A randomized trial of standard-dose versus half-dose rabeprazole, clarithromycin, and amoxicillin in the treatment of Helicobacter pylori infection

European Journal of Gastroenterology and Hepatology

Volumn 23, Issue 10, 2011, Pages 865-870

  Mansour, Nabil M ^a   Hashash, Jana G ^a   El Halabi, Mustapha ^a   Ghaith, Ola ^a   Maasri, Karim ^a   Sukkarieh, Ismail ^a   Malli, Ahmad ^a   Sharara, Ala I ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

adverse events; dyspepsia; eradication; gastritis

Indexed keywords

AMOXICILLIN; CARBON 14; CLARITHROMYCIN; RABEPRAZOLE;

ADULT; ARTICLE; CLINICAL TRIAL; DRUG COST; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SAFETY; ERADICATION THERAPY; FEMALE; HELICOBACTER INFECTION; HUMAN; INTENTION TO TREAT ANALYSIS; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; NAUSEA; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZATION; STANDARD; TREATMENT DURATION; UREA BREATH TEST;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ADULT; AMOXICILLIN; ANTI-BACTERIAL AGENTS; CHRONIC DISEASE; CLARITHROMYCIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED;

EID: 80052668752     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/MEG.0b013e3283496502     Document Type: Article

References (29)

