: Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice. J Neurosci (2008) 28: 9451-9462.
-
(2008)
J Neurosci
, vol.28
, pp. 9451-9462
-
-
McColl, B.W.1
Rothwell, N.J.2
Allan, S.M.3
-
8
-
-
0035478029
-
Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia
-
Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, Fini ME and Lo EH: Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci (2001) 21: 7724-7732.
-
(2001)
J Neurosci
, vol.21
, pp. 7724-7732
-
-
Asahi, M.1
Wang, X.2
Mori, T.3
Sumii, T.4
Jung, J.C.5
Moskowitz, M.A.6
Fini, M.E.7
Lo, E.H.8
-
9
-
-
34548204870
-
Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracerebral hemorrhage
-
Lee CZ, Xue Z, Zhu Y, Yang GY and Young WL: Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracerebral hemorrhage. Stroke (2007) 38: 2563-2568.
-
(2007)
Stroke
, vol.38
, pp. 2563-2568
-
-
Lee, C.Z.1
Xue, Z.2
Zhu, Y.3
Yang, G.Y.4
Young, W.L.5
-
10
-
-
33947493391
-
Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
-
Yang Y, Estrada EY, Thompson JF, Liu W and Rosenberg GA: Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab (2007) 27: 697-709.
-
(2007)
J Cereb Blood Flow Metab
, vol.27
, pp. 697-709
-
-
Yang, Y.1
Estrada, E.Y.2
Thompson, J.F.3
Liu, W.4
Rosenberg, G.A.5
-
11
-
-
0031459856
-
Increased gelatinase a (mmp-2) and gelatinase b (mmp-9) activities in human brain after focal ischemia
-
Clark AW, Krekoski CA, Bou SS, Chapman KR and Edwards DR: Increased gelatinase a (mmp-2) and gelatinase b (mmp-9) activities in human brain after focal ischemia. Neurosci Lett (1997) 238: 53-56.
-
(1997)
Neurosci Lett
, vol.238
, pp. 53-56
-
-
Clark, A.W.1
Krekoski, C.A.2
Bou, S.S.3
Chapman, K.R.4
Edwards, D.R.5
-
12
-
-
0037418038
-
Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke
-
Montaner J, Molina CA, Monasterio J, Abilleira S, Arenillas JF, Ribo M, Quintana M and Alvarez-Sabin J: Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke. Circulation (2003) 107: 598-603.
-
(2003)
Circulation
, vol.107
, pp. 598-603
-
-
Montaner, J.1
Molina, C.A.2
Monasterio, J.3
Abilleira, S.4
Arenillas, J.F.5
Ribo, M.6
Quintana, M.7
Alvarez-Sabin, J.8
-
13
-
-
34249822233
-
Serum cellular fibronectin and matrix metalloproteinase-9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke: A multicenter confirmatory study
-
Castellanos M, Sobrino T, Millan M, Garcia M, Arenillas J, Nombela F, Brea D, Perez de la Ossa N, Serena J, Vivancos J, Castillo J and Davalos A: Serum cellular fibronectin and matrix metalloproteinase-9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke: A multicenter confirmatory study. Stroke (2007) 38: 1855-1859.
-
(2007)
Stroke
, vol.38
, pp. 1855-1859
-
-
Castellanos, M.1
Sobrino, T.2
Millan, M.3
Garcia, M.4
Arenillas, J.5
Nombela, F.6
Brea, D.7
Perez de la Ossa, N.8
Serena, J.9
Vivancos, J.10
Castillo, J.11
Davalos, A.12
-
14
-
-
0035149749
-
Reactive oxygen radicals in signaling and damage in the ischemic brain
-
Chan PH: Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab (2001) 21: 2-14.
-
(2001)
J Cereb Blood Flow Metab
, vol.21
, pp. 2-14
-
-
Chan, P.H.1
-
15
-
-
33744815599
-
Evaluating therapeutic targets for reperfusion-related brain hemorrhage
-
Maier CM, Hsieh L, Crandall T, Narasimhan P and Chan PH: Evaluating therapeutic targets for reperfusion-related brain hemorrhage. Ann Neurol (2006) 59: 929-938.
-
(2006)
Ann Neurol
, vol.59
, pp. 929-938
-
-
Maier, C.M.1
Hsieh, L.2
Crandall, T.3
Narasimhan, P.4
Chan, P.H.5
-
16
-
-
34249845166
-
Neurotoxic effects of exogenous recombinant tissue-type plasminogen activator on the normal rat brain
-
Goto H, Fujisawa H, Oka F, Nomura S, Kajiwara K, Kato S, Fujii M, Maekawa T and Suzuki M: Neurotoxic effects of exogenous recombinant tissue-type plasminogen activator on the normal rat brain. J Neurotrauma (2007) 24: 745-752.
-
(2007)
J Neurotrauma
, vol.24
, pp. 745-752
-
-
Goto, H.1
Fujisawa, H.2
Oka, F.3
Nomura, S.4
Kajiwara, K.5
Kato, S.6
Fujii, M.7
Maekawa, T.8
Suzuki, M.9
-
17
-
-
24644519846
-
Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia
-
Tsuji K, Aoki T, Tejima E, Arai K, Lee SR, Atochin DN, Huang PL, Wang X, Montaner J and Lo EH: Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke (2005) 36: 1954-1959.
