Leukemia inhibitory factor downregulates human papillomavirus-16 oncogene expression and inhibits the proliferation of cervical carcinoma cells

Infectious Diseases in Obstetrics and Gynecology

Volumn 2011, Issue , 2011, Pages

  Teng, Nelson N H ^a   Bay, Joseph M ^a   Patterson, Bruce K ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKEMIA INHIBITORY FACTOR; LUCIFERASE; MESSENGER RNA; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN;

ARTICLE; CELL CYCLE REGULATION; CELL DEATH; CELL PROLIFERATION; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 6; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REGULATOR GENE; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA; VIRUS ONCOGENE; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; METABOLISM; ONCOGENE; PATHOLOGY; PHOSPHORYLATION; PROMOTER REGION; TUMOR CELL LINE; UTERINE CERVIX TUMOR; VIROLOGY; VIRUS CELL TRANSFORMATION;

CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, VIRAL; DOWN-REGULATION; FEMALE; HUMAN PAPILLOMAVIRUS 16; HUMANS; LEUKEMIA INHIBITORY FACTOR; LUCIFERASES; ONCOGENES; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TRANSFECTION; UTERINE CERVICAL NEOPLASMS;

EID: 80052676053     PISSN: 10647449     EISSN: 10980997     Source Type: Journal    
DOI: 10.1155/2011/463081     Document Type: Article

References (33)