1. Everhart JE. Recent developments in the epidemiology of Helicobacter pylori. Gastroenterol Clin North Am 2000; 29:559-578.
2. Labenz J, Borsch G. Evidence for the essential role of Helicobacter pylori in gastric ulcer disease. Gut 1994; 35:19-22. (Pubitemid 24059465)
3. Bechi P, Balzi M, Becciolini A, Maugeri A, Raggi CC, Amorosi A, Dei R. Helicobacter pylori and cell proliferation of the gastric mucosa: possible implications for gastric carcinogenesis. Am J Gastroenterol 1996; 91:271-276. (Pubitemid 26067334)
4. Tytgat GN. Peptic ulcer and Helicobacter pylori: eradication and relapse. Scand J Gastroenterol Suppl 1995; 210:70-72.
5. Solcia E, Villani L, Fiocca R, Luinetti O, Boldorini R, Trespi E, Perego M. Effects of eradication of Helicobacter pylori on gastritis in duodenal ulcer patients. Scand J Gastroenterol Suppl 1994; 201:28-34. (Pubitemid 24165471)
6. Chey WD, Wong BC. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol 2007; 102:1808-1825. (Pubitemid 47206706)
7. Malfertheiner P, Megraud F, O'Morain C, Hungin AP, Jones R, Axon A, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht 2-2000 consensus report. Aliment Pharmacol Ther 2002; 16:167-180. (Pubitemid 34146357)
8. Graham DY, Fischbach L. Helicobacter pylori treatment in the era of increasing antibiotic resistance. Gut 2010; 59:1143-1153.
9. Hsu PI, Lai KH, Wu CJ, Tseng HH, Tsay FW, Peng NJ, et al. High-dose versus low-dose esomeprazole-based triple therapy for Helicobacter pylori infection. Eur J Clin Invest 2007; 37:724-730. (Pubitemid 47256175)
10. Van der Wouden EJ, van Zwet AA, Vosmaer GD, Oom JA, de Jong A, Kleibeuker JH. Rapid increase in the prevalence of metronidazole-resistant Helicobacter pylori in the Netherlands. Emerg Infect Dis 1997; 3:385-389. (Pubitemid 127431704)
11. Sharara AI, Chedid M, Araj GF, Barada KA, Mourad FH. Prevalence of Helicobacter pylori resistance to metronidazole, clarithromycin, amoxycillin and tetracycline in Lebanon. Int J Antimicrob Agents 2002; 19:155-158. (Pubitemid 34168177)
12. Soweid AM, Haidar CN, Farshoukh L, Moukhachen OE, Mourad FH, Barada KA. Efficacy and safety of a ten-day Helicobacter pylori eradication regimen with rabeprazole, amoxicillin and clarithromycin. Am J Gastroenterol 2003; 98 (s9):S39-S39.
13. Ellenrieder V, Fensterer H, Waurick M, Adler G, Glasbrenner B. Influence of clarithromycin dosage on pantoprazole combined triple therapy for eradication of Helicobacter pylori. Aliment Pharmacol Ther 1998; 12:613-618. (Pubitemid 28327957)
14. Kihira K, Satoh K, Saifuku K, Kawakami S, Fukazawa K, Ishino Y. Rabeprazole, amoxycillin and low-or high-dose clarithromycin for cure of Helicobacter pylori infection. Aliment Pharmacol Ther 2000; 14: 1083-1087. (Pubitemid 30618171)
15. Choi IJ, Jung HC, Choi KW, Kim JH, Ahn DS, Yang US, et al. Efficacy of low-dose clarithromycin triple therapy and tinidazole-containing triple therapy for Helicobacter pylori eradication. Aliment Pharmacol Ther 2002; 16: 145-151. (Pubitemid 34123875)
16. Cammarota G, Cianci R, Cannizzaro O, Martino A, Fedeli P, Lecca PG, et al. High-dose versus low-dose clarithromycin in 1-week triple therapy, including rabeprazole and levofloxacin, for Helicobacter pylori eradication. J Clin Gastroenterol 2004; 38:110-114. (Pubitemid 38134147)
17. Kuwayama H, Luk G, Yoshida S, Nakamura T, Kubo M, Uemura N, et al. Efficacy of a low-dose omeprazole-based triple-therapy regimen for Helicobacter pylori eradication independent of cytochrome P450 genotype: the Japanese MACH study. Clin Drug Investig 2005; 25:293-305. (Pubitemid 40806943)
18. Higuchi K, Maekawa T, Nakagawa K, Chouno S, Hayakumo T, Tomono N, et al. Efficacy and safety of Helicobacter pylori eradication therapy with omeprazole, amoxicillin and high-and low-dose clarithromycin in Japanese patients: a randomised, double-blind, multicentre study. Clin Drug Investig 2006; 26:403-414. (Pubitemid 43927054)
19. Keshavarz AA, Bashiri H, Rahbar M. Omeprazole-based triple therapy with low-versus high-dose of clarithromycin plus amoxicillin for H. pylori eradication in Iranian population. World J Gastroenterol 2007; 13:930-933. (Pubitemid 46470307)
20. Huang J, Hunt RH. The importance of clarithromycin dose in the management of Helicobacter pylori infection: a meta-analysis of triple therapies with a proton pump inhibitor, clarithromycin and amoxycillin or metronidazole. Aliment Pharmacol Ther 1999; 13:719-729. (Pubitemid 29276840)
21. Lind T, Veldhuyzen van Zanten S, Unge P, Spiller R, Bayerdorffer E, O'Morain C, et al. Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH I study. Helicobacter 1996; 1:138-144. (Pubitemid 126671139)
22. Bigard MA, Delchier JC, Riachi G, Thibault P, Barthelemy P. One-week triple therapy using omeprazole, amoxycillin and clarithromycin for the eradication of Helicobacter pylori in patients with non-ulcer dyspepsia: influence of dosage of omeprazole and clarithromycin. Aliment Pharmacol Ther 1998; 12:383-388. (Pubitemid 28182222)
23. De Boer WA, Tytgat GN. How to treat Helicobacter pylori infection-should treatment strategies be based on testing bacterial susceptibility? A personal viewpoint. Eur J Gastroenterol Hepatol 1996; 8:709-716. (Pubitemid 26241603)
24. De Boer WA, van Etten RJ, Lai JY, Schneeberger PM, van de Wouw BA, Driessen WM. Effectiveness of quadruple therapy using lansoprazole, instead of omeprazole, in curing Helicobacter pylori infection. Helicobacter 1996; 1:145-150. (Pubitemid 126671140)
25. Graham DY. A reliable cure for Helicobacter pylori infection? Gut 1995; 37:154-156.
26. Malfertheiner P, Megraud F, O'Morain C, Bell D, Bianchi Porro G, Deltenre M, et al. Current European concepts in the management of Helicobacter pylori infection: the Maastricht consensus report. The European Helicobacter Pylori Study Group (EHPSG). Eur J Gastroenterol Hepatol 1997; 9:1-2. (Pubitemid 27047348)
27. Graham DY, Lu H, Yamaoka Y. Therapy for Helicobacter pylori infection can be improved: sequential therapy and beyond. Drugs 2008; 68: 725-736. (Pubitemid 351550527)
28. Graham DY. Antibiotic resistance in Helicobacter pylori: implications for therapy. Gastroenterology 1998; 115:1272-1277. (Pubitemid 28485620)
29. Sasaki M, Ogasawara N, Utsumi K, Kawamura N, Kamiya T, Kataoka H, et al. Changes in 12-year first-line eradication rate of Helicobacter pylori based on triple therapy with proton pump inhibitor, amoxicillin and clarithromycin. J Clin Biochem Nutr 2010; 47:53-58.