-
(2005)
Stroke
, vol.36
, pp. 1954-1959
-
-
Tsuji, K.1
Aoki, T.2
Tejima, E.3
Arai, K.4
Lee, S.R.5
Atochin, D.N.6
Huang, P.L.7
Wang, X.8
Montaner, J.9
Lo, E.H.10
-
18
-
-
0034836428
-
Lrp: A multifunctional scavenger and signaling receptor
-
Herz J and Strickland DK: Lrp: A multifunctional scavenger and signaling receptor. J Clin Invest (2001) 108: 779-784.
-
(2001)
J Clin Invest
, vol.108
, pp. 779-784
-
-
Herz, J.1
Strickland, D.K.2
-
19
-
-
34147143557
-
Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit
-
Polavarapu R, Gongora MC, Yi H, Ranganthan S, Lawrence DA, Strickland D and Yepes M: Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit. Blood (2007) 109: 3270-3278.
-
(2007)
Blood
, vol.109
, pp. 3270-3278
-
-
Polavarapu, R.1
Gongora, M.C.2
Yi, H.3
Ranganthan, S.4
Lawrence, D.A.5
Strickland, D.6
Yepes, M.7
-
20
-
-
20944452152
-
Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis
-
Benchenane K, Berezowski V, Ali C, Fernandez-Monreal M, Lopez-Atalaya JP, Brillault J, Chuquet J, Nouvelot A, MacKenzie ET, Bu G, Cecchelli R, Touzani O and Vivien D: Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis. Circulation (2005) 111: 2241-2249.
-
(2005)
Circulation
, vol.111
, pp. 2241-2249
-
-
Benchenane, K.1
Berezowski, V.2
Ali, C.3
Fernandez-Monreal, M.4
Lopez-Atalaya, J.P.5
Brillault, J.6
Chuquet, J.7
Nouvelot, A.8
MacKenzie, E.T.9
Bu, G.10
Cecchelli, R.11
Touzani, O.12
Vivien, D.13
-
21
-
-
0142137232
-
Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator
-
Wang X, Lee SR, Arai K, Tsuji K, Rebeck GW and Lo EH: Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med (2003) 9: 1313-1317.
-
(2003)
Nat Med
, vol.9
, pp. 1313-1317
-
-
Wang, X.1
Lee, S.R.2
Arai, K.3
Tsuji, K.4
Rebeck, G.W.5
Lo, E.H.6
-
22
-
-
33750704292
-
Activated protein c inhibits tissue plasminogen activator-induced brain hemorrhage
-
Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernandez JA, LaRue B, Griffin JH, Chopp M and Zlokovic BV: Activated protein c inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med (2006) 12: 1278-1285.
-
(2006)
Nat Med
, vol.12
, pp. 1278-1285
-
-
Cheng, T.1
Petraglia, A.L.2
Li, Z.3
Thiyagarajan, M.4
Zhong, Z.5
Wu, Z.6
Liu, D.7
Maggirwar, S.B.8
Deane, R.9
Fernandez, J.A.10
LaRue, B.11
Griffin, J.H.12
Chopp, M.13
Zlokovic, B.V.14
-
23
-
-
63949085383
-
Dissociation and protection of the neurovascular unit after thrombolysis and reperfu-sion in ischemic rat brain
-
Yamashita T, Kamiya T, Deguchi K, Inaba T, Zhang H, Shang J, Miyazaki K, Ohtsuka A, Katayama Y and Abe K: Dissociation and protection of the neurovascular unit after thrombolysis and reperfu-sion in ischemic rat brain. J Cereb Blood Flow Metab (2009) 29: 715-725.
-
(2009)
J Cereb Blood Flow Metab
, vol.29
, pp. 715-725
-
-
Yamashita, T.1
Kamiya, T.2
Deguchi, K.3
Inaba, T.4
Zhang, H.5
Shang, J.6
Miyazaki, K.7
Ohtsuka, A.8
Katayama, Y.9
Abe, K.10
-
24
-
-
0037229213
-
Edaravone Acute Infarction Study Group: Effect of a novel free radical scavenger, edaravone (mci-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters
-
Edaravone Acute Infarction Study Group: Effect of a novel free radical scavenger, edaravone (mci-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis (2003) 15: 222-229.
-
(2003)
Cerebrovasc Dis
, vol.15
, pp. 222-229
-
-
-
25
-
-
32144453826
-
Stroke-Acute Ischemic NXY Treatment (SAINT) Trial Investigators: Nxy-059 for acute ischemic stroke
-
Lees KR, Zivin JA, Ashwood T, Davalos A, Davis SM, Diener HC, Grotta J, Lyden P, Shuaib A, Hardemark HG and Wasiewski WW; Stroke-Acute Ischemic NXY Treatment (SAINT) Trial Investigators: Nxy-059 for acute ischemic stroke. N Engl J Med (2006) 354: 588-600.