1. Zur Hausen H., Human papillomaviruses in the pathogenesis of anogenital cancer Virology 1991 184 1 9 13
2. Walboomers J. M., Jacobs M. V., Manos M. M., Bosch F. X., Kummer J. A., Shah K. V., Snijders P. J. F., Peto J., Meijer C. J. L. M., Muoz N., Human papillomavirus is a necessary cause of invasive cervical cancer worldwide Journal of Pathology 1999 189 1 12 19 (Pubitemid 29406813)
3. Jones S. B., Cancer in the developing world: a call to action British Medical Journal 1999 319 7208 505 508 (Pubitemid 29391364)
4. Pecorelli S., Favalli G., Zigliani L., Odicino F., Cancer in women International Journal of Gynecology and Obstetrics 2003 82 3 369 379 (Pubitemid 37120520)
5. Scheurlen W., Stremlau A., Gissmann L., Rearranged HPV 16 molecules in an anal and in a laryngeal carcinoma International Journal of Cancer 1986 38 5 671 676 (Pubitemid 17189125)
6. Niv A., Sion-Vardi N., Gatot A., Nash M., Fliss D. M., Identification and typing of human papillomavirus (HPV) in squamous cell carcinoma of the oral cavity and oropharynx Journal of Laryngology and Otology 2000 114 1 41 46 (Pubitemid 30040199)
7. Amarante M. K., Watanabe M. A., The possible involvement of virus in breast cancer Journal of Cancer Research and Clinical Oncology 2009 135 3 329 337
8. Narimatsu R., Patterson B. K., High-throughput cervical cancer screening using intracellular human papillomavirus E6 and E7 mRNA quantification by flow cytometry American Journal of Clinical Pathology 2005 123 5 716 723 (Pubitemid 40586489)
9. Yasmeen A., Bismar T. A., Kandouz M., Foulkes W. D., Desprez P. Y., Al Moustafa A. E., E6/E7 of HPV type 16 promotes cell invasion and metastasisof human breast cancer cells Cell Cycle 2007 6 16 2038 2042 (Pubitemid 47327892)
10. Yoshida S., Kajitani N., Satsuka A., Nakamura H., Sakai H., Ras modifies proliferation and invasiveness of cells expressing human papillomavirus oncoproteins Journal of Virology 2008 82 17 8820 8827
11. Amine A., Rivera S., Opolon P., Dekkal M., Biard D. S. F., Bouamar H., Louache F., McKay M. J., Bourhis J., Deutsch E., Vozenin-Brotons M. C., Novel anti-metastatic action of cidofovir mediated by inhibition of E6/E7, CXCR4 and Rho/ROCK signaling in HPV tumor cells PLoS ONE 2009 4 3
12. Jiang M., Milner J., Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference Oncogene 2002 21 39 6041 6048
13. Butz K., Denk C., Ullmann A., Scheffner M., Hoppe-Seyler F., Induction of apoptosis in human papillomavirus-positive cancer cells by peptide aptamers targeting the viral E6 oncoprotein Proceedings of the National Academy of Sciences of the United States of America 2000 97 12 6693 6697 (Pubitemid 30412776)
14. Wells S. I., Francis D. A., Karpova A. Y., Dowhanick J. J., Benson J. D., Howley P. M., Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways EMBO Journal 2000 19 21 5762 5771
15. Jiang M., Milner J., Selective silencing of viral gene E6 and E7 expression in HPV-positive human cervical carcinoma cells using small interfering RNAs Methods in Molecular Biology 2005 292 401 420
16. Wang W., Sima N., Kong D., Luo A., Gao Q., Liao S., Li W., Han L., Wang J., Wang S., Lu Y., Wang D., Xu G., Zhou J., Meng L., Ma D., Selective targeting of HPV-16 E6/E7 in cervical cancer cells with a potent oncolytic adenovirus and its enhanced effect with radiotherapy in vitro and vivo Cancer Letters 2010 291 1 67 75
17. Koivusalo R., Krausz E., Helenius H., Hietanen S., Chemotherapy compounds in cervical cancer cells primed by reconstitution of p53 function after short interfering RNA-mediated degradation of human papillomavirus 18 E6 mRNA: opposite effect of siRNA in combination with different drugs Molecular Pharmacology 2005 68 2 372 382 (Pubitemid 41058301)
18. Gunawardana D. H., Basser R. L., Davis I. D., Cebon J., Mitchell P., Underhill C., Kilpatrick T. J., Reardon K., Green M. D., Bardy P., Amor P., Crump D., Ng S., Nation R. L., Begley C. G., A phase I study of recombinant human leukemia inhibitory factor in patients with advanced cancer Clinical Cancer Research 2003 9 6 2056 2065 (Pubitemid 36687625)
19. Stahl N., Boulton T. G., Farruggella T., Ip N. Y., Davis S., Witthuhn B. A., Quelle F. W., Silvennoinen O., Barbieri G., Pellegrini S., Ihle J. N., Yancopoulos G. D., Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 receptor components Science 1994 263 5143 92 95 (Pubitemid 24076263)
20. Megeney L. A., Perry R. L., LeCouter J. E., Rudnicki M. A., bFGF and LIF signaling activates STAT3 in proliferating myoblasts Developmental Genetics 1996 19 2 139 145 (Pubitemid 26391252)
21. Abell K., Bilancio A., Clarkson R. W., Tiffen P. G., Altaparmakov A. I., Burdon T. G., Asano T., Vanhaesebroeck B., Watson C. J., Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition Nature Cell Biology 2005 7 4 392 398 (Pubitemid 40533129)
22. Yasumoto S., Taniguchi A., Sohma K., Epidermal growth factor (EGF) elicits down-regulation of human papillomavirus type 16 (HPV-16) E6/E7 mRNA at the transcriptional level in an EGF-stimulated human keratinocyte cell line: functional role of EGF-responsive silencer in the HPV-16 long control region Journal of Virology 1991 65 4 2000 2009
23. Zur Hausen H., Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis Journal of the National Cancer Institute 2000 92 9 690 698 (Pubitemid 30365529)
24. Kyo S., Inoue M., Nishio Y., Nakanishi K., Akira S., Inoue H., Yutsudo M., Tanizawa O., Hakura A., NF-IL6 represses early gene expression of human papillomavirus type 16 through binding to the noncoding region Journal of Virology 1993 67 2 1058 1066 (Pubitemid 23032086)
25. Iglesias M., Plowman G. D., Woodworth C. D., Interleukin-6 and interleukin-6 soluble receptor regulate proliferation of normal, human papillomavirus-immortalized, and carcinoma-derived cervical cells in vitro American Journal of Pathology 1995 146 4 944 952
26. Rorke E. A., Zhang D., Choo C. K., Eckert R. L., Jacobberger J. W., TGF- -mediated cell cycle arrest of HPV16-immortalized human ectocervical cells correlates with decreased E6/E7 mRNA and increased p53 and p21(WAF-1) expression Experimental Cell Research 2000 259 1 149 157
27. Nindl I., Steenbergen R. D., Schurek J. O., Meijer C. J., Van Der Valk P., Snijders P. J. F., Assessment of TGF- 1-mediated growth inhibition of HPV-16- and HPV-18-transfected foreskin keratinocytes during and following immortalization Archives of Dermatological Research 2003 295 7 297 304 (Pubitemid 38058233)
28. Arany I., Grattendick K. J., Whitehead W. E., Ember I. A., Tyring S. K., A functional interferon regulatory factor-1 (IRF-1)-binding site in the upstream regulatory region (URR) of human papillomavirus type 16 Virology 2003 310 2 280 286 (Pubitemid 37487628)
29. Kim K. Y., Blatt L., Taylor M. W., The effects of interferon on the expression of human papillomavirus oncogenes Journal of General Virology 2000 81 3 695 700 (Pubitemid 30105499)
30. Gao W., Thompson L., Zhou Q., Putheti P., Fahmy T. M., Strom T. B., Metcalfe SU. M., Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6 Cell Cycle 2009 8 9 1444 1450
31. Pollard J. W., Tumour-educated macrophages promote tumour progression and metastasis Nature Reviews Cancer 2004 4 1 71 78 (Pubitemid 38082155)
32. Patterson B. K., Tjernlund A., Andersson J., Endogenous inhibitors of HIV: potent anti-HIV activity of leukemia inhibitory factor Current Molecular Medicine 2002 2 8 713 722 (Pubitemid 35385971)
33. Shukla S., Shishodia G., Mahata S., Hedau S., Pandey A., Bhambhani S., Batra S., Basir S. F., Das B. C., Bharti A. C., Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection Molecular Cancer 2010 9 282