Synthesis and evaluation of furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline as anticancer and multidrug resistance reversal agents

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5934-5938

  Zou, Zhi Hong ^a,b   Lan, Xiao Bu ^a,c   Qian, Hai ^a   Huang, Wen Long ^a   Li, Yun Man ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SOUTHEAST UNIVERSITY   (China)

^c GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Anticancer; Multidrug resistance; Nitric oxide; Tetrahydroisoquinoline

Indexed keywords

DOXORUBICIN; NITRIC OXIDE DONOR; TETRAHYDROISOQUINOLINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN K 562; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOXORUBICIN; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; HUMANS; INHIBITORY CONCENTRATION 50; K562 CELLS; MOLECULAR TARGETED THERAPY; NITRIC OXIDE; P-GLYCOPROTEINS; RHODAMINE 123; TETRAHYDROISOQUINOLINES; TRIAZOLES; VERAPAMIL;

EID: 80052605854     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.077     Document Type: Article

References (22)

1. R.L. Juliano, and V. Ling Biochim. Biophys. Acta 455 1976 152
2. F.J. Sharom Pharmacogenomics 9 2008 105
3. U.A. Germann, I. Pastan, and M.M. Gottesman Semin. Cell Biol. 4 1993 63
4. Y. Li, H.B. Zhang, W.L. Huang, and Y.M. Li Bioorg. Med. Chem. Lett. 18 2008 3652
5. R. Krishna, and L.D. Mayer Eur. J. Pharm. Sci. 11 2000 265
6. W. Klinkhammer, H. Muller, C. Globisch, I.K. Pajeva, and M. Wiese Bioorg. Med. Chem. 17 2009 2524
7. Thomson-Pharma-Database. http://www.thomson-pharma.com, updated to 10 march, 2011.
8. D.R. Siemens, J.P. Heaton, M.A. Adams, J. Kawakami, and C.H. Graham Urology 74 2009 878
9. S. Kotamraju, C.L. Williams, and B. Kalyanaraman Cancer Res. 67 2007 7386
10. D. Maksimovic-Ivanic, S. Mijatovic, L. Harhaji, D. Miljkovic, D. Dabideen, K. Fan Cheng, K. Mangano, G. Malaponte, Y. Al-Abed, M. Libra, G. Garotta, F. Nicoletti, and S. Stosic-Grujicic Mo.l Cancer Ther. 7 2008 510
11. R.W. Li, and Y.H. Zhang Acta Pharm. Sin. 36 2001 821
12. S. Moharram, A. Zhou, L.I. Wiebe, and E.E. Knaus J. Med. Chem. 47 2004 1840
13. R.H. Manske Chem Rev. 1942 1942 145
14. J.S. Buck J. Am. Chem. Soc. 56 1934 2799
15. W. Huang, L. He, and S. Peng Chin. J. Med. Chem. 9 1999 26
16. T. Mosmann J. Immunol. Methods 65 1983 55
17. J. Carmichael, W.G. DeGraff, A.F. Gazdar, J.D. Minna, and J.B. Mitchell Cancer Res. 47 1987 936
18. S.A. Jabbar, P.R. Twentyman, and J.V. Watson Br. J. Cancer 60 1989 523
19. E. Lambert, J.K. Rees, and P.R. Twentyman Leukemia 6 1992 1063
20. J.W. Lella Bull. Hist. Med. 75 2001 760
21. C. Ludescher, J. Thaler, D. Drach, J. Drach, M. Spitaler, C. Gattringer, H. Huber, and J. Hofmann Br. J. Haematol. 82 1992 161
22. M. Fontaine, W.F. Elmquist, and D.W. Miller Life Sci. 59 1996 1521