Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes

Neuroscience Letters

Volumn 503, Issue 1, 2011, Pages 6-9

  Meena, Jairam ^a   Ojha, Rakesh ^a   Muruganandam, A V ^b   Krishnamurthy, Sairam ^a  

^a BANARAS HINDU UNIVERSITY   (India)

^b Natreon Inc   (India)

Author keywords

Asparagus racemosus; Cholinesterase; Competitive inhibition; Monoamine oxidase; Saponins

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; ASPARAGUS RACEMOSUS EXTRACT; CHOLINESTERASE; GALANTAMINE; HEXANE; METHANOL; MOCLOBIMIDE; MONOAMINE OXIDASE A INHIBITOR; PHYSOSTIGMINE; SAPONIN; SELEGILINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; IC 50; IN VITRO STUDY; MALE; MONOAMINERGIC SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOLVENT EXTRACTION;

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ACETYLTHIOCHOLINE; ANIMALS; BRAIN; BUTYRYLCHOLINESTERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; KINETICS; MALE; MICE; MICE, INBRED ICR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PLANT EXTRACTS;

EID: 80052651801     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.07.051     Document Type: Article

References (19)

1. Bhattacharya S.K., Bhattacharya A., Chakrabarti A. Adaptogenic activity of Siotone, a polyherbal formulation of Ayurvedic rasayanas. Indian J. Exp. Biol. 2004, 38:119-128.
2. Charles M., Mc Ewan J. Metabolism of amino acids and amines, monoamine oxidase (human serum/plasma and rabbit serum). Methods in Enzymology 1971, vol. 18B:686-698. Academic Press, New York and London.
3. Cummings J.L. The role of cholinergic agents in the management of behavioral disturbances in Alzheimer's disease. Int. J. Neuropsychopharmacol. 2000, 3:21-29.
4. Dahanukar S.A., Kulkarni R.A., Rege N.N. Pharmacology of medicinal plants and natural products. Indian J. Pharmacol. 2000, 32:S81-S118.
5. Ellman G., Courtney K.D., Andres J.V., Featherstone R. A new and rapid colorimetric determination of acetyl cholinesterase activity. Biochem. Pharmacol. 1961, 7:88-95.
6. Giacobini E., Cholinesterases New roles in brain function and in Alzheimer's disease. Neurochem. Res. 2003, 28:515-522.
7. Hayes P.Y., Jahidin A.H., Lehmann R.P., Penman K., Kitching W., De Voss J.J. Structural revision of Shatavarin I and IV, the major components from the roots of A. racemosus. Tetrahedron Lett. 2006, 47:6965-6969.
8. Liebowitz M.R., Hollander E., Schneier F., Campeas R., Welkowitz L., Hatterer J., Fallon B. Reversible and irreversible monoamine oxidase inhibitors in other psychiatric disorders. Acta Psychiatr. Scand. Suppl. 1990, 360:29-34.
9. Lineweaver H., Burk D. The determination of enzyme dissociation constants. J. Am. Chem. Soc. 1934, 56:65846.
10. Lowry O.H., Rosebrough N.J., Farr A.N., Randall R.J. Protein measurement with Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
11. Nag M., Nandy N. Serotonin and benzylamine oxidation by type A and B MAO of rat brain in presence of organophosphate pesticides. Indian J. Exp. Biol. 2001, 39(8):802-806.
12. Naoi M., Nagatsu T. Quinoline and quininaldines as naturally occurring inhibitors specific for type A monoamine oxidase. Life Sci. 1978, 40:1075-1082.
13. Ojha R., Sahu A.N., Muruganandam A.V., Singh G.K., Sairam K. Asparagus racemosus enhances memory and protects against amnesia in rodent models. Brain Cogn. 2010, 74:1-9.
14. Overstreet D.H., Russell R.W., Helps S.C., Messenger M. Selective breeding for sensitivity to the anti-cholinesterase DFP. Psychopharmacology 1979, 65:15-20.
15. Overstreet D.H., Russell R., Crocker A., Schiller G. Selective breeding for differences in cholinergic function: pre-postsynaptic mechanisms involved in sensitivity to the anti cholinesterase DFP. Brain Res. 1984, 294:327-332.
16. Packer S., Berman S.A. Serotonin syndrome precipitated by the monoamine oxidase inhibitor linezolid. Am. J. Psychiatry 2007, 164:346-347.
17. Quitkin F.M., Stewart J.W., Mc Grath P.J., Tricamo E., Rabkin J.G., Ocepek-Welikson K., Nunes E., Harrison W., Klein D.F. Columbia atypical depression. A subgroup of depressives with better response to MAOI than to tricyclic antidepressants or placebo. Br. J. Psychiatry Suppl. 1993, 21:30-34.
18. Singh G.K., Garabadu D., Muruganandam A.V., Joshi V.K., Krishnamurthy S. Antidepressant activity of Asparagus racemosus in rodent models. Pharmacol. Biochem. Behav. 2009, 91:283-290.
19. Wilcock G.K., Esiri M.M., Bowen D.M., Smith C.C. Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities. J. Neurol. Sci. 1982, 57:407-417.