-
(2006)
N Engl J Med
, vol.354
, pp. 588-600
-
-
Lees, K.R.1
Zivin, J.A.2
Ashwood, T.3
Davalos, A.4
Davis, S.M.5
Diener, H.C.6
Grotta, J.7
Lyden, P.8
Shuaib, A.9
Hardemark, H.G.10
Wasiewski, W.W.11
-
26
-
-
34547795720
-
SAINT n Trial Investigators: Nxy-059 for the treatment of acute ischemic stroke
-
Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, Diener HC, Ashwood T, Wasiewski WW and Emeribe U; SAINT II Trial Investigators: Nxy-059 for the treatment of acute ischemic stroke. N Engl J Med (2007) 357: 562-571.
-
(2007)
N Engl J Med
, vol.357
, pp. 562-571
-
-
Shuaib, A.1
Lees, K.R.2
Lyden, P.3
Grotta, J.4
Davalos, A.5
Davis, S.M.6
Diener, H.C.7
Ashwood, T.8
Wasiewski, W.W.9
Emeribe, U.10
-
27
-
-
0000393508
-
Antioxidant activity of 3-methyl-l-phenyl-2-pyrazolin-5-one
-
Yamamoto Y KT, Watanabe K, Watanabe K: Antioxidant activity of 3-methyl-l-phenyl-2-pyrazolin-5-one. Redox Rep (1996) 2: 333-338.
-
(1996)
Redox Rep
, vol.2
, pp. 333-338
-
-
Yamamoto, Y.1
Watanabe, K.T.2
Watanabe, K.K.3
-
28
-
-
46749118298
-
Activation of pdgf-cc by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
-
Su EJ, Fredriksson L, Geyer M, Folestad E, Cale J, Andrae J, Gao Y, Pietras K, Mann K, Yepes M, Strickland DK, Betsholtz C, Eriksson U and Lawrence DA: Activation of pdgf-cc by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke. Nat Med (2008) 14: 731-737.
-
(2008)
Nat Med
, vol.14
, pp. 731-737
-
-
Su, E.J.1
Fredriksson, L.2
Geyer, M.3
Folestad, E.4
Cale, J.5
Andrae, J.6
Gao, Y.7
Pietras, K.8
Mann, K.9
Yepes, M.10
Strickland, D.K.11
Betsholtz, C.12
Eriksson, U.13
Lawrence, D.A.14
-
29
-
-
53749085742
-
Melatonin decreases matrix metallo proteinase-9 activation and expression and attenuates reperfusion-induced hemorrhage following transient focal cerebral ischemia in rats
-
HungYC, Chen TY, Lee EJ, Chen WL, Huang SY, Lee WT, Lee MY, Chen HY and Wu TS: Melatonin decreases matrix metallo proteinase-9 activation and expression and attenuates reperfusion-induced hemorrhage following transient focal cerebral ischemia in rats. J Pineal Res (2008) 45: 459-467.
-
(2008)
J Pineal Res
, vol.45
, pp. 459-467
-
-
Hung, Y.C.1
Chen, T.Y.2
Lee, E.J.3
Chen, W.L.4
Huang, S.Y.5
Lee, W.T.6
Lee, M.Y.7
Chen, H.Y.8
Wu, T.S.9
-
30
-
-
0036195260
-
Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats
-
Sumii T and Lo EH: Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats. Stroke (2002) 33: 831-836.
-
(2002)
Stroke
, vol.33
, pp. 831-836
-
-
Sumii, T.1
Lo, E.H.2
-
31
-
-
58149357102
-
Extension of the thrombolytic time window with minocycline in experimental stroke
-
Murata Y, Rosell A, Scannevin RH, Rhodes KJ, Wang X and Lo EH: Extension of the thrombolytic time window with minocycline in experimental stroke. Stroke (2008) 39: 3372-3377.
-
(2008)
Stroke
, vol.39
, pp. 3372-3377
-
-
Murata, Y.1
Rosell, A.2
Scannevin, R.H.3
Rhodes, K.J.4
Wang, X.5
Lo, E.H.6
-
32
-
-
0036281174
-
Effects of the spin trap agent disodium- [(tert-butylimino) methyl] benzene-1, 3-disulfonate n-oxide (generic nxy-059) on intracerebral hemorrhage in a rabbit large clot embolic stroke model: Combination studies with tissue plasminogen activator
-
Lapchak PA, Araujo DM, Song D, Wei J, Purdy R and Zivin JA: Effects of the spin trap agent disodium- [(tert-butylimino) methyl] benzene-1, 3-disulfonate n-oxide (generic nxy-059) on intracerebral hemorrhage in a rabbit large clot embolic stroke model: Combination studies with tissue plasminogen activator. Stroke (2002) 33: 1665-1670.
-
(2002)
Stroke
, vol.33
, pp. 1665-1670
-
-
Lapchak, P.A.1
Araujo, D.M.2
Song, D.3
Wei, J.4
Purdy, R.5
Zivin, J.A.6
|