FTY720 blocks egress of T cells in part by abrogation of their adhesion on the lymph node sinus

Journal of Immunology

Volumn 187, Issue 5, 2011, Pages 2244-2251

  Zhi, Liang ^a,b   Kim, Pilhan ^a,b,e   Thompson, Brian D ^a,b   Pitsillides, Costas ^a,b   Bankovich, Alexander J ^c,d   Yun, Seok Hyun ^a,b   Lin, Charles P ^a,b   Cyster, Jason G ^c,d   Wu, Mei X ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; FINGOLIMOD; PROTEIN G ALPHA I2; PROTEIN G ALPHA I3; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ADHESION; CELL TRANSPORT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; INTERNALIZATION; LYMPH NODE; LYMPH NODE SINUS; LYMPH VESSEL ENDOTHELIUM; LYMPHOCYTE MIGRATION; LYMPHOCYTOPENIA; MALE; MOUSE; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; T LYMPHOCYTE; WILD TYPE;

ANIMALS; CELL ADHESION; CELL SEPARATION; CHEMOTAXIS, LEUKOCYTE; FLOW CYTOMETRY; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; IMMUNOSUPPRESSIVE AGENTS; LYMPH NODES; MICE; MICE, KNOCKOUT; PROPYLENE GLYCOLS; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; T-LYMPHOCYTES;

EID: 80052655561     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1100670     Document Type: Article

References (35)

1. Brinkmann, V., A. Billich, T. Baumruker, P. Heining, R. Schmouder, G. Francis, S. Aradhye, and P. Burtin. 2010. Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat. Rev. Drug Discov. 9: 883-897.
2. Brinkmann, V., J. G. Cyster, and T. Hla. 2004. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am. J. Transplant. 4: 1019-1025. (Pubitemid 38868590)
3. Luo, Z. J., T. Tanaka, F. Kimura, and M. Miyasaka. 1999. Analysis of the mode of action of a novel immunosuppressant FTY720 in mice. Immunopharmacology 41: 199-207. (Pubitemid 29243822)
4. Matloubian, M., C. G. Lo, G. Cinamon, M. J. Lesneski, Y. Xu, V. Brinkmann, M. L. Allende, R. L. Proia, and J. G. Cyster. 2004. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427: 355-360. (Pubitemid 38133663)
5. Gräler, M. H., and E. J. Goetzl. 2004. The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. FASEB J. 18: 551-553.
6. Hale, J. J., W. Neway, S. G. Mills, R. Hajdu, C. Ann Keohane, M. Rosenbach, J. Milligan, G. J. Shei, G. Chrebet, J. Bergstrom, et al. 2004. Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720. Bioorg. Med. Chem. Lett. 14: 3351-3355. (Pubitemid 38624622)
7. Lo, C. G., Y. Xu, R. L. Proia, and J. G. Cyster. 2005. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J. Exp. Med. 201: 291-301. (Pubitemid 40189438)
8. Sinha, R. K., C. Park, I. Y. Hwang, M. D. Davis, and J. H. Kehrl. 2009. B lymphocytes exit lymph nodes through cortical lymphatic sinusoids by a mechanism independent of sphingosine-1-phosphate-mediated chemotaxis. Immunity 30: 434-446.
9. Pham, T. H., T. Okada, M. Matloubian, C. G. Lo, and J. G. Cyster. 2008. S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity 28: 122-133.
10. Rosen, H., and E. J. Goetzl. 2005. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat. Rev. Immunol. 5: 560-570. (Pubitemid 40961333)
11. Beals, C. R., C. B. Wilson, and R. M. Perlmutter. 1987. A small multigene family encodes Gi signal-transduction proteins. Proc. Natl. Acad. Sci. USA 84: 7886-7890. (Pubitemid 17162810)
12. Kim, S. Y., S. L. Ang, D. B. Bloch, K. D. Bloch, Y. Kawahara, C. Tolman, R. Lee, J. G. Seidman, and E. J. Neer. 1988. Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines. Proc. Natl. Acad. Sci. USA 85: 4153-4157.
13. Thompson, B. D., Y. Jin, K. H. Wu, R. A. Colvin, A. D. Luster, L. Birnbaumer, and M. X. Wu. 2007. Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling. J. Biol. Chem. 282: 9547-9555. (Pubitemid 47104623)
14. Jin, Y. Z., B. D. Thompson, Z. Y. Zhou, Y. Fu, L. Birnbaumer, and M. X. Wu. 2008. Reciprocal function of Galphai2 and Galphai3 in graft-versus-host disease. Eur. J. Immunol. 38: 1988-1998.
15. Rudolph, U., M. J. Finegold, S. S. Rich, G. R. Harriman, Y. Srinivasan, P. Brabet, G. Boulay, A. Bradley, and L. Birnbaumer. 1995. Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat. Genet. 10: 143-150.
16. Jin, Y., and M. X. Wu. 2008. Requirement of Galphai in thymic homing and early T cell development. Mol. Immunol. 45: 3401-3410.
17. Wu, M. X., J. F. Daley, R. A. Rasmussen, and S. F. Schlossman. 1995. Monocytes are required to prime peripheral blood T cells to undergo apoptosis. Proc. Natl. Acad. Sci. USA 92: 1525-1529.
18. Sanna, M. G., J. Liao, E. Jo, C. Alfonso, M. Y. Ahn, M. S. Peterson, B. Webb, S. Lefebvre, J. Chun, N. Gray, and H. Rosen. 2004. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J. Biol. Chem. 279: 13839-13848. (Pubitemid 38468916)
19. Kim, P., M. Puoris'haag, D. Côté, C. P. Lin, and S. H. Yun. 2008. In vivo confocal and multiphoton microendoscopy. J. Biomed. Opt. 13: 010501.
20. Novak, J., I. Georgakoudi, X. Wei, A. Prossin, and C. P. Lin. 2004. In vivo flow cytometer for real-time detection and quantification of circulating cells. Opt. Lett. 29: 77-79.
21. Georgakoudi, I., N. Solban, J. Novak, W. L. Rice, X. Wei, T. Hasan, and C. P. Lin. 2004. In vivo flow cytometry: a new method for enumerating circulating cancer cells. Cancer Res. 64: 5044-5047. (Pubitemid 39006514)
22. Dhabhar, F. S., A. H. Miller, B. S. McEwen, and R. L. Spencer. 1995. Effects of stress on immune cell distribution. Dynamics and hormonal mechanisms. J. Immunol. 154: 5511-5527.
23. Mandala, S., R. Hajdu, J. Bergstrom, E. Quackenbush, J. Xie, J. Milligan, R. Thornton, G. J. Shei, D. Card, C. Keohane, et al. 2002. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296: 346-349. (Pubitemid 34303689)
24. Jo, E., M. G. Sanna, P. J. Gonzalez-Cabrera, S. Thangada, G. Tigyi, D. A. Osborne, T. Hla, A. L. Parrill, and H. Rosen. 2005. S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chem. Biol. 12: 703-715. (Pubitemid 43142048)
25. Zhang, Y., M. J. Finegold, Y. Jin, and M. X. Wu. 2005. Accelerated transition from the double-positive to single-positive thymocytes in G alpha i2-deficient mice. Int. Immunol. 17: 233-243. (Pubitemid 40372646)
26. Hwang, I. Y., C. Park, and J. H. Kehrl. 2007. Impaired trafficking of Gnai2+/- and Gnai2-/- T lymphocytes: implications for T cell movement within lymph nodes. J. Immunol. 179: 439-448. (Pubitemid 46986560)
27. Grigorova, I. L., S. R. Schwab, T. G. Phan, T. H. Pham, T. Okada, and J. G. Cyster. 2009. Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells. Nat. Immunol. 10: 58-65.
28. Bajénoff, M., J. G. Egen, L. Y. Koo, J. P. Laugier, F. Brau, N. Glaichenhaus, and R. N. Germain. 2006. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25: 989-1001. (Pubitemid 44914055)
29. Halin, C., M. L. Scimone, R. Bonasio, J. M. Gauguet, T. R. Mempel, E. Quackenbush, R. L. Proia, S. Mandala, and U. H. Von Andrian. 2005. The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. Blood 106: 1314-1322. (Pubitemid 41129595)
30. Ledgerwood, L. G., G. Lal, N. Zhang, A. Garin, S. J. Esses, F. Ginhoux, M. Merad, H. Peche, S. A. Lira, Y. Ding, et al. 2008. The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics. Nat. Immunol. 9: 42-53. (Pubitemid 350286203)
31. Arnold, C. N., E. C. Butcher, and D. J. Campbell. 2004. Antigen-specific lymphocyte sequestration in lymphoid organs: lack of essential roles for alphaL and alpha4 integrin-dependent adhesion or Galphai protein-coupled receptor signaling. J. Immunol. 173: 866-873. (Pubitemid 38924260)
32. Huang, T. T., Y. Zong, H. Dalwadi, C. Chung, M. C. Miceli, K. Spicher, L. Birnbaumer, J. Braun, and R. Aranda. 2003. TCR-mediated hyper-responsiveness of autoimmune Galphai2(-/-) mice is an intrinsic naïve CD4(+) T cell disorder selective for the Galphai2 subunit. Int. Immunol. 15: 1359-1367. (Pubitemid 37369329)
33. Mullershausen, F., F. Zecri, C. Cetin, A. Billich, D. Guerini, and K. Seuwen. 2009. Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. Nat. Chem. Biol. 5: 428-434.
34. Lorenowicz, M. J., M. Fernandez-Borja, and P. L. Hordijk. 2007. cAMP signaling in leukocyte transendothelial migration. Arterioscler. Thromb. Vasc. Biol. 27: 1014-1022. (Pubitemid 46641986)
35. Wei, S. H., H. Rosen, M. P. Matheu, M. G. Sanna, S. K. Wang, E. Jo, C. H. Wong, I. Parker, and M. D. Cahalan. 2005. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat. Immunol. 6: 1228-1235. (Pubitemid 43045634)